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CN-121973497-A - Tablet production tabletting device

CN121973497ACN 121973497 ACN121973497 ACN 121973497ACN-121973497-A

Abstract

A tablet production tabletting device comprises a forming disc, wherein a plurality of forming cavities are formed in the forming disc, lower supporting columns are movably arranged on the lower portions of the forming cavities in a penetrating mode respectively, upper tabletting columns are arranged on the upper portions of the forming cavities in a penetrating mode respectively in a penetrating mode, the lower supporting columns and the upper tabletting columns are arranged in a matched mode, a plurality of heat exchange channels which are communicated with each other are arranged in the forming disc on the outer side of the forming cavities, and inlets and outlets of the heat exchange channels are connected with a coolant inlet pipe and a coolant outlet pipe respectively. The application adopts the mode that the upper tabletting cylinder and the lower tabletting cylinder are respectively arranged on the upper side and the lower side of the forming cavity and are matched, so that the forming cavity can be pushed out after compression forming, and the temperature of the forming cavity can be controlled by arranging the coolant lead-in channel and the coolant lead-out channel, thereby avoiding the problems of black spots on the surface and the like caused by over-temperature and the like in the compression process.

Inventors

  • LI YUANYUAN
  • SUN MAOCAI
  • SUN LIYONG

Assignees

  • 山东圣鲁制药有限公司

Dates

Publication Date
20260505
Application Date
20251219

Claims (10)

  1. 1. A tablet production tabletting device is characterized by comprising a forming disc, wherein a plurality of forming cavities are formed in the forming disc, a lower supporting column is movably penetrated in the lower portion of each forming cavity, an upper tabletting column is penetrated in the upper portion of each forming cavity, the lower supporting column and the upper tabletting column are matched, a plurality of heat exchange channels which are communicated are formed in the forming disc outside the forming cavity, and inlets and outlets of the heat exchange channels are respectively connected with a coolant inlet pipeline and a coolant outlet pipeline.
  2. 2. The tablet production tabletting device according to claim 1, wherein a lower supporting plate is arranged at the lower part of the lower supporting column body, a lifting piston cylinder is arranged below the lower supporting plate, and a lifting piston rod extends out of the lifting piston cylinder and is fixedly connected with the middle part of the lower supporting plate; An upper pressing plate is arranged at the upper part of the upper pressing cylinder, an upper pressing piston cylinder is arranged above the upper pressing plate, and an upper pressing piston rod extends out of the upper pressing piston cylinder and is fixedly connected with the middle part of the upper pressing plate.
  3. 3. A tablet production tabletting device as in claim 1, wherein the heat exchange channels are arranged helically in height direction and adjacent to at least one side of the forming cavity.
  4. 4. A tablet production tabletting device according to claim 1, wherein the coolant is cooling water at a temperature of 5-10 ℃.
  5. 5. The tablet production tabletting device according to claim 1, wherein anti-sticking reinforcing coatings are respectively arranged on the inner wall of the forming cavity, the upper tabletting cylinder and the lower supporting cylinder.
  6. 6. The tablet production tabletting device according to claim 5, wherein the anti-sticking strengthening coating comprises 50-60 parts by mass of acrylic resin; 4-6 parts of epoxy resin; 1-3 parts of nano zirconia; 0.5-1 part of active carbon; 1-1.5 parts of dibenzoyl peroxide.
  7. 7. The tablet production tabletting apparatus according to claim 6, wherein the activated carbon is modified in the following manner: Uniformly dispersing 0.5-1 part of active carbon into 10-12 times of methanol to obtain a first dispersion liquid; Heating the first dispersion liquid to 40-50 ℃, and dropwise adding 1-1.5 parts of dibenzoyl peroxide until the dripping is completed; Then heating to 60-70 ℃ and continuing to obtain the mixed solution of the activated carbon and the dibenzoyl peroxide by 2-3 h.
  8. 8. A tablet production tabletting device as in claim 7, wherein: completely mixing the mixed solution, 1-3 parts of nano zirconia, 4-6 parts of epoxy resin and 50-60 parts of acrylic resin to obtain a coating raw material, wherein the epoxy resin and the acrylic resin are calculated according to the net content; and (3) coating the coating raw materials on the inner wall of the tabletting cavity in a reciprocating spraying manner, forming an outer coating on the outer sides of the upper tabletting cylinder and the lower supporting cylinder, and forming an anti-sticking reinforced coating after heating and shaping the outer coating at 130-150 ℃.
  9. 9. A tablet production tabletting device according to claim 8, wherein the thickness of the outer coating is 200-400 μm and the number of spraying to and fro is not less than 5.
  10. 10. The tablet production tabletting device according to claim 8, wherein the epoxy resin is an acetone solution of the epoxy resin, and the mass concentration of the epoxy resin is 30-40wt%; The acrylic resin is an acetone solution of the acrylic resin, and the mass concentration of the acrylic resin is 30-40wt%.

