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CN-121971581-A - Life-prolonging and health-preserving pharmaceutical composition

CN121971581ACN 121971581 ACN121971581 ACN 121971581ACN-121971581-A

Abstract

The application discloses a life-prolonging health-preserving pharmaceutical composition which comprises the following components of prepared rehmannia root, polygonum multiflorum, epimedium, male silk moth, shizandra berry, tribulus terrestris, dried ginger, angelica sinensis, bighead atractylodes rhizome, liquorice, cistanche salsa, rhizoma cibotii, pseudo-ginseng, winter wheat, dendrobium, dried orange peel, glossy privet fruit, poria cocos, eucommia ulmoides, ligusticum chuanxiong, rhizoma alismatis, dried summer, lily, bulbus fritilariae, rhizoma anemarrhenae, spina date seed, coix seed, medicated leaven, astragalus mongholicus, morinda officinalis, chicken's gizzard-skin, musk, raspberry, codonopsis pilosula, phellinus igniarius, gecko, scorpion and eupolyphaga. The medicated leaven is prepared by combining femtosecond wall breaking technology and ancient method, and double fermentation, the drug effect is improved by 8-10 times, and the medicated leaven can improve the oxidation resistance of organism, remove free radical, immunity and nerve protection function, delay aging, and treat the chronic diseases. The preparation comprises decoction, oral liquid, pill and medicated liquor. The composition can remarkably improve antioxidant enzyme activities such as SOD and CAT, reduce MDA content, and improve cognition and motor ability.

Inventors

  • WANG XIANDIAN

Assignees

  • 王显典

Dates

Publication Date
20260505
Application Date
20260327

Claims (10)

