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CN-121975362-A - Deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-ore removal functions and preparation method and application thereof

CN121975362ACN 121975362 ACN121975362 ACN 121975362ACN-121975362-A

Abstract

The invention relates to the technical field of medical materials, and discloses a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-ore-shedding functions, and a preparation method and application thereof. The preparation method comprises the steps of preparing a deep eutectic solvent by mixing SBMA and glycerol or glycerol and gallic acid, adding a cross-linking agent ethylene glycol dimethacrylate and an initiator into the deep eutectic solvent, uniformly mixing, coating the mixture on a PETG substrate, and curing under the action of the initiator to form a continuous and compact deep eutectic eutectoid gel coating. The invention constructs a dense hydrogen bond network through a deep eutectic system formed by SBMA and glycerin, obviously improves the hydrophilicity and lubricity of the coating, can effectively reduce the adhesion of bacteria and proteins in the oral cavity, keeps the surface of the corrector clean, provides a feasible and efficient technical path for long-term biological functionalization of the invisible corrector, and can be applied to the fields of other oral medical instruments and biological functional coatings in an expanding manner.

Inventors

  • CHEN XINGYU
  • GAO AO

Assignees

  • 西南交通大学

Dates

Publication Date
20260505
Application Date
20251218

Claims (10)

  1. 1. The preparation method of the deep eutectic eutectoid gel coating with the functions of resisting bacteria, adhesion and ore removal is characterized by comprising the following steps of: s1, taking sulfobetaine methacrylate as a hydrogen bond acceptor, taking glycerol or glycerol and gallic acid as hydrogen bond donors, mixing the hydrogen bond acceptor and the hydrogen bond donors, and stirring under heating to form a uniform and transparent deep eutectic solvent; S2, adding a cross-linking agent ethylene glycol dimethacrylate and an initiator into the deep eutectic solvent, uniformly mixing, coating the mixture on a PETG substrate, and curing under the action of the initiator to form a continuous and compact deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-desquamation functions on the surface of the PETG substrate.
  2. 2. The method for preparing the deep eutectic eutectoid gel coating with the antibacterial, anti-adhesion and anti-demineralization functions according to claim 1, wherein the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is 1:3-5, and/or the gallic acid accounts for 0-10% of the molar amount of the glycerol.
  3. 3. The method for preparing the deep eutectic eutectoid gel coating with the functions of resisting bacteria, resisting adhesion and preventing ore removal according to claim 2, wherein the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is 1:4, and the gallic acid accounts for 4-6% of the molar amount of the glycerol.
  4. 4. The method for preparing a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-ore removal functions according to claim 1, wherein the heating temperature of a deep eutectic solvent is 30-45 ℃ when gallic acid is not contained, and the heating temperature of the deep eutectic solvent is 50-60 ℃ when gallic acid is contained.
  5. 5. The method for preparing the deep eutectic eutectoid gel coating with the antibacterial, anti-adhesion and anti-mine functions according to claim 1, wherein the dosage of the cross-linking agent is 0.5-5% of the molar amount of the hydrogen bond receptor, and/or the addition concentration of the initiator is 0.1-1 wt%.
  6. 6. The preparation method of the deep eutectic eutectoid gel coating with the antibacterial, anti-adhesion and anti-mine functions, which is disclosed in claim 1, is characterized in that the initiator is a photoinitiator Irgacure 2959, and ultraviolet light with the wavelength of 365 nm and the power of 10-20 mW/cm < 2 > is adopted for curing.
  7. 7. The method for preparing the deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-desquamation functions according to claim 1, wherein the PETG substrate is subjected to surface modification treatment before being coated, and the surface modification method is as follows: 1) Placing the PETG substrate into a plasma cleaning machine, and performing plasma surface activation treatment at a power of 30-50W for 1-5 min to introduce surface hydroxyl groups and active sites; 2) Immersing the PETG substrate subjected to plasma treatment into a mixed solution of ethanol and water of 3- (methacryloyloxy) propyl trimethoxysilane (IBMA-Silane), reacting for 1-5 hours at a constant temperature of 40-60 ℃ to enable the Silane coupling agent to form a compact organic silicon layer on the surface of the PETG substrate, and washing and drying after the reaction is finished.
  8. 8. The method of preparing a deep eutectic eutectoid gel coat with antibacterial, anti-adhesion and anti-mine functions according to any one of claims 1 to 7, wherein the PETG substrate is a contact corrector or a sheet for preparing a contact corrector.
  9. 9. A deep eutectic eutectoid gel coating prepared by the method of any one of claims 1-8.
  10. 10. Use of the deep eutectic eutectoid gel coating of claim 9 for surface modification of an invisible appliance.

