Search

CN-121978362-A - Sample analysis device and valve fault detection method thereof

CN121978362ACN 121978362 ACN121978362 ACN 121978362ACN-121978362-A

Abstract

In order to execute related functions when the sample analysis device works, the control valve of the sample analysis device needs to be closed and opened according to a certain opening and closing time sequence, and the fault detection of the control valve can be realized in the normal working process of the sample analysis device and even the control valve with the fault can be specifically positioned through the opening and closing time sequence of the control valve related in the sample analysis device and the electric signal change in the time period of the opening and closing time sequence.

Inventors

  • WU JIE
  • RUAN CHULIANG

Assignees

  • 深圳迈瑞生物医疗电子股份有限公司

Dates

Publication Date
20260505
Application Date
20241031

Claims (20)

  1. 1. The sample analysis device is characterized by comprising a sample analysis functional module, a power supply module, an electric signal detection module and a controller; The sample analysis functional module is used for executing one or more functions required by sample detection, and comprises at least a sample sucking component, a liquid path component, a sample bearing component and a valve component, wherein the sample sucking component is used for acquiring a sample, the liquid path component is connected with the sample sucking component, the sample bearing component is used for providing a place for sample detection, the valve component is connected with at least one of the sample sucking component, the liquid path component and the sample bearing component, the valve component comprises a control valve, the control valve has two opening and closing states, the opening and closing states comprise an opening state and a closing state, and the control valve can be controlled to be opened and closed by the controller to be switched between different opening and closing states; The power supply module is used for supplying power to a control valve of the valve assembly; the electric signal detection module is used for detecting an electric signal of the power supply module for supplying power to the control valve of the valve assembly; the controller is used for: Receiving a working instruction; Controlling the sample analysis functional module to execute one or more functions required for sample detection according to the working instruction so as to control a control valve in the valve assembly to switch an opening and closing state according to a target opening and closing time sequence; acquiring a target electric signal of a time period corresponding to the target opening and closing time sequence of the valve assembly through the electric signal detection module; and judging whether a control valve with a fault exists in the valve assembly according to the target electric signal.
  2. 2. The sample analysis device of claim 1, wherein the electrical signal detection module is configured to detect a total electrical signal of all control valves of the valve assembly, the electrical signal detection module being a current signal detection module, the total electrical signal being a total current.
  3. 3. The sample analysis device of claim 1 or 2, wherein the controller determines whether a malfunctioning control valve is present in the valve assembly based on the target electrical signal, comprising: Acquiring a characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target opening and closing time sequence of the valve assembly, wherein the characteristic signal is used for representing the change condition of an electric signal along with time when a control valve in the valve assembly normally switches an opening and closing state according to the target opening and closing time sequence; Judging whether the target electric signal is abnormal or not according to the characteristic signal so as to determine whether a control valve with a fault exists in the valve assembly, wherein the target electric signal comprises the electric signals detected by the electric signal detection module at a plurality of moments in a time period corresponding to the target opening and closing time sequence of the valve assembly.
  4. 4. The sample analysis device of claim 3, wherein the controller obtains a signature signal corresponding to the target opening and closing timing of the valve assembly based at least on the target opening and closing timing of the valve assembly, comprising: Determining a target control valve of which the opening and closing states need to be switched in the valve assembly according to the target opening and closing time sequence of the valve assembly and a target closing time sequence of the target control valve which is closed according to time sequence, determining a characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target closing time sequence of the target control valve, or Determining a target control valve of which the opening and closing states need to be switched in the valve assembly according to the target opening and closing time sequence of the valve assembly, and determining a characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target opening time sequence of the target control valve.
  5. 5. The sample analyzer of claim 3 or 4, wherein the controller obtains a characteristic signal corresponding to the target opening and closing timing of the valve assembly based at least on the target opening and closing timing of the valve assembly, comprising determining a target control valve whose opening and closing state is to be switched in the valve assembly based on the target opening and closing timing of the valve assembly, and obtaining a characteristic signal corresponding to the target opening and closing timing of the valve assembly based on the target opening and closing timing of the valve assembly and a characteristic quantity of each of the target control valves, wherein the characteristic quantity of the target control valve includes an electrical signal variation of the target control valve due to the switching of the opening and closing state; preferably, the determining the characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target closing time sequence of the target