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CN-121971779-A - Multidimensional sensing interventional guide wire and preparation method and application thereof

CN121971779ACN 121971779 ACN121971779 ACN 121971779ACN-121971779-A

Abstract

The invention relates to the field of medical instruments, in particular to a multidimensional sensing interventional guide wire, and a preparation method and application thereof. The multidimensional sensing interventional guide wire comprises a guide wire body, a pressure sensing unit, a temperature sensing unit and a plurality of strain sensing units, wherein the pressure sensing unit, the temperature sensing unit and the strain sensing units are distributed along the axial direction of the guide wire body, the pressure sensing unit determines the contact position and the contact pressure of the guide wire body, the temperature sensing unit monitors the temperature change of medium around the guide wire body in real time, the strain sensing unit acquires the bending angle and the space posture information of the guide wire body in real time, an electrode of the pressure sensing unit is positioned at the end part of the guide wire body, an electrode of the temperature sensing unit is arranged after being axially adjacent to an electrode of the pressure sensing unit, and an electrode of the strain sensing unit is arranged after being axially adjacent to the temperature sensing electrode and is positioned in the middle of the guide wire body. The invention has compact structure and high flexibility, and can realize the perception of multiple physical quantities on an extremely small curved surface.

Inventors

  • LI DONGSHENG
  • YANG RUXIAO
  • LIU HUICONG

Assignees

  • 苏州大学

Dates

Publication Date
20260505
Application Date
20251225

Claims (10)

  1. 1. A multidimensional sensing interventional guidewire, comprising: a guidewire body (10); The pressure sensing unit (20) is distributed along the axial direction of the guide wire main body (10) and is used for determining the contact position and the contact pressure of the guide wire main body (10), wherein the pressure sensing unit (20) comprises at least one piezoresistance effect unit (201), at least one triboelectric effect unit (202), a first conductive lead (203) respectively connected with the piezoresistance effect unit (201) and the triboelectric effect unit (202) and a first signal leading-out end (204) connected with the first conductive lead (203); the temperature sensing unit (30) is distributed along the axial direction of the guide wire main body (10) and is used for monitoring the temperature change of a medium around the guide wire main body (10) in real time, wherein the temperature sensing unit (30) comprises a temperature sensing electrode (301), a second conductive lead (302) connected with the temperature sensing electrode (301) and a second signal leading-out end (303) connected with the second conductive lead (302); The strain sensing units (40) are distributed along the axial direction of the guide wire main body (10) and acquire bending angle and space posture information of the guide wire main body (10) in real time, wherein the strain sensing units (40) comprise strain sensing electrodes (401), third conductive leads (402) connected with the strain sensing electrodes (401) and third signal leading-out ends (403) connected with the third conductive leads (402); wherein the piezoresistive effect-based unit (201) and the triboelectric effect-based unit (202) are located at the end of the guide wire body (10), the temperature sensing electrode (301) is located immediately after the piezoresistive effect-based unit (201) and the triboelectric effect-based unit (202) in the axial direction, and the strain sensing electrode (401) is located immediately after the temperature sensing electrode (301) in the axial direction and is located in the middle of the guide wire body (10).
  2. 2. The multidimensional sensing interventional guide wire according to claim 1, wherein the piezoresistive effect-based unit (201) is of a multi-layer composite structure and comprises a flexible protective layer (2011), a first functional layer (2012) and a first touch sensing electrode (2013) from top to bottom, the first touch sensing electrode (2013) is a nano silver ink electrode and provides a stable conductive path, the first functional layer (2012) is a pressure sensitive ink layer, and the resistance changes with compression or stretching under the action of external force.
  3. 3. The multidimensional sensing interventional guide wire according to claim 1, wherein the triboelectric effect unit (202) is a multi-layer composite structure, comprising a second functional layer (2021) and a second tactile sensing electrode (2022) from top to bottom, wherein the second tactile sensing electrode (2022) is a nano silver ink electrode, and provides a stable conductive path.
  4. 4. A multidimensional sensing interventional guidewire according to claim 3, wherein the second functional layer (2021) is a PDMS and PTFE composite membrane.
  5. 5. The multidimensional sensing interventional guide wire according to claim 1, wherein the temperature sensing electrode (301) is a periodic curve structure formed by temperature sensitive ink jet printing, the peaks and valleys of which alternate and the wave vector direction is parallel to the axis of the guide wire body (10).
  6. 6. The multidimensional sensing interventional guide wire according to claim 1, wherein the strain sensing electrode (401) is a first periodic curve structure and a second periodic curve structure formed by strain sensitive ink jet printing, adjacent ends of the first periodic curve structure and the second periodic curve structure are connected, peaks and troughs of the first periodic curve structure and the second periodic curve structure alternate and a wave vector direction is parallel to the guide wire body (10) axis.
  7. 7. The multi-dimensional perception interventional guide wire according to claim 1, wherein the first conductive lead (203), the second conductive lead (302) and the third conductive lead (402) are formed of nano silver ink.
  8. 8. The multidimensional sensing interventional guide wire according to claim 1, wherein the strain sensing units (40) are provided with four strain sensing units (40) symmetrically arranged at 0 °, 90 °, 180 ° and 270 ° positions along the circumference of the guide wire body (10).
  9. 9. A method of making a multidimensional sensing interventional guide wire according to any one of claims 1-8, comprising the steps of: s1, preprocessing a guide wire main body (10) to enable an active layer to be formed on the surface of the guide wire main body (10); S2, spraying nano silver ink on a first preset area of the outer wall of the guide wire main body (10) to form a first touch sense electrode (2013) based on a piezoresistive effect unit (201), a second touch sense electrode (2022) based on a triboelectric effect unit (202) and a first conductive lead (203), wherein the first touch sense electrode (2013) and the second touch sense electrode (2022) are respectively connected to a first signal leading-out end (204) through the first conductive lead (203); Forming a first functional layer (2012) over the first tactile electrode (2013), followed by spin coating PDMS on the first functional layer (2012) to form a protective layer (2011); spraying PDMS and PTFE composite film on the second touch sensing electrode (2022) to form a second functional layer (2021); Meanwhile, spraying temperature sensing ink on a second preset area of the outer wall of the guide wire main body (10) to form a temperature sensing electrode (301), and spraying nano silver ink on the end part of the temperature sensing electrode (301) to form a second conductive lead (302) and connecting the second conductive lead to a second signal leading-out end (303); The strain sensitive ink is sprayed and printed on a third preset area of the outer wall of the guide wire main body (10) to form a strain sensing electrode (401), and the two ends of the strain sensing electrode (401) are formed into a third conductive lead (402) by spraying and printing nano silver ink and are connected to a third signal leading-out end (403); s3, spin coating PDMS on the surface of the guide wire main body (10) to form a protective film, and reinforcing the connection part.
  10. 10. Use of a multidimensional sensing interventional guidewire according to any one of claims 1-8 in vascular interventions.

