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CN-121971577-A - Traditional Chinese medicine formula for treating hypertension and preparation method thereof

CN121971577ACN 121971577 ACN121971577 ACN 121971577ACN-121971577-A

Abstract

The invention relates to a traditional Chinese medicine formula for treating hypertension and a preparation method thereof, and relates to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine formula for treating hypertension comprises, by weight, 25-35 parts of mother-of-pearl, 25-35 parts of radix cynanchi, 10-20 parts of concha haliotidis, 10-20 parts of semen cassiae, 10-20 parts of radix salviae miltiorrhizae, 10-15 parts of rhodiola rosea, 10-15 parts of radix puerariae, 8-12 parts of uncaria, 8-12 parts of radix curcumae, 8-12 parts of ligusticum wallichii, 8-12 parts of apocynum venetum, 8-12 parts of rhizoma alismatis, 8-12 parts of herba taxilli and the like. The invention mainly optimizes the composition and dosage of the traditional Chinese medicine formula and matches with the traditional Chinese medicine extraction process under proper parameters, thereby obviously prolonging the effective period of the traditional Chinese medicine composition for reducing the blood pressure, reducing the medication frequency of patients with hypertension to a certain extent, relieving the economic pressure of the patients and having wide clinical application prospect.

Inventors

  • SUN LONGFEI
  • Yu Su Fu River Abulaiti
  • YAO LAN
  • GUO LONGLONG
  • AN DONGQING

Assignees

  • 新疆医科大学第四附属医院

Dates

Publication Date
20260505
Application Date
20260408

Claims (10)

  1. 1. The traditional Chinese medicine formula for treating hypertension is characterized by comprising the following raw materials in parts by weight: 25-35 parts of mother-of-pearl, 25-35 parts of radix platycodi, 10-20 parts of concha haliotidis, 10-20 parts of semen cassiae, 10-20 parts of radix salviae miltiorrhizae, 10-15 parts of rhodiola rosea, 10-15 parts of radix puerariae, 8-12 parts of uncaria, 8-12 parts of radix curcumae, 8-12 parts of ligusticum wallichii, 8-12 parts of apocynum venetum, 8-12 parts of rhizoma alismatis, 8-12 parts of mistletoe, 8-12 parts of leonurus, 8-12 parts of new tower flowers and 3-7 parts of liquorice.
  2. 2. The traditional Chinese medicine formula for treating hypertension according to claim 1, wherein the sum of parts by weight of the mother-of-pearl and the radix stemonae is A and the sum of parts by weight of the concha haliotidis, the semen cassiae and the radix salviae miltiorrhizae is B=4:3.
  3. 3. The traditional Chinese medicine formula for treating hypertension according to claim 1, wherein the traditional Chinese medicine formula for treating hypertension comprises the following raw materials in parts by weight: 30 parts of mother-of-pearl, 30 parts of radix platycodi, 15 parts of concha haliotidis, 15 parts of semen cassiae, 15 parts of radix salviae miltiorrhizae, 12 parts of rhodiola rosea, 12 parts of radix puerariae, 10 parts of uncaria, 10 parts of radix curcumae, 10 parts of ligusticum wallichii, 10 parts of apocynum venetum, 10 parts of rhizoma alismatis, 10 parts of mistletoe, 10 parts of motherwort, 10 parts of new tower flower and 5 parts of liquorice.
  4. 4. A method for preparing a traditional Chinese medicine formula for treating hypertension according to any one of claims 1-3, which is characterized in that the method for preparing the traditional Chinese medicine formula for treating hypertension comprises the following steps: pulverizing Concha Margaritifera and radix Serratae, mixing, adding into mixed solvent composed of absolute ethanol, ethyl acetate and n-hexane, and reflux extracting to obtain first extract; Adding the rest components in the traditional Chinese medicine formula into water for second reflux extraction to obtain a second extract; Mixing the first extract and the second extract to obtain the traditional Chinese medicine formula for treating hypertension.
  5. 5. The method for preparing a traditional Chinese medicine formula for treating hypertension according to claim 4, wherein the mixed solvent is composed of ethyl acetate, absolute ethyl alcohol and n-hexane in a volume ratio of 70:23:7.
  6. 6. The method for preparing a traditional Chinese medicine formula for treating hypertension according to claim 4, wherein the addition amount of the mixed solvent is 5-10 times of the total weight of the mother-of-pearl and the radix stemonae.
  7. 7. The method for preparing a traditional Chinese medicine formula for treating hypertension according to claim 4, wherein the working condition parameters of the first reflux extraction comprise normal pressure, temperature of 90-95 ℃ and time of 60-90 min, and the times of 1-3 times.
  8. 8. The method for preparing a traditional Chinese medicine formula for treating hypertension according to claim 4, wherein the second reflux extraction mode is reduced pressure reflux extraction, and the working condition parameters of the reduced pressure reflux extraction comprise that the pressure is 35-42kPa, the temperature is 77-85 ℃, the time is 60-90 min, and the times are 1-3.
  9. 9. The method for preparing the traditional Chinese medicine formula for treating hypertension according to claim 8, wherein the working condition parameters of the reduced pressure reflux extraction comprise the pressure of 40kPa, the temperature of 82 ℃ and the time of 60-90 min, and the times of 1-3 times.
  10. 10. The method for preparing a traditional Chinese medicine formula for treating hypertension according to claim 4, wherein the weight of the water added during the second reflux extraction is 8-12 times of the total weight of each traditional Chinese medicine.

