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CN-121971576-A - Composition for treating nervous headache and preparation method thereof

CN121971576ACN 121971576 ACN121971576 ACN 121971576ACN-121971576-A

Abstract

The invention provides a composition for treating nervous headache and a preparation method thereof, belonging to the technical field of medicines. Adding the Chinese medicinal powder into saline water for decoction after steam explosion treatment, filtering, standing filtrate to separate hydrochloric acid extract, adding filter residue into ethanol, adsorbing by a magnetic adsorbent, eluting and desorbing after magnet separation, recovering eluent to obtain alcohol extract, mixing and grinding the alcohol extract with the hydrochloric acid extract and flunarizine hydrochloride/nimodipine eutectic crystal, and filling the mixture into capsules to obtain the composition for treating the nervous headache. The invention treats the neuropathic migraine by combining traditional Chinese medicine and western medicine, realizes the treatment of both principal and secondary aspect of disease, has good effect and quick and durable effect.

Inventors

  • JIANG YAN
  • ZHAO JIA
  • GAO LILI
  • SUN YONGYE

Assignees

  • 养系列(山东)生物科技有限公司

Dates

Publication Date
20260505
Application Date
20260407

Claims (10)

  1. 1. A preparation method of a composition for treating nervous headache is characterized by adding traditional Chinese medicine powder into saline water for decoction after steam explosion treatment, filtering, standing filtrate to separate out hydrochloric acid extract, adding filter residues into ethanol for adsorption by a magnetic adsorbent, eluting and desorbing after magnet separation, recovering eluent to obtain alcohol extract, mixing and grinding the alcohol extract with hydrochloric acid extract and flunarizine hydrochloride/nimodipine eutectic crystal, and filling the mixture into capsules to prepare the composition for treating nervous headache.
  2. 2. The method of manufacturing according to claim 1, comprising the steps of: S1, dissolving flunarizine hydrochloride in ethanol to form a transparent solution, adding nimodipine, stirring and dissolving, filtering, recovering part of ethanol under reduced pressure, volatilizing in an opening, and drying to obtain flunarizine hydrochloride/nimodipine eutectic; s2, performing steam explosion treatment on the traditional Chinese medicine powder, drying and collecting the powder; S3, adding the powder into water, adding salt, decocting, filtering while the powder is hot, standing, cooling, crystallizing, performing suction filtration, repeatedly extracting filter residues, combining suction filtration solids, washing and drying to obtain a hydrochloric acid extract; S4, adding the dried filter residue obtained in the step 3 into ethanol, adding a magnetic adsorbent, heating by microwaves, stirring, extracting and adsorbing, separating by a magnet, eluting and desorbing solids, collecting an eluent, recovering the eluent, washing a product, and drying to obtain an alcohol extract; S5, mixing and grinding the flunarizine hydrochloride/nimodipine eutectic crystal, the hydrochloric acid extract and the alcohol extract, and encapsulating to prepare the composition for treating the nervous headache.
  3. 3. The preparation method according to claim 2, wherein the mass ratio of the flunarizine hydrochloride to the nimodipine in the step S1 is 1:6-10.
  4. 4. The preparation method of claim 2, wherein the traditional Chinese medicine powder in the step S2 is prepared by cleaning, mixing, drying and crushing the following raw materials, by weight, 10-15 parts of ligusticum wallichii, 3-5 parts of eucommia ulmoides leaves, 10-15 parts of wild chrysanthemum, 3-5 parts of eucommia ulmoides, 20-30 parts of gastrodia elata, 5-10 parts of angelica sinensis, 5-10 parts of radix bupleuri, 3-5 parts of radix curcumae, 3-5 parts of notopterygium roots and 2-7 parts of dried orange peel, wherein the conditions of the steam explosion treatment are that the explosion pressure is 0.5-0.8MPa, the maintenance pressure time is 100-200S and the moisture content is 30-50%.
  5. 5. The preparation method according to claim 2, wherein in the step S3, the solid-to-liquid ratio of the powder to the water is 1:5-10g/mL, the NaCl concentration of the system after adding the salt is 4-8wt%, the time of the decoction is 1-3h, and the number of times of the repeated extraction is 1-2.
  6. 6. The preparation method of claim 2, wherein in the step S4, the solid-to-liquid ratio of the filter residue to the ethanol is 1:3-5g/mL, the mass ratio of the filter residue to the magnetic adsorbent is 10:0.5-1.5, the microwave heating temperature is 40-60 ℃, the microwave power is 300-500W, the stirring, extracting and adsorbing time is 30-60min, and the eluent adopted in the eluting is a mixed solution of glacial acetic acid, methanol and ethyl acetate, and the volume ratio is 1-2:4-6:2-3.
  7. 7. The method according to claim 2, wherein the magnetic adsorbent in step S4 is prepared by the following method: Adding graphene oxide into water to obtain a dispersion liquid, adding ferric chloride and ferrous chloride, performing ultrasonic dispersion uniformly, adding ammonia water, performing heating and stirring reaction, performing magnet separation, washing and drying to obtain magnetic graphene oxide; Adding magnetic graphene oxide into Tris-HCl solution, adding dopamine hydrochloride, heating and stirring for reaction, separating by a magnet, washing, adding solid into water, adding tannic acid, stirring and mixing, separating by a magnet, washing, and drying to obtain modified graphene oxide; Adding nano silicon dioxide into ethanol, adding an epoxy silane coupling agent, heating and stirring for reaction, centrifuging, washing and drying to obtain modified nano silicon dioxide; And T4, adding the modified graphene oxide and the modified nano silicon dioxide into water, stirring for reaction, and spray drying to obtain the magnetic adsorbent.
  8. 8. The preparation method of the modified graphene oxide, the dopamine hydrochloride and the tannic acid are characterized in that the mass ratio of graphene oxide to ferric chloride to ferrous chloride in the step T1 is 1-2:1.62:3.24, the temperature of the heating and stirring reaction is 75-85 ℃ and the time is 1-2h, the concentration of the Tris-HCl solution in the step T2 is 40-60mmol/L, the mass ratio of the magnetic graphene oxide to the dopamine hydrochloride to the tannic acid is 10:2-4:1-2, the temperature of the heating and stirring reaction is 40-50 ℃ and the time is 3-5h, the stirring and mixing time is 3-5h, the average particle size of the nano silicon dioxide in the step T3 is 100-200nm, the mass ratio of the nano silicon dioxide to the epoxy silane coupling agent is 10:0.5-1, the temperature of the heating and stirring reaction is 40-50 ℃ and the time is 1-3h, and the mass ratio of the modified graphene oxide to the modified silicon dioxide in the step T4 is 2-4:4-8-20 h.
  9. 9. The preparation method according to claim 2, wherein the mass ratio of the flunarizine hydrochloride/nimodipine eutectic, the hydrochloric acid extract and the alcohol extract in the step S5 is 1-2:3-5:2-5.
  10. 10. A composition for the treatment of nervous headache prepared by the method of any one of claims 1 to 9.

