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CN-121972247-A - Digital micro-control flow device and driving system

CN121972247ACN 121972247 ACN121972247 ACN 121972247ACN-121972247-A

Abstract

The invention relates to a digital micro-control flow device and a driving system, wherein the digital micro-control flow device comprises a shell and two micro-control mechanisms, the shell is provided with a containing cavity, a liquid drop operation port communicated with the containing cavity is formed in the shell, the two micro-control mechanisms are arranged on the shell, a digital micro-control chip is arranged in the shell and comprises an upper polar plate and a lower polar plate which are sequentially arranged along the height direction of the shell, two ends of the upper polar plate are correspondingly connected with the two micro-control mechanisms one by one, and each micro-control mechanism can drive one end of the upper polar plate connected with the corresponding micro-control mechanism to move relative to the lower polar plate so as to adjust the distance or the relative inclination angle between the upper polar plate and the lower polar plate. The invention can realize the integral lifting of the upper polar plate and the distance between the upper polar plate and the lower polar plate and the lifting of one side and/or the lowering of one side by respectively adjusting the two mechanisms, thereby changing the inclination angle of the upper polar plate.

Inventors

  • LIU ZHIYONG
  • Xiong Wenyao
  • LIAO GUANGLAN
  • WANG JIANXIN

Assignees

  • 华中科技大学

Dates

Publication Date
20260505
Application Date
20260306

Claims (10)

  1. 1. A digital micro-control flow device, comprising: The digital micro-flow control clamp (11) comprises a shell (111) and two micro-adjustment control mechanisms (112), wherein the shell (111) is provided with a containing cavity, a liquid drop operation port communicated with the containing cavity is formed in the shell (111), and the two micro-adjustment control mechanisms (112) are arranged on the shell (111); The digital micro-fluidic chip (12) is arranged in the shell (111), the digital micro-fluidic chip (12) comprises an upper polar plate (121) and a lower polar plate (122) which are sequentially arranged along the height direction of the shell (111), two ends of the upper polar plate (121) are connected to the two fine tuning control mechanisms (112) in a one-to-one correspondence mode, and each fine tuning control mechanism (112) can drive one end of the upper polar plate (121) connected with the corresponding fine tuning control mechanism to move relative to the lower polar plate (122) so as to adjust the distance or the relative inclination angle between the upper polar plate (121) and the lower polar plate (122).
  2. 2. The digital micro-control flow device according to claim 1, wherein the housing (111) comprises a top plate (1111) and a bottom plate (1112), the top plate (1111) and the bottom plate (1112) are covered to enclose and form the accommodating cavity, the droplet operation opening is formed on the top plate (1111), and the two micro-adjustment control mechanisms (112) are both arranged on the top plate (1111).
  3. 3. The digital micro-control flow device according to claim 2, wherein the top plate (1111) comprises a circuit board cover plate (11111) and two fixing frames (11112), the circuit board cover plate (11111) is arranged between the two fixing frames (11112), the circuit board cover plate (11111) and the two fixing frames (11112) are covered with the bottom plate (1112) to enclose to form the accommodating cavity, the liquid drop operation opening is formed in the circuit board cover plate (11111), and the two micro-control mechanisms (112) are arranged on the two fixing frames (11112) in a one-to-one correspondence.
  4. 4. The digital micro-control flow device according to claim 1, wherein the digital micro-control flow fixture (11) comprises an upper circuit board (113) and a lower circuit board (114), the upper circuit board (113) being electrically connected to the lower pole plate (122), the lower circuit board (114) being electrically connected to the upper pole plate (121).
  5. 5. The digital micro-fluidic device of claim 4, wherein the upper plate (121) comprises a first substrate layer (1211), a first electrode layer (1212), and a first hydrophobic layer (1213) stacked in that order from top to bottom.
  6. 6. The digital micro-fluidic device of claim 4, wherein the bottom plate (122) comprises a second substrate layer (1221), a second electrode layer (1222), a dielectric layer (1223), and a second hydrophobic layer (1224) stacked in order from bottom to top.
  7. 7. The digital micro-control flow device according to claim 3, wherein the fine adjustment control mechanism (112) comprises a clamping plate (1121) and an adjusting bolt (1122), the clamping plate (1121) is of a hollow structure, the clamping plate (1121) is sleeved at one end of the upper polar plate (121), and the tail of the adjusting bolt (1122) penetrates through the fixing frame (11112) and is abutted against the clamping plate (1121).
  8. 8. The digital micro-control flow device according to claim 7, wherein the fine adjustment control mechanism (112) includes a locking member (1123), the locking member (1123) being provided at one side of the housing (111), the locking member (1123) being configured to lock the adjustment bolt (1122).
  9. 9. A digital micro-control flow driving system, comprising: The digital micro-control flow device (10) of claim 4; And a control board (20), wherein the control board (20) is electrically connected with the upper circuit board (113) and the lower circuit board (114).
  10. 10. The digital micro-control current driving system according to claim 9, wherein the control board (20) comprises a power input module (21), a boost module (22), a control module (23), a signal isolation module (24), an upper polar plate signal output module (25) and a lower polar plate high voltage output module (26), the power input module (21) is used for supplying power to the boost module (22) and the control module (23), the signal input end of the signal isolation module (24) is electrically connected with the signal output end of the control module (23), the voltage input end of the upper polar plate signal output module (25) and the voltage input end of the lower polar plate high voltage output module (26) are electrically connected with the two output ends of the boost module (22) in a one-to-one correspondence manner, the signal input end of the upper polar plate signal output module (25) and the signal input end of the lower polar plate high voltage output module (26) are electrically connected with the two signal output ends of the signal isolation module (24), and the signal input end of the lower circuit board (113) is electrically connected with the voltage input end of the upper polar plate (114).

