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CN-121971683-A - Nursing pad for old people and preparation method thereof

CN121971683ACN 121971683 ACN121971683 ACN 121971683ACN-121971683-A

Abstract

The invention belongs to the field of nursing pad preparation, and particularly relates to an aged nursing pad and a preparation method thereof. The nursing pad for the aged comprises an upper layer pad, a middle layer pad and a lower layer pad, wherein the middle layer pad consists of an odor absorbent and the like, the odor absorbent consists of a polypeptide substance and the like, and the amino acid sequence of the polypeptide substance is AHKSKLHQHVWRY, so that the nursing pad can absorb trans-2-nonenal and diacetyl which are peculiar smell representatives. The upper layer pad has certain absorption capacity, can inhibit microorganism growth, the middle layer pad can provide certain supporting force, and maintain relatively dry contact body feeling, and the lower layer pad realizes the final seepage prevention effect, so that the nursing pad is prevented from being unattractive after long-term use, and the like. The nursing pad for the aged prepared by the invention reduces the body taste of the aged, is friendly to the aged and has better nursing effect.

Inventors

  • CUI YE
  • LI XIAOMEI
  • ZHANG ZONGMIN
  • LI QIONG
  • JIANG YUANLI
  • LI XIANG

Assignees

  • 遵义医科大学附属医院

Dates

Publication Date
20260505
Application Date
20240416

Claims (7)