  1. 1. The life-prolonging and health-preserving pharmaceutical composition is characterized by being prepared from the following raw materials, by weight, 250-400g of prepared rehmannia root, 130-200g of polygonum multiflorum, 150-220g of epimedium, 35-70 g of male silkworm moth, 140-200g of schisandra chinensis, 90-140g of tribulus terrestris, 50-110g of dried ginger, 120-180g of Chinese angelica, 60-115g of bighead atractylodes rhizome, 65-120g of liquorice, 62-97g of cistanche, 180-228g of rhizoma cibotii, 52-96g of pseudo-ginseng, 50-79g of winter wheat, 58-110g of dendrobium nobile, 128-210g of dried orange peel, 120-198g of glossy privet fruit, 65-120g of poria cocos, 110-205g of eucommia ulmoides, 100-156g of ligusticum chuanxiong, 50-116g of rhizoma alismatis, 58-80g of dried grass, 80-130g of lily, 68-130g of bulbus fritillariae cirrhosae, 68-130g of fructus zizyphi spinosae, 62-120g of coicis, 59-116g of coix seed, 53-98g of medicated leaven, 70-120g of astragalus root, 70-120g of radix codonopsis pilosulae, 30-150 g of dried orange peel, 150-212 g of Chinese wolfberry, 150 g of dried orange peel and 150 g of dried orange peel.
  2. 2. A traditional Chinese medicine preparation for prolonging life and preserving health is characterized in that the active ingredient of the traditional Chinese medicine preparation is the traditional Chinese medicine composition of claim 1.
  3. 3. The life-prolonging and health-preserving traditional Chinese medicine preparation according to claim 2, wherein the traditional Chinese medicine preparation is an oral preparation.
  4. 4. The life-prolonging and health-preserving traditional Chinese medicine preparation according to claim 3, wherein the oral preparation is any one of decoction, oral liquid, pill or medicinal liquor.
  5. 5. The life-prolonging and health-preserving traditional Chinese medicine preparation according to claim 4, wherein the preparation method of the oral preparation is as follows: (1) Breaking cell wall in femtosecond method comprises pulverizing radix rehmanniae Preparata, polygoni Multiflori radix, herba Epimedii, bombycis Mori, fructus Schisandrae chinensis, fructus Tribuli, zingiberis rhizoma, radix Angelicae sinensis, atractylodis rhizoma, glycyrrhrizae radix, cistanchis herba, rhizoma Cibotii, notoginseng radix, fructus Tritici Levis, herba Dendrobii, pericarpium Citri Tangerinae, fructus Ligustri Lucidi, poria, eucommiae cortex, rhizoma Ligustici Chuanxiong, alismatis rhizoma, succinum, bulbus Lilii, bulbus Fritillariae Cirrhosae, rhizoma anemarrhenae, semen Ziziphi Spinosae, coicis semen, massa Medicata Fermentata, radix astragali, radix Morindae officinalis, endothelium corneum Gigeriae Galli, moschus, rubi radix Codonopsis, phellinus linteus, gekko Swinhonis, scorpio, and Eupolyphaga Seu Steleophaga to obtain medicinal powder; (2) The ancient method of decoction comprises placing the above medicinal materials powder into a marmite, adding cold water, soaking for 20-30min, rapidly boiling with strong fire, and keeping slightly boiling state for 25-35min to obtain decoction; (3) Filtering the decoction with multi-layer gauze or 0.45 μm filter membrane to remove coarse particles and insoluble residues to obtain clarified decoction; (4) Sterilizing the clarified liquid medicine at 126 ℃ for 15min to obtain sterilized liquid medicine; (5) Fermenting Massa Medicata Fermentata by adding the powder of femtosecond wall-broken Massa Medicata Fermentata into the sterilized liquid medicine, soaking and fermenting for 60 days, sterilizing at 126 deg.C for 15min to obtain fermented liquid medicine; (6) Secondary fermentation of Massa Medicata Fermentata, namely adding the fermented liquid into the femtosecond wall-broken Massa Medicata Fermentata powder again, sealing a jar, fermenting for 60 days to obtain secondary fermented liquid, and sterilizing at 126 ℃ for 15min to obtain sterilized fermented liquid; (7) The preparation is prepared by preparing the sterilized and fermented liquid medicine into decoction, oral liquid, pill or medicinal liquor.
  6. 6. The life-prolonging health-preserving traditional Chinese medicine preparation according to claim 5, wherein the preparation method of the oral liquid in the step (7) is characterized in that the sterilized fermentation liquid medicine is concentrated to 30% -40% ethanol in a reduced pressure rotary evaporator, the purified water with the same volume is added into the concentrated extract, the sweetener and the potassium sorbate are added, the pH value is regulated to 6.5-7.5, the mixture is stirred for 10-15min in a water bath with the temperature of 60-70 ℃, and the oral liquid is obtained after sterilization, namely the oral liquid is filled into a pre-sterilized glass bottle, sterilized for 30min by adopting high-pressure steam with the temperature of 115 ℃ and the pressure of 0.2MPa, and naturally cooled.
  7. 7. The life-prolonging health-preserving traditional Chinese medicine preparation according to claim 5, wherein the pill preparation method in the step (7) is characterized in that the sterilized fermentation liquor is concentrated into a viscous paste in a reduced pressure rotary evaporator, 5-10% of glycerin and 10-15% of starch are added, the mixture is stirred uniformly to form a plastic paste, the paste is dripped into cooled vegetable oil or silicone oil to form spherical dripping pills, and then the spherical dripping pills are dried at 40-50 ℃ for 12-24 hours, sterilized at 126 ℃ for 15min and packaged.
  8. 8. The life-prolonging life-preserving traditional Chinese medicine preparation according to claim 6, wherein the sweetener is dipotassium glycyrrhizinate.
  9. 9. The life-prolonging health-preserving traditional Chinese medicine preparation according to claim 5, wherein the preparation method of the medicinal liquor in the step (7) is characterized in that the sterilized medicinal liquor in the step (4) is added into sorghum liquor with the alcoholicity of not less than 60 degrees, and is mixed, and double fermentation is carried out with medicated leaven powder to obtain the medicinal liquor.
  10. 10. The life-prolonging and health-preserving pharmaceutical composition according to claim 1, wherein the pharmaceutical composition is applied to preparation of life-prolonging and health-preserving traditional Chinese medicine preparations.