Description

Composition for treating nervous headache and preparation method thereof Technical Field The invention relates to the technical field of medicines, in particular to a composition for treating nervous headache and a preparation method thereof. Background Headache is a very common symptom in clinic, and mainly occurs in various acute or chronic diseases, especially in the nervous system, and has the defects of high incidence and common recurrence. Nervous headache is a common clinical type among headaches, and is also called as mental headache, and most people in modern society can have nervous headache, so that the nervous headache has serious influence on life and work of people. Most of the causes of the nervous headache are caused by mental stress, the main symptoms are sustained headache and oppression, the nervous headache can drive the whole head and nerves to generate negative emotion, the normal life of a patient is influenced, the disease is easy to repeatedly occur, the disease course and the treatment period are long, the physical and mental health of the patient is seriously influenced, and the life quality of the patient is reduced. The current methods for treating nervous headache are various, including surgical treatment, drug treatment, acupuncture, massage, high-pressure oxygen inhalation, needle and drug combination method, etc. to relieve clinical symptoms and alleviate pain of patients. The efficacy, safety and patient compliance of drug therapy are relatively more advantageous. The traditional Chinese medicine has more treatment methods for the nervous headache, and the nervous headache is generally classified into headache with liver yang hyperactivity, headache with deficiency of qi and blood and headache with blockage of phlegm stasis according to dialectical methods. The Chinese medicine for treating nervous headache mainly comprises a Chinese medicine compound preparation such as a gastrodia tuber uncaria drink or granule, blood nourishing and brain refreshing granules, taiji Tongtian oral liquid, tongqiaohua decoction, tongqiaoling capsule, pain relieving and calming granules and the like. The traditional Chinese medicine mainly takes the functions of activating blood circulation to remove blood stasis, nourishing blood, clearing heart fire, dredging orifices and relieving pain as a treatment method, and achieves a certain clinical curative effect. However, the medicine has the problems of poor medicine effect, long medicine taking time, low patient compliance and the like. Therefore, there is a need to develop a composition for the treatment of neuropathic headache that is not only more desirable in terms of both therapeutic efficacy and safety, but also effectively avoids recurrence and has a relatively short onset of action, thereby improving patient compliance. Disclosure of Invention The invention aims to provide a composition for treating nervous headache and a preparation method thereof, and the composition treats the nervous migraine by a method combining traditional Chinese medicine and western medicine, so that the composition can treat both principal and secondary aspect of disease, has good effect, takes effect rapidly and permanently, can effectively avoid relapse, reduces the consumption of western medicine, reduces side effects and improves compliance of patients. The technical scheme of the invention is realized as follows: The invention provides a preparation method of a composition for treating nervous headache, which comprises the steps of performing steam explosion treatment on traditional Chinese medicine powder, adding the traditional Chinese medicine powder into saline water, decocting, filtering, standing filtrate to separate out hydrochloric acid extract, adding filter residues into ethanol, adsorbing the filter residues through a magnetic adsorbent, eluting and desorbing the filter residues after magnet separation, recovering eluent to obtain alcohol extract, mixing and grinding the alcohol extract with hydrochloric acid extract and flunarizine hydrochloride/nimodipine eutectic crystal, and filling the mixture into capsules to prepare the composition for treating nervous headache. As a further improvement of the invention, the method comprises the following steps: S1, dissolving flunarizine hydrochloride in ethanol to form a transparent solution, adding nimodipine, stirring and dissolving, filtering, recovering part of ethanol under reduced pressure, volatilizing in an opening, and drying to obtain flunarizine hydrochloride/nimodipine eutectic; The flunarizine hydrochloride has selective antagonism to calcium ions, can resist vasospasm, epilepsy and cerebral vasoconstriction and can relieve headache symptoms, but the single use of the flunarizine hydrochloride has the advantages of long treatment course, large dosage, long-term administration, unstable curative effect, easy relapse of illness, and symptoms such as gastrointestinal reaction, nervous symptom