Search

CN-121973520-A - Medical high-barrier easy-uncovering composite film and preparation method thereof

CN121973520ACN 121973520 ACN121973520 ACN 121973520ACN-121973520-A

Abstract

The invention relates to the technical field of medical composite films, in particular to a medical high-barrier easy-uncovering composite film and a preparation method thereof. The high-barrier functional layer is composed of a syndiotactic polystyrene film dispersed with metal organic framework nano particles and a fluorine-containing polyimide layer laminated on the inner side of the syndiotactic polystyrene film, and the easy-to-tear adhesive layer comprises hydrogenated styrene-isoprene-styrene block copolymer, hydrogenated petroleum resin and polyethylene glycol-based shear thickening fluid microcapsules. The rigid support of syndiotactic polystyrene film and damping dissipation of microcapsule cooperate to realize stable and controllable stripping force, and the fluorine-containing polyimide layer provides fast passage of sterilizing gas. The composite film has excellent high-barrier property, sterilization adaptability and stable easy-to-uncover property.

Inventors

  • ZHANG JUN
  • WU HUIHONG

Assignees

  • 太仓合翔包装材料有限公司

Dates

Publication Date
20260505
Application Date
20260120

Claims (8)

  1. 1. The utility model provides a medical high barrier property easily takes off complex film which characterized in that includes from outside to inside in proper order: Printing a layer; a high barrier functional layer comprising a polymer matrix film and a selective gas permeable polymer layer laminated inside the polymer matrix film; an easy-release adhesive layer comprising a thermoplastic elastomer, a tackifying resin, and shear-responsive energy dissipating microcapsules dispersed therein; and the heat seal layer is formed by compositely connecting the layers through an adhesive medium.
  2. 2. The medical high barrier frangible composite membrane according to claim 1, wherein the polymer matrix membrane is a crystalline aromatic polymer membrane, and microporous adsorptive nanofillers are dispersed in the crystalline aromatic polymer membrane, wherein the printing layer and the high barrier functional layer, and the high barrier functional layer and the frangible adhesive layer are bonded by a reactive polyolefin compatilizer, and wherein the frangible adhesive layer and the heat sealing layer further comprise nano inorganic oxide particles.
  3. 3. The medical high-barrier easy-to-tear composite film according to claim 2, wherein the printing layer is a biaxially oriented polyethylene terephthalate film; the crystalline aromatic polymer film is a syndiotactic polystyrene film, the microporous adsorptive nano filler is metal organic framework nano particles, and the selective gas permeable polymer layer is a special polyimide layer with high barrier property to water vapor and high permeability to ethylene oxide gas; the shear response type energy dissipation microcapsule is a shear thickening fluid microcapsule taking polyethylene glycol as a matrix, the thermoplastic elastomer is a hydrogenated styrene-isoprene-styrene block copolymer, and the tackifying resin is hydrogenated petroleum resin; the heat-sealing film is a modified polyethylene film; The reactive polyolefin compatilizer is anhydrous maleic anhydride grafted polyolefin adhesive resin, and the nano inorganic oxide particles are nano silicon dioxide particles.
  4. 4. The medical high-barrier easy-uncovering composite film according to claim 3, wherein the thickness of the biaxially oriented polyethylene terephthalate film is 12-25 μm, the thickness of the syndiotactic polystyrene film is 10-30 μm, the metal organic framework nano-particles are zeolite imidazole ester framework nano-particles with the particle diameter of 50-200 nm, and the special polyimide layer is a fluorine-containing polyimide layer containing hexafluoroisopropyl side groups, and the thickness of the fluorine-containing polyimide layer is 1-5 μm; The shear-response energy dissipation microcapsule has an average particle size of 5-30 mu m, and the internally wrapped shear thickening fluid consists of a polyethylene glycol dispersion medium with a molecular weight of 200-600 and a fumed silica dispersion phase with a particle size of 10-100 nm, wherein the mass fraction of the fumed silica is 15-35%; The styrene content of the hydrogenated styrene-isoprene-styrene block copolymer is 13-30%, and the softening point of the hydrogenated petroleum resin is 100-125 ℃; The density of the modified polyethylene film is 0.910-0.930g/cm 3 ; the grafting rate of maleic anhydride of the reactive polyolefin compatilizer is 0.8-1.5%, and the particle size of the nano silicon dioxide particles is 10-50 nm.
