CN-121978258-A - Chromatograph rapid heating method, chromatograph rapid heating system, intelligent terminal and storage medium

CN121978258ACN 121978258 ACN121978258 ACN 121978258ACN-121978258-A

Abstract

The invention relates to the technical field of chromatographic analysis and discloses a rapid heating method, a rapid heating system, an intelligent terminal and a storage medium of a chromatograph, wherein the method comprises the steps of applying high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column, and generating heating power by virtue of vortex; the method comprises the steps of enabling carrier gas heat to preheat carrier gas, forming a convection heat exchange field by forced heat exchange with the outer surface of the chromatographic column, generating a temperature gradient by heating power, exciting a thermoelectric effect of a metal pipe wall to generate thermoelectric potential, inverting the current average temperature and the thermoelectric trend based on a calibration relation, constructing a composite heat field by synergistically regulating and controlling current and carrier gas flow, switching the regulating and controlling parameters of high-frequency alternating current and the preheating carrier gas to a steady-state maintaining mode when the current average temperature reaches a preset target temperature and temperature trend information shows that temperature distribution tends to be steady, and enabling the chromatographic column to enter a constant-temperature control stage.

Inventors

LI JIE
MENG SHUO
CAO YONG
LI TAO

Assignees

瑞莱谱(杭州)医疗科技有限公司

Dates

Publication Date: 20260505
Application Date: 20260408

Claims (10)

