CN-121973484-A - Completely biodegradable medical antibacterial liquid collecting bag and preparation method thereof

Abstract

The invention discloses a completely biodegradable medical antibacterial liquid collecting bag and a preparation method thereof. The preparation method comprises the steps of firstly, blending and modifying PBAT, PLA, znO, EA, PETS, ADR-4468=70-95:3-30:0.1-2.0:0.1-0.5:0.1-2.0:0.1-0.3, blowing films to obtain a semitransparent biodegradable film bag, secondly, blending and granulating PBAT, PLA, talc, PPA, ADR-4468=80-95:5-20:0.1-2.0:0.1-5.0:0.1-0.3, casting films to obtain a film, thirdly, coating starch glue on the casting films, compounding the film bag with PLA non-woven fabrics to obtain a non-woven fabric-film composite material, fourthly, bonding the film bag with the composite material in a hot pressing mode, and cutting the film bag to obtain a finished product. The liquid collecting bag can be completely biodegraded, has antibacterial property and is environment-friendly, and is suitable for various medical liquid collecting scenes.

Inventors

• ZHANG HUILIANG
• ZHANG XIAOYING
• SUN ZHIGUO
• LIU HE
• SUN JINGRAN
• ZHAO YAN
• ZHANG ZHIXIN
• PAN HONGWEI
• BIAN JUNJIA
• YANG HUILI
• JIN BAOCHANG
• WANG MINGYU

Assignees

• 吉林弗朗医疗科技有限公司
• 中国科学院长春应用化学研究所

Dates

Publication Date

20260505

Application Date

20260317

Claims (8)

1. 1. A fully biodegradable medical antibacterial liquid collecting bag and a preparation method thereof are characterized in that the preparation is divided into four steps, wherein the first step is carried out by preparing film blowing special resin by using poly terephthalic acid-adipic acid-butanediol ester (PBAT), polylactic acid (PLA), zinc oxide (ZnO), erucamide (EA), pentaerythritol monoglyceride (PETS) and chain extender ADR-4468 according to proportion, preparing a semitransparent biodegradable film bag by film blowing, printing, sticking and pressing bone strips and heat sealing, the second step is carried out by preparing film blowing special resin by using PBAT, PLA, zinc oxide (ZnO), talcum powder (Talc), plasticizer poly adipic acid 1, 2-propanediol ester (PPA) and chain extender ADR-4468 according to proportion, preparing film casting special resin by using an extruder through extrusion granulation, the third step is carried out by coating biodegradable starch glue on the film casting film, compounding the film casting film with polylactic acid by using a multilayer compounding machine, rolling to obtain the biodegradable non-woven fabric-film composite material, and the fourth step is carried out by carrying out by rolling on the semitransparent biodegradable film-nonwoven film composite film, the semitransparent film-the biodegradable film and the polylactic acid composite film, the medical film is bonded by a thermal pressing and the adhesive tape, and the medical antibacterial liquid collecting bag.
2. 2. The PBAT of claim 1, wherein the weight average molecular weight of the PBAT is 7 x 10 4 g/mol to 3 x 10 5 g/mol.
3. 3. PLA according to claim 1, characterized in that the weight average molecular weight of the PLA is 1.5 x 10 5 g/mol to 2.5 x 10 5 g/mol.
4. 4. The PPA according to claim 1, wherein said PPA has a weight average molecular weight of from 3.0 x 10 3 g/mol to 1.8 x 10 4 g/mol.
5. 5. A fully biodegradable medical antibacterial liquid collecting bag and a preparation method thereof are characterized in that in the first step of preparation, special resin for film blowing is prepared by blending and modifying poly terephthalic acid-butanediol (PBAT), polylactic acid (PLA), zinc oxide (ZnO), erucic acid amide (EA), pentaerythritol monoglyceride (PETS) and a chain extender ADR-4468 according to a proportion, the special resin for film blowing is prepared by film blowing, printing, bone sticking and bone pressing and bag making by heat sealing, the weight ratio of PBAT, PLA, znO, EA, PETS, ADR-4468 is 70-95:3-30:0.1-2.0:0.1-0.5:0.1-2.0:0.1-0.3, the weighed special resin for film blowing is prepared by adding the special resin into a double-screw extruder after the evenly mixing, the special resin for film blowing is prepared by weighing PBAT, PLA, znO, EA, PETS, ADR-4468 according to the weight ratio of PBAT, PLA, znO, EA, PETS, ADR-4468 of 70-95:5-30:0.1-0.0.1-4468, the special resin for film blowing is obtained by granulating after the special resin for film blowing is carried out at the temperature of 160-300 ℃ and the speed of the extruder. The film blowing resin is added into a film blowing machine, the film blowing temperature is sequentially set to 180 ℃, 185 ℃ and 185 ℃ from 1 region to 5 region, the die head temperature of the film blowing machine is set to 190 ℃, the blowing ratio is 3-4, the film blowing traction rate is 6-10m/min, and the film thickness is controlled to be 20-30 mu m.
6. 6. A fully biodegradable medical antibacterial liquid collecting bag and a preparation method thereof are characterized in that in the second step of preparation, PBAT, PLA, zinc oxide (ZnO), talcum powder (Talc), plasticizer poly (1, 2-propylene glycol adipate) (PPA) and chain extender ADR-4468 are used for blending modification according to a proportion, extrusion granulation is carried out by an extruder to prepare resin special for film coating, the resin special for film coating is processed by a casting machine to obtain a casting film, the weight ratio of PBAT, PLA, znO, talc, PPA, ADR-4468 is 80-95:5-20:0.1-2.0:0.1-5.0:0.1-5.0:0.5-5.0:0.1-0.3, the weight ratio of PBAT, PLA, znO, talc, PPA, ADR-4468 is 80-95:5:0.1-2.0:0.1-5.0:0.5-5.0:0.1-0.3, the weighed resin special for film coating is added into a twin-screw extruder after being mixed, the temperature of the extruder is set to 160-190 ℃ and the temperature of the extruder is 100-300 ℃ after the resin special for film coating is evenly dried. And (3) using a film coating machine to carry out film casting on the modified special resin at 180-210 ℃ at the rotating speed of 40-300 r/min, and carrying out film casting on the film at the outlet of the film coating machine in a molten state, so as to obtain the film casting film by winding, wherein the thickness of the film casting film is controlled at 15-25 mu m.
7. 7. The preparation method is characterized in that in the third step of the preparation method, the cast film is coated with biodegradable paste starch glue, the glue coating temperature is set to be 60-80 ℃, and the glue coating temperature and polylactic acid non-woven fabric are rolled and compounded by a multi-layer compounding machine, and the biodegradable non-woven fabric-film composite material is obtained by rolling;
8. 8. A completely biodegradable medical antibacterial liquid collecting bag and a preparation method thereof are characterized in that in the fourth step of the preparation, the semitransparent biodegradable film bag and a non-woven fabric-film composite material are subjected to composite hot-pressing adhesion by a hot press, bone strip sticking and cutting, and the hot-pressing temperature is set to be 180-200 ℃ to obtain the biodegradable medical antibacterial liquid collecting bag.