  5. 5. The medical high-barrier easy-to-tear composite film according to claim 4, wherein the syndiotactic polystyrene film is a biaxially oriented crystalline film with a longitudinal tensile modulus of 3.5-5.0 GPa, and is used as a rigid support layer to limit macroscopic deformation of a peeling region; The selective gas permeation polymer layer has a free volume fraction of 5-15% to form a transmission channel for ethylene oxide molecules to pass through quickly, the metal organic framework nano particles are dispersed in an amorphous region of the syndiotactic polystyrene film, and the effective pore window size is 2.9-4.0A.
  6. 6. A method for preparing a medical high-barrier easy-to-tear composite film according to any one of claims 1 to 5, comprising the following steps: S1, dispersing and mixing polyethylene glycol dispersion medium and fumed silica, and performing ultrasonic dispersion until a stable hydrogen bond network is formed, so as to obtain a shear thickening fluid core material; the pH value of the system is regulated to enable the capsule wall to grow and solidify, and finally, the shear-response energy dissipation microcapsule is obtained through centrifugation, washing and drying; S2, selecting nano particles with zeolite imidazole ester skeleton structures, carrying out surface modification by using vinyl trimethoxy silane, mixing the modified nano particles with syndiotactic polystyrene slices, carrying out melt blending by a double-screw extruder, realizing dispersion by using a high-shear threaded element, and cooling and granulating extruded bars to obtain functional master batches; S3, melting and extruding the prepared functional master batch, casting the master batch into a sheet, quenching the sheet to obtain a thick sheet, and longitudinally stretching the thick sheet to form a longitudinally oriented syndiotactic polystyrene-based film; s4, mixing the hydrogenated styrene-isoprene-styrene segmented copolymer, the hydrogenated petroleum resin and the shear response type energy dissipation microcapsule, adopting a reciprocating single-screw mixer to carry out mild mixing, and mixing the special modified polyethylene film material with nano silicon dioxide particles; S5, selecting a biaxially oriented polyethylene terephthalate film as a printing layer, carrying out corona treatment on the biaxially oriented polyethylene terephthalate film, melting anhydrous maleic anhydride grafted polyolefin adhesive resin, and sequentially laminating and compounding the printing layer, the high-barrier functional layer and the composite film as a reactive polyolefin compatilizer to finally prepare the medical high-barrier easy-uncovering composite film.
  7. 7. The medical high-barrier easy-to-tear composite film according to claim 6, wherein in the step S3, the prepared functional master batch is melted, extruded and cast into a thick sheet, the thick sheet is subjected to longitudinal stretching at 100-120 ℃ and stretching multiplying power is 3.0-3.5 times to form a longitudinal oriented syndiotactic polystyrene-based film, a polyamide acid solution containing hexafluoroisopropyl side groups is prepared as a precursor of a special polyimide layer, a solvent is dimethylacetamide, the solid content is controlled to be 13-18%, the viscosity is controlled to be 2000-3000 cP, the polyamide acid solution is uniformly coated on one side of the longitudinally stretched base film through a micro gravure coating process, then the base film is fed into a transverse stretching oven, a solvent is volatilized at a section of 130-150 ℃, the transverse stretching is performed at a stretching section of 160-200 ℃ and is subjected to transverse stretching at 3.0-4.0 times, and finally the base film is subjected to heat setting at 230-250 ℃ for 10-15 seconds, so that the high-barrier functional layer is finally obtained.
  8. 8. The medical high-barrier easy-to-tear composite film according to claim 6, wherein in the step S4, a hydrogenated styrene-isoprene-styrene block copolymer with a styrene content of 13-30%, a hydrogenated petroleum resin with a softening point of 100-125 ℃ and shear-responsive energy dissipation microcapsules are mixed, mild mixing is carried out at 160-170 ℃ by adopting a reciprocating single screw mixer, meanwhile, a special modified polyethylene film material with a density of 0.910-0.930g/cm 3 and nano silicon dioxide particles with a particle size of 10-50 nm are mixed, a hanger type double-layer coextrusion die with a fluorine plating runner surface is used for coextruding an easy-to-tear adhesive layer material and a heat sealing layer material, the die temperature is controlled at 180-195 ℃, the die gap is set at 0.8-1.0 mm, the melt stretch ratio is controlled at 20-30 times, and the composite film of the easy-to-tear adhesive layer and the heat sealing layer is obtained after cooling.

