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CN-121972065-A - Compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring mixing device

CN121972065ACN 121972065 ACN121972065 ACN 121972065ACN-121972065-A

Abstract

The invention relates to the technical field of stirring and mixing of granular raw materials, in particular to a compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device, which comprises a plurality of processing frames which are uniformly distributed from top to bottom and have upward openings, wherein the bottoms of the processing frames are provided with discharge holes, stirring mechanisms are arranged in the processing frames, the device adopts a mode of combining layered paving and alternate superposition, firstly, active ingredients are singly stirred and leveled, then are overlapped with auxiliary materials layer by layer, the active ingredients are uniformly attached to the surfaces of the auxiliary materials through throwing, and the problem that the active ingredients are directly mixed and are easy to disperse and uneven can be solved through multistage gradual dilution, so that the content accuracy of the medicine is improved, and the uniform standard of each capsule ingredient is ensured.

Inventors

  • CHEN BINGCHAO
  • Guo Lizhan
  • HUANG JUBIN
  • CHEN RENXIA

Assignees

  • 山西皇城相府药业股份有限公司

Dates

Publication Date
20260505
Application Date
20260407

Claims (10)

  1. 1. The pretreatment stirring mixing device for the compound dibazol hydrochlorothiazide capsule raw material is characterized by comprising a plurality of treatment frames (1) which are uniformly distributed from top to bottom and have upward openings, wherein a discharge hole (11) is formed in the bottom of each treatment frame (1), and a stirring mechanism (2) is arranged in each treatment frame (1); the device also comprises a plurality of annular frames (3) which are matched with the processing frames (1) one by one, wherein the processing frames (1) are rotatably arranged in the annular frames (3); Support frames (4) are symmetrically arranged along the radial direction of the processing frame (1), and the annular frames (3) are arranged on the support frames (4) at the corresponding sides through connecting plates (41); The stirring mechanism (2) comprises a rotating shaft (21) which is rotatably arranged at the middle position in the bottom of the processing frame (1) through a bearing, a stirring frame (22) is arranged on the rotating shaft (21), and a plurality of stirring rods (23) are uniformly arranged at the bottom of the stirring frame (22) along the length direction; A lifting frame (24) capable of moving up and down is arranged on the rotating shaft (21) in a sliding manner, the stirring rods (23) penetrate through the lifting frame (24), and a scraping plate (25) is arranged at the bottom of the lifting frame (24) and between two adjacent stirring rods (23); The linkage connecting rod (241) is installed at crane (24) top, and linkage connecting rod (241) top runs through corresponding stirring frame (22) and is provided with the structure of buckling, and processing frame (1) inner wall is provided with continuous hob (242), and the structure of buckling leans on hob (242).
  2. 2. The pretreatment stirring mixing device for the compound dibazol hydrochlorothiazide capsule raw material according to claim 1 is characterized in that an extending frame (31) is arranged on the annular frame (3), a driving shaft (32) is rotatably arranged on the extending frame (31) through a bearing, and a gear (32) is arranged on the driving shaft; The processing frame (1) is provided with an annular rack plate (34) meshed with a corresponding gear (33), the driving shaft (32) can drive the processing frame (1) to rotate through the meshing of the gear (33) and the annular rack plate (34), and the rotating direction of the processing frame (1) is opposite to the rotating direction of the rotating shaft (21).
  3. 3. The pretreatment stirring mixing device for the compound dibazol hydrochlorothiazide capsule raw materials according to claim 1 is characterized in that a connecting plate (41) corresponding to any supporting frame (4) is respectively provided with a lifting rod (42) in a penetrating and sliding manner, a linkage rod (43) is arranged at the top of the lifting rod (42), a lifting cylinder (44) is arranged on the connecting plate (41), and the telescopic end of the lifting cylinder (44) is connected with the corresponding linkage rod (43); The lifting rod (42) is provided with fixing plates (45) which are in one-to-one correspondence with the processing frames (1), the fixing plates (45) are provided with annular plates (46) coaxial with the corresponding processing frames (1), and annular grooves are formed in the inner side walls of the annular plates (46).
  4. 4. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 3 is characterized in that a plugging plate (47) for opening and closing the discharging hole (11) is arranged at the bottom of the discharging hole, the plugging plate (47) is connected with the bottom of a corresponding treatment frame (1) through a telescopic spring rod, and the plugging plate (47) is arranged in the annular groove in a limiting sliding manner; The lifting cylinder (44) can drive the plugging plate (47) to move up and down so as to realize the opening and closing of the discharge hole (11).
  5. 5. The pretreatment stirring mixing device for compound dibazol hydrochlorothiazide capsule raw materials of claim 4 is characterized in that the top of the plugging plate (47) is provided with a triangular prism structure which is horizontally placed, and a plurality of drawing and inserting rods (471) are uniformly arranged; The lifting cylinder (44) can drive the connecting plate (41) to reciprocate up and down through the cooperation of the lifting rod (42) and the linkage rod (43), and then drive the plugging plate (47) to reciprocate up and down, and the plugging rod (471) can loosen raw materials near the discharge hole (11).
  6. 6. The pretreatment stirring mixing device for compound dibazol hydrochlorothiazide capsule raw materials of claim 1 is characterized in that the bending structure can slide along a screw rod (242) when rotating along a rotating shaft (21), and the lifting frame (24) is driven to synchronously move upwards under the limit action of the screw rod (242); When the bending structure moves to the top limit position of the screw rod (242), the bending structure can naturally slide down to the penultimate section of the screw rod (242) along the guide inclined plane of the screw rod (242), and continuously rotate along with the rotating shaft (21) to repeat lifting actions.
  7. 7. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device of claim 1 is characterized in that a transmission mechanism (5) is arranged between two adjacent treatment frames (1) on the other support frame (4), the transmission mechanism (5) comprises fixed frames (51) symmetrically arranged along the length direction of the support frame (4), transmission shafts (52) are rotatably arranged between the fixed frames (51) through bearings, and the transmission shafts (52) are in transmission connection with the corresponding rotation shafts (21) of the two adjacent treatment frames (1) through a belt transmission mode.
  8. 8. The pretreatment stirring mixing device for compound dibazol hydrochlorothiazide capsule raw materials according to claim 7, wherein a belt wheel close to the upper part of the circumferential surface of a transmission shaft (52) is provided with a belt wheel I (521), belt wheels sleeved at one ends of all rotating shafts (21) towards each other are provided with a belt wheel II (211), belt wheels sleeved at the bottom of the transmission shaft (52) are provided with a belt wheel III (522), the diameter of the belt wheel I (521) is larger than that of the belt wheel II (211), the diameter of the belt wheel II (211) is equal to that of the belt wheel III (522), and the rotating speed of the rotating shafts (21) distributed from top to bottom can be gradually reduced.
  9. 9. The pretreatment stirring mixing device for the compound dibazol hydrochlorothiazide capsule raw materials according to claim 1, wherein the treatment frame (1) rotates during blanking, the lifting frame (24) is driven to move downwards through the cooperation of the spiral rod (242) and the bending structure, the stirring rod (23) keeps a rotating state relative to the treatment frame (1), and the lifting frame (24) moves downwards to scrape the raw materials to a concave area of the discharge hole (11).
  10. 10. The pretreatment stirring mixing device for compound dibazol hydrochlorothiazide capsule raw materials of claim 1, wherein the bending structure scrapes raw materials attached to a screw rod (242) in the process of moving on the screw rod (242); The raw materials poured into the processing frame (1) are always positioned below the stirring frame (22) and keep a distance from the stirring frame (22) so as to avoid obstructing the stirring rod (23) from rotating normally and circumferentially.

