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CN-121977910-A - Calibration piece for calibrating collagen content measurement and method and system for measuring collagen content

CN121977910ACN 121977910 ACN121977910 ACN 121977910ACN-121977910-A

Abstract

The invention relates to a calibration piece for calibrating collagen content measurement and a method and a system for measuring the collagen content. The calibration member comprises a plurality of groups of collagen components with different collagen contents, wherein when the calibration member is scanned by a CT device, the corresponding relation of the collagen content-CT value is obtained based on CT scanning data of at least two groups of collagen components in the plurality of groups of collagen components and the collagen content of each of the at least two groups of collagen components. The method comprises the steps of scanning the calibration piece through CT equipment to obtain a corresponding relation between the collagen content and the CT value, scanning a measuring object through the CT equipment to obtain CT scanning data of the measuring object, and obtaining the collagen content in the measuring object based on the corresponding relation between the CT scanning data of the measuring object and the collagen content-CT value.

Inventors

  • ZHANG KUN

Assignees

  • 湖南中医药大学

Dates

Publication Date
20260505
Application Date
20260331

Claims (9)

  1. 1. A calibration piece for calibrating a collagen content measurement, comprising a plurality of sets of collagen components having different collagen contents from each other, wherein when the calibration piece is scanned by a CT apparatus, a correspondence of collagen content-CT value is obtained based on CT scan data of at least two sets of collagen components among the plurality of sets of collagen components and respective collagen contents of the at least two sets of collagen components.
  2. 2. The calibration element of claim 1, wherein the calibration element comprises a phantom and a collagen-water mixed solution.
  3. 3. A calibration element according to claim 2, wherein the phantom comprises a plurality of regions, each region having a body of collagen material disposed thereon, the body of collagen material on each region having a collagen composition having a collagen content different from each other.
  4. 4. A method for measuring collagen content, comprising the steps of: scanning the calibration piece of any one of claims 1-3 by a CT apparatus to obtain CT scan data for the at least two sets of collagen components; obtaining a corresponding relation of collagen content-CT value based on CT scan data of the at least two groups of collagen components and respective collagen content of the at least two groups of collagen components; scanning the measuring object by the CT equipment to obtain CT scanning data of the measuring object, and And obtaining the collagen content in the measured object based on the corresponding relation between the CT scanning data of the measured object and the collagen content-CT value.
  5. 5. The method of claim 4, wherein the collagen content-CT value corresponds to y=kx+b, where y is the collagen content and x is the CT value.
  6. 6. A system for measuring collagen content, comprising: a CT apparatus configured to: scanning the calibration part according to any one of claims 1-3 to obtain CT scan data of said at least two sets of collagen components, and Scanning a measurement object to obtain CT scan data of the measurement object, and A computing unit configured to: Obtaining a collagen content-CT value correspondence based on CT scan data of the at least two sets of collagen components and respective collagen contents of the at least two sets of collagen components, and And obtaining the collagen content in the measured object based on the corresponding relation between the CT scanning data of the measured object and the collagen content-CT value.
  7. 7. The system of claim 6, wherein the collagen content-CT value corresponds to y=kx+b, where y is collagen content and x is CT value.
  8. 8. A computer readable storage medium having encoded thereon instructions that, when executed, implement the method of claim 4 or 5.
  9. 9. A computer program product comprising a computer program which, when executed, implements the method of claim 4 or 5.

Description

Calibration piece for calibrating collagen content measurement and method and system for measuring collagen content Technical Field The present invention relates to the field of medical testing, and more particularly to a calibration piece for calibrating a collagen content measurement and a method and system for measuring collagen content. Background Collagen (also known as collagen), which is very important for the living body. Particularly, in the human body, collagen is a protein with the largest content in the human body, is an extremely important structural protein component of connective tissues such as skin, bone and cartilage, teeth, tendons, ligaments and blood vessels throughout each organ of human tissues, and is involved in physiological actions such as morphological composition, proliferation, differentiation, adhesion, migration, development of individuals, reproduction, information transmission, coagulation, tissue repair and the like of cells, and is also involved in the prevention and treatment of skin aging and the occurrence of certain diseases. Therefore, in clinical testing, it is highly desirable to measure the collagen content in humans. Various analytical methods commonly used in biochemistry and analytical chemistry are cumbersome, although quantification of collagen can be performed. Another type of high pressure liquid chromatography not only requires the provision of specialized equipment and adds complexity, but also has significant limitations. Moreover, these methods cannot detect living bodies, and require that an ex-vivo sample be obtained and then detected. Therefore, a new technology is needed to conveniently and accurately measure the collagen content of an object. Disclosure of Invention The present invention is directed to overcoming the above and/or other problems in the art. By scanning the calibration piece for calibrating the measurement of the collagen content provided by the invention by CT (computed tomography) equipment, the method and the system for measuring the collagen content can realize accurate measurement of the collagen content in a human body or other objects. According to a first aspect of the present invention, there is provided a calibration piece for calibrating a collagen content measurement, which may include a plurality of sets of collagen components having different collagen contents from each other, wherein when the calibration piece is scanned by a CT apparatus, a correspondence of collagen content-CT value is obtained based on CT scan data of at least two sets of collagen components among the plurality of sets of collagen components and respective collagen contents of the at least two sets of collagen components. According to a second aspect of the present invention, there is provided a method for measuring collagen content, which may include the steps of scanning the calibration piece of the present invention by a CT apparatus to obtain CT scan data of the at least two sets of collagen components, obtaining a correspondence of collagen content-CT value based on the CT scan data of the at least two sets of collagen components and the collagen content of each of the at least two sets of collagen components, scanning a measurement object by the CT apparatus to obtain CT scan data of the measurement object, and obtaining collagen content in the measurement object based on the CT scan data of the measurement object and the correspondence of the collagen content-CT value. According to a third aspect of the present invention, a system for measuring collagen content is provided, which may comprise a CT apparatus and a calculation unit. The CT apparatus may be configured to scan the calibration piece of the present invention to obtain CT scan data of the at least two sets of collagen components, and to scan a measurement object to obtain CT scan data of the measurement object. The calculation unit may be configured to obtain a correspondence of collagen content-CT value based on CT scan data of the at least two sets of collagen components and respective collagen contents of the at least two sets of collagen components, and to obtain collagen content in the measurement object based on the correspondence of CT scan data of the measurement object and the collagen content-CT value. Through a great deal of experiments, the inventor of the present application finds that CT scan data (CT values) obtained after different collagen contents and different collagen components corresponding to the collagen contents are scanned by the same CT apparatus (under the same system parameters) have a one-to-one correspondence, and the relationship is basically linear. Based on the great findings, the inventor skillfully introduces a calibration piece comprising a plurality of groups of collagen components with different contents, and can obtain the corresponding relation of the collagen content-CT value under the CT equipment with high precision based on CT scanning da