Description

Completely biodegradable medical antibacterial liquid collecting bag and preparation method thereof Technical Field The invention relates to the field of modification of high polymer materials, in particular to a completely biodegradable medical antibacterial liquid collecting bag and a preparation method thereof. Background The biodegradable medical antibacterial liquid collecting bag is an environment-friendly material combining a biodegradable non-woven fabric-film composite material and a biodegradable blow-molded film bag composite material, and aims to reduce the pollution of traditional plastic products to the environment. The traditional casting film and the resin special for blowing film and the non-woven fabric material are mainly polyethylene and polypropylene, and are not biodegradable. The PBAT is copolyester of terephthalic acid, adipic acid and butanediol and has the characteristic of biodegradability, and the biodegradable non-woven fabric is generally prepared from natural fibers (such as cotton, hemp and bamboo pulp) or bio-based synthetic fibers (such as PLA polylactic acid, PBAT, PHA and the like) by carding, air-laying or melt-blowing. These fibers are biodegradable and can be broken down by microorganisms in a particular environment (e.g., compost). The biodegradable non-woven fabric-membrane composite material is formed by adhering a layer of biodegradable polymer film (such as PLA, PBAT, PBS or starch-based material) on the surface of the biodegradable non-woven fabric through a melt extrusion process, so that the material has the properties of water resistance, oil resistance, heat sealing and the like. The PBAT/PLA blend which is not blended and modified has low melt flow rate, is difficult to meet the high-speed stretching rate required by the production process, is easy to shrink and deform in the film spraying cooling process, has serious necking phenomenon, and is difficult to obtain the non-woven film spraying composite material with uniform film thickness. Common small-molecule plasticizers, such as citric acid esters, generate a large amount of irritant volatile substances in the process of casting the plasticized polylactic acid, influence the health of human bodies and the production environment, and are not suitable for casting processing. The biological degradation performance is that under the condition of industrial composting (high temperature and high humidity and microorganism action), the material can be decomposed into CO 2, water and biomass within a few months, and the degradation speed is slower in natural environment but is far faster than that of the traditional plastic. The plasticizer selected by the invention is poly (1, 2-propylene glycol) adipate, and the poly (1, 2-propylene glycol) adipate has the advantages of higher boiling point, low volatility, no smoke emission in the film spraying process, good environmental sanitation, high viscosity, no toxicity and biodegradability, can improve the melt flow rate of the film spraying resin, reduce the film thickness, improve the film spraying production efficiency, and can maintain the biodegradation advantage. 1, 2-propanediol polyadipate with PBAT, PLA blending can not only improve the compatibility of PBAT and PLA, but also obviously improve the melt index of the blend, so that the blend is suitable for the film to be formed effectively under the action of gravity in the casting process required by the preparation and processing of the casting film, the film does not break and does not bubble, znO can obviously improve the antibacterial property of the film, reduce the viability of escherichia coli and staphylococcus aureus, ADR-4468 molecular chains are provided with epoxy functional groups, can chemically react with hydroxyl and carboxyl ends of PBAT and PLA, can obviously improve the viscosity and the film tensile strength and the tear resistance of the PBAT/PLA blend, and the PBAT/PLA blending modified blown film and the casting film are provided with tear resistance, The puncture-resistant property and the property of being capable of being adhered tightly with PLA non-woven fabrics, and the preparation of the soft and comfortable completely biodegradable non-woven fabric-film composite material has advanced and innovative technology and process. The biodegradable medical antibacterial liquid collecting bag has wide application field, and can be used for meeting different requirements of different body parts of patients in the medical and health field. The material is favorable for protecting the environment and has very important application value. Disclosure of Invention The invention solves the technical problem of providing a completely biodegradable medical antibacterial liquid collecting bag and a preparation method thereof, wherein the liquid collecting bag has complete biodegradability and antibacterial function. The invention provides a completely biodegradable medical antibacteria