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CN-121971592-A - Antibacterial gel imitating intravaginal environment

CN121971592ACN 121971592 ACN121971592 ACN 121971592ACN-121971592-A

Abstract

The invention relates to the technical field of antibacterial gel, and discloses an antibacterial gel imitating an intravaginal environment, S1, fully swelling A phase for standby at normal temperature; S2, fully dissolving the phase B, adding the phase A, uniformly stirring, S3, fully stirring and dissolving the phase C, the phase D and the phase E, adding the mixed phase of S2, uniformly stirring, standing or defoaming under negative pressure, and filling. The radix sophorae flavescentis extract has the functions of resisting bacteria, diminishing inflammation, relieving itching and easing pain and improving the environment of the vagina, the cortex moutan extract has the functions of resisting inflammation, resisting oxidation and improving skin health on the vagina, the fructus cnidii extract can relieve pudendum itch and the like on the vagina, chitosan contained in the quaternized amino acid has the functions of promoting healing and improving the environment of the vagina, and simultaneously has the function of sterilizing together with quaternary ammonium salt in the quaternized amino acid, wherein the amino acid group has the function of moisturizing.

Inventors

  • YAN ZICHEN
  • ZHANG DAN
  • ZHAO HUAJUN
  • SUN YANHONG

Assignees

  • 山东融元康医疗科技有限公司

Dates

Publication Date
20260505
Application Date
20260205

Claims (7)

  1. 1. An antibacterial gel imitating an intravaginal environment is characterized by comprising the following components in parts by weight: 0.5-5 parts by weight of carbomer and 10-12 parts by weight of water; 0.5-5 parts by weight of carboxymethyl chitosan and 8-14 parts by weight of water; 0.5-5 parts by weight of sodium hyaluronate and 10-15 parts by weight of water; 0.01-1 weight part of recombinant humanized collagen and 12-16 weight parts of water; 3-10 parts of kuh-seng extract, 0.01-1 part of tree peony root bark extract, 0.01-1 part of fructus cnidii extract, 0.35-0.355 part of triclosan, 0.4-0.8 part of quaternized amino acid and 12-20 parts of water.
  2. 2. The antibacterial gel imitating an intravaginal environment according to claim 1, wherein the quaternized amino acid is prepared by the process of: (1) Adding chitosan and epsilon-caprolactone into a reactor, stirring uniformly, adding stannous octoate catalyst, introducing nitrogen for protection at 115-130 ℃, reacting for 6-12h, washing and drying after the reaction is finished to obtain caprolactone modified chitosan; (2) Adding caprolactone modified chitosan into ethanol solvent for dissolution, heating in water bath at 75-90 ℃, then adding 2, 3-epoxypropyl trimethyl ammonium chloride at constant pressure, reacting for 8-10h, washing with absolute ethanol after the reaction, drying, dialyzing and concentrating to obtain quaternized chitosan; (3) Adding quaternized chitosan and L-phenylalanine into N, N-dimethylformamide solvent, stirring and dissolving, continuously adding p-toluenesulfonic acid catalyst into the solvent, stirring and reacting for 7-10h at 90-110 ℃, and performing reduced pressure distillation, filtering, washing and drying after the completion of the reaction to obtain an intermediate; (4) Adding the intermediate, polyvinyl alcohol and beta-cyclodextrin into a stirrer, and reacting for 20-30min at 40-60 ℃ to obtain the quaternized amino acid.
  3. 3. The antibacterial gel imitating an intra-vaginal environment according to claim 2, wherein the mass ratio of the chitosan, epsilon-caprolactone and stannous octoate catalyst in the step (1) is 1:1.2-1.5:0.01-0.02.
  4. 4. The antibacterial gel imitating an intra-vaginal environment according to claim 2, wherein the mass ratio of caprolactone-modified chitosan to 2, 3-epoxypropyl trimethyl ammonium chloride in the step (2) is 1:0.8-1.3.
  5. 5. The antibacterial gel imitating an intra-vaginal environment according to claim 2, wherein the mass ratio of the quaternized chitosan, the L-phenylalanine and the p-toluenesulfonic acid catalyst in the step (3) is 1.1-1.4:1:0.02-0.03.
  6. 6. The antibacterial gel imitating an intra-vaginal environment according to claim 2, wherein the mass ratio of the intermediate, the polyvinyl alcohol and the beta-cyclodextrin in the step (4) is 1:2-4.6:0.9-1.2.
  7. 7. A method of preparing an antibacterial gel according to any one of claims 1 to 6, wherein the method of preparing an antibacterial gel according to the intravaginal environment comprises: S1, fully swelling the phase A at 40-60 ℃ for standby at normal temperature; S2, after the phase B is fully dissolved, adding the phase A, and uniformly stirring; S3, fully stirring and dissolving the C phase, the D phase and the E phase, adding the mixed phase of the S2, stirring uniformly, and filling after standing or negative pressure defoaming.