Description

Medical high-barrier easy-uncovering composite film and preparation method thereof Technical Field The invention relates to the technical field of medical composite films, in particular to a medical high-barrier easy-uncovering composite film and a preparation method thereof. Background With the rapid development of medical technology, extremely high demands are being made on packaging materials for disposable sterile medical devices. The ideal medical package not only needs to provide physical protection and microbial barrier, but also must accommodate specific sterilization patterns and be easily and safely openable for clinical use. However, the existing medical flexible packaging materials still have the following defects in practical application: 1. Although the traditional breathable material has good air permeability, is favorable for the entry and exit of ethylene oxide gas, has weak capability of blocking water vapor, and has high cost or risk of pollution of paper dust particles. While the traditional compact polymer film can effectively block water vapor and bacteria, the traditional compact polymer film also can block the permeation of ethylene oxide sterilizing gas, so that the sterilizing time is too long; 2. the existing easy-to-tear film is mostly prepared by blending and modifying polybutene or ethylene-vinyl acetate copolymer and the like to realize interfacial stripping or cohesive stripping. However, these materials are prone to "stick-slip" during the stripping process due to the instability of the elastic energy storage and release process of the polymer chains. Therefore, we propose a medical high-barrier easy-uncovering composite film and a preparation method thereof for solving the problems. Disclosure of Invention The invention aims to solve the defects in the prior art, and provides a medical high-barrier-property easy-uncovering composite film and a preparation method thereof. The medical high-barrier easy-to-tear composite film comprises a printing layer, a high-barrier functional layer, an easy-to-tear adhesive layer and a heat sealing layer, wherein the printing layer comprises a polymer matrix film and a selective gas-permeable polymer layer laminated on the inner side of the polymer matrix film, the easy-to-tear adhesive layer comprises a thermoplastic elastomer, tackifying resin and shear-response energy dissipation microcapsules dispersed in the thermoplastic elastomer, the tackifying resin and the shear-response energy dissipation microcapsules, and the heat sealing layer is in composite connection with each other through an adhesive medium. The medical high-barrier easy-to-tear composite film is characterized in that the polymer matrix film is a crystalline aromatic polymer film, microporous adsorption nano-filler is dispersed in the crystalline aromatic polymer film, the printing layer and the high-barrier functional layer and the easy-to-tear adhesive layer are adhered through a reactive polyolefin compatilizer, and the easy-to-tear adhesive layer and the heat sealing layer also contain nano inorganic oxide particles. The medical high-barrier-property easy-uncovering composite film comprises a printing layer, a crystalline aromatic polymer film, a selective gas permeation polymer layer, a shear response type energy dissipation microcapsule, a thermoplastic elastomer, a heat sealing film, a reactive polyolefin compatilizer, a nano inorganic oxide particle and a nano silica particle, wherein the printing layer is a biaxially oriented polyethylene terephthalate film, the crystalline aromatic polymer film is a syndiotactic polystyrene film, the microporous adsorptive nano filler is metal organic framework nano particles, the selective gas permeation polymer layer is a special polyimide layer which has high barrier property to water vapor and high permeability to ethylene oxide gas, the shear response type energy dissipation microcapsule is a shear thickening fluid microcapsule taking polyethylene glycol as a matrix, the thermoplastic elastomer is a hydrogenated styrene-isoprene-styrene block copolymer, the tackifying resin is hydrogenated petroleum resin, the heat sealing film is a modified polyethylene film, the reactive polyolefin compatilizer is anhydrous maleic anhydride grafted polyolefin bonding resin, and the nano inorganic oxide particle is nano silica particle. The medical high-barrier-property easy-uncovering composite film is characterized in that the thickness of a biaxially oriented polyethylene terephthalate film is 12-25 mu m, the thickness of a syndiotactic polystyrene film is 10-30 mu m, the metal organic framework nano particles are zeolite imidazole ester framework nano particles, the particle size of the zeolite imidazole ester framework nano particles is 50-200 nm, the special polyimide layer is fluorine-containing polyimide layer containing hexafluoroisopropyl side groups, the thickness of the fluorine-containing polyimide layer is 1-5 mu m, the avera