Search

CN-121971575-A - Traditional Chinese medicine composition for treating fibromyalgia syndrome as well as preparation method and application thereof

CN121971575ACN 121971575 ACN121971575 ACN 121971575ACN-121971575-A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular discloses a traditional Chinese medicine composition for treating fibromyalgia syndrome, a preparation method and application thereof, the traditional Chinese medicine composition is prepared from 12 raw medicinal materials including prepared fleece-flower root, fingered citron, radix pseudostellariae, suberect spatholobus stem, rose, chinese yam, white hyacinth bean, turmeric, lucid ganoderma, longan pulp, flos albiziae and date, and has the effects of soothing liver, strengthening spleen, nourishing blood, promoting blood circulation, calming heart, tranquilizing mind, and activating collaterals to relieve pain. The results of pharmacodynamic experimental study and clinical observation show that the traditional Chinese medicine composition can obviously relieve pain of patients, improve depression symptoms and can be used for treating fibromyalgia syndrome.

Inventors

  • GAO YUXI
  • WU FUYOU
  • QIN LIHONG

Assignees

  • 佳木斯大学

Dates

Publication Date
20260505
Application Date
20260402

Claims (9)

  1. 1. A traditional Chinese medicine composition for treating fibromyalgia syndrome is characterized by being prepared from 12 raw medicinal materials including radix polygoni multiflori preparata, fingered citron, radix pseudostellariae, caulis spatholobi, rose, chinese yam, white hyacinth bean, turmeric, lucid ganoderma, longan pulp, flos albiziae and jujube.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following traditional Chinese medicine components in parts by weight: 5-30 parts of prepared fleece-flower root, 5-20 parts of fingered citron, 5-30 parts of radix pseudostellariae, 5-30 parts of suberect spatholobus stem 3-15 Parts of rose, 5-30 parts of yam, 5-20 parts of white hyacinth bean and 5-15 parts of turmeric 5-20 Parts of lucid ganoderma, 5-20 parts of longan pulp, 5-15 parts of flos albiziae, and 3-15 parts of jujube.
  3. 3. The traditional Chinese medicine composition according to claim 2, which is characterized by being prepared from the following traditional Chinese medicine components in parts by weight: 10-20 parts of prepared fleece-flower root, 5-15 parts of fingered citron, 10-20 parts of radix pseudostellariae, and 10-25 parts of suberect spatholobus stem 5-10 Parts of rose, 10-20 parts of yam, 9-12 parts of white hyacinth bean and 6-12 parts of turmeric 9-15 Parts of lucid ganoderma, 9-15 parts of longan pulp, 6-12 parts of flos albiziae, and 5-10 parts of jujube.
  4. 4. The traditional Chinese medicine composition according to claim 3, which is prepared from the following traditional Chinese medicine components in parts by weight: 15 parts of prepared fleece-flower root, 10 parts of fingered citron, 15 parts of radix pseudostellariae, 20 parts of suberect spatholobus stem Rose 6 weight portions, yam 15 weight portions, white hyacinth bean 10 weight portions and turmeric 9 weight portions 12 Parts of lucid ganoderma, 12 parts of longan pulp, 9 parts of flos albiziae, and 6 parts of jujube.
  5. 5. A pharmaceutical product, characterized by being prepared from the traditional Chinese medicine composition according to any one of claims 1-4 as raw materials.
  6. 6. The pharmaceutical product according to claim 5, wherein the pharmaceutical product is one of an oral liquid, a tablet, a pill, a mixture, a capsule, a syrup, and a granule.
  7. 7. A method of preparing the pharmaceutical product of claim 5, comprising the steps of: (1) Taking 12 raw medicinal materials of prepared fleece-flower root, fingered citron, radix pseudostellariae, suberect spatholobus stem, rose, chinese yam, white hyacinth bean, turmeric, lucid ganoderma, longan pulp, albizia flower and jujube, cleaning and removing impurities, wherein the Chinese yam and turmeric are thoroughly moistened and cut into thick slices, the fingered citron is thoroughly moistened and cut into shreds, the white hyacinth bean is fried to be light yellow with focal spots by a clear frying method, and the jujube is stoned for later use; (2) Weighing the raw material decoction pieces processed in the prescription dosage step (1), adding 6-10 times of water, decocting and extracting for 2-3 times, each time for 0.5-2 hours, filtering, collecting and mixing the decoctions, concentrating under reduced pressure to relative density of 1.05-1.4 at 50-60 ℃ to obtain extract; (3) Adding pharmaceutically acceptable auxiliary materials into the extract obtained in the step (2), and preparing clinically acceptable dosage forms by using a conventional process.
  8. 8. The use of the Chinese medicinal composition according to claim 1 in the preparation of a medicament for treating fibromyalgia syndrome.
  9. 9. The use according to claim 8, wherein the treatment of fibromyalgia syndrome is a liver and kidney deficiency, liver depression and spleen deficiency, stasis and disturbance of the mind, with symptoms of dull pain or stinging around the body, unstable pain, listlessness, soreness of waist and knees, depressed mood, chest distress and hypochondriac distention, numbness of limbs, insomnia, palpitation, anxiety and amnesia.