Description

Tablet production tabletting device Technical Field The application relates to a tablet production tabletting device. Background The tablet refers to a tablet solid medicament obtained by mixing and pressing active ingredients and auxiliary materials, and has extremely wide application range. In the compression process, the melting point of some effective components (namely bulk drugs) is lower, eutectic phenomenon is easy to occur with low melting point auxiliary materials, and the physical state of tablet cores is possibly changed in the tabletting process, so that the stability of external forms is also influenced, the existing tabletting cavity is required to be improved, the appearance damage of tabletting is avoided in the tabletting process, and the accuracy of weight control and the later coating operation are influenced. Disclosure of Invention In order to solve the problems, the application provides a tablet production tabletting device which comprises a forming disc, wherein a plurality of forming cavities are arranged on the forming disc, lower supporting columns are respectively and movably penetrated in the lower parts of the forming cavities, upper tabletting columns are respectively penetrated in the upper parts of the forming cavities, the lower supporting columns and the upper tabletting columns are matched, a plurality of heat exchange channels which are communicated are arranged in the forming disc outside the forming cavities, and inlets and outlets of the heat exchange channels are respectively connected with a coolant inlet pipeline and a coolant outlet pipeline. The application adopts the mode that the upper tabletting cylinder and the lower tabletting cylinder are respectively arranged on the upper side and the lower side of the forming cavity and are matched, so that the forming cavity can be pushed out after compression forming, and the temperature of the forming cavity can be controlled by arranging the coolant lead-in channel and the coolant lead-out channel, thereby avoiding the problems of black spots on the surface and the like caused by over-temperature and the like in the compression process. Preferably, a lower supporting plate is arranged at the lower part of the lower supporting column body, a lifting piston cylinder is arranged below the lower supporting plate, and a lifting piston rod extends out of the lifting piston cylinder and is fixedly connected with the middle part of the lower supporting plate; An upper pressing plate is arranged at the upper part of the upper pressing cylinder, an upper pressing piston cylinder is arranged above the upper pressing plate, and an upper pressing piston rod extends out of the upper pressing piston cylinder and is fixedly connected with the middle part of the upper pressing plate. Preferably, the heat exchange channels are spirally arranged in the height direction and are adjacent to at least one side of the molding cavity. Preferably, the coolant is cooling water with a temperature of 5-10 ℃. Preferably, anti-sticking reinforcing coatings are respectively arranged on the inner wall of the forming cavity, the upper tabletting cylinder and the lower supporting cylinder. The anti-sticking reinforced coating provided by the application mainly has two functions, namely, an anti-sticking function is realized on one hand, the strength of the anti-sticking reinforced coating is improved during friction on the other hand, and abrasion is avoided during the use process. Preferably, the anti-sticking reinforced coating comprises 50-60 parts by weight of acrylic resin; 4-6 parts of epoxy resin; 1-3 parts of nano zirconia; 0.5-1 part of active carbon; 1-1.5 parts of dibenzoyl peroxide. Preferably, the activated carbon is modified as follows: Uniformly dispersing 0.5-1 part of active carbon into 10-12 times of methanol to obtain a first dispersion liquid; Heating the first dispersion liquid to 40-50 ℃, and dropwise adding 1-1.5 parts of dibenzoyl peroxide until the dripping is completed; Then heating to 60-70 ℃ and continuing to obtain the mixed solution of the activated carbon and the dibenzoyl peroxide by 2-3 h. The application adopts the dibenzoyl peroxide to modify the active carbon, so that the dibenzoyl peroxide and the active carbon are compounded, and the active carbon is used as the center of the compounding of the epoxy resin and the acrylic resin in the later period, so that the active carbon can be uniformly distributed in the coating, the zirconium oxide can be combined to play a role in balancing the flexibility of the coating in the use process, the rigidity and the flexibility are balanced, and the overall wear resistance is improved. Preferably, the mixed solution, 1-3 parts of nano zirconia, 4-6 parts of epoxy resin and 50-60 parts of acrylic resin are completely mixed to obtain a coating raw material, wherein the epoxy resin and the acrylic resin are calculated according to the net content; and (3) coating the coating raw mat