control valve comprises determining the characteristic signal corresponding to the target opening and closing time sequence of the valve assembly according to the target closing time sequence of the target control valve and the characteristic quantity of each target control valve, wherein the characteristic quantity of the target control valve comprises the electric signal change quantity caused by switching the target control valve from an opening state to a closing state; Preferably, the determining the characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target opening and closing time sequence of the target control valve comprises determining the characteristic signal corresponding to the target opening and closing time sequence of the valve assembly according to the target opening and closing time sequence of the target control valve and the characteristic quantity of each target control valve, wherein the characteristic quantity of the target control valve comprises the electric signal change quantity caused by switching the target control valve from a closed state to an open state.
  6. 6. The sample analysis device of any one of claims 3 to 5, wherein the signature signal comprises a time-varying target signature signal profile.
  7. 7. The sample analysis device of any one of claims 3 to 6, wherein the controller determining whether the target electrical signal is abnormal based on the characteristic signal to determine whether a malfunctioning control valve is present in the valve assembly comprises: Determining a target control valve of which the opening and closing states need to be switched in the valve assembly and a time sequence of each target control valve to be switched according to the target opening and closing time sequence of the valve assembly; And judging whether the target electric signal is abnormal or not according to the characteristic signal, and if so, positioning the control valve with the fault in the valve assembly based on the moment corresponding to the abnormal target electric signal and the switching time sequence of the target control valve.
  8. 8. The sample analyzer of claim 7, wherein the controller determines whether there is an abnormality in the target electrical signal based on the characteristic signal, and if so, locates a malfunctioning control valve in the valve assembly based on a time corresponding to the abnormal target electrical signal and a timing at which the target control valve is switched, comprising: If the time corresponding to the abnormal target electric signal is the time corresponding to the time when the target control valve is switched, determining the target control valve which needs to be switched at the corresponding time in the target switching time as the control valve with the fault, and/or, And if the time corresponding to the abnormal target electric signal is not the time corresponding to the time when the target control valve is switched, determining the non-target control valve of which the opening and closing state of the valve assembly is not required to be switched in the target opening and closing time sequence as the control valve with the fault.
  9. 9. The sample analyzer of claim 7 or 8, wherein the controller determines whether there is an abnormality in the target electrical signal based on the characteristic signal, and if so, locates a malfunctioning control valve in the valve assembly based on a timing corresponding to the abnormal target electrical signal and a timing at which the target control valve is switched, comprising: Matching the target characteristic electrical signal curve with curves corresponding to the electrical signals at a plurality of moments to determine whether the target characteristic electrical signal curve and the curves corresponding to the electrical signals at the same moment are abnormal or not; if so, locating the failed control valve in the valve assembly according to the time when the abnormality occurs and the time sequence when the target control valve is switched.
  10. 10. The sample analysis device according to claim 1 or 2, further comprising a signal generation module for superimposing an alternating voltage signal of a preset waveform on a supply voltage of the supply module; The controller obtains a target electric signal of a time period corresponding to the target opening and closing time sequence of the valve assembly through the electric signal detection module, and comprises the steps of controlling the signal generation module to superimpose the alternating voltage signal with a preset waveform on the power supply voltage in the time period corresponding to the target opening and closing time sequence, and obtaining an alternating current signal caused by superimposing the alternating voltage signal with the preset waveform according to the current signal detected by the current signal detection module; the controller judges whether a control valve with a fault exists in the valve assembly according to the target electric signal, and the controller comprises the steps of calculating target inductance of the valve assembly according to the alternating voltage signal and the alternating current signal with preset waveforms, and judging whether the control valve with the fault exists in the valve assembly according to the target inductance.
  11. 11. The sample analyzer of claim 10, wherein the controller controls the signal generation module to alternately perform a first action and a second action within a period of time corresponding to the target opening and closing timing, the first action being to superimpose the alternating voltage of a preset waveform, the second action being to stop superimposing the alternating voltage of a preset waveform; the controller calculates the alternating current signal according to current signals respectively detected by the current signal detection module in the adjacent first action and the second action.
