Search

CN-121975285-A - Fibrous membrane, raw material composition of fibrous membrane, and preparation method and application of raw material composition

CN121975285ACN 121975285 ACN121975285 ACN 121975285ACN-121975285-A

Abstract

The invention discloses a fiber membrane, a raw material composition of the fiber membrane, a preparation method and application thereof. The raw material composition of the fiber membrane comprises a matrix material, a solvent and an additive, wherein the matrix material comprises polycaprolactone, the additive is salt, the salt comprises potassium salt and/or sodium salt, the content of the matrix material is 0.03-0.1g/mL, the content of the additive is 0.01-4%, and the mass percent of the additive and the matrix material is the percentage. And (3) carrying out electrostatic spinning by using a spinning solution containing the raw material composition to obtain the fiber membrane. The raw material composition can be used for stable spinning, and can also ensure that the obtained fiber film has good morphology and excellent anti-inflammatory effect in practical application.

Inventors

  • ZHANG HAO
  • FENG BEI
  • XIANG LI
  • LI FEN
  • SHI YU
  • XIAO QIONG
  • LIU YIWEI
  • YAN YI
  • YE LINCAI

Assignees

  • 上海交通大学医学院附属上海儿童医学中心

Dates

Publication Date
20260505
Application Date
20260126

Claims (10)

  1. 1. A raw material composition of a fiber membrane is characterized by comprising a matrix material, a solvent and an additive, wherein, The matrix material comprises polycaprolactone; the additive is a salt, and the salt comprises potassium salt and/or sodium salt; the content of the matrix material is 0.03-0.1g/mL; The content of the additive is 0.01% -4%, and the percentage is the mass percentage of the additive and the matrix material.
  2. 2. The raw material composition of a fibrous membrane according to claim 1, wherein the raw material composition of the fibrous membrane satisfies one or more of the following conditions: (1) The potassium salt comprises KCl; (2) The sodium salt comprises one or more of NaCl, SDS and NaHCO 3 , preferably NaCl; (3) The content of the matrix material is 0.03-0.06g/mL; (4) The content of the additive is 0.05% -3%, preferably 0.1%; (5) The solvent includes one or more of hexafluoroisopropanol, trifluoroethanol and dimethylformamide, for example hexafluoroisopropanol.
  3. 3. The raw material composition for fiber membrane according to claim 1, wherein the matrix material is polycaprolactone, the additive is potassium salt and/or sodium salt, the solvent is hexafluoroisopropanol, the content of the matrix material is 0.03-0.06g/mL, and the content of the additive is 0.05% -3%.
  4. 4. The raw material composition for a fiber film according to any one of claims 1 to 3, wherein the matrix material is polycaprolactone, the additive is KCl, the solvent is hexafluoroisopropanol, the content of the matrix material is 0.03g/mL or 0.06g/mL, and the content of the additive is 0.01%, 0.05%, 0.1% or 3%; or the matrix material is polycaprolactone, the additive is NaCl, the solvent is hexafluoroisopropanol, the content of the matrix material is 0.06g/mL, and the content of the additive is 0.1%; Or the matrix material is polycaprolactone, the additive is SDS, the solvent is hexafluoroisopropanol, the content of the matrix material is 0.06g/mL, and the content of the additive is 0.1%; Or the matrix material is polycaprolactone, the additive is NaHCO 3 , the solvent is hexafluoroisopropanol, the content of the matrix material is 0.06g/mL, and the content of the additive is 0.1%.
  5. 5. A method for preparing a fibrous membrane, comprising the steps of: The fiber film is prepared by electrostatic spinning with a spinning solution, wherein the spinning solution comprises the raw material composition of the fiber film according to any one of claims 1 to 4.
  6. 6. The method of making a fibrous membrane of claim 5, wherein the method of making a fibrous membrane meets one or more of the following conditions: (1) In the electrostatic spinning, the applied voltage is-1 to-30 kV, preferably-3 to-25 kV, for example-12 kV; (2) In the electrospinning, the injection rate is 0.1-10mL/h, preferably 0.3-1mL/h, for example 0.5mL/h; (3) In the electrospinning, the receiving distance is 5 to 20cm, preferably 10 to 20cm, for example 15cm; (4) In the electrospinning, the ambient temperature is 22-30 ℃, for example 26 ℃; (5) In the electrospinning, the ambient humidity is 50% -70%, for example 50%; (6) The preparation of the spinning solution comprises the steps of premixing the matrix material and the solvent and then mixing with the additive.
  7. 7. The method for producing a fiber film according to claim 5 or 6, wherein in the electrospinning, the applied voltage is-3 to-25 kV, the injection rate is 0.1 to 10mL/h, and the receiving distance is 5 to 20cm; Preferably, in the electrostatic spinning, the applied voltage is-12 kV, the injection rate is 0.5mL/h, and the receiving distance is 15cm.
  8. 8. A fibrous membrane produced by the method of producing a fibrous membrane according to any one of claims 5 to 7.
  9. 9. The fibrous membrane of claim 8, wherein the fibrous membrane satisfies one or both of the following conditions: (1) The fiber membrane contains fibers with a diameter of 100-350nm, preferably 100-200nm; (2) The pore size of the fibrous membrane is 6-10. Mu.m, preferably 6-8. Mu.m.
  10. 10. Use of a raw material composition of a fibrous membrane according to any one of claims 1 to 4 or a fibrous membrane according to claim 8 or 9 for the preparation of an implant material.