Description

Multidimensional sensing interventional guide wire and preparation method and application thereof Technical Field The invention relates to the field of medical instruments, in particular to a multidimensional sensing interventional guide wire, and a preparation method and application thereof. Background Cardiovascular and cerebrovascular diseases are serious diseases with high mortality and disability rates in the global scope, wherein stenosis or occlusion lesions of coronary arteries, cerebral arteries and peripheral blood vessels are common and serious. In order to restore the smooth blood flow and improve focal perfusion, interventional therapy techniques have been rapidly developed. As one of the most critical operating instruments in interventional procedures, a guidewire assumes the core functions of vascular access, lesion passage and navigation of the delivery instrument, with mechanical and handling properties directly affecting the safety and success rate of the procedure. The guide wire used clinically at present is mainly based on nickel-titanium alloy or stainless steel wire cores, and different supporting force, torsion control performance and trafficability are realized by changing taper, compliant section structure and surface coating. However, these conventional designs still rely primarily on the experience of the physician and X-ray fluoroscopy to perform the procedure, and only provide general position and profile information of the guidewire, which does not reflect the real-time status of the vascular environment. When the guide wire advances in a narrow, bent or severely diseased blood vessel, a doctor can hardly judge the real interaction relation between the tip of the guide wire and the blood vessel wall according to images, and can not sense whether contact, penetration, blocking or potential damage occurs, so that operation risks exist. In addition, the existing guide wires cannot provide key information such as force feedback, tactile feedback or temperature change, and a doctor lacks a real 'touch' in the operation process, and the defect is more obvious especially in a minimally invasive robotic system or a remote intervention platform. In recent years, interventional medical devices have been widely used in the treatment of cardiovascular, cerebrovascular and peripheral vascular diseases, wherein the flexibility, controllability and safety of an interventional guide wire as a key operation element directly affect the operation effect. In order to realize accurate and reliable vascular access and supporting and conveying, students at home and abroad continuously discuss a technical scheme for integrating multiple functions in a guide wire. In terms of terminal force sensing, researchers have tried to adopt structures such as piezoelectric films, MEMS pressure chips, ion gel capacitance sensors and the like so as to realize detection of contact force of the front end of a guide wire or the wall surface of a guide tube. Such sensors have high sensitivity, but are generally bulky, stiff, difficult to integrate on small diameter guidewires, and may compromise the original flexibility and passability of the guidewire. In terms of temperature and strain sensing, common schemes include Fiber Bragg Grating (FBG) sensors and strain resistive sensing units. The FBG sensor has the advantages of high sensitivity and electromagnetic interference resistance, but is complex in arrangement and high in cost, and batch integration is difficult to realize on a submillimeter flexible structure. The strain resistance sensor has a simple structure, but the traditional metal printing or vapor plating process is difficult to form stable continuous wires on a curved surface, and the reliability and consistency are insufficient. With the development of flexible electronic and spray coating manufacturing technologies, researchers begin to adopt conductive polymers, silver nanoparticles, carbon nanotubes and other materials to construct a multifunctional sensing layer on a flexible substrate in a spray coating, printing or coating mode, so as to realize synchronous sensing of bending, temperature and stress. However, the resolution and the adhesive force of the traditional spray coating or printing pattern in the curved surface area are limited, so that the application requirements of the guide wire in the small-diameter and high-bending environments are difficult to meet, and meanwhile, most schemes still mainly use a single sensing mode, so that a multifunctional integrated structure is difficult to form. In summary, although the prior art can realize the local sensing function, the problems of insufficient force feedback, single mode, incomplete sensing and the like still exist, and a stable and continuous multi-mode sensing structure is difficult to form on the surface of a micro guide wire. An integrated scheme for realizing multi-dimensional integrated sensing on a small-diameter flexible guide wir