Search

CN-121975323-A - Antibacterial polysulfone composite material and preparation method and application thereof

CN121975323ACN 121975323 ACN121975323 ACN 121975323ACN-121975323-A

Abstract

The invention discloses an antibacterial polysulfone composite material and a preparation method and application thereof, which belong to the technical field of high polymer materials, and the uniform dispersion and no agglomeration of thorn-shaped antibacterial hollow microspheres in a polysulfone matrix are realized through the strong coordination effect and the mechanical interlocking effect of Schiff base polysulfone powder on thorn-shaped antibacterial hollow microspheres, so that the interfacial compatibility of inorganic filler and a polymer matrix is effectively improved; according to the invention, through ammoniation and condensation reaction, a Schiff base structure is covalently grafted in a molecular chain of chloromethylated polysulfone powder, the Schiff base structure carries antibacterial activity, and the thorn-shaped antibacterial hollow microsphere is firmly anchored in a matrix through a coordination bond, so that the thorn-shaped antibacterial hollow microsphere is not easy to migrate, and the special structure of the thorn-shaped antibacterial hollow microsphere can assist the thorn-shaped antibacterial hollow microsphere to be embedded in the polysulfone matrix, so that the thorn-shaped antibacterial hollow microsphere is not easy to separate out.

Inventors

  • CHEN PEILONG
  • SU JIAZHENG
  • ZHAO YUANYUAN
  • SU PAN

Assignees

  • 安徽聚芳新材料科技有限公司

Dates

Publication Date
20260505
Application Date
20260316

Claims (10)

  1. 1. The preparation method of the antibacterial polysulfone composite is characterized by comprising the following steps: the method comprises the steps of taking benzene rings in a polysulfone powder structure as reaction sites, and attacking the benzene rings by taking chloromethyl methyl ether as an electrophile to obtain chloromethyl polysulfone powder; step two, performing Schiff base dehydration condensation reaction on aminated polysulfone powder and 2-acetylpyridine to obtain Schiff base polysulfone powder; step three, taking the silicon dioxide microspheres as sacrificial templates, reacting copper nitrate with silicon dioxide to generate copper silicate, and generating anisotropic growth in a hydrothermal environment to form thorn-shaped nano structures so as to obtain thorn-shaped antibacterial hollow microspheres; and step four, adding Schiff base polysulfone powder, thorn-shaped antibacterial hollow microspheres and carbon nanotubes into an injection molding machine according to the mass ratio of 2:0.4:0.05, and performing injection molding to obtain the antibacterial polysulfone composite material.
  2. 2. The method for preparing the antibacterial polysulfone composite material according to claim 1, wherein the chloromethylated polysulfone powder is specifically prepared by the following steps: adding 1, 2-dichloroethane and polysulfone powder into a reaction kettle, stirring and stirring for 8-9h at 80-90 ℃ and 500-600r/min, naturally cooling to room temperature, then adding chloromethyl methyl ether and stannic chloride, heating to 60-65 ℃, continuously stirring for 50-52h, filtering after the reaction is finished, washing the product with deionized water and absolute ethyl alcohol for 2-4 times respectively, and vacuum drying at 60-70 ℃ to constant weight to obtain chloromethylated polysulfone powder.
  3. 3. The method for preparing the antibacterial polysulfone composite according to claim 2, wherein the dosage ratio of 1, 2-dichloroethane, polysulfone powder, chloromethyl methyl ether and stannic chloride is 250-260ml:10-12g:50-52g:25-27g.
  4. 4. The method for preparing an antibacterial polysulfone composite according to claim 1, wherein the aminated polysulfone powder is prepared by the specific steps of: Adding 1, 3-propylene diamine, toluene and N, N-dimethylformamide into a reaction kettle, stirring for 20-30min at 20-25 ℃ and 500-600r/min, then adding chloromethylated polysulfone powder, heating to 100-110 ℃ under the protection of nitrogen, continuously stirring for 18-20h, after the reaction is finished, respectively washing the product with toluene and ethanol for 2-4 times, drying at 60-70 ℃ to constant weight, transferring the product into 5-7% anhydrous sodium carbonate solution with mass fraction, stirring for 4-5h at 20-25 ℃ and 500-600r/min, filtering, respectively washing the product with deionized water and absolute ethanol for 2-4 times, and drying at 60-70 ℃ to constant weight to obtain aminated polysulfone powder.
  5. 5. The method for preparing an antibacterial polysulfone composite according to claim 4, wherein the dosage ratio of 1, 3-propanediamine, toluene, N-dimethylformamide and chloromethylated polysulfone powder is 20-30g:40-50mL:40-50mL:4-5g.
  6. 6. The method for preparing the antibacterial polysulfone composite according to claim 1, wherein the specific preparation steps of the schiff base polysulfone powder are as follows: adding aminated polysulfone powder, 2-acetylpyridine and absolute ethyl alcohol into a reaction kettle, refluxing and stirring for 20-22h under the protection of nitrogen at 70-80 ℃ and 500-600r/min, filtering after the reaction is finished, respectively washing the product with deionized water and absolute ethyl alcohol for 2-4 times, and drying at 60-70 ℃ to constant weight to obtain Schiff base polysulfone powder.
  7. 7. The method for preparing an antibacterial polysulfone composite according to claim 6, wherein the dosage ratio of aminated polysulfone powder, 2-acetylpyridine and absolute ethyl alcohol is 5-8g:20-22g:40-50mL.
  8. 8. The preparation method of the antibacterial polysulfone composite according to claim 1, wherein the specific preparation steps of the thorn-shaped antibacterial hollow microsphere are as follows: Mixing the silicon dioxide microspheres and deionized water according to the dosage ratio of 100-120mg:20-30mL to obtain silicon dioxide dispersion liquid, adding copper nitrate, the silicon dioxide dispersion liquid, deionized water and ammonia water with mass fraction of 25-28% into a polytetrafluoroethylene reaction kettle, ultrasonically dispersing for 40-60min, heating to 140-150 ℃ and continuously stirring for 24-26h, filtering, respectively washing the product with deionized water and absolute ethyl alcohol for 2-4 times, and vacuum drying at 60-70 ℃ to obtain thorn-shaped antibacterial hollow microspheres; the dosage ratio of the copper nitrate to the silicon dioxide dispersion liquid to the deionized water to the ammonia water is 0.75-0.80g to 20-22mL to 30-40mL to 1-2mL.
  9. 9. An antibacterial polysulfone composite prepared by the preparation method of any one of claims 1-8.
  10. 10. The use of an antimicrobial polysulfone composite according to claim 9 in medical electronics.