1. A method for rapidly heating up a chromatograph, the method comprising: S1, applying high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in a chromatograph to obtain vortex of the chromatographic column, and generating heating power of the chromatographic column by the vortex; s2, carrying out heat energization on carrier gas of an air source system in the chromatograph to obtain preheated carrier gas of the chromatograph, and carrying out forced heat exchange on the preheated carrier gas and the outer surface of the chromatographic column to obtain a convection heat exchange field of the chromatographic column; S3, applying the heating power to the chromatographic column to generate a temperature gradient of the chromatographic column, and exciting a thermoelectric effect of a metal pipe wall in the chromatographic column based on the temperature gradient to generate a thermoelectric electromotive force of the chromatographic column; S4, quantitatively inverting the thermoelectric potential according to the calibration relation between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and the thermoelectric trend information of the chromatographic column; s5, according to the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow parameter of the preheating carrier gas are subjected to cooperative regulation and control to construct a cooperative composite thermal field of the chromatographic column; S6, when the current average temperature reaches a preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be stable, switching the regulating and controlling parameters of the high-frequency alternating current and the preheating carrier gas to a stable maintenance mode, and enabling the chromatographic column to enter a constant temperature control stage.
2. The method of claim 1, wherein the step of applying a high frequency alternating current to an electromagnetic coil around a column in the chromatograph to obtain a vortex of the column and generating a heating power of the column from the vortex comprises: inputting a driving signal with adjustable amplitude and frequency into a high-frequency power supply to generate high-frequency alternating current of the high-frequency power supply; loading the high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in the chromatograph so as to excite an alternating magnetic field inside the electromagnetic coil; The magnetic force lines of the alternating magnetic field penetrate through the metal pipe wall of the chromatographic column, and electromagnetic field-eddy current coupling is carried out on the conductive material of the metal pipe wall to obtain a closed eddy current loop of the chromatographic column; And based on the inherent resistance of the metal pipe wall, performing Joule heat conversion on the closed vortex circuit to obtain the heating power of the chromatographic column.
3. The method of claim 1, wherein said thermally energizing a carrier gas of a gas source system in said chromatograph to obtain a preheated carrier gas of said chromatograph, and forcibly exchanging heat between said preheated carrier gas and an outer surface of said chromatographic column to obtain a convective heat exchange field of said chromatographic column, comprises: The carrier gas output by the gas source system in the chromatograph is guided to be conveyed to a preheating cavity at the periphery of the chromatographic column, and the carrier gas is electrically heated in the preheating cavity to obtain the preheating carrier gas of the chromatograph; Injecting the preheated carrier gas into an annular flow guiding structure of the chromatographic column; In the annular flow guiding structure, carrying out flow field shaping optimization on the preheated carrier gas to obtain directional high-speed airflow of the chromatographic column; and carrying out gas-solid interface heat transfer on the directional high-speed airflow and the outer wall surface of the chromatographic column to obtain a convective heat exchange field of the chromatographic column.
4. The rapid temperature increase method of claim 2, wherein the applying the heating power to the chromatographic column to generate a temperature gradient of the chromatographic column and exciting a thermoelectric effect of a metal tube wall in the chromatographic column based on the temperature gradient to generate a thermoelectromotive force of the chromatographic column comprises: Non-uniform thermal deposition is carried out inside the metal tube wall through the heating power, so that the temperature gradient of the chromatographic column is obtained; establishing a stable thermodynamic driving force between two ends of the metal pipe wall according to the temperature gradient; based on the thermodynamic driving force, charge carriers of the metal tube wall are directionally migrated to trigger the seebeck effect of the metal tube wall; and collecting potential differences generated by the Seebeck effect through electrodes arranged at two ends of the metal tube wall so as to generate the thermoelectromotive force of the chromatographic column.
5. The method of claim 4, wherein quantitatively inverting the thermoelectric potential according to a calibration relationship between the thermoelectric potential and a reference average temperature in the chromatographic column to obtain current average temperature and temperature difference trend information of the chromatographic column, comprises: Based on the material properties of the metal pipe wall, performing linear regression fit on the thermoelectromotive force and the reference average temperature of the chromatographic column to obtain a calibration relation between the thermoelectromotive force and the reference average temperature; mapping the thermoelectric potential into a corresponding temperature original value according to the calibration relation; Performing thermoelectric nonlinear correction on the temperature original value to obtain the current average temperature of the chromatographic column; Collecting the current average temperature at different moments, and performing instantaneous gradient calculation on the current average temperature at adjacent moments to obtain the axial temperature instantaneous variation of the chromatographic column, wherein the calculation formula of the axial temperature instantaneous variation is as follows: ; In the formula, For the moment of time Is used for the instantaneous change of the axial temperature of the steel plate, For the moment of time The current average temperature that is acquired is, Is the immediately previous time The current average temperature that is acquired is, For a preset acquisition fixed time interval, Is a preset thermal inertia correction coefficient, Is a natural constant which is used for the production of the high-temperature-resistant ceramic material, A thermal diffusion time constant for the metal tube wall; And extracting trend characteristics of the directionality and convergence of the axial temperature transient variation to obtain temperature difference trend information of the chromatographic column.
6. The method of claim 1, wherein the co-controlling the current parameter of the high-frequency alternating current and the flow parameter of the pre-heating carrier gas according to the current average temperature and the temperature difference trend information to construct the co-combined thermal field of the chromatographic column comprises: Performing error mapping on the difference between the current average temperature and a preset target temperature to obtain a first amplitude adjustment instruction of the high-frequency alternating current and a first flow adjustment instruction of the preheating carrier gas flow; The first amplitude adjustment instruction and the first flow adjustment instruction are subjected to isotropic correction according to the temperature change direction indicated by the temperature difference trend information, so that a second amplitude adjustment instruction and a second flow adjustment instruction of the chromatographic column are obtained; According to the temperature change rate indicated by the temperature difference trend information, performing response time sequence registration on the second amplitude adjustment instruction and the second flow adjustment instruction to obtain a target current regulation parameter and a target flow regulation parameter of the chromatographic column; According to the target current regulation and control parameters, adjusting the high-frequency alternating current of the electromagnetic coil, and according to the target flow regulation and control parameters, adjusting the preheating carrier gas of the chromatographic column; And coupling and superposing the induction eddy current heat generated by the regulated high-frequency alternating current and the forced convection heat formed by the regulated pre-heating carrier gas to construct the synergistic composite thermal field of the chromatographic column.
7. The method of claim 6, wherein when the current average temperature reaches a preset target temperature and the trend information of the temperature difference indicates that the temperature distribution tends to be steady state, switching the control parameters of the high-frequency alternating current and the preheating carrier gas to a steady state maintaining mode to make the chromatographic column enter a constant temperature control stage, comprising: When the current average temperature reaches the preset target temperature and the temperature change rate of the temperature difference trend information is continuously lower than a preset stability threshold value, judging that the temperature distribution of the chromatographic column reaches a quasi-steady state condition; switching the current amplitude of the high-frequency alternating current from a dynamic adjustment mode to a narrow fluctuation mode based on the quasi-steady state condition, and switching the flow of the preheating carrier gas from a regulation mode to a constant flow supply mode; in the narrow fluctuation mode and the constant flow supply mode, performing directional correction on the amplitude of the high-frequency alternating current according to the deviation between the current average temperature and the preset target temperature; and when the corrected current average temperature is positioned in the interval of the preset target temperature and the temperature change rate of the temperature difference trend information is lower than the preset stability threshold value, confirming that the chromatographic column enters a constant temperature control stage.
8. A chromatograph rapid warming system for implementing the chromatograph rapid warming method of claim 1, the system comprising: the eddy current induction heating module is used for applying high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in the chromatograph so as to obtain eddy current of the chromatographic column, and heating power of the chromatographic column is generated by the eddy current; the gas-heat forced convection module is used for carrying out heat energization on the carrier gas of the gas source system in the chromatograph to obtain preheating carrier gas of the chromatograph, and carrying out forced heat exchange on the preheating carrier gas and the outer surface of the chromatographic column to obtain a convection heat exchange field of the chromatographic column; a thermoelectric signal generation module for applying the heating power to the chromatographic column to generate a temperature gradient of the chromatographic column, and exciting a thermoelectric effect of a metal tube wall in the chromatographic column based on the temperature gradient to generate a thermoelectric electromotive force of the chromatographic column; The temperature inversion analysis module is used for quantitatively inverting the thermoelectric potential according to the calibration relation between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and the temperature difference trend information of the chromatographic column; The cooperative thermal field construction module is used for carrying out cooperative regulation and control on the current parameters of the high-frequency alternating current and the flow parameters of the preheating carrier gas according to the current average temperature and temperature difference trend information so as to construct a cooperative composite thermal field of the chromatographic column; and the constant temperature maintenance switching module is used for switching the regulation and control parameters of the high-frequency alternating current and the preheating carrier gas to a steady state maintenance mode when the current average temperature reaches a preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady state, so that the chromatographic column enters a constant temperature control stage.
9. A smart terminal comprising a memory, a processor and a computer program stored on the memory, characterized in that the processor executes the computer program to implement the steps of the method of any one of claims 1 to 7.
10. A storage medium having stored thereon a computer program, which when executed by a processor performs the steps of the method according to any of claims 1 to 7.

