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CN-121975331-A - Medical liquid silica gel and preparation method thereof

CN121975331ACN 121975331 ACN121975331 ACN 121975331ACN-121975331-A

Abstract

The invention discloses medical liquid silica gel and a preparation method thereof, and relates to the technical field of silica gel materials. The method comprises the steps of drying polydimethylsiloxane with vinyl at the end and vinyl at the side chain, taking part of the polydimethylsiloxane to carry out addition reaction with dehydrated 1H, 2H-perfluoro decyl dimethyl silane to obtain a fluorine-containing modified liquid silica gel matrix, coating a silicon dioxide layer outside the dopamine-coated nano diamond, grafting vinyl trimethoxy silane and octyl triethoxy silane to obtain modified wear-resistant filler, mixing the fluorine-containing modified liquid silica gel matrix, the modified wear-resistant filler, vinyl MQ silicon resin and a catalyst to prepare a component A, mixing the rest of dry base gel with hydrogen-containing silicone oil and 3-methyl-1-butyn-3-ol to prepare a component B, and finally mixing and solidifying the component A, B. The liquid silica gel prepared by the invention has excellent wear resistance and mechanical property, and is suitable for the field of medical appliances.

Inventors

  • WANG YUNFENG

Assignees

  • 广东晟峰新材料科技有限公司

Dates

Publication Date
20260505
Application Date
20260304

Claims (10)

  1. 1. The preparation method of the medical liquid silica gel is characterized by comprising the following steps of: (1) Carrying out vacuum drying treatment on polydimethylsiloxane with vinyl ends and vinyl side chains to obtain dry base adhesive, and dividing the dry base adhesive into two parts; (2) Dehydrating 1H, 2H-perfluorodecyl dimethyl silane to obtain dehydrated fluorosilane; (3) Under the protection of inert gas, carrying out addition reaction on the first part of dry base rubber obtained in the step (1) and dehydrated fluorosilane in the presence of a platinum-vinyl siloxane complex catalyst, and removing unreacted monomers in vacuum after the reaction to obtain a fluorine-containing modified liquid silica gel matrix; (4) Dispersing nano diamond in a solvent, adding dopamine hydrochloride to perform polymerization reaction, and forming a polydopamine coating layer on the surface of the nano diamond to obtain PDA@ND powder; (5) Carrying out hydrolysis polycondensation reaction by using tetraethoxysilane, and coating a silicon dioxide layer outside the PDA@ND powder to obtain a PDA@ND@SiO 2 compact core-shell filler; (6) Grafting vinyl trimethoxy silane and octyl triethoxy silane on the surface of the PDA@ND@SiO 2 compact core-shell filler to obtain a modified wear-resistant filler; (7) Mixing fluorine-containing modified liquid silica gel matrix, modified wear-resistant filler, vinyl MQ silicon resin and platinum-vinyl siloxane complex catalyst, and grinding, dispersing and defoaming to obtain a component A; (8) Mixing the second part of the dry base adhesive reserved in the step (1), hydrogen-containing silicone oil and 3-methyl-1-butine-3-alcohol to obtain a component B; (9) And uniformly mixing the component A and the component B, defoaming, and heating and curing to obtain the composite material.
  2. 2. The method for preparing a liquid silica gel for medical use according to claim 1, wherein in the step (3), the mass ratio of the first dry base gel to the dehydrated fluorosilane is 90 (7-9).
  3. 3. The method for preparing medical liquid silica gel according to claim 1, wherein in the step (4), the mass ratio of the nano diamond to the dopamine hydrochloride is 8 (2-3).
  4. 4. The method for preparing a liquid silica gel for medical use according to claim 1, wherein in the step (5), the mass ratio of pda@nd powder to ethyl orthosilicate is 5 (13-16).
  5. 5. The method for preparing medical liquid silica gel according to claim 1, wherein in the step (6), the mass ratio of PDA@ND@SiO 2 compact core-shell filler to vinyltrimethoxysilane is 4 (1-2).
  6. 6. The method for preparing medical liquid silica gel according to claim 1, wherein in the step (6), the mass ratio of the PDA@ND@SiO 2 compact core-shell filler to the octyl triethoxysilane is 4 (0.5-1.0).
  7. 7. The preparation method of the medical liquid silica gel according to claim 1, wherein in the step (7), the mass ratio of the fluorine-containing modified liquid silica gel matrix to the modified wear-resistant filler to the vinyl MQ silicone resin is 98 (3-5).
  8. 8. The method for preparing a medical liquid silica gel according to claim 1, wherein in the step (8), the mass ratio of the second dry base gel to the hydrogen-containing silicone oil to the 3-methyl-1-butyn-3-ol is 80 (18-20) (0.1-0.2).
  9. 9. The method for preparing a liquid silica gel for medical use according to claim 1, wherein in the step (9), the mass ratio of the component A to the component B is 1 (0.9 to 1.1).
  10. 10. A liquid silica gel for medical use, characterized in that it is prepared by the method according to any one of the preceding claims 1-9.

