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CN-121978187-A - Cross-channel recessive coupling processing method for multi-channel electrochemical workstation

CN121978187ACN 121978187 ACN121978187 ACN 121978187ACN-121978187-A

Abstract

The application provides a cross-channel implicit coupling processing method for a multi-channel electrochemical workstation, and relates to the field of data processing. According to the method, a compensation electrode bus is introduced into a liquid phase environment boundary, and a channel identifier, a channel state set and a space adjacent mapping relation are combined, so that an operation time axis is divided into an identification window, a cancellation window and an immune window on the premise that main test waveforms of all channels are not changed, the implicit coupling characteristics of the cross channels are extracted through heuristic disturbance and echo, directional compensation injection is implemented in the cancellation window based on an echo template, and an environment common mode is judged by means of the immune window, so that identifiable, distinguishable and inhibitable control of the implicit cross-channel coupling caused by liquid phase condition change in a multi-channel electrochemical workstation is realized. By implementing the technical scheme provided by the application, the real source of the osmotic effect can be conveniently and timely identified and effectively inhibited, so that the accuracy of the multichannel electrochemical measurement result is improved.

Inventors

  • SONG WENSU
  • ZHANG JIANYONG
  • ZHANG YI
  • LIU SISI
  • LIU TING

Assignees

  • 武汉科思特仪器股份有限公司

Dates

Publication Date
20260505
Application Date
20260408

Claims (10)

