CN-121971630-A - Protective preparation for eliminating esophagus injury caused by feeding stick of dairy cows and preparation method and application thereof

Abstract

The invention provides a protective preparation for eliminating esophagus injury caused by feeding bars of dairy cows, and a preparation method and application thereof, and belongs to the technical field of veterinary medicinal preparations. The invention breaks through the high crystallinity of polyethylene glycol by utilizing the interpenetration effect between polyethylene glycol PEG and acetylated mono-diglycerol fatty acid ester, so that the original fragile protective preparation forms a coating layer to have extremely strong ductility and toughness, the stress is not broken and the protective preparation is not dropped in touch, the composite hydrogenated oil and the composite wax are highly compatible with PEG in a hot melting state, a waxy protective layer is formed on the surface after cooling, the protective layer is contacted with cow saliva to generate super lubrication effect after being softened by an esophagus heating shell while providing hydrophobic performance, and the composite cow rumen disintegrating agent forms a micro-pore channel in the tough coating layer, so that the feeding rod can be ensured to act rapidly after entering the rumen, and finally the protective preparation for eliminating the esophagus damage caused by the feeding rod of the cow is obtained.

Inventors

• YANG WEI
• ZHANG BINGBING
• LI ZHENDONG
• XIA CHENG
• BAI YUNLONG
• SONG YUXI
• KUAI XINYUE
• HUANG YI
• ZHAO YUQI

Assignees

• 黑龙江八一农垦大学

Dates

Publication Date

20260505

Application Date

20260206

Claims (10)

1. 1. The protective preparation for eliminating esophagus damage caused by feeding a dairy cow stick is characterized by comprising, by mass, 40-70 parts of polyethylene glycol, 10-35 parts of acetylated mono-diglyceride fatty acid ester, 5-18 parts of compound palm oil, 8-22 parts of compound wax and 0.5-7 parts of compound dairy cow rumen-soluble disintegrating agent.
2. 2. The protective preparation according to claim 1, which is characterized by comprising, by mass, 45-65 parts of polyethylene glycol, 12-30 parts of acetylated mono-diglyceride fatty acid ester, 8-15 parts of compound palm oil, 10-18 parts of compound wax and 1-5 parts of compound dairy cow rumen-soluble disintegrating agent.
3. 3. The protective preparation according to claim 1, wherein the composite palm oil consists of hydrogenated palm oil and palm oil in a mass ratio of (3-7): 1.
4. 4. The protective formulation of claim 1, wherein the complex wax consists of low temperature soy wax, paraffin wax, microcrystalline wax, and coconut wax.
5. 5. The protective preparation according to claim 1, wherein the mass ratio of the low-temperature soybean wax, paraffin wax, microcrystalline wax to coconut wax is (1-3): (1-2): 1:1.
6. 6. The protective formulation of claim 1, wherein the composite dairy cow rumen-soluble disintegrant consists of croscarmellose sodium, sodium carboxymethyl starch, polysorbate 80.
7. 7. A method for preparing the protective preparation for eliminating esophageal damage caused by feeding bars of cows according to any one of claims 1-6, which is characterized by comprising the following steps: (1) Mixing polyethylene glycol, acetylated mono-diglyceride fatty acid ester, compound palm oil and compound wax, stirring and heating to obtain a solution; (2) Under the heating condition, adding a composite dairy cow rumen soluble disintegrating agent into the solution obtained in the step (1), and stirring to obtain a dispersion; (3) And (3) injecting the dispersion liquid obtained in the step (2) into a mould, and sequentially cooling and demoulding to obtain the protective preparation for eliminating the esophagus damage caused by feeding the dairy cows.
8. 8. The application of the protective preparation for eliminating the esophagus damage caused by the dairy cow feeding bar in preparing the medicine for eliminating the esophagus damage caused by the dairy cow feeding bar is characterized in that the protective preparation for eliminating the esophagus damage caused by the dairy cow feeding bar is prepared by the preparation method of claim 1-6 or the preparation method of claim 7.
9. 9. The application according to claim 1, which is characterized by comprising the following steps of heating and melting the protective preparation for eliminating esophagus damage caused by feeding a dairy cow to obtain coating liquid; Immersing the dairy cow feeding rod into the coating liquid, taking out and carrying out air-cooling solidification to obtain the dairy cow feeding rod wrapped by the protective preparation, so as to eliminate esophagus damage caused by the dairy cow feeding rod by utilizing the wrapped protective preparation.
10. 10. The application of claim 1, wherein the heating and melting temperature is 50-60 ℃, the air cooling solidification adopts 10-15 ℃ cold air flow, and the air cooling solidification time is 2-5 min.

