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CN-121975605-A - Quick extraction element of tissue for pathology experiments

CN121975605ACN 121975605 ACN121975605 ACN 121975605ACN-121975605-A

Abstract

The invention discloses a tissue rapid extraction device for pathological experiments, which relates to the technical field of pathological tissue extraction, and comprises a barrel body and a sampling needle, wherein the sampling needle is fixed at one end of the barrel body and is communicated with the inside of the barrel body, the tissue rapid extraction device also comprises a positioning part, the positioning part comprises a fixing seat and a positioning barrel, the fixing seat is fixed at one end, close to the sampling needle, of the barrel body, the positioning barrel is fixed at the vacant end of the fixing seat, the positioning barrel is of a cylindrical structure with hollow inside and open ends, the inner side surface of the positioning barrel is in contact with the outer side surface of the sampling needle, a through hole is formed in the side surface of the sampling needle, a cavity is formed in the positioning barrel, a preformed hole is formed in the inner side surface of the positioning barrel, the preformed hole is parallel to the through hole, a screen mesh is fixed in the preformed hole and is abutted against the outer side surface of the sampling needle, the screen mesh is used for intercepting tissue strips, separation of blood and tissue strips can be realized in the extraction process, pathological tissues can be rapidly extracted, and the accuracy of experimental results is improved.

Inventors

  • CHEN YUNMING

Assignees

  • 陈云明

Dates

Publication Date
20260505
Application Date
20260109

Claims (10)

  1. 1. The rapid tissue extraction device for the pathology experiments comprises a cylinder (100) and a sampling needle (140), and is characterized in that the sampling needle (140) is fixed at one end of the cylinder (100), and the sampling needle (140) is communicated with the inside of the cylinder (100); also comprises a positioning part (130); the positioning part (130) comprises a fixed seat (131) and a positioning cylinder (132), the fixed seat (131) is fixed at one end of the cylinder body (100) close to the sampling needle (140), and the positioning cylinder (132) is fixed at the spare end of the fixed seat (131); The positioning cylinder (132) is of a cylindrical structure with hollow inside and two open ends, and the inner side surface of the positioning cylinder is contacted with the outer side surface of the sampling needle (140); The side of the sampling needle (140) is provided with a through hole (141), the inside of the positioning cylinder (132) is provided with a cavity, the inner side of the positioning cylinder (132) is provided with a preformed hole, the preformed hole is parallel to the through hole (141), a screen (1321) is fixed in the preformed hole, and the screen (1321) is abutted against the outer side of the sampling needle (140); The screen (1321) is configured to intercept a tissue strip, and blood can pass through the screen (1321) into the cavity of the positioning cylinder (132).
  2. 2. The rapid tissue extraction device for pathological experiments according to claim 1, wherein a negative pressure tube (120) is fixed on the side surface of the cylinder (100) close to the sampling needle (140), and one end of the negative pressure tube (120) extends into the cylinder (100); the negative pressure pipe (120) is used for increasing negative pressure in the cylinder (100) and sucking pathological tissues extracted from the sampling needle (140) into the cylinder (100); An interception net is fixed in the cylinder body (100) close to the negative pressure pipe (120), and the interception net is used for intercepting tissue strips.
  3. 3. The rapid tissue extraction device for pathological experiments according to claim 1, wherein the fixing base (131) is a cylinder which is hollow in the interior and is close to an opening at one end of the cylinder body (100), and the free end of the cylinder body is fixed with the positioning cylinder (132); the inside of the fixing base (131) is provided with a cavity, and the cavity of the fixing base (131) is communicated with the cavity of the positioning cylinder (132).
  4. 4. The rapid tissue extraction device for pathological experiments according to claim 2, wherein one end of the negative pressure tube (120) is fixed with an adsorption tube (122), and the spare end of the adsorption tube (122) extends into the cylinder (100); A branch pipe (121) is fixed on the negative pressure pipe (120), one end of the branch pipe (121) extends into the negative pressure pipe (120), and the other end of the branch pipe (121) extends into the cavity of the fixing seat (131); valves are fixed on the branch pipe (121) and the adsorption pipe (122).
  5. 5. The rapid tissue extraction device for pathological experiments according to claim 1, wherein a cannula is fixed at the position of the sampling needle (140) close to the cylinder (100), a cannula (160) is fixed at the middle part of one end of the cylinder (100) close to the sampling needle (140), and the cannula is clamped and embedded on the cannula (160).
  6. 6. The rapid tissue extraction device for pathological experiments according to claim 1, wherein the inner side surface of the fixing seat (131) is provided with internal threads, the side surface of the cylinder (100) is provided with external threads near the fixing seat (131), and the fixing seat (131) is in threaded connection with the cylinder (100).
  7. 7. The rapid tissue extraction device for pathological experiments according to claim 1, wherein a baffle (150) is fixed in the cylinder (100), the baffle (150) is positioned above the adsorption tube (122), and a sealing cover (161) is sleeved at the cannula (160); A through hole is formed in the middle of the partition plate (150), a water outlet pipe (151) is fixed on the partition plate (150) close to the sampling needle (140), pre-cooling PBS is filled above the partition plate (150), and the pre-cooling PBS is used for cleaning blood on the surface of the tissue strip; An on-off valve is fixed on the water outlet pipe (151) and is used for controlling water outlet.
  8. 8. The rapid tissue extraction device for pathological experiments according to claim 7, wherein the side surface of the cylinder (100) is provided with a through groove, the inside of the through groove is connected with a sealing plate (170) in a sealing way, a clamping plate is fixed on the outer side of the sealing plate (170), the side surface of the cylinder (100) is provided with a clamping groove, and the clamping plate is fixed in the clamping groove.
  9. 9. The rapid tissue extraction device for pathological experiments according to claim 1, further comprising a storage part (180); the storage part (180) comprises a positioning groove (181), a storage box (182) and a sealing plug (1822); The positioning groove (181) is formed in the outer side face of the cylinder body (100), the storage box (182) is hollow in the inside and is open at one side far away from the sampling needle (140), and the storage box (182) is internally filled with RNA stabilizer; the sealing plug (1822) is a high-density polypropylene plug body and is detachably fixed at the opening end of the storage box (182); A magnet strip (1821) is fixed on the storage box (182) close to the positioning groove (181), a metal sheet is fixed in the positioning groove (181), and the magnet strip (1821) and the metal sheet are magnetically adsorbed.
  10. 10. The rapid tissue extraction device for pathological experiments according to claim 9, wherein the plurality of storage parts (180) are provided, and the plurality of storage parts (180) are uniformly distributed on the outer side surface of the cylinder (100) at intervals.