Description

Antibacterial gel imitating intravaginal environment Technical Field The invention relates to the technical field of antibacterial gel, in particular to an antibacterial gel imitating an intravaginal environment. Background The gynecological gel is a gynecological medicine and gel, and can be used for treating various gynecological vaginitis and cervicitis, including bacterial vaginitis, mixed vaginitis, gonococcus infection, chronic cervicitis, cervical erosion, etc. The antibacterial gel in the current market has the problems that the antibacterial effect is insufficient and the market demand cannot be met, for example, the patent CN202010930545.8 discloses an antibacterial gel for gynecology and a preparation method thereof, and the gynecological antibacterial gel has no irritation to vaginal mucosa cells, high safety and excellent stability, is easy to be absorbed by a human body, can make skin of female private parts moist, fresh and healthy after being used, but has lower antibacterial effect. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides an antibacterial gel imitating the environment in the vagina, which has better antibacterial effect. (II) technical scheme In order to achieve the purpose, the invention provides the following technical scheme that the antibacterial gel imitating the environment in the vagina comprises the following components in parts by weight: 0.5-5 parts by weight of carbomer and 10-12 parts by weight of water; 0.5-5 parts by weight of carboxymethyl chitosan and 8-14 parts by weight of water; 0.5-5 parts by weight of sodium hyaluronate and 10-15 parts by weight of water; 0.01-1 weight part of recombinant humanized collagen and 12-16 weight parts of water; 3-10 parts of kuh-seng extract, 0.01-1 part of tree peony root bark extract, 0.01-1 part of fructus cnidii extract, 0.35-0.355 part of triclosan, 0.4-0.8 part of quaternized amino acid and 12-20 parts of water. Preferably, the preparation method of the quaternized amino acid comprises the following steps: (1) Adding chitosan and epsilon-caprolactone into a reactor, stirring uniformly, adding stannous octoate catalyst, introducing nitrogen for protection at 115-130 ℃, reacting for 6-12h, washing and drying after the reaction is finished to obtain caprolactone modified chitosan; (2) Adding caprolactone modified chitosan into ethanol solvent for dissolution, heating in water bath at 75-90 ℃, then adding 2, 3-epoxypropyl trimethyl ammonium chloride at constant pressure, reacting for 8-10h, washing with absolute ethanol after the reaction, drying, dialyzing and concentrating to obtain quaternized chitosan; (3) Adding quaternized chitosan and L-phenylalanine into N, N-dimethylformamide solvent, stirring and dissolving, continuously adding p-toluenesulfonic acid catalyst into the solvent, stirring and reacting for 7-10h at 90-110 ℃, and performing reduced pressure distillation, filtering, washing and drying after the completion of the reaction to obtain an intermediate; (4) Adding the intermediate, polyvinyl alcohol and beta-cyclodextrin into a stirrer, and reacting for 20-30min at 40-60 ℃ to obtain the quaternized amino acid. Preferably, the mass ratio of the chitosan, epsilon-caprolactone and stannous octoate catalyst in the step (1) is 1:1.2-1.5:0.01-0.02. Preferably, the mass ratio of the caprolactone-modified chitosan to the 2, 3-epoxypropyl trimethyl ammonium chloride in the step (2) is 1:0.8-1.3. Preferably, the mass ratio of the quaternized chitosan, the L-phenylalanine and the p-toluenesulfonic acid catalyst in the step (3) is 1.1-1.4:1:0.02-0.03. Preferably, the mass ratio of the intermediate, the polyvinyl alcohol and the beta-cyclodextrin in the step (4) is 1:2-4.6:0.9-1.2. Preferably, the preparation method of the antibacterial gel imitating the intravaginal environment comprises the following steps: S1, fully swelling the phase A at 40-60 ℃ for standby at normal temperature; S2, after the phase B is fully dissolved, adding the phase A, and uniformly stirring; S3, fully stirring and dissolving the C phase, the D phase and the E phase, adding the mixed phase of the S2, stirring uniformly, and filling after standing or negative pressure defoaming. (III) beneficial technical effects The carboxymethyl chitosan has anti-inflammatory effect on vagina, can improve various symptoms caused by colpitis, such as pain, itch, secretion increase and the like, can activate macrophages, and can strengthen the functions of the macrophages, thereby enhancing immunity, and has positive effects on preventing and treating some vaginal infectious diseases; The recombinant humanized collagen has the effects of moisturizing the vagina, improving vaginal dryness and enhancing vaginal wall elasticity, has high homology with the collagen sequence of vaginal mucosal tissues, can quickly permeate to the injured parts of the mucous membrane, participates in tissue regeneratio