Description

Antibacterial polysulfone composite material and preparation method and application thereof Technical Field The invention belongs to the technical field of high polymer materials, and particularly relates to an antibacterial polysulfone composite material and a preparation method and application thereof. Background Polysulfone is an important place in the medical field and can be used for preparing medical instruments, medical consumables, dental appliances, drug delivery systems, internal implants and other products. With the continuous improvement of the life quality of residents, the public increasingly attach importance to health problems, and the market demands of medical related products are continuously increasing. Therefore, the polysulfone is subjected to modification research, excellent antibacterial and impact resistance are given to the material, the comprehensive use performance of the material is improved, the application range of the material in the medical field is further widened, and the material has important practical application significance and wide market development prospect. The Chinese patent application with publication number of CN118755266A discloses a high impact resistant polyphenylsulfone composite material and a preparation method thereof, in the scheme, double bonds on the surfaces of functionalized polyphenylsulfone and modified montmorillonite react with mercapto groups in dimercaptoborate and pyridine Schiff base copper complex, and then the composite material is prepared after injection molding, the mercapto groups adopted in the scheme are combined with the double bonds, but the interface binding force is weak, so that the impact resistance of the composite material is obviously reduced, inorganic filler is not uniformly dispersed, the interface binding force is poor, self-repairing and antibacterial functions cannot be effectively realized, and the use requirements of high impact resistance and long-term stability are difficult to achieve. Disclosure of Invention The invention aims to provide an antibacterial polysulfone composite material, a preparation method and application thereof, and the antibacterial polysulfone composite material realizes uniform dispersion and no agglomeration of thorn-shaped antibacterial hollow microspheres in a polysulfone matrix through the strong coordination effect and the mechanical interlocking effect of Schiff base polysulfone powder on thorn-shaped antibacterial hollow microspheres, and effectively improves the interfacial compatibility of inorganic filler and a polymer matrix. The aim of the invention can be achieved by the following technical scheme: the preparation method of the antibacterial polysulfone composite material comprises the following steps: The method comprises the steps of taking benzene rings in a polysulfone powder structure as reaction sites, attacking the benzene rings through chloromethyl methyl ether as an electrophile to obtain chloromethyl polysulfone powder, and carrying out ammonification reaction on the end chloromethyl of the chloromethyl polysulfone powder and one end amino of 1, 3-propanediamine to obtain aminated polysulfone powder. Step two, schiff base polysulfone powder is obtained through Schiff base dehydration condensation reaction between aminated polysulfone powder and 2-acetylpyridine. And thirdly, taking the silicon dioxide microspheres as sacrificial templates, reacting copper nitrate with silicon dioxide to generate copper silicate, and generating anisotropic growth in a hydrothermal environment to form thorn-shaped nano structures so as to obtain thorn-shaped antibacterial hollow microspheres. And step four, adding Schiff base polysulfone powder, thorn-shaped antibacterial hollow microspheres and carbon nanotubes into an injection molding machine according to the mass ratio of 2:0.4:0.05, and performing injection molding to obtain the antibacterial polysulfone composite material. Further, the chloromethylated polysulfone powder is specifically prepared as follows: adding 1, 2-dichloroethane and polysulfone powder into a reaction kettle, stirring and stirring for 8-9h at 80-90 ℃ and 500-600r/min, naturally cooling to room temperature, then adding chloromethyl methyl ether and stannic chloride, heating to 60-65 ℃, continuously stirring for 50-52h, filtering after the reaction is finished, washing the product with deionized water and absolute ethyl alcohol for 2-4 times respectively, and vacuum drying at 60-70 ℃ to constant weight to obtain chloromethylated polysulfone powder. Further, the dosage ratio of 1, 2-dichloroethane, polysulfone powder, chloromethyl methyl ether and tin tetrachloride is 250-260mL:10-12g:50-52g:25-27g. Further, the aminated polysulfone powder is prepared by adding 1, 3-propanediamine, toluene and N, N-dimethylformamide into a reaction kettle, stirring for 20-30min at 20-25 ℃ and 500-600r/min, then adding chloromethylated polysulfone powder, heating to 100-110 ℃ under