Description

Quick extraction element of tissue for pathology experiments Technical Field The invention belongs to the technical field of pathological tissue extraction, and particularly relates to a rapid tissue extraction device for pathological experiments. Background The pathological tissue experiment simulates highly similar human diseases on animals mainly through modes of gene editing, special feeding or drug induction and the like, then continuous and controllable observation and experiment are carried out on the animals, after the diseased animals are euthanized, pathological tissues are extracted from the diseased animals, sampling of pathological areas is generally carried out through a sampling needle, a great amount of blood is adsorbed on the sampling tissue due to exudation of blood in the sampling process, and blood cells in the blood are mixed in target primary cells, so that the separation purity and the accuracy of subsequent experimental results are affected. The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. Disclosure of Invention The invention aims to provide a rapid tissue extraction device for pathological experiments, which can solve the problems that the separation purity and the accuracy of subsequent experimental results are affected due to the fact that a large amount of blood is adsorbed on a sampling tissue. In order to achieve the above object, a specific embodiment of the present invention provides the following technical solution: the rapid tissue extraction device for pathology experiments comprises a cylinder body and a sampling needle, wherein the sampling needle is fixed at one end of the cylinder body and is communicated with the inside of the cylinder body; the device also comprises a positioning part; The positioning part comprises a fixed seat and a positioning cylinder, the fixed seat is fixed at one end of the cylinder body, which is close to the sampling needle, and the positioning cylinder is fixed at the spare end of the fixed seat; The positioning cylinder is of a cylindrical structure with a hollow inside and two open ends, and the inner side surface of the positioning cylinder is contacted with the outer side surface of the sampling needle; The side surface of the sampling needle is provided with a through hole, the inside of the positioning cylinder is provided with a cavity, the inner side surface of the positioning cylinder is provided with a preformed hole, the preformed hole is parallel to the through hole, a screen is fixed in the preformed hole, and the screen is abutted against the outer side surface of the sampling needle; The screen is used for intercepting tissue strips, and blood can pass through the screen and enter the cavity of the positioning cylinder. In one or more embodiments of the invention, a negative pressure pipe is fixed on the side surface of the cylinder body near the sampling needle, and one end of the negative pressure pipe extends into the cylinder body; The negative pressure tube is used for increasing negative pressure in the cylinder body and sucking pathological tissues extracted from the sampling needle into the cylinder body. In one or more embodiments of the invention, an interception net is fixed in the cylinder body near the negative pressure pipe, and the interception net is used for intercepting the tissue strip. In one or more embodiments of the present invention, the fixing seat is a cylinder with a hollow interior and an opening near one end of the cylinder, and the spare end of the cylinder is fixed with the positioning cylinder; the fixing seat is internally provided with a cavity, and the cavity of the fixing seat is communicated with the cavity of the positioning cylinder. In one or more embodiments of the present invention, an adsorption tube is fixed at one end of the negative pressure tube, and a spare end of the adsorption tube extends into the cylinder; a branch pipe is fixed on the negative pressure pipe, one end of the branch pipe extends into the negative pressure pipe, and the other end of the branch pipe extends into the cavity of the fixing seat; valves are fixed on the branch pipes and the adsorption pipes. In one or more embodiments of the invention, a plug bush is fixed at the position of the sampling needle close to the cylinder body, a cannula is fixed at the middle part of one end of the cylinder body close to the sampling needle, and the plug bush is clamped and embedded on the cannula. In one or more embodiments of the present invention, the inner side surface of the fixing seat is provided with an internal thread, the side surface of the cylinder body is provided with an external thread near the fixing seat, and the fixing seat is in threaded connectio