Description

Chromatograph rapid heating method, chromatograph rapid heating system, intelligent terminal and storage medium Technical Field The invention relates to the technical field of chromatographic analysis, in particular to a chromatograph rapid heating method, a chromatograph rapid heating system, an intelligent terminal and a storage medium. Background The traditional chromatograph has the problems of large loss and uneven distribution in the heat transfer process due to the fact that the temperature rising mode of the traditional chromatograph depends on a single heating mechanism, so that the chromatographic column has a slow temperature rising speed, and the target analysis temperature is difficult to reach quickly. And the temperature gradient regulation and control precision is not enough in the heating process, and the heat exchange between the metal pipe wall and the carrier gas is lack of cooperative coordination, so that the preparation time of sample analysis is prolonged, and the separation effect and the reliability of detection data are possibly influenced by poor temperature stability. In the prior art, the response hysteresis of a temperature feedback and regulation system is obvious, and the accurate capture and dynamic adjustment of the temperature difference trend in the temperature rising process are lacked. The carrier gas preheating link has low heat energizing efficiency, cannot form a high-efficiency convection heat exchange field, further restricts the improvement of the heating rate, and increases the energy consumption, so that how to improve the quick heating efficiency of the chromatograph becomes a problem to be solved urgently. Disclosure of Invention The disclosure provides a chromatograph rapid heating method, a chromatograph rapid heating system, an intelligent terminal and a storage medium. In a first aspect, the present disclosure provides a chromatograph rapid warming method comprising: S1, applying high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in a chromatograph to obtain vortex of the chromatographic column, and generating heating power of the chromatographic column by the vortex; s2, carrying out heat energization on carrier gas of an air source system in the chromatograph to obtain preheated carrier gas of the chromatograph, and carrying out forced heat exchange on the preheated carrier gas and the outer surface of the chromatographic column to obtain a convection heat exchange field of the chromatographic column; S3, applying the heating power to the chromatographic column to generate a temperature gradient of the chromatographic column, and exciting a thermoelectric effect of a metal pipe wall in the chromatographic column based on the temperature gradient to generate a thermoelectric electromotive force of the chromatographic column; S4, quantitatively inverting the thermoelectric potential according to the calibration relation between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and the thermoelectric trend information of the chromatographic column; s5, according to the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow parameter of the preheating carrier gas are subjected to cooperative regulation and control to construct a cooperative composite thermal field of the chromatographic column; S6, when the current average temperature reaches a preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be stable, switching the regulating and controlling parameters of the high-frequency alternating current and the preheating carrier gas to a stable maintenance mode, and enabling the chromatographic column to enter a constant temperature control stage. In a preferred embodiment, the applying a high frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in a chromatograph to obtain an eddy current of the chromatographic column and generating heating power of the chromatographic column from the eddy current comprises: inputting a driving signal with adjustable amplitude and frequency into a high-frequency power supply to generate high-frequency alternating current of the high-frequency power supply; loading the high-frequency alternating current to an electromagnetic coil at the periphery of a chromatographic column in the chromatograph so as to excite an alternating magnetic field inside the electromagnetic coil; The magnetic force lines of the alternating magnetic field penetrate through the metal pipe wall of the chromatographic column, and electromagnetic field-eddy current coupling is carried out on the conductive material of the metal pipe wall to obtain a closed eddy current loop of the chromatographic c