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CN-121975688-A - Bifidobacterium adolescentis FMBL B250316 MQ with antioxidant and life prolonging functions and application thereof

CN121975688ACN 121975688 ACN121975688 ACN 121975688ACN-121975688-A

Abstract

The invention belongs to the technical field of microorganisms, and in particular relates to bifidobacterium FMBL B250316 MQ with the functions of resisting oxidation and prolonging service life and application thereof, which are preserved in China center for type culture collection (China center for type culture collection) for 9 months and 18 days, wherein the preservation number is CCTCC M20252061, and the bifidobacterium FMBL B250316 MQ can utilize galactooligosaccharide, soybean oligosaccharide and isomaltooligosaccharide, has good acid resistance, bile salt resistance and antibacterial properties, has the functions of resisting oxidation, resisting aging and prolonging service life, can be used for preparing medicines with the functions of resisting oxidation, resisting aging and prolonging service life, and has wide application prospect.

Inventors

  • NI YONGQING
  • SUN HAILONG
  • MI QI
  • Zhao Quanhao
  • ZHANG HUIMIN
  • HUANG LILI
  • WEI XIAOJING

Assignees

  • 石河子大学

Dates

Publication Date
20260505
Application Date
20260130

Claims (10)

  1. 1. A bifidobacterium adolescentis (Bifidobacterium adolescentis) FMBL B250316 MQ with oxidation resistance and life prolonging functions is characterized in that the bifidobacterium adolescentis is preserved in China center for type culture collection (CCTCC M20252061) at the 18 th month of 2025.
  2. 2. A microbial inoculum comprising bifidobacterium adolescentis FMBL B250316 MQ as claimed in claim 1.
  3. 3. A freeze-dried preparation comprising the Bifidobacterium adolescentis FMBL B250316 MQ according to claim 1.
  4. 4. Use of bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof as claimed in claim 1 or a microbial inoculum as claimed in claim 2 or a freeze-dried agent as claimed in claim 3 in antioxidation or in the preparation of antioxidation products, wherein the products are foods, medicines or health care products.
  5. 5. Use of bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof as claimed in claim 1 or a microbial agent as claimed in claim 2 or a lyophilizate as claimed in claim 3 in the manufacture of an anti-ageing medicament.
  6. 6. Use of bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof as claimed in claim 1 or a microbial agent as claimed in claim 2 or a lyophilizate as claimed in claim 3 in the manufacture of a medicament for prolonging life.
  7. 7. An antioxidant product comprising an antioxidant active ingredient, wherein the antioxidant active ingredient comprises bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof or a microbial agent of claim 2 or a freeze-drying agent of claim 3 of claim 1.
  8. 8. An anti-aging medicament, comprising an anti-aging active ingredient, wherein the anti-aging active ingredient comprises bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof or a microbial agent of claim 2 or a freeze-dried agent of claim 3 according to claim 1.
  9. 9. A life-prolonging product comprising a life-prolonging active ingredient comprising bifidobacterium adolescentis FMBL B250316 MQ or a strain broth or a fermentation broth of bifidobacterium adolescentis FMBL B250316 according to claim 1 or a microbial agent according to claim 2 or a lyophilizate according to claim 3.
  10. 10. A bacteriostatic product comprising bifidobacterium adolescentis FMBL B250316 MQ or a strain broth or a fermentation sterile supernatant thereof of claim 1 or a fungicide of claim 2 or a lyophilizate of claim 3.

Description

Bifidobacterium adolescentis FMBL B250316 MQ with antioxidant and life prolonging functions and application thereof Technical Field The invention relates to the technical field of microorganisms, in particular to bifidobacterium adolescentis FMBL B250316 MQ with the functions of resisting oxidation and prolonging service life and application thereof. Background Aging is a complex physiological process in which body functions gradually deteriorate with age, and is closely related to the occurrence of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases, and metabolic syndrome. Among the many theories of aging mechanisms, the theory of oxidative stress is widely accepted. The theory holds that when the accumulation of active oxygen in the body exceeds the self-scavenging capacity of the body, oxidative stress is initiated, and oxidative damage of biological macromolecules such as protein, lipid, DNA and the like is caused, so that cell aging and tissue function decline are accelerated, and the aging process of the whole body is promoted. Therefore, enhancing the antioxidant capacity of the body to alleviate oxidative damage has become one of the key strategies for anti-aging research. With the deep research of microbiology, the use of probiotics to regulate oxidative stress shows good application prospect. Studies have shown that some strains of Lactobacillus and Bifidobacterium have a certain antioxidant and anti-aging capacity, such as scavenging DPPH radicals and hydroxy radicals, alleviating oxidative damage of cells, regulating aging-related intestinal flora disorders, and enhancing body immunity. However, different strains often have different antioxidant activities, environmental tolerance and practical application effects due to differences in sources, living environments and genetic backgrounds. Longevity, particularly good longevity, is the result of the combined action of a variety of factors, such as longevity genes, healthy lifestyle, and optimistic attitudes. When the subject group of the inventor is used for researching long-life population, excellent strains with obvious antioxidant activity and life prolonging functions are screened from intestinal microorganisms of the long-life population, and high-quality single strain resources and scientific basis are provided for developing new-generation anti-aging functional foods, health-care products and microecologics. Disclosure of Invention The invention aims at providing bifidobacterium adolescentis (Bifidobacterium adolescentis) FMBL B250316 MQ which is preserved in China center for type culture collection (CCTCC M20252061) in the year 2025, 9 and 18, and the preservation address is China university of Wuhan. The second object of the present invention is to provide a microbial inoculum comprising the bifidobacterium adolescentis FMBL B250316 MQ. The third object of the present invention is to provide a freeze-dried preparation comprising the bifidobacterium adolescentis FMBL B250316 MQ. The fourth object of the invention is to provide the application of the bifidobacterium adolescentis FMBL B250316 MQ or the strain fermentation liquor or the fermentation sterile supernatant thereof or the microbial inoculum or the freeze-drying agent in the antioxidation or the preparation of the antioxidation product, wherein the product is food, medicine or health care product. The fifth purpose of the invention is to provide the application of the bifidobacterium adolescentis FMBL B250316 MQ or the strain fermentation liquor or the fermentation sterile supernatant or the microbial inoculum or the freeze-drying agent in the preparation of anti-aging medicines. The sixth object of the invention is to provide the application of the bifidobacterium adolescentis FMBL B250316 MQ or the strain fermentation liquor or the fermentation sterile supernatant or the microbial inoculum or the freeze-drying agent in preparing medicines with long service life. The seventh object of the present invention is to provide an antioxidant product, which comprises an antioxidant active ingredient, wherein the antioxidant active ingredient comprises the bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof, or the microbial inoculum or the freeze-drying agent. The eighth object of the present invention is to provide an anti-aging medicament, which comprises an anti-aging active ingredient, wherein the anti-aging active ingredient comprises the bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth or a fermentation sterile supernatant thereof, or the microbial inoculum or the freeze-drying agent. A ninth object of the present invention is to provide a life-prolonging product comprising a life-prolonging active ingredient, wherein the life-prolonging active ingredient comprises the bifidobacterium adolescentis FMBL B250316 MQ or a strain fermentation broth thereof o