CN-121978215-A - Separation column resin saturation online monitoring method and system

CN121978215ACN 121978215 ACN121978215 ACN 121978215ACN-121978215-A

Abstract

The invention discloses a method and a system for on-line monitoring of resin saturation of a separation column, which belong to the technical field of medical appliances and comprise the steps of acquiring real-time acoustic impedance data of an inlet end and an outlet end of the separation column; the method comprises the steps of calculating the instantaneous difference of real-time acoustic impedance data of an inlet end and an outlet end as the instantaneous difference of the real-time acoustic impedance, measuring radial blood flow velocity distribution in the middle section of a separation column, generating a flow field disturbance factor according to the radial blood flow velocity distribution, applying local pulse thrust to a resin bed layer in the separation column, obtaining the disturbed instantaneous acoustic impedance difference, generating a relaxation recovery curve according to the change of the disturbed instantaneous acoustic impedance difference along with time, and solving the problems that the existing monitoring method cannot adapt to the non-Newtonian fluid characteristics of blood and the disturbance of dynamic fluctuation of the flow field on monitoring signals, so that the monitoring precision is insufficient, further eliminating non-adsorptivity signal deviation caused by the fluctuation of the flow field, and further improving the monitoring precision of the resin saturation.

Inventors

GU LONG
WANG GUAN
Su Xingkang

Assignees

福建睿斯科医疗技术有限公司

Dates

Publication Date: 20260505
Application Date: 20260327

Claims (10)

