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CN-121975217-A - Polyethylene composite film for medicine packaging and preparation method thereof

CN121975217ACN 121975217 ACN121975217 ACN 121975217ACN-121975217-A

Abstract

The invention relates to the technical field of high polymer materials, in particular to a polyethylene composite film for medicine packaging and a preparation method thereof, wherein the polyethylene composite film comprises, by mass, 75-85 parts of linear low-density polyethylene, 10-20 parts of high-density polyethylene, 5-8 parts of OV-POSS hybrid nanocellulose, 4-6 parts of a polyvinyl crosslinking monomer and 0.3-0.5 part of an initiator, and the OV-POSS hybrid nanocellulose is prepared from mercapto nanocellulose and octavinyl POSS through mercapto-alkene click reaction. The OV-POSS hybridized nanocellulose is used as a 'molecular pinning point', and forms a three-dimensional cross-linked network with a polyvinyl cross-linked monomer and PE chain free radicals under the action of an initiator in a film system, so that molecular level interface coupling is realized, the problem of interface defect of traditional physical blending of nanocellulose is solved, performance degradation caused by aggregation is avoided, migration risk of medicine contents is reduced, and the safety requirement of medicinal packaging is met.

Inventors

  • JIANG YUHAO

Assignees

  • 蒋宇浩

Dates

Publication Date
20260505
Application Date
20260201

Claims (9)

  1. 1. The polyethylene composite film for medicine packaging is characterized by comprising, by mass, 75-85 parts of linear low-density polyethylene, 10-20 parts of high-density polyethylene, 5-8 parts of OV-POSS hybrid nanocellulose, 4-6 parts of a polyvinyl crosslinking monomer and 0.3-0.5 part of an initiator; The OV-POSS hybrid nanocellulose is prepared from sulfhydrylation nanocellulose and octavinyl POSS through sulfhydrylation-alkene click reaction.
  2. 2. The polyethylene composite film for medicine packaging according to claim 1, wherein the preparation method of the OV-POSS hybrid nanocellulose comprises the steps of dispersing the sulfhydrylation nanocellulose in DMF, adding octavinyl POSS and a photoinitiator benzoin dimethyl ether, stirring for 10-30min, reacting for 2-3h under ultraviolet radiation, filtering, washing and drying to obtain the OV-POSS hybrid nanocellulose.
  3. 3. The polyethylene composite film for medicine packaging according to claim 2, wherein the mass ratio of the sulfhydryl nanocellulose, DMF, octavinyl POSS and benzoin dimethyl ether is 1:30 (0.5-0.7) to (0.05-0.1).
  4. 4. A polyethylene composite film for pharmaceutical packaging according to claim 2 or 3, characterized in that the preparation method of the sulfhydrylated nanocellulose comprises the following steps: A1, adding nano cellulose into a THF solvent, stirring and dispersing, and adding mercaptopropionic acid to obtain a reaction solution; a2, EDC and DMAP are added into the reaction solution, stirred and reacted for 3 to 8 hours at 55 to 65 ℃, filtered, washed and dried to obtain the sulfhydrylation nanocellulose.
  5. 5. The polyethylene composite film for medicine packaging according to claim 4, wherein the mass ratio of the nanocellulose, THF, mercaptopropionic acid, EDC and DMAP is 1:40 (0.8-1.1): (0.05-0.08): (0.03-0.05).
  6. 6. The polyethylene composite film for pharmaceutical packaging according to claim 1, wherein the initiator comprises one or more of dicumyl peroxide, benzoyl peroxide, t-butyl peroxybenzoate, methyl ethyl ketone peroxide.
  7. 7. The polyethylene composite film for pharmaceutical packaging according to claim 1, wherein the polyvinyl crosslinking monomer comprises one or more of trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, pentaerythritol triallyl ether, pentaerythritol tetraallyl ether, pentaerythritol triacrylate, pentaerythritol tetraacrylate.
  8. 8. A method for producing a polyethylene composite film for pharmaceutical packaging according to any one of claims 1 to 3, 5 to 7, comprising the steps of: s1, premixing linear low-density polyethylene, high-density polyethylene and OV-POSS hybridized nanocellulose for 3-5min at the rotating speed of 1500-2000rpm to obtain premix; s2, adding a polyvinyl crosslinking monomer and an initiator into the premix, and mixing for 5-10min at the rotating speed of 500-800rpm to obtain a mixture; and S3, adding the mixture into a double-screw extruder for melting, extruding and granulating, and then blowing to form a film to obtain the polyethylene composite film for medicine packaging.
  9. 9. The method for preparing the polyethylene composite film for medicine packaging according to claim 8, wherein the technological parameters of the twin-screw extruder are that a feeding section is 150-160 ℃, a melting section is 160-180 ℃, a homogenizing section is 170-180 ℃, a machine head temperature is 165-175 ℃, and a screw rotating speed is 150-300 rpm.