Description

Protective preparation for eliminating esophagus injury caused by feeding stick of dairy cows and preparation method and application thereof Technical Field The invention relates to the technical field of veterinary medicine preparations, in particular to a protective preparation for eliminating esophagus injury caused by feeding bars of dairy cows, and a preparation method and application thereof. Background In modern dairy cow breeding, oral administration by a feeder, magnet or calcium-magnesium supplementing and other mineral substances have become conventional means for preventing metabolic diseases such as postpartum paralysis. However, the existing dairy cow feeding bars are large in size, high in hardness and rough in surface, and in the feeding process, the rough bars are extremely easy to scratch the esophagus due to tender and tender mucosa of the dairy cow esophagus. In addition, some nutrition supplementing bars, such as calcium chloride and the like, have great effect on oesophageal irritation and damage, cause inflammation, ulcer and even perforation, and seriously influence the feeding and health of cows. The existing coating material has the physical defects that part of the product is too fragile, is easy to fall off in a piece under transportation and feeding extrusion, and part of the product has insufficient lubrication degree, so that the esophagus injury caused by feeding cannot be effectively relieved. Therefore, the development of a protective preparation which can tightly wrap a matrix without falling off, has extremely strong ductility and lubrication feeling and can effectively protect esophagus is a problem to be solved in the field of livestock veterinary drugs at present. Disclosure of Invention The invention aims to provide a protective preparation for eliminating esophagus injury caused by feeding bars of dairy cows, a preparation method and application thereof, the protective preparation provided by the invention has strong adhesive force, the surface of the basal body of the feeding rod tightly wrapped by the dairy cows is not fallen off, the ductility is excellent, the lubricity is good, and the esophagus injury caused by the feeding rod of the dairy cows can be avoided. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a protective preparation for eliminating oesophageal injury caused by dairy cow feeding bars, which is characterized by comprising, by mass, 40-70 parts of polyethylene glycol, 10-35 parts of acetylated mono-diglyceride fatty acid ester, 5-18 parts of compound palm oil, 8-22 parts of compound wax and 0.5-7 parts of compound dairy cow rumen-soluble disintegrating agent. The rumen-soluble disintegrating agent is prepared from the following raw materials, by mass, 45-65 parts of polyethylene glycol, 12-30 parts of acetylated mono-diglyceride fatty acid ester, 8-15 parts of compound palm oil, 10-18 parts of compound wax and 1-5 parts of compound rumen-soluble disintegrating agent for dairy cows. Preferably, the composite palm oil consists of hydrogenated palm oil and palm oil with the mass ratio of (3-7): 1. Preferably, the composite wax consists of low temperature soy wax, paraffin wax, microcrystalline wax and coconut wax. Preferably, the mass ratio of the low-temperature soybean wax, paraffin wax, microcrystalline wax and coconut wax is (1-3): 1-2): 1:1. Preferably, the composite dairy cow rumen-soluble disintegrating agent consists of croscarmellose sodium, sodium carboxymethyl starch and polysorbate 80. The invention also provides a preparation method of the protective preparation for eliminating esophagus injury caused by feeding a dairy cow stick, which comprises the following steps: (1) Mixing polyethylene glycol, acetylated mono-diglyceride fatty acid ester, compound palm oil and compound wax, stirring and heating to obtain a solution; (2) Under the heating condition, adding a composite dairy cow rumen soluble disintegrating agent into the solution obtained in the step (1), and stirring to obtain a dispersion; (3) And (3) injecting the dispersion liquid obtained in the step (2) into a mould, and sequentially cooling and demoulding to obtain the protective preparation for eliminating the esophagus damage caused by feeding the dairy cows. The invention also provides application of the protective preparation for eliminating the esophagus damage caused by the dairy cow feeding rod in preparing medicines for eliminating the esophagus damage caused by the dairy cow feeding rod, and the protective preparation for eliminating the esophagus damage caused by the dairy cow feeding rod is prepared by the protective preparation for eliminating the esophagus damage caused by the dairy cow feeding rod or the preparation method. Preferably, the method comprises the following steps of heating and melting the protective preparation for eliminating esophagus damage caused by feeding the dairy c