Description

Traditional Chinese medicine formula for treating hypertension and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for treating hypertension and a preparation method thereof. Background Hypertension is a common chronic cardiovascular disease, and is mainly characterized by a sustained elevation of systemic arterial blood pressure, and can be accompanied by functional or organic impairment of organs such as heart, brain, kidneys and the like. The existing treatment of hypertension mainly depends on drug treatment, and commonly used antihypertensive drugs comprise diuretics, calcium channel blockers, angiotensin Converting Enzyme Inhibitors (ACEI), angiotensin II receptor Antagonists (ARB) and the like. Although these western medicines are able to control blood pressure to some extent, there are some limitations. For example, the efficacy after stopping the drug has a short effective period, which results in a high frequency of drug administration, which not only brings inconvenience to the life of the patient, but also aggravates the economic burden of the patient. Disclosure of Invention In order to solve the problems, the invention provides a traditional Chinese medicine formula for treating hypertension and a preparation method thereof. In a first aspect, the invention provides a traditional Chinese medicine formula for treating hypertension and a preparation method thereof, wherein the traditional Chinese medicine formula for treating hypertension comprises the following raw materials in parts by weight: 25-35 parts of mother-of-pearl, 25-35 parts of radix platycodi, 10-20 parts of concha haliotidis, 10-20 parts of semen cassiae, 10-20 parts of radix salviae miltiorrhizae, 10-15 parts of rhodiola rosea, 10-15 parts of radix puerariae, 8-12 parts of uncaria, 8-12 parts of radix curcumae, 8-12 parts of ligusticum wallichii, 8-12 parts of apocynum venetum, 8-12 parts of rhizoma alismatis, 8-12 parts of mistletoe, 8-12 parts of leonurus, 8-12 parts of new tower flowers and 3-7 parts of liquorice. Further, the sum A of the weight parts of the mother-of-pearl and the radix stemonae and the sum B of the weight parts of the concha haliotidis, the semen cassiae and the radix salviae miltiorrhizae satisfy the following relation that A is B=4:3. Further, the traditional Chinese medicine formula for treating hypertension comprises the following raw materials in parts by weight: 30 parts of mother-of-pearl, 30 parts of radix platycodi, 15 parts of concha haliotidis, 15 parts of semen cassiae, 15 parts of radix salviae miltiorrhizae, 12 parts of rhodiola rosea, 12 parts of radix puerariae, 10 parts of uncaria, 10 parts of radix curcumae, 10 parts of ligusticum wallichii, 10 parts of apocynum venetum, 10 parts of rhizoma alismatis, 10 parts of mistletoe, 10 parts of motherwort, 10 parts of new tower flower and 5 parts of liquorice. In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine formula for treating hypertension according to the first aspect, as shown in fig. 1, comprising the following steps: pulverizing Concha Margaritifera and radix Serratae, mixing, adding into mixed solvent composed of absolute ethanol, ethyl acetate and n-hexane, and reflux extracting to obtain first extract; Adding the rest components in the traditional Chinese medicine formula into water for second reflux extraction to obtain a second extract; Mixing the first extract and the second extract to obtain the traditional Chinese medicine formula for treating hypertension. Further, the mixed solvent consists of ethyl acetate, absolute ethyl alcohol and n-hexane in a volume ratio of 70:23:7. Further, the addition amount of the mixed solvent is 5-10 times of the total weight of the mother-of-pearl and the radix platyphyllae. Further, the working condition parameters of the first reflux extraction include normal pressure, the temperature of 90-95 ℃ and the time of 60-90 min, and the times of 1-3 times. Further, the second reflux extraction mode is reduced pressure reflux extraction, and the working condition parameters of the reduced pressure reflux extraction comprise that the pressure is 35-42kPa, the temperature is 77-85 ℃, the time is 60-90 min, and the times are 1-3 times. Further, the working condition parameters of the reduced pressure reflux extraction comprise that the pressure is 40kPa, the temperature is 82 ℃, the time is 60-90 min, and the times are 1-3 times. Further, when the second reflux extraction is performed, the added weight of the water is 8-12 times of the total weight of each traditional Chinese medicine. Compared with the prior art, the technical scheme provided by the embodiment of the invention has at least the following advantages: The embodiment of the invention provides a traditional Chinese medicine formula for treating hypertension and a