  12. 12. The sample analysis device of claim 10, wherein the controller to determine whether a malfunctioning control valve is present in the valve assembly based on the target inductance comprises: Acquiring a characteristic inductance corresponding to the target opening and closing time sequence of the valve assembly at least according to the target opening and closing time sequence of the valve assembly, wherein the characteristic inductance is used for representing the change condition of the inductance along with time when a control valve in the valve assembly normally switches an opening and closing state according to the target opening and closing time sequence; And judging whether the target inductance is abnormal or not according to the characteristic inductance so as to determine whether a control valve with a fault exists in the valve assembly, wherein the target inductance comprises inductances calculated at a plurality of moments in a time period corresponding to the target opening and closing time sequence of the valve assembly.
  13. 13. The sample analyzer of claim 9, wherein the controller obtains a characteristic inductance corresponding to the target opening and closing timing of the valve assembly based at least on the target opening and closing timing of the valve assembly, comprising determining a target control valve whose opening and closing state is to be switched in the valve assembly based on the target opening and closing timing of the valve assembly, and determining a characteristic inductance corresponding to the target opening and closing timing of the valve assembly based on the target opening and closing timing of the valve assembly and a characteristic quantity of each of the target control valves, wherein the characteristic quantity of the target control valve includes an inductance change amount of the target control valve due to the switching of the opening and closing state.
  14. 14. The sample analysis device of claim 12 or 13, wherein the characteristic inductance comprises a target characteristic inductance profile that varies over time.
  15. 15. The sample analysis device of any one of claims 12 to 14, wherein the controller determining whether the target inductance is abnormal based on the characteristic inductance to determine whether a malfunctioning control valve is present in the valve assembly comprises: Determining a target control valve of which the opening and closing states need to be switched in the valve assembly and a time sequence of each target control valve to be switched according to the target opening and closing time sequence of the valve assembly; and judging whether the target inductance is abnormal or not according to the characteristic inductance, and if so, positioning the control valve with the fault in the valve assembly based on the moment corresponding to the abnormal target inductance and the switching time sequence of the target control valve.
  16. 16. The sample analysis device of claim 15, wherein the controller determines whether there is a target inductance anomaly based on the characteristic inductance, and if so, locates a malfunctioning control valve in the valve assembly based on a time corresponding to the anomalous target inductance and a timing at which the target control valve is switched, comprising: If the time corresponding to the abnormal target inductance is the time corresponding to the time when the target control valve is switched, determining the target control valve which needs to be switched at the corresponding time in the target switching time as the control valve with the fault, and/or, And if the time corresponding to the abnormal target inductance is not the time corresponding to the time when the target control valve is switched, determining the non-target control valve of which the opening and closing state of the valve assembly is not required to be switched in the target opening and closing time sequence as the control valve with the fault.
  17. 17. The sample analysis device of claim 15 or 16, wherein the controller determines whether there is a target inductance abnormality based on the characteristic inductance, and if so, locates a malfunctioning control valve in the valve assembly based on a time corresponding to the abnormal target inductance and a timing at which the target control valve is switched, comprising: Matching the target characteristic inductance curve with curves corresponding to the target inductances at a plurality of moments to determine whether the target characteristic inductance curve and the curves are abnormal at the same moment; if so, locating the failed control valve in the valve assembly according to the time when the abnormality occurs and the time sequence when the target control valve is switched.
  18. 18. The sample analysis device of any one of claims 1 to 17, wherein the work instructions comprise at least one of test instructions, wash instructions, and maintenance instructions.
  19. 19. The sample analysis device according to claim 18, wherein in the case where the work order received by the controller is the test order, the controller controls the sample analysis function module to perform one or more functions required for sample detection according to the work order, including a function of performing suction and discharge of a sample, a function of performing measurement of a sample at a site of sample detection; In the case that the working instruction received by the controller is the cleaning instruction, the controller controls the sample analysis functional module to execute one or more functions required for sample detection according to the working instruction, including a function of executing cleaning; In the case that the work instruction received by the controller is the maintenance instruction, the controller controls the sample analysis function module to perform one or more functions required for sample detection according to the work instruction, including performing maintenance work on the sample analysis device.
  20. 20. The sample analyzer of any one of claims 1 to 17, wherein the controller is further configured to, upon receiving a self-test command, switch the open/close state of each control valve in the valve assembly according to a preset target open/close timing sequence in response to the self-test command, to traverse all the control valves in the valve assembly, and obtain, by the electrical signal detection module, a target electrical signal for a time period corresponding to the preset target open/close timing sequence, and determine whether a failed control valve exists in the valve assembly according to the target electrical signal.

