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CN-121978358-A - Liquid path control device and method for biochemical analyzer with automatic gas-liquid separation

CN121978358ACN 121978358 ACN121978358 ACN 121978358ACN-121978358-A

Abstract

The invention relates to a liquid path control device and a liquid path control method for a biochemical analyzer with automatic gas-liquid separation, wherein the device comprises a power source and a flow divider, the power source is connected with an inlet of the flow divider through a main pipeline so as to pump external detergent into the flow divider, the flow divider is provided with a plurality of outlets for outputting the detergent with bubbles removed outwards, each outlet is connected with a sample sampling unit, a reagent sampling unit, a stirring cleaning unit and other cleaning units through a branch pipeline respectively, the probability of residual bubbles in the detergent output by the outlets connected with the sample sampling unit, the reagent sampling unit, the stirring cleaning unit and the other cleaning units is gradually increased, and each branch pipeline is provided with a cleaning valve. The invention has the advantages that the bubble separation is realized based on the principle that the gas naturally floats in the liquid, an external degassing membrane or a negative pressure device is not needed, the complexity and the manufacturing cost of the system are obviously reduced, and the operation reliability is improved.

Inventors

  • LIAO HUIMING
  • WU SHIYOU
  • LI YINQIANG
  • QIN ZHENZHU

Assignees

  • 桂林优利特医疗电子有限公司

Dates

Publication Date
20260505
Application Date
20260108

Claims (7)

  1. 1. A biochemical analyzer liquid pipeline control device with automatic gas-liquid separation is characterized by comprising a power source (1) and a flow divider (2), wherein the power source (1) is connected with an inlet of the flow divider (2) through a main pipeline to pump external detergent into the flow divider (2), the flow divider (2) is provided with a plurality of outlets for outputting the detergent with bubbles removed outwards, each outlet is connected with a sample sampling unit (3), a reagent sampling unit (4), a stirring and cleaning unit (5) and other cleaning units (6) through a branch pipeline respectively, the probability of residual bubbles in the detergent output by the outlets of the sample sampling unit (3), the reagent sampling unit (4), the stirring and cleaning unit (5) and the other cleaning units (6) is gradually increased, and a cleaning valve (7) is arranged on each branch pipeline.
  2. 2. The biochemical analyzer liquid path control device with automatic gas-liquid separation according to claim 1, wherein the outlet comprises a first outlet (8), a second outlet (9), a third outlet (10), a fourth outlet (11), a fifth outlet (12) and a sixth outlet (13), wherein the diverter (2) is a box structure with a cavity inside, and the diverter (2) is inclined towards the left with respect to the horizontal, the first outlet (8), the second outlet (9), the third outlet (10) and the fourth outlet (11) are respectively arranged at the left side of the diverter (2) from bottom to top, and the fifth outlet (12) and the sixth outlet (13) are respectively arranged at the top of the diverter (2); The first outlet (8) is connected with the sample sampling unit (3) through a branch pipeline, the second outlet (9) is connected with the reagent sampling unit (4) through a branch pipeline, the third outlet (10) and the fourth outlet (11) are respectively connected with different stirring and cleaning units (5) through a branch pipeline, and the fifth outlet (12) and the sixth outlet (13) are respectively connected with different other cleaning units (6) through a branch pipeline.
  3. 3. The biochemical analyzer liquid path control device with automatic gas-liquid separation according to claim 1, characterized in that the flow divider (2) is inclined 60 ° -70 ° to the left with respect to the horizontal plane.
  4. 4. The biochemical analyzer liquid path control device with automatic gas-liquid separation according to claim 1, wherein a first bubble detection device (14) is provided on a branch pipe of the first outlet (8) connected to the sample sampling unit (3), and the first bubble detection device (14) is provided between the sample sampling unit (3) and the corresponding purge valve (7).
  5. 5. The biochemical analyzer liquid path control device with automatic gas-liquid separation according to claim 4, wherein a second bubble detection device (15) is provided on a branch pipe of the second outlet (9) connected to the reagent sampling unit (4), and the second bubble detection device (15) is provided between the reagent sampling unit (4) and the corresponding purge valve (7).
  6. 6. The biochemical analyzer liquid path control device with automatic gas-liquid separation according to claim 5, further comprising a control device electrically connected to the first bubble detecting device (14), the second bubble detecting device (15) and all the purge valves (7), respectively.
  7. 7. A control method of a liquid path control device for a biochemical analyzer having an automatic gas-liquid separation according to any one of claims 1 to 6, comprising the steps of: Step 1, firstly, a control device opens a cleaning valve (7) and activates a power source (1) of a detergent, the power source (1) conveys the detergent to a flow divider (2), and the flow divider (2) outputs a bubble-free detergent and a bubble-containing detergent respectively; Step 2, a part of the bubble-free detergent enters the sample sampling unit (3) through the corresponding cleaning valve (7) and the first bubble detection device (14), and the other part of the bubble-free detergent enters the reagent sampling unit (4) through the corresponding cleaning valve (7) and the second bubble detection device (15): If no bubbles are detected by the first bubble detection device (14) and the second bubble detection device (15) in the current cleaning period, the control device finishes cleaning the sample sampling unit (3) and the reagent sampling unit (4) according to the program and then directly enters the next testing period; If the first bubble detection device (14) and/or the second bubble detection device (15) detect bubbles in the current cleaning period, the control device judges that the next sampling is abnormal, the sampling is skipped automatically, and meanwhile, the exhaust bubble flushing of one test period is executed at the cleaning positions of the sample sampling unit (3) and the reagent sampling unit (4); step 3, cleaning the stirring cleaning unit (5) and other cleaning units (6) by using the bubble-containing detergent through corresponding cleaning valves (7); And 4, closing the corresponding cleaning valve (7) by the control device according to a preset program, and finishing the cleaning of the unit.