  1. 1. The nursing pad for the aged is characterized by comprising an upper layer pad, a middle layer pad and a lower layer pad, wherein the upper layer pad and the middle layer pad are body contact layers, the middle layer pad is rectangular or round corner rectangular, the front surface of the middle layer pad is contacted with the upper layer pad, and the back surface of the middle layer pad is contacted with the lower layer pad; the upper layer pad consists of a pad sleeve and a filler, wherein the pad sleeve is made of pure cotton, and the filler consists of 20-30 parts of microcrystalline cellulose, 10-15 parts of a bacteriostatic agent and 50-70 parts of cotton in parts by weight; the middle layer pad is composed of the following raw materials, by mass, 50-80 parts of odor absorbent, 30-40 parts of sisal hemp, 40-50 parts of polyvinylpyrrolidone, 10-15 parts of multi-wall carbon nanotubes and 100-140 parts of diphenylmethane diisocyanate; The odor absorbent consists of the following materials, by mass, 30-50 parts of polypeptide substances, 10-15 parts of dodecyl methyl pentasiloxane, 80-90 parts of hydrogen-containing polymethyl siloxane and 120-140 parts of polyvinyl alcohol resin; the lower layer pad is made of HPDE material or TPO material.
  2. 2. The nursing pad for the aged according to claim 1, wherein the antibacterial agent is a natural plant extract, is one or more of dandelion, garden balsam stem, pericarpium zanthoxyli and asiatic crabapple herb extracts, and has an antibacterial rate of 80-90% on staphylococcus aureus, escherichia coli and candida albicans.
  3. 3. The aged care pad according to claim 2, wherein the upper layer pad is prepared by the following method: H1. Fully mixing microcrystalline cellulose with a bacteriostat, and obtaining a dried material in a spray drying mode, wherein the air inlet temperature is 60-80 ℃, the rotating speed is 2000-2400rpm, and the sample injection amount is 80-100mL/h; H2. mixing cotton with two sides of the dry material, filling into the pad sleeve, and sewing into separate cells to obtain the upper pad.
  4. 4. The pad of claim 3, wherein the polypeptide has an amino acid sequence AHKSKLHQHVWRY, i.e., alanine-histidine-lysine-serine-lysine-leucine-histidine-glutamine-histidine-valine-tryptophan-arginine-tyrosine, and is prepared and synthesized by using NPC monomers, and the preparation method comprises the following steps: s1, obtaining corresponding amino acid NPC monomers and tyrosine according to the amino acid sequence of polypeptide substances, wherein the molar ratio of alanine NPC monomer to histidine NPC monomer to lysine NPC monomer to serine NPC monomer to leucine NPC monomer to glutamine NPC monomer to valine NPC monomer to tryptophan NPC monomer to arginine NPC monomer to tyrosine is 1:3:2:1:1:1:1:1:1:1; S2, dissolving an arginine NPC monomer in dimethylacetamide, adding 3-tert-butyl aminopropionate, mixing, and continuously stirring the mixture at 60-80 ℃ at a stirring speed of 200-250rpm for 2-4 hours to obtain a mixture A; S3, adding tyrosine, dicyclohexylcarbodiimide and N-hydroxysuccinimide ester into the mixture A obtained in the step S2, continuously stirring for 10-12 hours, then placing in ice water for standing for 1-2 hours, filtering by a filter membrane, washing the precipitate with water for 3-5 times, and performing vacuum freeze drying to obtain a substance B; S4, repeating the step S2 on tryptophan NPC monomer to obtain a mixture C, then adding the substance B, dicyclohexylcarbodiimide and N-hydroxysuccinimide ester obtained in the step S3, continuously stirring for 10-12 hours, then standing in ice water for 1-2 hours, filtering by a filter membrane, washing the precipitate with water for 3-5 times, and performing vacuum freeze drying to obtain a substance D; s5, sequentially repeating the step S4 of valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer and alanine NPC monomer until a substance N is obtained; S6, dissolving the substance N obtained in the step S5 in methyl tertiary butyl ether, standing for 1-2 hours, centrifuging for 20-30 minutes under the centrifugal force of 800-1000g, discarding the supernatant, washing the precipitate with water for 3-5 times, centrifuging again, and purifying by silica gel chromatography to obtain a polypeptide substance; in the step S2, the molar ratio of arginine NPC monomer to dimethylacetamide to 3-tert-butyl aminopropionate is 8-10:3-5:2-4; In the step S3, the mol ratio of tyrosine to dicyclohexylcarbodiimide to N-hydroxysuccinimide ester is 6-8:0.4-0.8:0.3-0.5, the condition of continuous stirring in the step S3 is consistent with that in the step S2, and the filtration is carried out by adopting a 0.45 mu m PES microporous membrane; In the step S6, the mass-volume ratio of the substance N to the methyl tertiary butyl ether is 20-30:100-140.
  5. 5. The pad for aged care according to claim 4, wherein the odor absorbent is prepared by the following method: V1. weighing dodecamethylpentasiloxane and hydrogen-containing polymethylsiloxane, placing in 1, 4-dioxane, heating to 50-60 ℃ and stirring at 250-280rpm for 30-45 minutes to obtain a mixture E; V2, placing polyvinyl alcohol resin and polypeptide substances into water, fully stirring until the polyvinyl alcohol resin and the polypeptide substances are uniformly mixed, adding the mixture into the mixture E obtained in the step V1, homogenizing the mixture for 30-40s by adopting a high-speed homogenizer with the speed of 3000-4000rpm, and then spraying to form plastic particles with the diameter of 300-400 mu m, thus obtaining the odor absorbent; the dosage of the 1, 4-dioxane in the step V1 is 2-3 times of the mass of the dodecyl methyl pentasiloxane; the water consumption in the step V2 is 3-4 times of the mass of the polyvinyl alcohol resin.
  6. 6. The aged care pad according to claim 5, wherein the middle pad is prepared by the following steps: T1 washing sisal hemp with water at 80-100deg.C for 1-2 hr, naturally airing, repeatedly washing, controlling water content to no more drip, soaking in 1-2% sodium hydroxide aqueous solution for 24-36 hr, taking out, washing with a large amount of clear water, naturally airing, and cutting into square small pieces of 0.5-0.8 cm; t2 dissolving polyvinylpyrrolidone in water, adding multiwall carbon nanotubes, and performing ultrasonic treatment at 100-120W for 3-4 hours to obtain liquid G; T3, mixing the small sisal hemp blocks obtained in the step T1 and the liquid G obtained in the step T2 with an odor absorbent and diphenylmethane diisocyanate, stirring until the mixture is uniformly dispersed, heating to 60-80 ℃, pouring the mixture into a shaper, and maintaining the mixture at 100-120 ℃ for 6-8 hours to obtain a middle layer pad; In the step T2, the mass volume of polyvinylpyrrolidone to water is 5-8:100-120.
  7. 7. A method of making an aged care pad according to any one of claims 1-6, wherein the method of making an aged care pad comprises: bonding the back of the middle layer pad with the lower layer pad by adopting an adhesive, and directly covering the upper layer pad on the front of the middle layer pad, or fixing the upper layer pad on the front of the middle layer pad by adopting a fixing auxiliary object to obtain the nursing pad for the aged; The lower pad should be completely bonded to the back of the middle pad and cover the four sides of the middle pad that are related to the thickness.

