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CN-121971791-A - Lesion discovery positioning and targeting drug guiding system and method based on acousto-optic coupling functional film layer

CN121971791ACN 121971791 ACN121971791 ACN 121971791ACN-121971791-A

Abstract

The invention relates to the technical fields of noninvasive medical imaging, acousto-optic coupling and targeted drug delivery, and discloses a lesion discovery positioning and targeted drug guiding system and method based on an acousto-optic coupling functional film layer. By means of intelligent processing equipment with acoustic, optical and signal processing capabilities, noninvasive discovery, accurate fault location, directional guiding and local enrichment of targeted drugs of human tissue/body fluid lesions are realized in a time sharing mode through the same physical area of the same acousto-optic coupling integrated functional film layer, the film layer multiplies frequency of a 20Hz-20kHz low-frequency signal into 2MHz-10MHz medical ultrasound to complete imaging location, and meanwhile, targeted drug guiding such as photo/acoustic power, magnetic targeting, ultrasonic transdermal penetration promotion and the like is realized through a special optical/energy conducting layer, so that the drug focus enrichment rate is improved, and the side effects of the whole body are reduced. The system does not need to transform equipment hardware, has flexible film form and wide suitability, integrates medical grade diagnosis and treatment functions in consumer-grade electronic equipment for the first time, realizes low-cost popularization, is suitable for targeted drug treatment guidance of various lesions such as solid tumors, virus infection stoves, chronic inflammatory stoves and the like, can be applied to multiple scenes such as families, primary medical treatment, hospitals and the like, and has the remarkable advantages of high accuracy and noninvasive safety.

Inventors

  • CHANG LE

Assignees

  • 常乐

Dates

Publication Date
20260505
Application Date
20260323

Claims (7)