Description

Deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-ore removal functions and preparation method and application thereof Technical Field The invention relates to the technical field of medical materials, in particular to a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-mine functions, and a preparation method and application thereof. Background With the wide application of the invisible orthodontic technology, the invisible appliance (such as a dental socket made of transparent polymer materials such as PETG (polyethylene terephthalate-1, 4-cyclohexanedimethanol ester) and the like) gradually replaces part of the traditional fixing and correcting mode due to the advantages of attractive appearance, detachability and the like. However, during long-term wear, due to the closed microenvironment formed between the invisible appliance and the tooth surface, saliva flow is limited, food residues and dental plaque are prone to accumulate, resulting in a local pH decrease, thereby accelerating dissolution of hydroxyapatite crystals in the enamel, inducing tooth demineralization. In addition, the invisible appliance has repeated friction on the tooth surface in the wearing and picking process, so that the mechanical damage and demineralization risk of the tooth enamel are further increased. Over time, localized demineralization can manifest as white spot lesions, affecting not only the aesthetics of the teeth, but also the potential for caries. The existing invisible appliance has mechanical correction function, lacks an effective antibacterial and anti-mine protection mechanism, and is difficult to maintain stable oral microenvironment in long-period treatment. At present, although research is attempted to endow certain biological functionality to the drug by drug impregnation, surface coating or polymer modification, the problems of uneven drug release, poor material adhesion, insufficient biocompatibility, complex preparation process and the like exist, and the clinical application is limited. Therefore, there is an urgent need to develop a functional coating material with antibacterial, anti-adhesion and anti-desquamation functions, which can form a stable, durable and controllable release protective layer on the surface of the invisible appliance, so as to prevent desquamation and plaque formation caused by unbalanced oral microenvironment, and promote tooth health and material comfort in the correction process. Disclosure of Invention In order to solve the defects of the conventional invisible appliance in the aspects of antibiosis, adhesion resistance, ore removal prevention and the like, the invention provides a deep eutectic eutectoid gel coating with antibiosis, adhesion resistance and ore removal prevention functions, a preparation method and application thereof. In order to achieve the above purpose, in one aspect, the present invention provides a method for preparing a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-mine functions, comprising the following steps: s1, taking sulfobetaine methacrylate as a hydrogen bond acceptor, taking glycerol or glycerol and gallic acid as hydrogen bond donors, mixing the hydrogen bond acceptor and the hydrogen bond donors, and stirring under heating to form a uniform and transparent deep eutectic solvent; S2, adding a cross-linking agent ethylene glycol dimethacrylate and an initiator into the deep eutectic solvent, uniformly mixing, coating the mixture on a PETG substrate, and curing under the action of the initiator to form a continuous and compact deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-desquamation functions on the surface of the PETG substrate. As a further preferable technical scheme of the invention, the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is 1:3-5, and/or the gallic acid accounts for 0-10% of the molar amount of the glycerol. As a further preferable technical scheme of the invention, the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is 1:4, and the gallic acid accounts for 4-6% of the molar amount of the glycerol. In the step S1, when gallic acid is not contained, the heating temperature of the deep eutectic solvent is 30-45 ℃, when gallic acid is contained, the heating temperature of the deep eutectic solvent is 50-60 ℃, and the stirring time is 10-100 minutes. As a further preferable technical scheme of the invention, the dosage of the cross-linking agent is 0.5-5% of the molar quantity of the hydrogen bond receptor, and/or the addition concentration of the initiator is 0.1-1 wt%. As a further preferable technical scheme of the invention, the initiator is 2-methyl-1-phenyl-1-acetone (also called as a photoinitiator 1173), and ultraviolet light with the wavelength of 365 nm and the power of 10-20 mW/cm < 2 > is adopted for curing. As a further preferable technical scheme of the