CN-121974904-A - Cationic amphiphilic AIE compound and application thereof in improving mask protective performance

Abstract

The invention discloses a cationic amphiphilic AIE compound and application thereof in improving mask protective performance, wherein AIE photosensitizer is used as a matrix, and substituent groups are introduced into the molecular structure of the AIE photosensitizer through simple quaternization reaction to prepare a positively charged AIE amphiphilic molecule. The AIE amphiphilic molecules can effectively generate active oxygen under fluorescent lamps or sunlight, and exhibit high-efficiency antibacterial activity. The AIE molecules are adsorbed on a Mask middle filter layer (Mask-TBP) in a soaking mode, and the obtained fabric Mask-TBP shows high bacterial filtration efficiency, can effectively inactivate bacteria within 10 minutes under a fluorescent lamp or sunlight, and has stable activity. The invention prevents bacteria from invading human bodies through two modes of physical separation and photodynamic killing, so that the mask keeps high filtering capacity for a long time, and the invention shows a sustainable and high-performance conventional synthetic mask fabric substitute and has potential application in manufacturing functional textiles.

Inventors

• ZHOU CHENGCHENG
• YU ZEYAO

Assignees

• 扬州大学

Dates

Publication Date

20260505

Application Date

20260128

Claims (6)

1. 1. A cationic amphiphilic AIE compound is characterized in that the structural formula of the compound is as follows: ; Wherein R is independently selected from alkyl, glycosyl and gallic acid with a hydrophobic chain length of 3-12, and X - is halogen anion.
2. 2. The compound of claim 1, wherein the compound has the formula: 。
3. 3. use of a compound according to claim 1 or 2 for the preparation of a bacterial fungicide.
4. 4. Use of a compound according to claim 1 or 2 in bacterial imaging.
5. 5. Use of a compound according to claim 1 or 2 for improving the protective properties of a mask.
6. 6. The use according to claim 5, comprising, The compound is adsorbed on the surface and the inside of the middle layer of the mask, so that the bacteria filtering efficiency of the mask is improved, the protective performance is improved, and the mask has water-resistant capability and long-term use stability.

Description

Cationic amphiphilic AIE compound and application thereof in improving mask protective performance Technical Field The invention belongs to the technical field of biological functional materials, and particularly relates to a cationic amphiphilic AIE compound and application thereof in improving mask protective performance. Background Respiratory infectious diseases are a great threat in the field of global public health, and masks as core personal protective equipment play an irreplaceable role in blocking transmission of respiratory pathogens and reducing infection risk. Respiratory pathogens are mainly transmitted through fungus-containing (toxic) droplets and direct contact, so that wearing the mask becomes a key means for protecting the general public and medical staff from pathogen invasion. However, the traditional mask only has a physical barrier function, the fiber surface of the mask is easy to become a storage carrier of pathogens, bacteria, viruses and the like can survive on the surface of the mask for a long time and propagate in a large quantity, and the secondary infection risk of a wearer can be greatly improved after long-term or repeated use. Therefore, the development of a novel mask functional material with high antibacterial activity, long-acting stability and environmental friendliness has important significance for promoting the upgrading and updating of protective equipment and realizing win-win of public health protection and ecological environment protection. Disclosure of Invention This section is intended to outline some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. The present invention has been made in view of the above and/or problems occurring in the prior art. It is therefore an object of the present invention to overcome the deficiencies in the prior art and to provide cationic amphiphilic AIE compounds. In order to solve the technical problems, the invention provides a cationic amphiphilic AIE compound, which has the following structural formula: ; Wherein R is independently selected from alkyl, glycosyl and gallic acid with a hydrophobic chain length of 3-12, and X - is halogen anion. As a preferable scheme of the compound, the structural formula of the compound is as follows: 。 it is still another object of the present invention to overcome the deficiencies in the prior art and to provide a method for preparing cationic amphiphilic AIE compounds, comprising, Under the protection of nitrogen, dissolving a photosensitizer TBP in acetonitrile, stirring until the photosensitizer TBP is completely dissolved, adding bromopropane, and placing the reaction mixture in an 80 ℃ oil bath for constant-temperature reaction for 14 hours; After the reaction is finished, spin-drying the solvent, and purifying the crude product by silica gel column chromatography by taking DCM/methanol as an eluent; Vacuum drying after purification to obtain a black-purple powdery target product TBP-Pr; The structural formula of TBP-Pr is: 。 as a preferred embodiment of the preparation method, the ratio of TBP and acetonitrile of the photosensitizer is 100 mg/10 mL. As a preferred embodiment of the preparation method of the invention, the ratio of the photosensitizer TBP to bromopropane is 100 mg/5 mL. The invention further aims to overcome the defects in the prior art and provide an application of the cationic amphiphilic compound in preparing a bacterial bactericide. It is another object of the present invention to overcome the deficiencies of the prior art and to provide the use of a compound in bacterial imaging. Another object of the present invention is to overcome the deficiencies of the prior art, and to provide an application of a cationic amphiphilic compound in improving the protective performance of a mask, comprising, The compound is adsorbed on the surface and the inside of the middle layer of the mask, so that the bacteria filtering efficiency of the mask is improved, the protective performance is improved, and the mask has water-resistant capability and long-term use stability. The invention has the beneficial effects that: (1) The compound disclosed by the invention introduces a hydrophobic chain into an AIE photosensitizer group to construct a cationic amphiphilic AIE photosensitizer, realizes effective combination with staphylococcus aureus based on static electricity and hydrophobic effect, can generate active oxygen under white light irradiation, and further improves the killing efficiency on staphylococcus aureus. (2) The mask has high filtering capacity through the modification of AIE molecules and two modes of physical separation and photodynamic killing, shows a sustainable and high-performance conventional synthetic mask fabric substitute, and has potential application in manufacturing of functional textiles. (3) The preparation method has the advantages of reducing safety and environmental risks, prolonging the service life of the