  1. 1. The lesion discovery positioning and targeting drug guiding system based on the acousto-optic coupling functional film layer is characterized by comprising at least one intelligent processing carrier, an acousto-optic coupling integrated functional film layer, a scanning mechanism, a targeting drug guiding module and a processing and positioning module; The intelligent processing carrier is an electronic device with an acoustic emission unit, a pickup unit, an optical unit and a processor, and can at least generate 20Hz-20kHz audio/vibration signals, collect echo signals, execute signal processing and control, and can be adapted without modifying hardware, including but not limited to mobile phones, tablets, computers, medical integrated machines, embedded terminals and special diagnosis and treatment hosts; The acousto-optic coupling integrated functional film layer is an integrated functional structure (continuous and complete, function is indistinct), is configured on a carrier in any form such as a flexible film, a hard film sheet, an equipment built-in layer, a coating film or a shell built-in component and the like, is realized by the same physical area in a time sharing way, comprises ① sound wave frequency conversion, focusing and transmission type human tissue/body fluid tomography, completes lesion discovery and accurate positioning, comprises ② targeted medicine directed energy/field coupling focusing delivery, realizes medicine focus enrichment, and at least comprises the following components in total thickness of 0.05mm-5 mm: the coupling matching layer is made of biocompatible materials (medical hydrophilic gel and optical resin) and is used for realizing acoustic/optical/energy impedance matching and eliminating air loss; The acoustic treatment layer is a multi-level resonant microcavity array formed by a micron-level film (preferably 0.5-5 μm) +an air gap (preferably 1-10 μm), the single-level frequency multiplication coefficient is 10-20, the three-level serial connection realizes 1000-8000 frequency multiplication, the low-frequency signal of 20Hz-20kHz is multiplied to the medical ultrasonic frequency band of 2MHz-10MHz, and the echo signal to noise ratio is more than or equal to 15dB; An optical/energy conducting layer made of optical resin, light-transmitting polymer, optical fiber array or conductive film (with adaptive electric perforation guide) with thickness of 0.01-0.1mm, wherein imaging optical signal is transmitted and conducted through the layer, and energy/field (light, sound and electricity) is guided to be focused and delivered through the layer, and magnetic guiding energy can penetrate the layer to directly act on focus; An acousto-optic isolation layer, which is made of anti-signal interference materials (porous acoustic foam and metal shielding films) and is used for avoiding imaging and guiding signal crosstalk; The scanning mechanism realizes the relative scanning of the carrier/membrane layer and the human body/body fluid, and the scanning mode comprises at least one of rotation, translation, arc swing, multi-equipment fixed array, human body/local limb movement and support device movement for bearing the human body; The targeting drug guiding module can generate one or more guiding energies/fields of photodynamic force, acoustic force, magnetic targeting focusing, ultrasonic transdermal penetration promotion and electroporation penetration promotion, the module can be integrated inside an intelligent treatment carrier, externally connected with a carrier interface or used as an independent unit to be attached to a membrane layer, the optical/acoustic/electric guiding energies are precisely focused on a focus area through an optical/energy conducting layer of the membrane layer, and the magnetic guiding energies directly act by penetrating through the membrane layer; the processing and positioning module realizes echo signal acquisition, noise reduction, tomographic image reconstruction, focus three-dimensional accurate positioning, time-sharing isolation control of imaging and guiding, guiding energy/field output adjustment, and can be integrated in a membrane layer by matching with a micro sensor to monitor physiological parameters of a guiding area in real time.
  2. 2. The system of claim 1, wherein the material, form, forming process and assembly mode of the acousto-optic coupling integrated functional film layer are all within the protection scope of the invention as long as the functions of acoustic frequency conversion focusing, lesion imaging positioning and targeted drug guiding energy/field coupling focusing delivery are realized, and the film layers in the forms of coating, film coating and the like are of continuous integrated structures, have complete functions and are not limited by the attachment of a factory built-in/user side during assembly.
  3. 3. The system of claim 1, wherein the system adopts an imaging and targeting drug guiding time-sharing isolation mechanism, and is realized by a processing and positioning module through time sequence scheduling, wherein an acoustic emission unit of an intelligent processing carrier and an echo acquisition channel of a shielding pick-up unit are closed before guiding, acoustic signal transmission is completely blocked, any acoustic signal emission and acquisition is forbidden in the guiding process, interference of guiding energy/fields is avoided, and after the guiding is finished, the processing and positioning module restarts the acoustic emission unit and the echo acquisition channel to restore an imaging function.
  4. 4. The system of claim 1, wherein the targeting agent comprises at least one of photodynamic targeting agent, sonodynamic targeting agent, magnetic nano drug-loaded particles, liposome targeting agent, and antibody coupled targeting agent, and the targeting agent guiding module is matched with a corresponding guiding mode according to the type of the targeting agent, wherein when electroporation is used for promoting permeation, an optical/energy conducting layer is embedded with a conductive film (a conductive polymer or a metal film) to realize micro-current conduction.
  5. 5. The system according to claim 1, wherein the targeted drug guidance of deep lesions (> 3 cm), blood lesions, whole body multiple lesions is achieved by multi-device multi-angle energy/field superposition using single or multiple arbitrary type carriers, including multi-device co-focusing, single-device multi-output head guidance, multi-device time-sharing irradiation guidance.
  6. 6. The lesion discovery positioning and targeting drug guiding method based on the acousto-optic coupling functional film layer is characterized by comprising the following steps of: The method comprises the steps of 1, configuring a film body, namely configuring an acousto-optic coupling integrated functional film layer in an acoustic and optical unit corresponding area of an intelligent processing carrier in any mode (film pasting, built-in, integrated, coating, film plating and embedded), so that a coupling matching layer is tightly attached to a part to be detected of a human body/body fluid, and an air gap is eliminated; Step 2, global scanning and lesion discovery, namely finishing global scanning of human tissues/body fluids through a scanning mechanism, enabling a low-frequency signal output by a carrier to be subjected to membrane layer frequency multiplication to be 2MHz-10MHz focused ultrasound and transmit a human body, and enabling a processing and positioning module to reduce noise, analyze and reconstruct a tomographic image after echo is acquired by frequency reduction, so as to find an abnormal lesion region; step 3, focus accurate positioning, wherein the processing and positioning module identifies focus boundaries and ranges based on the tomographic images and calibrates three-dimensional accurate coordinates thereof; Step 4, time-sharing isolation targeting drug guiding, namely closing an acoustic emission unit and an echo acquisition channel through a processing and positioning module, applying the targeting drug to a human body, accurately focusing guiding energy/field of the targeting drug guiding module on a focus three-dimensional coordinate area through the same physical area of a membrane layer, delivering optical/acoustic/electric guiding energy through an optical/energy conducting layer, delivering magnetic guiding energy through the membrane layer, and realizing directional movement, local enrichment or transdermal/tissue permeation guiding of the drug; step 5, verifying the medicine focus enrichment condition by restarting the acoustic emission unit and the echo acquisition channel through the processing and positioning module, quantitatively analyzing the medicine concentration by adopting high performance liquid chromatography or near infrared fluorescence imaging, comparing the medicine concentration with focus medicine concentration of a conventional administration mode (oral/intravenous injection/body surface coating) at the same time point under the same dosage, wherein the enrichment lifting rate is more than or equal to 60 percent, and recording diagnosis and treatment data such as tomographic images, focus coordinates, guide parameters and the like in the whole process; And 6, deep/multiple focus treatment, wherein deep focus (> 3 cm) is realized by multi-equipment multi-angle cooperative energy/field superposition, and the whole body multiple focus is guided in a multi-equipment array distributed type partition manner in a multiple-time manner.
  7. 7. The method of claim 6, wherein the lesion in step 6 comprises at least one of a solid tumor, a blood tumor, a viral infection focus, a chronic inflammation focus, and a fibrosis focus, and the intelligent processing carrier is consumer electronic equipment (mobile phone, tablet) to realize medical imaging positioning and targeting drug guiding functions without modifying hardware, thereby greatly reducing diagnosis and treatment equipment cost.

