CN-121972245-A - High-precision microfluidic liquid control device and precise control method thereof

CN121972245ACN 121972245 ACN121972245 ACN 121972245ACN-121972245-A

Abstract

The invention discloses a high-precision microfluidic liquid control device and a precise control method thereof; the invention relates to the technical field of microfluidics, which comprises a box body, a controller, an installation and placement assembly, a control and adjustment assembly and a storage and control assembly, wherein the installation and placement assembly is used for fixing a guide pipe through a vertical plate and a slot, the control and adjustment assembly is used for extruding the guide pipe by a motor and a belt driving pressing plate to realize accurate flow regulation, the storage and control assembly integrates a storage box and a pipeline to avoid leakage pollution, and the controller is used for intelligently linking the assemblies. The invention solves the problems of low control precision, easy leakage and complicated operation of the traditional device, realizes high-precision and intelligent control of trace liquid, and improves experimental efficiency and accuracy.

Inventors

HUI WENHAO
WEI MINGJI
WANG XINYU
ZHANG YUE
ZHU ZHEN
Hui Zhihan
ZHANG KAI
LI JIAMING

Assignees

海棠芯(淮安)科技有限公司

Dates

Publication Date: 20260505
Application Date: 20260129

Claims (10)

1. The high-precision microfluidic liquid control device is characterized by comprising a box body (1), a controller (2) detachably connected to the top of the box body (1), an installation and placement component (3) arranged on one side of the inside of the box body (1), a control and adjustment component (4) arranged in the inside of the box body (1) and a storage control component (5) arranged in the inside of the box body (1); The installation and placement assembly (3) comprises a vertical plate (301) fixedly connected to one side of the inside of the box body (1), a slot (302) formed in the surface of the vertical plate (301), a guide pipe (303) connected in a matched mode to the inside of the slot (302) and a movable slot (304) formed in the surface of the vertical plate (301), wherein the inside of the movable slot (304) is communicated with the inside of the slot (302); The control and regulation assembly (4) comprises a first motor (401) detachably connected to the bottom of the inside of the box body (1), a second motor (402) detachably connected to the top of the inside of the box body (1), a rotating shaft (403) connected with the output ends of the first motor (401) and the second motor (402), a rotating roller (404) detachably connected to one end of the rotating shaft (403), a belt (405) cooperatively connected between the rotating rollers (404), a transverse plate (406) detachably connected to one side surface of the belt (405) and a pressing plate (407) fixedly connected to the surface of the transverse plate (406), wherein the pressing plate (407) is movably connected to the inside of the movable groove (304), and one end of the pressing plate (407) is in surface contact with the guide pipe (303); The storage control assembly (5) comprises an installation box (501) detachably connected to the inside of the box body (1), a control box (502) detachably connected to the inside of the installation box (501), a storage box (503) detachably connected to the inside of the control box (502), a water inlet pipe (504) cooperatively connected to one end of the storage box (503), a control valve (505) cooperatively connected to the surface of the water inlet pipe (504) and a water outlet pipe (506) cooperatively connected to the bottom of the storage box (503), wherein one end of the water inlet pipe (504) is cooperatively connected with the guide pipe (303); The controller (2) is electrically connected with the first motor (401), the second motor (402) and the control valve (505).
2. The high-precision microfluidic liquid control device according to claim 1, wherein the vertical plates (301) are vertically distributed, the plurality of grooves (302) are uniformly distributed along the height direction of the vertical plates (301), and each groove (302) is correspondingly connected with one conduit (303) in a matched manner.
3. The high-precision microfluidic liquid handling device according to claim 2, wherein the movable groove (304) extends along the length direction of the vertical plate (301), the movable groove (304) is communicated with each groove (302), and the pressing plate (407) can move along the length direction of the movable groove (304).
4. The high-precision microfluidic liquid control device according to claim 2, wherein the first motor (401) and the second motor (402) are symmetrically distributed on the upper side and the lower side of the inside of the box body (1), and the rotating roller (404) realizes synchronous rotation through a belt (405) to drive the transverse plate (406) and the pressing plate (407) to move.
5. The high-precision microfluidic liquid handling device according to claim 4, wherein the pressure plate (407) is of an arc-shaped structure, the radian of the pressure plate (407) is matched with the radian of the surface of the conduit (303), and the pressure plate (407) regulates the flow of internal liquid by extruding the conduit (303).
6. The high-precision microfluidic liquid control device according to claim 4, wherein the conduit (303) is made of flexible corrosion-resistant materials, and a sealing structure is arranged at a connection part of the conduit (303) and the water inlet pipe (504) to avoid liquid leakage.
7. The high-precision microfluidic liquid handling device according to claim 6, wherein the control valve (505) is an electromagnetic control valve (505), and the control valve (505) receives a signal through the controller (2) to adjust the liquid flow rate of the water inlet pipe (504).
8. The high-precision microfluidic liquid control device according to claim 7, wherein the number of the storage boxes (503) is multiple, the storage boxes (503) are uniformly distributed along the inside of the control box (502), and each storage box (503) is correspondingly provided with a water inlet pipe (504) and a water outlet pipe (506).
9. The high-precision microfluidic liquid control device according to claim 1, wherein the controller (2) is internally provided with a precise control program, and the precise control of the liquid flow can be realized by adjusting the rotation speeds of the first motor (401) and the second motor (402) and controlling the extrusion force of the pressing plate (407) on the guide pipe (303).
10. The precise control method based on the high-precision microfluidic liquid control device of claim 9 is characterized by comprising the following steps: the method comprises the steps of firstly, assembling and debugging equipment, namely, installing a guide pipe (303) in a slot (302) of a vertical plate (301) in a matched manner, ensuring that a pressing plate (407) is positioned in a movable slot (304) and is in contact with the surface of the guide pipe (303), installing a first motor (401), a second motor (402) and a rotating roller (404), ensuring that a belt (405) is connected in a matched manner and rotates smoothly, installing a storage box (503) in a control box (502), connecting a water inlet pipe (504) with the guide pipe (303) and a water outlet pipe (506), installing a control valve (505), connecting a controller (2) with the first motor (401), the second motor (402) and the control valve (505), and starting the controller (2) to finish self-inspection; step two, liquid storage and preparation, namely injecting liquid to be controlled into a storage tank (503) through a water inlet pipe (504), closing a control valve (505), and setting liquid flow parameters through a controller (2) according to experimental requirements; Starting a first motor (401) and a second motor (402), driving a rotating shaft (403) and a rotating roller (404) to rotate by the motors, and driving a transverse plate (406) and a pressing plate (407) to move along a movable groove (304) by synchronous operation of a belt (405), wherein the pressing plate (407) extrudes a guide pipe (303), and the rotating speed of the motors is regulated by a controller (2) to control extrusion force of the pressing plate (407) so as to realize accurate regulation and control of liquid flow in the guide pipe (303); Step four, liquid transmission and use, namely opening a control valve (505), conveying the liquid in a conduit (303) to a storage tank (503) through a water inlet pipe (504), or guiding the liquid in the storage tank (503) out for use through a water outlet pipe (506) according to experimental requirements, wherein a controller (2) monitors the flow state in real time, dynamically adjusts the extrusion force of a pressing plate (407), and maintains stable flow; step five, the experiment is ended and cleaned, namely, the first motor (401), the second motor (402) and the control valve (505) are closed, and liquid transmission is stopped; Step six, equipment maintenance, namely checking whether a guide pipe (303) is worn or not and whether a sealing structure is good or not, if the guide pipe is damaged, replacing the guide pipe in time, cleaning dust on the surfaces of a rotating roller (404) and a belt (405), ensuring smooth transmission, and checking the connection state of a controller (2) and each component, so as to ensure the normal use of the equipment next time.