Description

Nursing pad for old people and preparation method thereof Technical Field The invention belongs to the field of nursing pad preparation, and particularly relates to an aged nursing pad and a preparation method thereof. Background The aged people have problems of reduced physical functions, chronic diseases and the like, and are limited by economic problems, life habit problems and the like because of nursing by professionals, so that most aged people have difficulty in obtaining comfortable nursing life. The nursing of the elderly has the following difficulties that the elderly often has the problems of reduced muscle strength, weakened balance ability and the like, and the elderly needs to be cared for once the elderly falls down and has fracture risk, the disabled elderly usually needs nursing staff to help bath dressing and the like, certain requirements are met on the physical strength of the nursing staff, the mental condition of the aged to be nursed needs to be considered, and professional nursing staff is lack. Thus, with conditional restrictions, suitable care facilities and equipment are used in the care of the elderly, helping to alleviate the difficulties of the care of the elderly. The nursing pad is a pad material with basic absorption capacity, can be used for nursing on beds of disabled old people and also can be used by other people with requirements, but the existing nursing pad often has the problems of poor absorption capacity, poor permeability, incapacity of effectively removing peculiar smell and the like, and limits the application of the nursing pad in the nursing of the old people. Disclosure of Invention Based on the above problems, the invention provides a nursing pad for the elderly, which comprises an upper pad, a middle pad and a lower pad, wherein the middle pad consists of an odor absorbent and the like, the odor absorbent consists of a polypeptide substance and the like, and the amino acid sequence of the polypeptide substance is AHKSKLHQHVWRY, so that higher absorption of trans-2-nonenal and diacetyl which are peculiar smell representatives can be realized. The nursing pad for the aged comprises an upper layer pad, a middle layer pad and a lower layer pad, wherein the upper layer pad and the middle layer pad are body contact layers, the middle layer pad is rectangular or round-corner rectangular, the front surface of the middle layer pad is contacted with the upper layer pad, and the back surface of the middle layer pad is contacted with the lower layer pad; The upper layer pad consists of a pad sleeve and a filler, wherein the pad sleeve is made of pure cotton, and the filler consists of 20-30 parts of microcrystalline cellulose, 10-15 parts of a bacteriostatic agent and 50-70 parts of cotton in parts by weight; the antibacterial agent is one or more of natural plant extracts, preferably herba Taraxaci, herba Speranskiae Tuberculatae, fructus Zanthoxyli and Asiatic Thalictrum herb extracts, and has antibacterial rate of 80-90% on Staphylococcus aureus (ATCC 6538), escherichia coli (8099) and Candida albicans (ATCC 10231); the preparation method of the upper layer pad comprises the following steps: H1. Fully mixing microcrystalline cellulose with a bacteriostat, and obtaining a dried material in a spray drying mode, wherein the air inlet temperature is 60-80 ℃, the rotating speed is 2000-2400rpm, and the sample injection amount is 80-100mL/h; H2. mixing cotton with two sides of the dry material, filling into the pad sleeve, and sewing into separate cells to obtain the upper pad. Preferably, the individual cells are diamond-shaped. The middle layer pad is composed of the following raw materials, by mass, 50-80 parts of odor absorbent, 30-40 parts of sisal hemp, 40-50 parts of polyvinylpyrrolidone, 10-15 parts of multi-wall carbon nanotubes and 100-140 parts of diphenylmethane diisocyanate; The odor absorbent consists of the following materials, by mass, 30-50 parts of polypeptide substances, 10-15 parts of dodecyl methyl pentasiloxane, 80-90 parts of hydrogen-containing polymethyl siloxane and 120-140 parts of polyvinyl alcohol resin; The amino acid sequence of the polypeptide substance is AHKSKLHQHVWRY, namely alanine-histidine-lysine-serine-lysine-leucine-histidine-glutamine-histidine-valine-tryptophan-arginine-tyrosine, and the polypeptide substance is specifically prepared and synthesized by adopting each amino acid NPC monomer, and the structural general formula of each amino acid NPC monomer is shown in figure 1. The preparation method of the polypeptide substance comprises the following steps: s1, obtaining corresponding amino acid NPC monomers and tyrosine according to the amino acid sequence of polypeptide substances, wherein the molar ratio of alanine NPC monomer to histidine NPC monomer to lysine NPC monomer to serine NPC monomer to leucine NPC monomer to glutamine NPC monomer to valine NPC monomer to tryptophan NPC monomer to arginine NPC monomer to tyrosine is