Description

Digital micro-control flow device and driving system Technical Field The invention relates to the technical field of microfluidics, in particular to a digital micro-control flow device and a driving system. Background The digital microfluidic technology is based on a dielectric wetting principle, and accurate control of tiny liquid drops, including movement, splitting, merging and other operations, is realized by applying an electric field between an upper polar plate and a lower polar plate of a microfluidic chip. The technology has wide application prospect in the fields of biomedical detection, high-throughput screening and the like due to the advantages of high precision, low reagent consumption, high automation degree and the like. However, the existing digital microfluidic chip generally adopts an integrated packaging design, and the distance between the upper polar plate and the lower polar plate is fixed and cannot be flexibly adjusted. In practical application, the distance between the polar plates has decisive influence on the strength of an electric field and the operation effect of liquid drops, namely, the electric field is weak when the distance is too large, the liquid drops are difficult to drive, and the liquid drops are easy to adhere when the distance is too small, so that the operation smoothness is influenced. In addition, the adaptability of the chip to electrodes with different sizes is limited due to the design of the fixed spacing, and the requirements of multiple scenes and diversified experiments are difficult to meet. The upper polar plate and the lower polar plate of most digital microfluidic chips in the current market are packaged into a whole, and can not be replaced independently, so that the chip has single function, limited service life and higher cost. Although some researches try to realize pitch adjustment through an external clamp, the structure is often complicated, the adjustment precision is low, the inclination adjustment is difficult to realize, and the requirements of high-precision and high-compatibility liquid drop control cannot be met. Disclosure of Invention Based on the expression, the invention provides a digital micro-flow control device and a driving system, which aim to solve the problem of fixed distance between an upper polar plate and a lower polar plate of the existing digital micro-flow control chip. The technical scheme for solving the technical problems is as follows: In a first aspect, the present invention provides a digital micro-control flow device, comprising: the digital micro-control flow clamp comprises a shell and two micro-adjustment control mechanisms, wherein the shell is provided with a containing cavity, a liquid drop operation port communicated with the containing cavity is formed in the shell, and the two micro-adjustment control mechanisms are arranged on the shell; The digital microfluidic chip is arranged in the shell and comprises an upper polar plate and a lower polar plate which are sequentially arranged along the height direction of the shell, two ends of the upper polar plate are connected with the two fine adjustment control mechanisms in a one-to-one correspondence manner, and each fine adjustment control mechanism can drive one end of the upper polar plate connected with the fine adjustment control mechanism to move relative to the lower polar plate so as to adjust the distance or the relative inclination angle between the upper polar plate and the lower polar plate. On the basis of the technical scheme, the invention can be improved as follows. Further, the shell comprises a top plate and a bottom plate, the top plate and the bottom plate are covered to enclose to form the accommodating cavity, the liquid drop operation opening is formed in the top plate, and the two fine adjustment control mechanisms are all arranged on the top plate. Further, the roof includes circuit board apron and two mounts, the circuit board apron is located two between the mount, circuit board apron and two mounts with the bottom plate lid closes with enclosing to establish and form hold the chamber, the liquid droplet operation mouth is seted up on the circuit board apron, two fine setting control mechanism one-to-one locates two on the mount. Further, the digital micro-control flow clamp comprises an upper circuit board and a lower circuit board, wherein the upper circuit board is electrically connected with the lower polar plate, and the lower circuit board is electrically connected with the upper polar plate. Further, the upper polar plate comprises a first basal layer, a first electrode layer and a first hydrophobic layer which are stacked in sequence from top to bottom. Further, the lower polar plate comprises a second basal layer, a second electrode layer, a dielectric layer and a second hydrophobic layer which are stacked in sequence from bottom to top. Further, the fine adjustment control mechanism comprises a clamping plate and an adj