Description

Liquid path control device and method for biochemical analyzer with automatic gas-liquid separation Technical Field The invention relates to the field of in-vitro diagnosis, in particular to a liquid path control device and method of a biochemical analyzer with automatic gas-liquid separation. Background In the field of In Vitro Diagnostics (IVD), biochemical analyzers are one of the core devices of clinical laboratory. The instrument is based on an optical principle, and is used for accurately and quantitatively analyzing specific biochemical components in body fluids such as human blood, urine and the like, and providing a key basis for diagnosis, treatment scheme formulation and prognosis evaluation of diseases. The device can rapidly and reliably reflect the change of the environment in the human body, and becomes an indispensable important tool in modern medical diagnosis. When the biochemical immunity analysis instrument runs, continuous transfer of the sample and the reagent to the reaction unit is required to be completed, and quantitative detection of the target specific component is realized based on a photoelectric colorimetry after the sample and the reagent are fully and uniformly mixed and reacted by the stirring module. In order to ensure continuous and effective operation of the system, each functional module needs to be thoroughly cleaned by a detergent after use so as to ensure the reliability of a detection result. The sample adding accuracy is a core element for determining the quantitative analysis performance of the system, and directly influences the accuracy of the detection result. It is noted that bubbles of uneven size are unavoidable during the supply and transport of the detergent during the cleaning cycle. If such bubbles invade the sampling unit, the sampling volume deviation or missing sampling can be caused, so that the detection result deviation or sampling failure is caused, the clinical diagnosis and treatment are delayed, and the accuracy of prognosis evaluation is affected. The technical bottleneck of the interference of bubbles on sampling precision is divided into two main solutions, namely, the first solution is to integrate a high-cost degassing module and a complex liquid path system to realize gas-liquid separation, and the second solution is to influence the sampling precision, so that retesting is executed after abnormal results are caused. The former has the defects of high manufacturing and maintenance cost, high system failure rate and the like, and the latter has the risk of misdiagnosis and missed diagnosis, directly reduces detection timeliness and is difficult to adapt to clinical rapid diagnosis requirements. Accordingly, a biochemical analyzer liquid path control device and a biochemical analyzer liquid path control method with automatic gas-liquid separation have been proposed, which can solve the above problems. Disclosure of Invention Aiming at the problems of complex structure, high cost and high maintenance difficulty of the existing gas-liquid separation device and the problems of delayed response, resource waste and diagnosis risk existing in the conventional method that the conventional method is difficult to effectively influence generated bubbles on sampling precision and only can trigger retesting depending on abnormal results, the invention aims to provide a liquid path control device and a liquid path control method for a biochemical analyzer with automatic gas-liquid separation. The technical scheme includes that the biochemical analyzer liquid path control device with the automatic gas-liquid separation comprises a power source and a flow divider, wherein the power source is connected with an inlet of the flow divider through a main pipeline to pump external detergent into the flow divider, the flow divider is provided with a plurality of outlets for outputting the detergent with bubbles removed outwards, each outlet is connected with a sample sampling unit, a reagent sampling unit, a stirring cleaning unit and other cleaning units through a branch pipeline, the probability of outputting residual bubbles in the detergent is gradually increased when the outlets of the sample sampling unit, the reagent sampling unit, the stirring cleaning unit and the other cleaning units are connected with each other, and a cleaning valve is arranged on each branch pipeline. The invention has the advantages that the bubble separation is realized based on the principle that the gas naturally floats in the liquid, an external degassing membrane or a negative pressure device is not needed, the complexity and the manufacturing cost of the system are obviously reduced, and the operation reliability is improved. Based on the technical scheme, the invention can be further improved as follows: The diverter is of a box body structure with a cavity inside, and is obliquely arranged towards the left relative to the horizontal plane, the first outlet, the second outle