  1. 1. A cross-channel implicit coupling processing method for a multi-channel electrochemical workstation, the method comprising: A compensation electrode bus arranged around the outer edge of the electrode array is preset in the same liquid phase environment, an injection link electrically isolated from a main measurement link is configured for the compensation electrode bus, a unique channel identifier is bound for each channel in the multi-channel electrochemical workstation, a channel state set is solidified, the compensation electrode bus is divided into a plurality of boundary segments, segment identifiers are bound for each boundary segment, and an adjacent mapping relation is obtained based on a spatial adjacent relation between the channel identifiers and the segment identifiers; dividing a global operation time axis into an identification window and a cancellation window under the condition of keeping execution of main test waveforms of all channels, and screening a target channel based on the channel state set and locking a range state and a protection state of a non-target channel when entering any identification window so as to enable the non-target channel to maintain stable observation conditions in the identification window; Superposing a heuristic disturbance which does not change a target reaction path aiming at the target channel in the identification window, associating the heuristic disturbance with a channel identifier of the target channel to form a disturbance event, synchronously collecting a current response sequence, a potential response sequence and a channel state set of the target channel, and aligning a time reference according to the disturbance event to intercept and form a fragment set containing a target channel fragment and a disturbed channel fragment; Performing echo extraction processing on each disturbed channel segment in the segment set to separate and retain a slowly-varying tailing component, generating a coupled echo segment, binding the coupled echo segment with a corresponding channel identifier, a release action mark in a protection state and the adjacent mapping relation, and aggregating the coupled echo segments between the same channel identifier pair under the condition of crossing a plurality of identification windows to form an echo template; when entering any cancellation window, identifying a target risk state based on a real-time channel state set, determining a disturbed channel set and a corresponding target segment set according to the adjacent mapping relation when the target risk state is detected, calling a segment template matched with the target segment set from the echo template to generate a compensation instruction, and driving the injection link to apply compensation injection to a compensation electrode bus boundary segment corresponding to the target segment set through the compensation instruction so as to form a cancellation effect opposite to a bias reconstruction trend corresponding to the segment template at a liquid phase environment boundary; and inserting an immune window in a preset period, suspending trial disturbance and compensation injection in the immune window, collecting a current response sequence and a potential response sequence of each channel at the same time to judge the consistency of low-frequency drift, limiting the corresponding change to be an environment common mode when the low-frequency drift shows full-channel synchronous enhancement and lacks a time alignment relation with a release action mark, and limiting the follow-up compensation injection to take effect on a section template corresponding to the release echo.
  2. 2. The cross-channel implicit coupling processing method for a multi-channel electrochemical workstation of claim 1, wherein the dividing the compensation electrode bus into a plurality of boundary segments and binding segment identifiers for each boundary segment, and obtaining an adjacency mapping relationship based on a spatial adjacency relationship between channel identifiers and segment identifiers, specifically comprises: determining a target space distance relation between each channel corresponding electrode and each boundary section of the compensation electrode bus, wherein the target space distance relation meets a preset distance based on space coordinate information of each channel corresponding electrode in the same liquid phase environment; Performing a weighted process on the target spatial distance relationship in combination with a span state representing a channel sensitivity level in the set of channel states to generate a weighted adjacency relationship reflecting both spatial proximity and channel sensitivity level; and solidifying the weighted adjacency relation into the adjacency mapping relation.
  3. 3. The method for cross-channel implicit coupling processing of a multi-channel electrochemical workstation of claim 1, wherein the dividing the global operation time axis into an identification window and a cancellation window under the condition of maintaining execution of main test waveforms of each channel, and when entering any one of the identification windows, screening a target channel based on the channel state set and locking a range state and a protection state of a non-target channel, so that the non-target channel maintains stable observation conditions in the identification window, specifically comprises: In the process of dividing a global operation time axis into the identification window and the cancellation window, constructing a time window scheduling mechanism based on a unified time reference, and carrying out joint evaluation on the range state, the protection state and the control mode state of each channel according to the channel state set before entering any identification window so as to screen target channels meeting preset identification conditions; After the target channel is determined, a state locking process is executed on the non-target channel, wherein the state locking process is used for keeping the range state and the protection state of the non-target channel unchanged in the identification window, and simultaneously enabling the non-target channel to execute the original main test waveform and the data acquisition flow so as to provide stable and consistent observation conditions for cross-channel implicit coupling caused by the target channel in the identification window.
  4. 4. The method according to claim 1, wherein within the identification window, superimposing a heuristic disturbance that does not change a target reaction path for the target channel, associating the heuristic disturbance with a channel identifier of the target channel to form a disturbance event, synchronously collecting a current response sequence, a potential response sequence and a channel state set of the target channel, and aligning a time reference according to the disturbance event to intercept and form a segment set including a target channel segment and a disturbed channel segment, and specifically comprising: Before the target channel is overlapped with the heuristic disturbance in the identification window, carrying out joint constraint configuration on the control mode state, the range state and the protection state of the target channel based on the channel state set so as to limit the overlapped amplitude, the overlapped duration and the overlapped time of the heuristic disturbance to be in a safe interval which does not trigger the protection action and does not change the target reaction path; While superposing the heuristic disturbance, binding the occurrence time and the duration of the heuristic disturbance with the channel identifier of the target channel to form a disturbance event; And during the action of the disturbance event, synchronously acquiring a current response sequence, a potential response sequence and a channel state set at corresponding time of each channel, aligning a unified time reference based on the disturbance event, and intercepting a data segment consistent with the time range of the disturbance event from the current response sequence and the potential response sequence of each channel to form a segment set comprising a target channel segment and a disturbed channel segment.
  5. 5. The method according to claim 1, wherein the performing echo extraction processing for each disturbed channel segment in the segment set to separate and retain a slowly varying tailing component, generating a coupled echo segment, binding the coupled echo segment with a corresponding channel identifier, a bleed-off action flag in a protection state, and the adjacency mapping relation, and aggregating coupled echo segments between the same channel identifier pair under a condition of crossing a plurality of recognition windows to form an echo template, specifically comprises: For each disturbed channel segment in the segment set, under the condition that the channel state set in the corresponding time range is confirmed to be kept stable, the disturbance event is used as a time anchor point to execute echo extraction processing on response change in the disturbed channel segment so as to distinguish transient response which synchronously occurs with the disturbance event from slow-varying tailing response which exists after the disturbance event is ended; And packaging the slow-changing tailing response into a coupled echo fragment, binding the coupled echo fragment with a corresponding channel identifier, a bleeding action mark in a channel state set and an adjacent mapping relation respectively, and executing consistency aggregation processing on the coupled echo fragment with the same target channel identifier and the disturbed channel identifier under the condition of crossing a plurality of identification windows to obtain the echo template.