Description

Compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring mixing device Technical Field The invention relates to the technical field of stirring and mixing of granular raw materials, in particular to a pretreatment stirring and mixing device for a compound dibazol hydrochlorothiazide capsule raw material. Background In the pharmaceutical industry, the compound dibazol hydrochlorothiazide capsule is a medicament commonly used for treating hypertension. The preparation is formed by combining the main active components of the dibazol (a granular vasodilator for reducing blood pressure and improving brain blood circulation) and the hydrochlorothiazide (a granular diuretic for promoting the discharge of excessive salt and moisture in the body so as to reduce the blood pressure), and in the preparation process, auxiliary materials are often required to be added in the raw material mixing process in order to facilitate the raw materials to prepare stable capsules. The traditional mixing mode is to uniformly stir and mix all raw materials for preparing the compound dibazol hydrochlorothiazide capsule by using the existing equipment, for example, patent application with publication number of CN205760725U discloses a particle mixing and stirring device, a first material guide plate is fixedly arranged at the upper end in a charging barrel, a first stirring roller group containing two stirring rollers side by side is rotatably arranged below the charging barrel, a second material guide plate is fixedly arranged below the first stirring roller group, a lower rotation mounting structure of the second stirring roller group is identical to that of the first stirring roller group, a third stirring roller group containing two coaxial stirring rollers is rotatably arranged below the second stirring roller group, and materials are uniformly and thoroughly mixed through five times when flowing from a feed inlet at the upper end of the charging barrel to a discharge outlet at the bottom, so that labor force is saved and working efficiency is improved. In the production process of the compound dibazol hydrochlorothiazide capsule, the actual ratio of active ingredients is usually lower, the main body is composed of various auxiliary materials to ensure the molding and stability of the capsule, and the uniform mixing process is adopted, so that all raw materials are required to be added into a charging barrel for stirring at one time, and the problem that firstly, as the ratio of two active ingredients in the total materials is limited, when the two active ingredients are directly mixed with a large amount of auxiliary materials together, the problem of uneven component dispersion is very easy to occur, although the device is subjected to repeated mixing through a five-stage serial stirring structure, the mixing modes of all stages are basically consistent, the fine dispersion is difficult to be carried out according to the characteristics of different materials, and the content accuracy of the medicine in each capsule cannot be ensured. Secondly, the physical properties of the active ingredients and the auxiliary materials, such as particle size distribution, density, surface properties and the like, are obviously different, and in the uniform stirring process, the property differences can lead to layering of the materials due to vibration and flow, so that quality fluctuation among different capsules in the same production batch is caused, and the uniformity and treatment safety of the product are directly influenced. Based on the above, in the state of the art, there is still room for improvement in the way of pre-treating, stirring and mixing the raw materials of the compound dibazol hydrochlorothiazide capsule. Disclosure of Invention In order to solve the technical problems in the prior art, the invention provides a pretreatment stirring mixing device for the raw materials of the compound dibazol hydrochlorothiazide capsule. The technical scheme is that the pretreatment stirring mixing device for the raw materials of the compound dibazol hydrochlorothiazide capsule comprises a plurality of treatment frames which are uniformly distributed from top to bottom and have upward openings, wherein a discharge hole is formed in the bottom of each treatment frame, and a stirring mechanism is arranged in each treatment frame. The device also comprises a plurality of annular frames which are matched with the processing frames one by one, and the processing frames are rotatably arranged in the annular frames. The support frames are symmetrically arranged along the radial direction of the processing frame, and the annular frame is arranged on the support frame on the corresponding side through the connecting plate. The stirring mechanism comprises a rotating shaft which is rotatably arranged at the middle position in the bottom of the processing frame through a bearing, a stirring frame is arranged on the rotating sh