Description

Sample analysis device and valve fault detection method thereof Technical Field The invention relates to the field of in-vitro diagnosis, in particular to a sample analysis device and a valve fault detection method of the sample analysis device. Background In vitro diagnosis (In Vitro Diagnosis, IVD) refers to a diagnostic method for determining disease or body function by detecting a human body sample (e.g., blood, body fluid, or tissue) outside the human body to obtain clinical diagnostic information. In an in vitro diagnostic device, the aspiration of fluids such as samples, reagents and washing fluids is often involved, and therefore the control of the fluid circuit components in the in vitro diagnostic device is involved, while one of the critical components in the fluid circuit components is a control valve (for example, a solenoid valve), the reliability of which directly affects the safety of the whole device, but in practical cases, failures caused by the inactivity and malfunction of the control valve occur. How to efficiently and conveniently detect the faults of a control valve in-vitro diagnostic equipment and even realize early warning in advance is a problem worthy of research. Disclosure of Invention In view of the above, the present invention provides a sample analysis device and a valve failure detection method for the sample analysis device, which will be described in detail below. According to a first aspect, in one embodiment there is provided a sample analysis device comprising a sample analysis function module, a power supply module, an electrical signal detection module, and a controller; The sample analysis functional module is used for executing one or more functions required by sample detection, and comprises at least a sample sucking component, a liquid path component, a sample bearing component and a valve component, wherein the sample sucking component is used for acquiring a sample, the liquid path component is connected with the sample sucking component, the sample bearing component is used for providing a place for sample detection, the valve component is connected with at least one of the sample sucking component, the liquid path component and the sample bearing component, the valve component comprises a control valve, the control valve has two opening and closing states, the opening and closing states comprise an opening state and a closing state, and the control valve can be controlled to be opened and closed by the controller to be switched between different opening and closing states; The power supply module is used for supplying power to a control valve of the valve assembly; the electric signal detection module is used for detecting an electric signal of the power supply module for supplying power to the control valve of the valve assembly; the controller is used for: Receiving a working instruction; Controlling the sample analysis functional module to execute one or more functions required for sample detection according to the working instruction so as to control a control valve in the valve assembly to switch an opening and closing state according to a target opening and closing time sequence; acquiring a target electric signal of a time period corresponding to the target opening and closing time sequence of the valve assembly through the electric signal detection module; and judging whether a control valve with a fault exists in the valve assembly according to the target electric signal. In one embodiment, the electrical signal detection module is configured to detect a total electrical signal of all control valves of the valve assembly, where the electrical signal detection module is a current signal detection module, and the total electrical signal is a total current. In one embodiment, the controller determines whether a failed control valve exists in the valve assembly according to the target electrical signal, including: Acquiring a characteristic signal corresponding to the target opening and closing time sequence of the valve assembly at least according to the target opening and closing time sequence of the valve assembly, wherein the characteristic signal is used for representing the change condition of an electric signal along with time when a control valve in the valve assembly normally switches an opening and closing state according to the target opening and closing time sequence; Judging whether the target electric signal is abnormal or not according to the characteristic signal so as to determine whether a control valve with a fault exists in the valve assembly, wherein the target electric signal comprises the electric signals detected by the electric signal detection module at a plurality of moments in a time period corresponding to the target opening and closing time sequence of the valve assembly. In one embodiment, the controller obtains a characteristic signal corresponding to the target opening and closing timing sequence of the valve assembly at