  6. 6. The cross-channel implicit coupling processing method for a multi-channel electrochemical workstation according to claim 1, wherein the identifying a target risk state based on a real-time channel state set when any one of the cancellation windows is entered, determining a disturbed channel set and a corresponding target segment set according to the adjacency mapping relation when the target risk state is detected, and retrieving a segment template matched with the target segment set from the echo template to generate a compensation instruction, and driving the injection link to apply compensation injection to a compensation electrode bus boundary segment corresponding to the target segment set through the compensation instruction so as to form a cancellation effect opposite to a bias reconstruction trend corresponding to the segment template at a liquid phase environment boundary, specifically comprising: when entering the cancellation window, carrying out joint judgment on the range state, the protection state and the control mode state of each channel based on a channel state set updated in real time to identify a target risk state, and determining a disturbed channel set and a target segment set adjacent to the space of the disturbed channel set according to the adjacent mapping relation after the target risk state is detected; a segment template with the spatial semantics consistent with the target segment set is called from the echo template to generate a compensation instruction, and the injection link is driven by the compensation instruction to apply compensation injection to the compensation electrode bus boundary segment corresponding to the target segment set, so that a cancellation effect opposite to the bias reconstruction trend represented by the segment template is formed at the liquid phase environment boundary; and simultaneously monitoring a current response sequence and a potential response sequence of the disturbed channel set in the cancellation window to verify a compensation effect and inhibit execution of the compensation instruction when an abnormal amplification trend is detected.
  7. 7. The method according to claim 1, wherein the steps of inserting an immune window in a preset period and suspending trial perturbation and compensation injection in the immune window, and simultaneously collecting a current response sequence and a potential response sequence of each channel to determine consistency of low-frequency drift, and limiting corresponding changes to an environmental common mode and limiting the effectiveness of subsequent compensation injection to a segment template corresponding to a bleeder echo when the low-frequency drift exhibits full-channel synchronous enhancement and lacks time alignment relation with a bleeder action mark comprise: Inserting an immune window in a global operation time axis according to a preset period, suspending trial disturbance and compensation injection when entering the immune window, synchronously collecting a current response sequence and a potential response sequence of each channel under the condition of keeping the execution of main test waveforms of each channel, and executing low-frequency drift consistency judgment based on a gradual change trend of the response of each channel in a corresponding time range of the immune window; When the low-frequency drift consistency judging result represents that the low-frequency drift presents full-channel synchronous enhancement and the synchronous enhancement and a release action mark in a channel state set lack of time alignment relation, limiting the synchronous enhancement to an environment common mode and generating the environment common mode mark, and limiting compensation injection in a subsequent cancellation window allows a segment template corresponding to a coupling echo fragment carrying the release action mark to take effect, so that the segment template corresponding to a non-release echo is prevented from executing compensation injection under the condition of the environment common mode.
  8. 8. A cross-channel implicit coupling processing system for a multi-channel electrochemical workstation, characterized in that the system is configured to perform a cross-channel implicit coupling processing method for a multi-channel electrochemical workstation as claimed in any one of claims 1 to 7, the system comprising an acquisition module and a processing module, wherein, The acquisition module is used for presetting a compensation electrode bus arranged around the outer edge of the electrode array in the same liquid phase environment, configuring an injection link which is electrically isolated from a main measurement link for the compensation electrode bus, binding a unique channel identifier for each channel in the multi-channel electrochemical workstation, solidifying a channel state set, dividing the compensation electrode bus into a plurality of boundary segments, binding segment identifiers for each boundary segment, and acquiring an adjacent mapping relation based on a spatial adjacent relation between the channel identifiers and the segment identifiers; The processing module is used for dividing a global operation time axis into an identification window and a cancellation window under the condition of keeping execution of main test waveforms of all channels, and screening a target channel based on the channel state set and locking the range state and the protection state of a non-target channel when entering any identification window so as to enable the non-target channel to maintain stable observation conditions in the identification window; The processing module is further configured to superimpose, in the identification window, a heuristic disturbance that does not change a target reaction path with respect to the target channel, correlate the heuristic disturbance with a channel identifier of the target channel to form a disturbance event, synchronously collect a current response sequence, a potential response sequence and a channel state set of the target channel, and align a time reference according to the disturbance event to intercept and form a segment set including a target channel segment and a disturbed channel segment; The processing module is further configured to perform echo extraction processing on each disturbed channel segment in the segment set to separate and retain a slowly-varying tailing component, generate a coupled echo segment, bind the coupled echo segment with a corresponding channel identifier, a bleeder action mark in a protection state, and the adjacency mapping relation, and aggregate the coupled echo segments between the same channel identifier pair under a condition of crossing multiple identification windows to form an echo template; The processing module is further configured to identify a target risk state based on a real-time channel state set when entering any cancellation window, determine a disturbed channel set and a corresponding target segment set according to the adjacency mapping relation when the target risk state is detected, call a segment template matched with the target segment set from the echo template to generate a compensation instruction, and drive the injection link to apply compensation injection to a compensation electrode bus boundary segment corresponding to the target segment set through the compensation instruction so as to form a cancellation effect opposite to a bias reconstruction trend corresponding to the segment template at a liquid phase environment boundary; The processing module is further configured to insert an immune window in a preset period, suspend trial disturbance and compensation injection in the immune window, and collect a current response sequence and a potential response sequence of each channel at the same time to determine consistency of low-frequency drift, and limit corresponding changes to an environmental common mode and limit subsequent compensation injection to take effect for a segment template corresponding to a released echo when the low-frequency drift presents full-channel synchronous enhancement and lacks time alignment relation with a released action mark.
  9. 9. An electronic device comprising a processor, a memory, a user interface, and a network interface, the memory for storing instructions, the user interface and the network interface each for communicating to other devices, the processor for executing the instructions stored in the memory to cause the electronic device to perform the method of any one of claims 1-7.
  10. 10. A non-transitory computer readable storage medium storing instructions which, when executed, perform the method of any one of claims 1 to 7.