Description

Life-prolonging and health-preserving pharmaceutical composition Technical Field The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a life-prolonging and health-preserving pharmaceutical composition. Background Along with the development of social economy and the improvement of living standard, the demands of people on health preservation are increasing, and life-prolonging health preservation products gradually become the focus of market attention. At present, the aging social process is accelerated, middle-aged and elderly people face the problems of physical function decline, immunity decline, metabolism slowing and the like, meanwhile, the middle-aged and young people have the trend of spreading sub-health state due to factors such as irregular work and rest, overlarge pressure and the like, and the requirements on safe and effective health-preserving and conditioning schemes are urgent. The existing health-preserving medicines or health-care products have the problems of single component and limited efficacy, and partial products only focus on the conditioning of a certain body function, so that the comprehensive maintenance of multiple viscera and multiple systems is difficult to realize. In addition, chemical synthesis components are added into part of the product, potential health risks can be brought to long-term administration, and the traditional pure traditional Chinese medicine preparation has the defects of slow effect, inconvenient dosage form, poor taste and the like, so that the compliance of users is influenced. The theory of traditional Chinese medicine emphasizes "whole body conditioning and treatment by differentiation", and the human health is considered to be closely related to the coordination of the viscera, qi, blood and body fluid. In the existing traditional Chinese medicine health preserving formula, the combination of single effects of tonifying qi and nourishing blood, nourishing liver and kidney, strengthening spleen and stomach, strengthening tendons and bones and the like is more, but the optimal formula capable of achieving the effect of considering both principal and secondary aspects and prolonging life is lacking. Meanwhile, the traditional Chinese medicine preparation has the problems of rough preparation process, low extraction rate of active ingredients, incomplete sterilization, insufficient stability and the like, and limits the quality and application and popularization of products. Therefore, research and development of a life-prolonging health-preserving pharmaceutical composition and a traditional Chinese medicine preparation which are scientific in components compatibility, comprehensive and balanced in efficacy, are combined with ancient processing by adopting a femtosecond wall breaking technology, are convenient in dosage form and high in safety, and are the technical problems to be solved urgently in the current health-preserving field. Disclosure of Invention Based on the above, the application aims to provide a life-prolonging and health-preserving pharmaceutical composition, which can effectively realize body care and life-prolonging effects. The application provides a life-prolonging health-preserving pharmaceutical composition, which is prepared from the following raw materials, by weight, 250-400g of prepared rehmannia root, 130-200g of polygonum multiflorum, 150-220g of epimedium, 35-70 g of male silkworm moth, 140-200g of schisandra chinensis, 90-140g of tribulus terrestris, 50-110g of dried ginger, 120-180g of Chinese angelica, 60-115g of bighead atractylodes rhizome, 65-120g of liquorice, 62-97g of cistanche, 180-228g of rhizoma cibotii, 52-96g of pseudo-ginseng, 50-79g of winter wheat, 58-110g of dendrobium nobile, 128-210g of dried orange peel, 120-198g of glossy privet fruit, 65-120g of poria cocos, 110-205g of eucommia ulmoides, 100-156g of Sichuan lovage rhizome, 50-116g of rhizoma alismatis, 58-80g of dried grass, 80-130g of lily, 68-130g of Sichuan fritillary bulb, 68-130g of rhizoma anemarrhenae, 62-120g of semen coicis 59-116g, 53-98g of medicated leaven, 70-120g of astragalus root, 70-120g of radix codonopsis pilosulae, 70-120g of dried orange peel, 30-210 g of Chinese wolfberry, 150-150 g of dried orange peel, 150 g of Chinese wolfberry, 150-220g of dried orange peel, 150 g of Chinese wolfberry, 150 g of dried orange peel, 150 g of black pepper, and the like. The application also provides a life-prolonging and health-preserving traditional Chinese medicine preparation, the active ingredients of which are the traditional Chinese medicine composition Preferably, the Chinese medicinal preparation is an oral preparation. Preferably, the oral preparation is any one of decoction, oral liquid, pill or medicinal liquor. Preferably, the preparation method of the oral preparation comprises the following steps: (1) Breaking cell wall in femtosecond method comprises pulverizing radix rehman