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CN-121971632-A - Composite auxiliary material combination for vacuum belt type drying process of Chinese medicine medlar thick paste and application thereof

CN121971632ACN 121971632 ACN121971632 ACN 121971632ACN-121971632-A

Abstract

The invention provides a composite auxiliary material combination for a vacuum belt type drying process of a traditional Chinese medicine medlar thick paste and application thereof, wherein the composite auxiliary material consists of 3.2-11.2 parts by weight of beta-cyclodextrin, 9.6-17.6 parts by weight of maltodextrin and 0.4-0.8 part by weight of silicon dioxide; the application method comprises the steps of concentrating the Chinese wolfberry extract into thick paste, adding the composite auxiliary materials into the thick paste, uniformly mixing the thick paste, and then carrying out vacuum belt drying treatment, wherein the composite auxiliary materials can effectively solve the problem of sticking phenomena and dry paste powder caking caused by sticking phenomena of the thick paste of the Chinese wolfberry in the vacuum belt drying process under a lower adding amount, and the prepared dry paste powder has good moisture absorption resistance.

Inventors

  • TANG KE
  • ZHONG CUILAN
  • LONG HAIYAN
  • LIU FENG
  • CHEN WEI

Assignees

  • 天地恒一制药股份有限公司

Dates

Publication Date
20260505
Application Date
20260408

Claims (10)

  1. 1. The composite auxiliary material combination for the vacuum belt type drying process of the Chinese medicinal medlar thick paste is characterized by comprising, by weight, 3.2-11.2 parts of beta-cyclodextrin, 9.6-17.6 parts of maltodextrin and 0.4-0.8 part of silicon dioxide.
  2. 2. The composite auxiliary material combination according to claim 1, wherein the composite auxiliary material combination comprises, by weight, 3.2-7.2 parts of beta-cyclodextrin, 13.6-17.6 parts of maltodextrin and 0.8 part of silicon dioxide.
  3. 3. The composite auxiliary material combination according to claim 1, wherein the composite auxiliary material combination comprises the following components in parts by weight of 7.2 parts of beta-cyclodextrin, 13.6 parts of maltodextrin and 0.8 part of silicon dioxide.
  4. 4. The composite auxiliary material combination according to claim 1, wherein the auxiliary material combination consists of the following components in parts by weight, 11.2 parts of beta-cyclodextrin, 9.6 parts of maltodextrin and 0.8 part of silicon dioxide.
  5. 5. The composite adjuvant combination of claim 1 wherein the silica in the composite adjuvant combination is 0.8 parts.
  6. 6. A preparation method of a Chinese medicinal medlar dry extract powder, which is characterized in that medlar extract is concentrated into thick paste, the composite auxiliary materials according to any one of claims 1 to 5 are added into the thick paste for combination, and the mixture is stirred uniformly, dried in a vacuum belt mode and crushed to obtain medlar dry extract powder.
  7. 7. The method according to claim 6, wherein the temperature of the paste when the composite auxiliary material composition is added is 60 ℃, and the relative density of the paste is 1.30-1.40 at 60 ℃.
  8. 8. The preparation method of claim 6, wherein the wolfberry fruit extract is concentrated into thick paste, and the solid content of the thick paste is 58% -65%.
  9. 9. The method according to any one of claims 6 to 8, wherein the drying temperature of the vacuum belt drying is 90 to 110 ℃.
  10. 10. A method for preparing medlar prescription granule, characterized in that medlar dry paste powder prepared by the preparation method of any one of claims 6 to 9 is adopted, maltodextrin is added to the prepared amount, and the medlar prescription granule is prepared by dry granulation after uniform mixing.

Description

Composite auxiliary material combination for vacuum belt type drying process of Chinese medicine medlar thick paste and application thereof Technical Field The invention relates to the technical field of drying in a traditional Chinese medicine preparation process, in particular to a composite auxiliary material combination for improving a vacuum belt type drying process of a traditional Chinese medicine medlar thick paste and application thereof. Background The traditional Chinese medicine formula granule is a granular preparation prepared by water extraction, separation, concentration, drying and granulation of single traditional Chinese medicine decoction pieces, and is an improved product of traditional Chinese medicine decoction pieces and decoction. In the production and drying process of traditional Chinese medicine formula particles, a spray drying or vacuum belt drying method is generally used. The spray drying process takes atomization dispersion and instant drying as cores, and the core principle is that feed liquid to be dried is dispersed into tiny fog drops through an atomizer, the fog drops are quickly contacted with high-temperature hot air, water evaporation is completed in a very short time, and powdery or tiny granular products are directly formed. The process is suitable for drying liquid and semi-liquid materials, such as biological extract, food slurry, etc. The vacuum belt drying process takes continuous belt conveying as a core, and the core principle is that materials to be dried are uniformly spread on a conveying belt, heat and mass transfer is carried out on the surfaces of the materials through hot air circulation, so that gradual removal of moisture is realized. In addition, the vacuum belt type drying has the characteristics of protecting heat-sensitive components, avoiding oxidization, being still efficient on materials with high viscosity, easy agglomeration, thermoplasticity and the like, having large productivity, high efficiency and the like, and is more suitable for the drying process in the production of the extractum type traditional Chinese medicine formula particles. However, the phenomenon of sticking tape can occur in the vacuum tape drying process, especially for medicinal materials with high sugar content such as jujube, matrimony vine, aster honey, stemona honey, etc. The adhesive tape is a very troublesome problem in the vacuum belt drying process of the thick paste of the traditional Chinese medicine formula particles, and the adhesive tape can cause the interruption of the drying process when the adhesive tape is serious, so that the production cannot be continued. When the traditional Chinese medicine containing more sugar is prepared into the formula granules, the conventional treatment mode is to adopt a mode of adding a large amount of auxiliary materials to solve the problem of sticking, the adding amount of the auxiliary materials is generally more than 1.5 times of that of the extract, the method for adding the auxiliary materials in a large amount solves the problem of sticking to a certain extent, the caking of dry paste powder is easy to occur, the content of active ingredients of a unit preparation can be reduced due to excessive auxiliary materials, and the dosage of patients is increased. Therefore, how to overcome the sticking problem of the traditional Chinese medicine thick paste during vacuum belt drying, avoid the caking phenomenon of dry paste powder, and reduce the dosage of auxiliary materials is very important. In the prior art, patent CN101862458B discloses an auxiliary material combination of betacyclodextrin and maltodextrin or dextrin, which is used for improving the wall sticking phenomenon in the spray drying process of traditional Chinese medicine formula granules. Patent CN106581685A discloses an auxiliary material combination consisting of maltodextrin, micro silica gel and microcrystalline cellulose, which is also used for improving or avoiding the problem of sticking to the wall of the traditional Chinese medicine extract in the spray drying process. The two prior arts are used for solving the wall sticking problem in the spray drying process, the problem of sticking in the vacuum belt drying process of the thick paste of the traditional Chinese medicine formula particles is not solved, and in terms of a drying mechanism, the spray drying is mainly performed by improving the glass transition temperature of materials, so that the materials are quickly solidified and the granularity is increased when heated, and sticking towers are relieved. Therefore, the core of solving the problem of sticking tape in vacuum belt drying is to improve the self-viscosity of the material. The two drying processes have essential differences in drying operation parts, mechanisms, technical problems and solving ways, and the corresponding technical targets, application scenes and required auxiliary material combinations are also obviously different.