Description

Cross-channel recessive coupling processing method for multi-channel electrochemical workstation Technical Field The application relates to the technical field of data processing, in particular to a cross-channel implicit coupling processing method for a multi-channel electrochemical workstation. Background Along with the continuous deepening of the application of electrochemical tests in the fields of material research, biosensing, energy device evaluation, on-line monitoring and the like, the multichannel electrochemical workstation gradually becomes an important technical means for improving the test efficiency and realizing parallel comparison analysis. However, in a parallel measurement scenario of a multi-channel electrochemical workstation, multiple electrode arrays are typically arranged within the same liquid phase environment to improve test throughput and ensure environmental condition consistency, but this structural layout is prone to introduce non-explicit cross-channel condition coupling risks during actual operation. When a local electrochemical reaction occurs on an electrode corresponding to a certain channel, local change of ion concentration distribution is caused in a liquid phase environment, so that a slowly evolving gradient is generated on the space and time dimensions of the electrolyte conductivity, and the gradient further acts on an input protection network, an antistatic structure or a discharge path shared in a multichannel system, so that tiny deviation of equivalent impedance distribution occurs. In this case, transient current changes, which should otherwise be limited to a single channel measurement link, may penetrate other channels via the shared guard and bleed structure in the form of very low amplitude, long time constants, and accumulate step by step in subsequent highly sensitive or integral measurements, manifesting as slow drift or pseudo-correlated response across the channels. Because the effect does not have obvious transient crosstalk characteristics and is easily covered by the overall background conductive characteristic under the condition of high salinity or high buffer capacity electrolyte, the existing system often misjudges the effect as environmental change or random noise, so that the effect is difficult to recognize in time and effectively inhibit, and the accuracy of a multichannel electrochemical measurement result is affected. Thus, there is an urgent need for a cross-channel implicit coupling process for a multi-channel electrochemical workstation. Disclosure of Invention The application provides a cross-channel recessive coupling processing method for a multi-channel electrochemical workstation, which is convenient for identifying the real source of the osmotic effect in time and effectively inhibiting the osmotic effect so as to improve the accuracy of a multi-channel electrochemical measurement result. The application provides a cross-channel recessive coupling processing method for a multi-channel electrochemical workstation, which comprises the steps of presetting a compensation electrode bus arranged around the outer edge of an electrode array in the same liquid phase environment, configuring an injection link which is electrically isolated from a main measurement link for the compensation electrode bus, binding unique channel identifiers for each channel in the multi-channel electrochemical workstation, solidifying a channel state set, dividing the compensation electrode bus into a plurality of boundary segments, binding segment identifiers for each boundary segment, and acquiring an adjacent mapping relation based on a spatial adjacent relation between the channel identifiers and the segment identifiers; dividing a global operation time axis into an identification window and a cancellation window under the condition of keeping the execution of main test waveforms of all channels, screening a target channel based on a channel state set and locking a range state and a protection state of a non-target channel when entering any identification window, enabling the non-target channel to maintain a stable observation condition in the identification window, superposing a heuristic disturbance which does not change a target reaction path on the target channel in the identification window, correlating the heuristic disturbance with a channel identifier of the target channel to form a disturbance event, synchronously collecting a current response sequence, a potential response sequence and a channel state set of the target channel, aligning a time reference according to the disturbance event to form a segment set containing a target channel segment and a disturbed channel segment, executing echo extraction processing on each disturbed channel segment in the segment set to separate and retain a slow-varying component, generating a coupling echo segment, and synchronizing the coupling echo segment with a corresponding channel identifier, binding a rel