1. The on-line monitoring method for the resin saturation of the separation column is characterized by comprising the following steps of: acquiring real-time acoustic impedance data of an inlet end and an outlet end of the separation column; Calculating the instantaneous difference of the real-time acoustic impedance data of the inlet end and the outlet end to be used as the real-time acoustic impedance instantaneous difference; measuring radial blood flow velocity distribution in the middle section of the separation column, and generating a flow field disturbance factor according to the radial blood flow velocity distribution; Applying local pulse thrust to a resin bed layer in the separation column, and obtaining an instantaneous acoustic impedance difference value after disturbance; generating a relaxation recovery curve according to the change of the instantaneous acoustic impedance difference value with time after disturbance, and extracting a relaxation characteristic value from the relaxation recovery curve; And correcting the real-time acoustic impedance transient difference by using a flow field disturbance factor to obtain a correction signal, integrating the correction signal, comparing an integration result with a relaxation characteristic value, and outputting a saturation warning signal according to the comparison result.
2. The method of on-line monitoring of resin saturation of a separation column of claim 1, wherein obtaining real-time acoustic impedance data for an inlet end and an outlet end of the separation column comprises: applying broadband acoustic wave excitation to the inlet end and the outlet end of the separation column, receiving the echo, gating and extracting the echo of the blood section through a time window, and acquiring an amplitude attenuation spectrum and a phase shift spectrum of blood on a broadband frequency band from the echo to serve as a blood frequency spectrum fingerprint; and identifying main component formants based on the blood frequency spectrum fingerprint, and measuring acoustic impedances of an inlet end and an outlet end according to the formant frequency to obtain a purified acoustic impedance change curve.
3. The method of on-line monitoring of saturation of a separation column resin of claim 2, wherein calculating instantaneous differences in real-time acoustic impedance data of the inlet and outlet ends comprises: time delay is carried out on the purified acoustic impedance change curve of the inlet end, the delay time is the average passing time of blood flowing from the inlet end to the outlet end, and a delay waveform containing rheological common mode noise is generated; And carrying out acoustic wave phase cancellation superposition on the purified acoustic impedance change curve of the outlet end and the delay waveform, and extracting the superposed signal as a pure adsorption contribution difference value.
4. The method for on-line monitoring of resin saturation of a separation column according to claim 3, wherein measuring radial blood flow velocity distribution in a middle section of the separation column and generating a flow field disturbance factor according to the radial blood flow velocity distribution comprises: applying multi-angle sound waves to the middle section of the separation column for incidence to obtain Doppler frequency shift clusters of blood flow at different radial depths; converting Doppler frequency shift clusters into equivalent acoustic impedance modulation coefficient sequences of radial layers; extracting a near wall surface velocity gradient index from the equivalent acoustic impedance modulation coefficient sequence; modulating the near-wall velocity gradient index and the delay waveform to generate a flow field disturbance factor.
5. The method for on-line monitoring of resin saturation of a separation column according to claim 4, wherein applying a local pulse thrust to a resin bed in the separation column comprises: Generating a physical disturbance trigger pulse based on the pure adsorption contribution difference signal and the flow field disturbance factor; Generating a multipath delay trigger signal based on a geometric acoustic model of the separation column according to the physical disturbance trigger pulse; And applying local pulse thrust to the resin bed layer according to the multipath delay trigger signals.
6. The method of on-line monitoring of resin saturation of a separation column of claim 5, wherein obtaining the perturbed instantaneous acoustic impedance difference comprises: after the local pulse thrust is applied, acoustic impedance data of different time points after disturbance are collected, and an acoustic impedance time sequence after disturbance is obtained; Differentiating the acoustic impedance time sequence after disturbance and the pure adsorption contribution difference before disturbance to obtain a net disturbance response curve; And extracting a relaxation characteristic value from the net disturbance response curve as an instantaneous acoustic impedance difference characteristic value after disturbance.
7. The method of on-line monitoring of separator resin saturation according to claim 6, wherein generating a relaxation recovery curve from a change over time of an instantaneous acoustic impedance difference after disturbance comprises: Generating a set of time-shifted copies with different time delays from the net disturbance response curve; Multiplying the original net disturbance response curve and each time offset copy to obtain an autocorrelation strength signal corresponding to each delay time; and sequencing the autocorrelation intensity signals corresponding to the delay times according to the delay times, and reconstructing the autocorrelation intensity signals into an autocorrelation function curve.
8. The method for on-line monitoring of saturation of a separation column resin according to claim 7, wherein extracting a relaxation characteristic value from a relaxation recovery curve comprises: identifying and extracting a dominant relaxation time constant from the autocorrelation function curve; The dominant relaxation time constant is encoded in combination with the initial amplitude of the net perturbation response curve to generate relaxation feature values.
9. The method for on-line monitoring of saturation of a resin in a separation column according to claim 8, wherein integrating the correction signal and comparing the integration result with the relaxation feature value, and outputting a saturation warning signal based on the comparison result, comprises: Carrying out acoustic amplitude modulation on the flow field disturbance factor and the pure adsorption contribution difference value to generate a flow field normalized adsorption signal; carrying out acoustic accumulation integration on the flow field normalized adsorption signal to generate an adsorption total amount characterization value; And comparing the adsorption total quantity representation value with the relaxation characteristic value by acoustic double threshold values, and outputting a saturation warning signal according to a comparison result.
10. The on-line monitoring system for the resin saturation of the separation column, which is applied to the on-line monitoring method for the resin saturation of the separation column according to any one of claims 1 to 9, is characterized by comprising: The data acquisition module is used for acquiring real-time acoustic impedance data of the inlet end and the outlet end of the separation column; the calculating module is used for calculating the instantaneous difference value of the real-time acoustic impedance data of the inlet end and the outlet end to be used as the instantaneous difference value of the real-time acoustic impedance; The disturbance generation module is used for measuring radial blood flow velocity distribution in the middle section of the separation column and generating a flow field disturbance factor according to the radial blood flow velocity distribution; The disturbance acquisition module is used for applying local pulse thrust to the resin bed layer in the separation column and acquiring the disturbed instantaneous acoustic impedance difference value; The characteristic extraction module is used for generating a relaxation recovery curve according to the change of the instantaneous acoustic impedance difference value after disturbance along with time and extracting a relaxation characteristic value from the relaxation recovery curve; and the saturation alarm module corrects the real-time acoustic impedance transient difference by using a flow field disturbance factor to obtain a corrected signal, integrates the corrected signal, compares an integration result with a relaxation characteristic value, and outputs a saturation alarm signal according to the comparison result.