Description

Lesion discovery positioning and targeting drug guiding system and method based on acousto-optic coupling functional film layer Technical Field The invention relates to the technical fields of noninvasive medical imaging, acousto-optic coupling and targeted drug delivery, in particular to an integrated system and method for realizing noninvasive discovery, accurate fault positioning, targeted drug targeted focus directional guiding and local enrichment of human tissue/body fluid lesions through an acousto-optic coupling integrated functional film layer by depending on intelligent processing equipment (comprising consumer-level electronic equipment and medical equipment), and is suitable for targeted drug treatment guiding of various lesions such as solid tumors, blood tumors, virus infection focus, chronic inflammation focus, fibrosis focus and the like. Background The existing targeted drug treatment has the problems of low focus enrichment rate and large systemic side effect, and the lesion discovery positioning and targeted drug delivery are discrete processes, which are completed by means of medical equipment with different high cost and large volume, and part of the equipment has ionization radiation/strong magnetic field taboo, so that the targeted drug is difficult to popularize in basic level and family scenes. The conventional consumer-level intelligent terminal (mobile phone, tablet and the like) has extremely high popularization rate, has no medical ultrasonic imaging capability, is not developed for targeted drug directional guiding, is only singly applied to imaging or treatment, does not disclose that 'acousto-optic transmission imaging positioning' and 'targeted drug accurate guiding' are combined through the same physical area of the same film, does not realize transformation-free adaptation with consumer-level electronic equipment, and lacks an integrated scheme with low cost and popularization. Clinical verification shows that accurate focusing of energy/fields such as light, sound, magnetism, electricity and the like can improve the focus enrichment rate of the targeted drug, and mild energy guiding is free of tissue damage. At present, a technical scheme for integrating lesion discovery and positioning with targeted drug guiding, adapting to consumer-level intelligent equipment, needing no hardware transformation, having low cost and easy popularization is needed, the problem that the existing targeted drug treatment and diagnosis equipment is discrete in pain point is solved, and meanwhile, the problems of ambiguous functional film layer structure and unclear guiding mechanism coupling in the prior art are overcome. Disclosure of Invention System composition The system of the invention is composed of at least one intelligent processing carrier, an acousto-optic coupling integrated functional film layer, a scanning mechanism, a targeting drug guiding module and a processing and positioning module, does not need to modify carrier hardware, realizes 'lesion discovery-accurate positioning-targeting drug guiding' integrated closed loop, and has the core innovation that the medical ultrasonic imaging and targeting drug guiding functions are integrated in consumer electronic equipment for the first time: The intelligent processing carrier comprises consumer electronic equipment (mobile phone and tablet) and medical equipment (medical integrated machine and special diagnosis and treatment host), and has the audio emission, echo collection and signal processing capabilities of 20Hz-20kHz, the optical signal unit is unnecessary to be configured, the system can be directly adapted without modifying hardware, the popularization advantage of the consumer equipment is fully exerted, and the use cost is reduced. The acoustic-optical coupling integrated functional film layer is a core integrated functional structure (continuous and complete, function is indistinct), imaging positioning and targeted medicine guiding are realized in the same region in a time sharing way, the form is flexible (film pasting/integration/coating and the like), and four layers of core structures work cooperatively: The coupling matching layer is made of biocompatible materials, eliminates air loss and realizes acoustic/optical/energy impedance matching; the acoustic treatment layer is a multistage resonant microcavity array, completes frequency multiplication conversion from a low-frequency signal to medical ultrasound, and ensures imaging precision; An optical/energy conducting layer, which is made of definite materials (optical resin, light-transmitting polymer, optical fiber array and conductive film) and has a thickness (0.01-0.1 mm) to realize imaging optical signal transmission and optical/acoustic/electric guiding energy focusing delivery, wherein magnetic guiding energy can directly penetrate; And the acousto-optic isolation layer is made of anti-interference materials, and imaging and guiding signal crosstalk are avo