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CN-121976311-A - Powdery nanofiber material, preparation method thereof and dressing

CN121976311ACN 121976311 ACN121976311 ACN 121976311ACN-121976311-A

Abstract

A powdery nanofiber material, a preparation method and dressing thereof belong to the technical field of biomedical materials. And (3) placing the nanofiber membrane in a dispersion medium for shearing and crushing treatment to obtain a dispersion liquid. And drying the dispersion liquid to obtain the powdery nanofiber material. The material for forming the nanofiber membrane comprises a high polymer material, wherein the high polymer material contains a hydrophobic high polymer material, and the proportion of the hydrophobic high polymer material in the total mass of the high polymer material is not lower than 60%. The dispersion medium comprises an alcohol substance, the vapor pressure of the alcohol substance at 25 ℃ is not lower than 5kPa, and the proportion of the alcohol substance in the total volume of the dispersion medium is not lower than 40%. According to the method, the powdery nanofiber material with smaller particle size can be prepared, and the powdery nanofiber material has a good extracellular matrix-like structure.

Inventors

  • YANG JUNFENG
  • ZHANG YIXIA
  • Zha Fangwen

Assignees

  • 惠州华阳医疗器械有限公司

Dates

Publication Date
20260505
Application Date
20260205

Claims (10)

  1. 1. A method of preparing a powdered nanofiber material comprising: The nanofiber membrane is placed in a dispersion medium to be sheared and crushed to obtain a dispersion liquid, and the dispersion liquid is dried to obtain a powdery nanofiber material; The material for forming the nanofiber membrane comprises a high polymer material, wherein the high polymer material contains a hydrophobic high polymer material, the proportion of the hydrophobic high polymer material in the total mass of the high polymer material is not lower than 60%, the dispersion medium comprises an alcohol substance, the vapor pressure of the alcohol substance at 25 ℃ is not lower than 5kPa, and the proportion of the alcohol substance in the total volume of the dispersion medium is not lower than 40%.
  2. 2. The method of claim 1, wherein the alcohol comprises at least one of t-butanol, ethanol, isopropanol, or methanol.
  3. 3. The preparation method of claim 2, wherein the alcohol accounts for 40% -90% of the total volume of the dispersion medium, and the balance is water.
  4. 4. The method according to claim 1, wherein the mass-to-volume ratio of the nanofiber membrane to the dispersion medium is 1 when the shearing pulverization treatment is performed (15~50)。
  5. 5. The method according to claim 4, wherein the nanofiber membrane is pre-sheared into a sheet-shaped pre-sheared object with a length of 1cm to 10cm and a width of 1cm to 10cm, and the pre-sheared object is placed in the dispersion medium to be subjected to the shearing and crushing treatment; optionally, the time of the shearing and crushing treatment is 1 min-10 min, and the rotating speed of the shearing and crushing is 3000 rpm/min-20000 rpm/min.
  6. 6. The method according to any one of claims 1 to 5, wherein the drying method comprises vacuum drying; optionally, standing the dispersion liquid for 5 to 60 minutes, removing the upper liquid, and vacuum drying the precipitate at 40 to 80 ℃ for 1 to 36 hours to obtain the powdery nanofiber material; Optionally, after vacuum drying, sieving the powdery nanofiber material, wherein the sieve pore diameter is 0.5 mm-5 mm.
  7. 7. The method according to claim 1, wherein the hydrophobic polymer material comprises at least one of polylactic acid-glycolic acid copolymer, polycaprolactone, polyvinyl butyral, polyglycolic acid, polylactic acid, or polyurethane; Optionally, the polymer material further comprises a hydrophilic polymer material, wherein the hydrophilic polymer material comprises at least one of polyvinyl alcohol, polyethylene glycol or polyethylene oxide, gelatin, crosslinked hyaluronic acid or crosslinked collagen; optionally, the ratio of the hydrophobic polymer material in the total mass of the polymer material is not less than 70%.
  8. 8. The method according to claim 1 or 7, wherein the nanofiber membrane is prepared by spinning a spinning solution containing the polymer material by using an electrostatic spinning technology; Optionally, the spinning parameters comprise a spinning voltage of 5 kV-30 kV, a spinning solution flow rate of 0.2 ml/h-1.0 ml/h, a receiving roller rotating speed of 400 r/min-800 r/min, a temperature of 20 ℃ to 35 ℃ and a humidity of 30% -80%.
  9. 9. A powdery nanofiber material characterized by being produced according to the production method of any one of claims 1 to 8.
  10. 10. A dressing comprising the powdered nanofiber material of claim 9.