Description

Separation column resin saturation online monitoring method and system Technical Field The invention relates to the technical field of medical equipment, in particular to a method and a system for on-line monitoring of resin saturation of a separation column. Background In the bedside blood purification treatment, the adsorption resin in the separation column is a component for removing toxic substances, inflammatory mediators and other harmful substances in the blood of a patient, the adsorption saturation of the adsorption resin directly determines the treatment effect and medical safety, the adsorbed toxins can be caused to reversely permeate back into the blood of the patient if the perfusion is not timely stopped after the resin adsorption reaches saturation, serious complications are caused, the resin adsorption capacity is wasted if the adsorption resin is stopped in advance, and the treatment cost and the burden of the patient are increased, so that the accurate and real-time online monitoring of the resin saturation of the separation column is very important. At present, the online monitoring method of the resin saturation is mostly based on a calibration model constructed by a fixed flow rate and a standard matrix, the principle is that the adsorption saturation state of the resin is indirectly judged by detecting the change of the solute concentration at the outlet end of a separation column, and the method has certain applicability in a laboratory simulation scene or a standardized industrial separation process, can meet basic monitoring requirements, but has certain technical limitations when being applied to a bedside blood purification scene, and is difficult to adapt to complex working conditions of clinical treatment. The bedside blood purification is characterized in that individual differences of patients are large, in addition, the hemodynamic state fluctuates in real time in the treatment process, on one hand, the blood flow speed and blood components of different patients, such as blood fat, blood platelets, plasma protein concentration and the like, are different, so that the physicochemical properties of blood are different, on the other hand, blood belongs to typical non-Newtonian fluid, the viscosity of the blood changes along with the change of a shear rate, the viscosity is influenced by heart pulsation, the flow field state is always in dynamic fluctuation, the existing calibration model is constructed based on fixed flow speed and standard matrix, the complexity of the clinical scene is not considered, the detection signal offset caused by the change of the resin adsorption saturation and the blood matrix and the hemodynamic fluctuation cannot be effectively distinguished, the error judgment of saturation easily occurs, the error judgment not only can cause the waste of resin resources, but also can cause toxin reverse osmosis due to the oversaturation of the resin, serious medical safety risks are brought to the patients, and the clinical treatment of bedside blood purification is originally intended. In addition, the on-line monitoring means commonly used in the prior art, such as ultraviolet-visible light spectrometry and near infrared spectrometry, are all required to be provided with an optical window on a blood pipeline to realize the penetration and reflection detection of light, but fibrinogen, platelets and other components in blood are extremely easy to be adsorbed and adhered on the surface of the optical window in the clinical use process of medical equipment, a layer of compact biological film is gradually formed, micro thrombus is formed in severe cases, the normal penetration and reflection of the light can be seriously interfered by pollutants on the surface of the optical window, so that a spectrum signal is distorted, the judgment of the resin saturation based on spectrum analysis is completely ineffective, meanwhile, due to the continuous requirement of bedside treatment, the on-line cleaning of the optical window cannot be performed in time, and the problems of complex operation, poor cleaning effect and the like exist in the on-line cleaning. Disclosure of Invention Aiming at the problems existing in the prior art, the invention aims to provide an on-line monitoring method and an on-line monitoring system for the saturation of the separation column resin, which can solve the technical problems that the existing monitoring method does not consider the individual difference of patients in bedside blood purification and common mode interference caused by hemodynamic fluctuation, and the saturation misjudgment is easy to occur. In order to solve the problems, the invention adopts the following technical scheme: In a first aspect, a method and a system for on-line monitoring of resin saturation of a separation column, comprising: acquiring real-time acoustic impedance data of an inlet end and an outlet end of the separation column; Calculating the instantaneous