Description

Traditional Chinese medicine composition for treating fibromyalgia syndrome as well as preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating fibromyalgia syndrome, and a preparation method and application thereof. Background Fibromyalgia syndrome (Fibromyalgia Syndrome, FMS), also known as fibromyalgia, is a chronic diffuse pain syndrome caused by central nervous sensory afferent treatment dysfunction. The core symptoms comprise chronic diffuse pain, sleep disorder or non-restorative sleep, fatigue and cognitive disorder, and are often accompanied with physical symptoms such as physical stiffness, paresthesia and the like and psychological symptoms such as anxiety, depression and the like. The prevalence rate of the disease reaches 1.3% -8%, the disease is better developed for the population of 40-60 years old, the female prevalence rate is obviously higher than that of men, and the disease is the second most rheumatic related disease next to osteoarthritis. Under the influence of social factors such as aging of population, increase of psychological pressure, increase of bad living habits and the like, the incidence rate of FMS (FMS) has a year-by-year rising trend, seriously influences the quality of life of patients, and has attracted extensive social attention. The etiology and pathogenesis of FMS is currently not completely understood, and it is widely believed that central sensitization is one of its primary mechanisms of pathogenesis, and other aspects such as neurotransmitter imbalance, abnormal neurological function, hypothalamic-pituitary-target gland axis abnormalities, etc. may also be associated with its pathogenesis. There are no satisfactory therapeutic drugs and treatment regimens for the treatment of FMS, and although there have been many drugs approved for the treatment of FMS, such as pregabalin, gabapentin (by modulating calcium channels, reducing central nervous system hyperexcitations), duloxetine, milnacipran (selective 5-hydroxytryptamine and norepinephrine reuptake inhibitors), etc., many patients terminate the treatment because of large individual differences in therapeutic effects, large side effects, and failure to tolerate or obtain substantial improvement. The medicine is also clinically used for relieving pain such as amitriptyline, cyclobenzaprine serving as a muscle relaxant, tramadol opioid and the like, and is also commonly used for clinic aiming at the psychological problems such as serious insomnia, depression, anxiety and the like which are often accompanied by the analgesic such as olanzapine, quetiapine and the like. The western medicines can only partially relieve symptoms and can not radically treat the fibromyalgia syndrome, and the curative effects of the medicines are different from person to person, so that the problems of side effects are more, and a plurality of patients can not obtain satisfactory clinical curative effects. Traditional Chinese medicine emphasizes the concept of overall and dialectical treatment, and performs systematic intervention on the core pathogenesis of fibromyalgia so as to relieve the pain and improve the accompanying symptoms such as fatigue, sleep, emotion and the like, so that the traditional Chinese medicine is expected to treat FMS. Although the Chinese medicine has no description of the disease name of "fibromyalgia", it can be classified into "arthralgia syndrome", "consumptive disease" and "depression syndrome" according to its clinical manifestations, it is also known that "peripheral arthralgia", "liver arthralgia", "tendons arthralgia", "qi arthralgia" and "muscular arthralgia" are used. The pathogenesis is mainly responsible for the internal injury of emotion, overstrain of the fatigue, liver qi stagnation, spleen failing to strengthen and transport, liver and kidney deficiency and the like, which is the complex syndrome of deficiency of the body, then qi and blood are in biochemical deficiency, unsmooth operation, pathological products such as qi stagnation, blood stasis, turbid phlegm and the like, blockage of channels and collaterals, formation of 'marked excess', and finally the coexistence of 'unRong pain' and 'unRong pain'. From the perspective of traditional Chinese medicine, common symptoms of fibromyalgia include liver depression and qi stagnation, qi deficiency and blood stasis, qi and blood deficiency, liver and kidney deficiency and the like. For treating the disease, the classic formulas such as bupleurum, liver soothing powder, ease powder, xuefu Zhuyu Tang and Guipi Tang are modified to be suitable for the treatment of the disease. At present, no Chinese patent medicine for treating fibromyalgia syndrome exists, so that a traditional Chinese medicine composition with definite curative effect is needed to enrich clinical medication choices. Disc