Description

Powdery nanofiber material, preparation method thereof and dressing Technical Field The application relates to the technical field of biomedical materials, in particular to a powdery nanofiber material, a preparation method and dressing thereof. Background Wound formation is mainly due to damaged skin, mucosal surfaces or damaged integrity of organ tissue. The healing process is complex, the wound is slowly improved, the medical dressing is required to be covered at the wound, and the dressing is replaced periodically, so that the wound healing is quickened, and the bacterial and microorganism infection is prevented. In the field of wound care, traditional dressings face significant challenges, especially when treating complex wounds. Such wounds include irregularly shaped or deeper wounds, often found in burns, wounds, surgical incisions, or chronic ulcers. The medical nanofiber membrane material is of a fiber network structure, has high porosity, large specific surface area and good biocompatibility, has a microstructure very similar to a natural extracellular matrix, and can support wound healing. However, most of the existing nanofiber membrane materials are continuous membrane structures, the morphology of which limits flexible filling and fitting capabilities, and thus are difficult to apply directly to irregular or deep wounds. Thus, there is a need to prepare a powdered nanofiber material that can be used for complex wound repair. Disclosure of Invention Based on the defects, the application provides a powdery nanofiber material, a preparation method and a dressing thereof, which can be used for repairing complex wounds. The application is realized in the following way: in a first aspect, examples of the present application provide a method of preparing a powdered nanofiber material comprising: And (3) placing the nanofiber membrane in a dispersion medium for shearing and crushing treatment to obtain a dispersion liquid. And drying the dispersion liquid to obtain the powdery nanofiber material. The material for forming the nanofiber membrane comprises a high polymer material, wherein the high polymer material contains a hydrophobic high polymer material, and the proportion of the hydrophobic high polymer material in the total mass of the high polymer material is not lower than 60%. The dispersion medium comprises an alcohol substance, the vapor pressure of the alcohol substance at 25 ℃ is not lower than 5kPa, and the proportion of the alcohol substance in the total volume of the dispersion medium is not lower than 40%. In general, nanofiber membranes are continuous membranous structures with larger dimensions that cannot be directly used for repair of complex wounds. However, the nanofiber membrane is directly sheared and crushed at high speed, and the nanofiber material obtained after the shearing is used for complex wounds, so that the repairing effect is poor. Through analysis, the nanofiber membrane is directly sheared, the fiber network morphology of the nanofiber material can be damaged, the retention rate of the extracellular matrix (extracellular matrix, ECM for short) like structure of the nanofiber material is low, and the repairing effect can be affected. Therefore, in order to prepare and obtain the powdery nanofiber membrane material with smaller particle size and uniform particle size, and improve the retention rate of the ECM structure of the powdery nanofiber material, the embodiment of the application places the nanofiber membrane with dominant hydrophobic polymer material in a dispersion medium for high-speed shearing and crushing, so that the powdery nanofiber material with fine and uniform particle size can be obtained, the dispersion medium consists of alcohol substances with vapor pressure not lower than 5kPa at 25 ℃, the proportion of the alcohol substances in the total volume of the dispersion medium is not less than 40%, a good fiber network structure can be maintained, the retention rate of the ECM structure of the powdery nanofiber material is improved, and the dressing can be prepared and is beneficial to repairing complex wounds. With reference to the first aspect, in an alternative embodiment of the present application, the alcohol includes at least one of tert-butanol, ethanol, isopropanol, or methanol. In the implementation process, the alcohol substance with proper vapor pressure is prepared into a dispersion medium, so that damage to the ECM structure of the nanofiber material in the shearing and crushing process can be reduced, and the prepared powdery nanofiber material not only has smaller and uniform particle size, but also has a good ECM structure. In combination with the first aspect, in an alternative embodiment of the present application, the proportion of the alcohol substance in the total volume of the dispersion medium is 40% -90%, and the balance is water. In the implementation process, 40% -90% of the alcohol substances are added into the dispersion med