Description

Fibrous membrane, raw material composition of fibrous membrane, and preparation method and application of raw material composition Technical Field The invention relates to a fiber membrane, a raw material composition of the fiber membrane, a preparation method and application thereof. Background In recent years, the nanofiber membrane prepared by adopting the electrostatic spinning technology has great potential in the biomedical field, and particularly has very wide development and application prospects in the aspect of anti-inflammatory. However, current research into anti-inflammatory nanofiber membranes still has the following limitations: 1. Drug load dependency problems mainstream methods achieve functionalization by loading anti-inflammatory drugs (such as ibuprofen (Ibuprofen), aspirin, celecoxib, etc.), but there are risks of drug burst (initial rapid release leading to local concentration too high), limited drug loading (affecting long-term efficacy), and drug self side effects (such as cytotoxicity requiring strict control of dose). In addition, the complicated preparation process increases the cost, for example, the ibuprofen-loaded fiber can be slowly released for 21 days, but the mechanical property of the fiber is changed due to the increase of the content of the medicine, and the precise regulation and control are needed. 2. The biocompatibility and the technological challenges of material modification are that although surface functionalization (such as galactose modification of PCL fibers) can enhance anti-inflammatory effect, chemical reaction (such as covalent bonding) is involved, biocompatible components can be introduced to trigger immune reaction, the process is complex (such as layer-by-layer assembly needs to be monitored in real time), and the stability of the effect is doubtful (such as the modified layer is hard to last in an in vivo environment). In addition, patent studies indicate that chemical crosslinkers, while improving strength, present a safety risk and an increase in cost. 3. The accuracy of physical structure regulation is insufficient, namely, the design of multilayer core-shell structure (such as like electrospun fiber or triaxial electrospun) or orientation can optimize the slow release of the medicine, but the preparation process needs fluid cooperation, the parameter control difficulty is high, and the uneven fiber diameter or structural defect is easy to cause. For example, the thickness of the selective layer constructed by the interfacial polymerization technology is only about 300nm, the sensitivity to the substrate pores is high, and the mass replication is difficult. In addition, although the existing preparation methods of the fiber membrane (such as changing solution concentration, viscosity, voltage, receiving distance and solvent system) are effective, the preparation methods are often mutually restricted, and the anti-inflammatory effect can not be ensured on the premise of ensuring spinnability and membrane integrity. Thus, there is a need for a simple, efficient, low cost, drug-independent method to make a nanofiber membrane that is intact and stable, yet retains excellent anti-inflammatory function. Disclosure of Invention In order to overcome the technical defects of the prior fiber membrane, the invention provides a fiber membrane, a raw material composition of the fiber membrane, a preparation method and application thereof. The raw material composition can be used for stabilizing spinning, can also ensure that the obtained fiber membrane has good morphology, and has excellent anti-inflammatory effect in practical application. In order to achieve the above purpose, the invention adopts the following technical scheme. The invention provides a raw material composition of a fiber membrane, which comprises a matrix material, a solvent and an additive, wherein the matrix material comprises a main component, The matrix material comprises polycaprolactone; the additive is a salt, and the salt comprises potassium salt and/or sodium salt; the content of the matrix material is 0.03-0.1g/mL; The content of the additive is 0.01% -4%, and the percentage is the mass percentage of the additive and the matrix material. In the present invention, the term "the content of the matrix material is 0.03 to 0.1g/mL" means that the mass of the matrix material is 0.03 to 0.1g in terms of 1mL of the solvent. The invention surprisingly discovers that under the condition of selecting potassium salt and/or sodium salt as an additive and matching with a certain dosage of the additive and a matrix material, not only can good appearance be ensured on the basis of stable spinning, but also excellent anti-inflammatory effect can be realized without auxiliary factors such as anti-inflammatory drugs and the like and without excessive optimization of spinning parameters, and the effect is even better than that of a fibrous membrane containing the anti-inflammatory drugs (such as ibup