Description

High-precision microfluidic liquid control device and precise control method thereof Technical Field The invention relates to the technical field of bridge microfluidic liquid control equipment, in particular to a high-precision microfluidic liquid control device and a precise control method thereof. Background The microfluidic liquid control technology is widely applied to the fields of biomedicine, chemical analysis and the like, and the core requirement is to realize accurate flow control and stable transmission of trace liquid. The traditional microfluidic liquid control device mostly adopts a single valve control structure, has limited flow regulation precision, is difficult to meet the high-precision experiment requirement, has a separated design of a liquid storage and transmission assembly, is complex in pipeline connection and easy to leak or pollute, and meanwhile, has slow regulation response and cannot be quickly adapted to liquid control scenes with different viscosity and flow requirements. The existing related device has obvious defects that although the microfluidic liquid conveying device disclosed in the patent number CN202210987654.3 has a basic conveying function, the device lacks a precise mechanical extrusion type flow regulating structure, has larger flow control error, is complex in connection between a storage box and a catheter and inconvenient to maintain, and is not integrated with an intelligent control module, needs manual adjustment, is complex in operation and is easy to cause human error. The existing high-precision microfluidic liquid control device has the following general problems that 1, the flow regulation precision is low, the accurate regulation and control of trace liquid are difficult to realize by a traditional valve or pump body control mode, 2, the connection of a liquid storage and transmission pipeline is complex, leakage and pollution are easy, the experimental accuracy is affected, 3, the regulation response is slow, the operation is complex, the liquid control requirements of different experimental scenes cannot be quickly adapted, the integrated intelligent control is lacked, the manual intervention is more, and the efficiency is low. Disclosure of Invention The invention aims to provide a high-precision microfluidic liquid control device and a precise control method thereof, so as to solve the problems in the background art. In order to solve the technical problems, the invention provides the following technical proposal that the device comprises a box body, a controller detachably connected to the top of the box body, an installation and placement component arranged at one side of the box body, a control and adjustment component arranged in the box body and a storage control component arranged in the box body; The installation and placement assembly comprises a vertical plate fixedly connected to one side of the inside of the box body, a slot formed in the surface of the vertical plate, a guide pipe matched and connected to the inside of the slot and a movable slot formed in the surface of the vertical plate, wherein the inside of the movable slot is communicated with the inside of the slot; The control and regulation assembly comprises a first motor detachably connected to the bottom of the inside of the box body, a second motor detachably connected to the top of the inside of the box body, a rotating shaft connected with the output ends of the first motor and the second motor, a rotating roller detachably connected to one end of the rotating shaft, a belt cooperatively connected between the rotating rollers, a transverse plate detachably connected to one side surface of the belt and a pressing plate fixedly connected to the surface of the transverse plate, wherein the pressing plate is movably connected to the inside of the movable groove, and one end of the pressing plate is in contact with the surface of the guide pipe; The storage control assembly comprises an installation box detachably connected to the inside of the box body, a control box detachably connected to the inside of the installation box, a storage box detachably connected to the inside of the control box, a water inlet pipe matched and connected to one end of the storage box, a control valve matched and connected to the surface of the water inlet pipe and a water outlet pipe matched and connected to the bottom of the storage box, and one end of the water inlet pipe is matched and connected with the guide pipe; The controller is electrically connected with the first motor, the second motor and the control valve. Preferably, the vertical plates are vertically distributed, the plurality of grooves are uniformly distributed along the height direction of the vertical plates, and each groove is correspondingly connected with a guide pipe in a matched mode. Preferably, the movable groove extends along the length direction of the vertical plate, the movable groove is communicated with each groo