Description

Medical liquid silica gel and preparation method thereof Technical Field The invention relates to the technical field of silica gel materials, in particular to medical liquid silica gel and a preparation method thereof. Background The liquid silica gel is used as an addition type organic silicon material with vinyl end-capped polydimethylsiloxane as a core matrix, has excellent biocompatibility, low-temperature flexibility, high-low temperature resistance, chemical stability and good molding processability, meets the medical biological evaluation standard and the medical material requirement, and becomes one of the most widely applied high polymer materials in the medical field. The medical dynamic sealing device is widely applied to various medical scenes such as medical catheters, interventional instrument accessories, medical dynamic sealing parts, medical consumables, oral medical instruments, breathing circuit connecting parts and the like, and plays an irreplaceable role in clinical diagnosis and treatment and operation of medical equipment. However, in the practical medical application process, most medical liquid silica gel products are in the working conditions of dynamic friction, reciprocating contact or mechanical extrusion for a long time, and the defect of insufficient intrinsic wear resistance of the traditional medical liquid silica gel is particularly remarkable, so that the defect is a key bottleneck for limiting the further application of the traditional medical liquid silica gel in the high-end medical field. For example, continuous interface friction can be generated in the process of inserting and extracting the medical interventional catheter, repeated abrasion contact can be generated in the dynamic sealing of the medical sealing element, surface friction damage can be generated in the process of repeatedly using medical and medical consumables, surface scratches, abrasion marks and even substrate peeling can be easily generated in traditional liquid silica gel under the scenes, the service life of medical products can be greatly shortened, the maintenance and replacement cost and the clinical use cost of medical equipment are increased, more serious, silica gel microparticles generated by abrasion are easy to dissolve and migrate, medical safety risks such as inflammation, thrombus and foreign body reaction of human tissues can be possibly caused, and the abrasion damage on the surfaces of products can also become attachment sites of bacteria and microorganisms, so that the probability of clinical infection is increased. In addition, the high-end medical instrument puts forward higher requirements on the wear resistance of the silica gel product, and the wear rate of the traditional liquid silica gel is difficult to meet the use requirements of products such as precise interventional instruments, long-acting medical sealing parts and the like. Disclosure of Invention The invention aims to provide medical liquid silica gel and a preparation method thereof, which aim to solve the technical problems proposed by the background technology. In order to achieve the above purpose, the present invention provides the following technical solutions: A preparation method of medical liquid silica gel comprises the following steps: (1) Carrying out vacuum drying treatment on polydimethylsiloxane with vinyl ends and vinyl side chains to obtain dry base adhesive, and dividing the dry base adhesive into two parts; (2) Dehydrating 1H, 2H-perfluorodecyl dimethyl silane to obtain dehydrated fluorosilane; (3) Under the protection of inert gas, carrying out addition reaction on the first part of dry base rubber obtained in the step (1) and dehydrated fluorosilane in the presence of a platinum-vinyl siloxane complex catalyst, and removing unreacted monomers in vacuum after the reaction to obtain a fluorine-containing modified liquid silica gel matrix; (4) Dispersing nano diamond in a solvent, adding dopamine hydrochloride to perform polymerization reaction, and forming a polydopamine coating layer on the surface of the nano diamond to obtain PDA@ND powder; (5) Carrying out hydrolysis polycondensation reaction by using tetraethoxysilane, and coating a silicon dioxide layer outside the PDA@ND powder to obtain a PDA@ND@SiO 2 compact core-shell filler; (6) Grafting vinyl trimethoxy silane and octyl triethoxy silane on the surface of the PDA@ND@SiO 2 compact core-shell filler to obtain a modified wear-resistant filler; (7) Mixing fluorine-containing modified liquid silica gel matrix, modified wear-resistant filler, vinyl MQ silicon resin and platinum-vinyl siloxane complex catalyst, and grinding, dispersing and defoaming to obtain a component A; (8) Mixing the second part of the dry base adhesive reserved in the step (1), hydrogen-containing silicone oil and 3-methyl-1-butine-3-alcohol to obtain a component B; (9) And uniformly mixing the component A and the component B, defoaming, and heating and curing to obt