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CN-121971790-A - Photoelectric microneedle system with bionic electric stimulation and drug controlled release functions

CN121971790ACN 121971790 ACN121971790 ACN 121971790ACN-121971790-A

Abstract

The invention discloses a photoelectric microneedle system with bionic electric stimulation and drug controlled release functions, which comprises a silicon film, hydrogel microneedles and a drug, wherein the silicon film is a silicon film array with two different doping types, and the hydrogel microneedles are arranged on the surface of the silicon film and contain the drug. Through the semiconductor films with different polarities arranged in an array, a photo-generated electric field with adjustable direction can be generated under illumination, so that the direction of the photo-generated electric field is consistent with an endogenous electric field formed after tissue injury, and wireless, accurate and controllable bionic electric stimulation is realized. Different doping types of semiconductor films generate different electric fields under illumination, and can realize directional migration and release of drug molecules with different charge properties as required. The photo-generated electric field can simulate and strengthen endogenous electric signals after skin injury, regulate and control cell migration, proliferation and reconstruction processes, and can synchronously drive drugs to be accurately released from the microneedle hydrogel.

Inventors

  • WANG HUACHUN
  • YE JINGLIN
  • HUANG JINWEI

Assignees

  • 中山大学

Dates

Publication Date
20260505
Application Date
20260303

Claims (10)

  1. 1. An optoelectronic microneedle device is provided, which comprises a substrate, characterized by comprising the following steps: The silicon film is a silicon film array with two different doping types; A hydrogel microneedle disposed on a surface of a silicon film, the hydrogel microneedle comprising a drug.
  2. 2. The optoelectronic microneedle system according to claim 1, wherein the silicon thin film array has a PN structure doped with phosphorus ions and/or boron ions.
  3. 3. The optoelectronic microneedle system according to claim 2, wherein the concentration of the phosphorus ion and the boron ion doping is 10 17 -10 20 , respectively.
  4. 4. The optoelectronic microneedle system according to claim 1, wherein the silicon film thickness is 1-12 μm.
  5. 5. The optoelectronic microneedle system according to claim 1, wherein the array arrangement of silicon thin films comprises two silicon thin films of different doping types alternately arranged longitudinally or laterally.
  6. 6. The optoelectronic microneedle system according to claim 1, wherein the arrangement of the silicon thin film array comprises a silicon thin film of one doping type being arranged at the center and a silicon thin film of another doping type being arranged around the silicon thin film of another doping type.
  7. 7. The optoelectronic microneedle system of claim 1, wherein the drug in the hydrogel microneedle comprises at least one of cefazolin, sodium hyaluronate, epidermal growth factor, lactoferrin, chitosan, cationic polypeptide, silver ion.
  8. 8. The optoelectronic microneedle system of claim 1, wherein the hydrogel microneedle is a drug-containing methacryloylated hydrogel microneedle.
  9. 9. A method of making the optoelectronic microneedle system of claims 1-8 comprising the steps of: (1) Preparing raw materials: Preparing a silicon thin, namely taking an SOI structure wafer, and respectively doping a top silicon film with phosphorus ions and boron ions to realize a pn junction; Preparing hydrogel microneedles, namely taking a methacryloylated hydrogel solution, adding a drug and a photoinitiator, mixing, transferring into a mold, performing vacuum defoamation, and finally performing ultraviolet irradiation curing; (2) Preparation of an optoelectronic microneedle system: Transferring the silicon film to the bottom of the cured hydrogel microneedle according to a certain arrangement mode, dripping hydrogel solution to coat the silicon film, performing light curing again, drying and demolding to obtain the photoelectric microneedle system.
  10. 10. The method of claim 9, wherein the concentration of the methacryloylated hydrogel solution is 5-15% w/v and the concentration of the drug in the hydrogel solution is 0.5-1.5mg/mL.

Description

Photoelectric microneedle system with bionic electric stimulation and drug controlled release functions Technical Field The invention relates to the field of semiconductor materials, biological materials and biomedical applications thereof, in particular to a photoelectric microneedle system with bionic electric stimulation and drug controlled release functions. Background With aging population and high incidence of chronic diseases, long-term pain, recurrent infections and even serious complications (such as sepsis and amputation) caused by partially difficult self-healing wounds (such as diabetic foot, pressure ulcers, venous ulcers, etc.) have attracted continued medical attention. Such difficult-to-heal wounds often accompany problems of local microenvironment disorders, insufficient blood supply, persistent inflammation, blocked cell migration, and the like, and traditional treatment modes (such as simple dressing, external medicine or debridement) often have difficulty in achieving ideal curative effects. Therefore, there is a need to develop innovative therapeutic techniques with more efficient, precise, multifunctional synergistic effects, providing more viable solutions for the clinic in order to improve the quality of life of patients. The skin spontaneously forms an endogenous electric field directed from the surrounding tissue to the wound center after injury, and when the wound area is used as the opposing cathode and the surrounding healthy skin is used as the anode, a weak but sustained potential gradient can direct cell migration, differentiation and polarity reconstruction. A large number of researches show that the endogenous electric signal can be simulated, enhanced or rebuilt through an external electric field, so that the migration of keratinocytes and fibroblasts can be obviously promoted, the closure of epithelium is accelerated, the angiogenesis is improved, and the wound healing is effectively promoted. At the same time, electrically-facilitated drug delivery techniques provide new strategies for the treatment of difficult-to-heal wounds. The core principle is that the migration behavior of drug molecules is regulated and controlled by applying an external electric field, so that the drug release rate, the total release amount and the diffusion path of the drug molecules in tissues are precisely controlled. Compared with the traditional drug delivery mode, the electric stimulation can not only realize the release according to the requirement, but also directionally deliver the drug to the deep tissue of the wound, thereby improving the local effective concentration and reducing the systemic side effect. In the aspect of drug carriers, the stimulus-responsive hydrogel is regarded as an important direction of a modern intelligent drug delivery system because of reversible physical or chemical structural changes under external stimulus such as pH, temperature, light, electricity, ion intensity and the like. The light response type hydrogel material can carry out space-time precise regulation and control on the drug release process by virtue of non-contact property, high spatial resolution and adjustable intensity and wavelength of light stimulation. By combining good biocompatibility and shape plasticity, the hydrogel can be formed into a microneedle array through mold molding, so that painless and minimally invasive percutaneous administration is realized, and the drug can penetrate through the stratum corneum barrier and be directly delivered to the focus area inside the wound, thereby greatly improving the treatment efficiency. In view of the key role of an endogenous electric field in wound healing and the advantages of the light response hydrogel microneedle in the on-demand administration, the synergistic integration of controllable photoelectric stimulation and intelligent drug delivery has important significance. Based on the method, a photoelectric response type hydrogel microneedle system which can simulate an endogenous electric field and realize the synchronous effect of electric stimulation and drug controlled release under the triggering of illumination is constructed, and the method is expected to further improve the microenvironment of wounds, strengthen cell repair behaviors and enhance drug curative effects, so that the overall treatment effect of difficult-to-heal wounds is improved. Disclosure of Invention In order to overcome the defects of the prior art, the invention provides a photoresponsive semiconductor film-hydrogel microneedle patch system combining an endogenous electric field simulation and drug controlled release, which solves the problems that the prior art needs wire connection and the endogenous electric field simulation is difficult, and the endogenous electric field simulation and the drug controlled release are difficult to combine. The first aspect of the present invention provides an optoelectronic microneedle system with bionic electrical stimu