Description

Polyethylene composite film for medicine packaging and preparation method thereof Technical Field The invention relates to the technical field of high polymer materials, in particular to a polyethylene composite film for medicine packaging and a preparation method thereof. Background Drug packaging is the last process in drug production as packaging material, containers that directly contact the drug, which is more an organic component of the drug. At present, common base materials of the medicine packaging composite film comprise polyethylene terephthalate (PET), polyethylene (PE), aluminum and the like, and the Polyethylene (PE) film is widely applied to medicine packaging due to chemical inertness, processing convenience and low cost. However, the conventional PE film has three technical bottlenecks: The traditional PE film has weak blocking capability to oxygen and water vapor, so that the medicine is easy to oxidize or deliquesce, and particularly has obvious influence on medicines with strong hygroscopicity or easy oxidation (such as antibiotics and traditional Chinese medicine preparations); the mechanical strength and the thermal stability are insufficient, the tensile strength, the puncture resistance and the high temperature resistance of the pure PE film are difficult to meet the requirements of high-temperature sterilization or long-term storage, and the pure PE film is easy to damage or deform due to external force or temperature change; The nano filler has poor dispersibility, the prior art generally adopts a mode of physically adding nano materials (such as nanocellulose) to improve the mechanical property of the PE film, but the filler is agglomerated due to poor interfacial compatibility, so that the comprehensive property of the film is reduced. Disclosure of Invention In view of the above, the invention aims to provide a polyethylene composite film for medicine packaging and a preparation method thereof, so as to solve the problem that the traditional PE film is insufficient in barrier property, mechanical strength and thermal stability. Based on the purposes, the invention provides a polyethylene composite film for medicine packaging, which comprises, by mass, 75-85 parts of linear low-density polyethylene, 10-20 parts of high-density polyethylene, 5-8 parts of OV-POSS hybrid nanocellulose, 4-6 parts of polyvinyl crosslinking monomer and 0.3-0.5 part of initiator; The OV-POSS hybrid nanocellulose is prepared from sulfhydrylation nanocellulose and octavinyl POSS through sulfhydrylation-alkene click reaction. Preferably, the preparation method of the OV-POSS hybrid nanocellulose comprises the steps of dispersing the sulfhydrylation nanocellulose in DMF, adding octavinyl POSS and a photoinitiator benzoin dimethyl ether, stirring for 10-30min, reacting for 2-3h under ultraviolet radiation, filtering, washing and drying to obtain the OV-POSS hybrid nanocellulose. Preferably, the mass ratio of the sulfhydrylation nanocellulose, DMF, octavinyl POSS and benzoin dimethyl ether is 1:30 (0.5-0.7) to (0.05-0.1). Preferably, the preparation method of the sulfhydrylation nanocellulose comprises the following steps: A1, adding nano cellulose into a THF solvent, stirring and dispersing, and adding mercaptopropionic acid to obtain a reaction solution; a2, EDC and DMAP are added into the reaction solution, stirred and reacted for 3 to 8 hours at 55 to 65 ℃, filtered, washed and dried to obtain the sulfhydrylation nanocellulose. Preferably, the mass ratio of the nanocellulose to the THF to the mercaptopropionic acid to the EDC to the DMAP is 1:40 (0.8-1.1): (0.05-0.08): (0.03-0.05). Preferably, the initiator comprises one or more of dicumyl peroxide, benzoyl peroxide, tert-butyl peroxybenzoate and methyl ethyl ketone peroxide. Preferably, the polyvinyl crosslinking monomer comprises one or more of trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, pentaerythritol triallyl ether, pentaerythritol tetraallyl ether, pentaerythritol triacrylate, pentaerythritol tetraacrylate. The invention further provides a preparation method of the polyethylene composite film for medicine packaging, which comprises the following steps: s1, premixing linear low-density polyethylene, high-density polyethylene and OV-POSS hybridized nanocellulose for 3-5min at the rotating speed of 1500-2000rpm to obtain premix; s2, adding a polyvinyl crosslinking monomer and an initiator into the premix, and mixing for 5-10min at the rotating speed of 500-800rpm to obtain a mixture; and S3, adding the mixture into a double-screw extruder for melting, extruding and granulating, and then blowing to form a film to obtain the polyethylene composite film for medicine packaging. Preferably, the technological parameters of the twin-screw extruder are that the feeding section is 150-160 ℃, the melting section is 160-180 ℃, the homogenizing section is 170-180 ℃, the temperature of a machine head is 165-175 ℃, and the rotating speed of a