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CN-121979332-A - Intelligent temperature control system and control method for reaction disc of biochemical analyzer

CN121979332ACN 121979332 ACN121979332 ACN 121979332ACN-121979332-A

Abstract

The invention relates to an intelligent temperature control system of a reaction disk of a biochemical analyzer and a control method, wherein the system comprises a temperature sensing unit, an environment temperature sensor, a thermal disturbance detection module, an adjusting control module, a refrigerating and heating module and a main control module, wherein the temperature sensing unit is used for collecting multi-region real-time temperature distribution data of the reaction disk and providing accurate data sources for temperature control, the environment temperature sensor is used for monitoring the internal environment temperature change of the instrument and providing environment parameters for anti-interference compensation, the thermal disturbance detection module is used for establishing a temperature disturbance model added by a reagent and providing disturbance predicted values so as to improve the anti-interference capability, the adjusting control module is used for realizing double closed loop control logic and calculating basic control quantity and compensation control quantity to generate a total control instruction, and the refrigerating and heating module is used for responding to the control instruction and adjusting the temperature of the reaction disk through refrigerating/heating actions and is used for data overall, parameter management and control instruction issuing. The invention has the advantages of improving the temperature precision of the reaction disk, greatly improving the response speed, remarkably enhancing the anti-interference capability and remarkably improving the temperature uniformity.

Inventors

  • LIAO SHICHENG
  • Nong Chenxiao
  • LIU CHAO

Assignees

  • 桂林优利特医疗电子有限公司

Dates

Publication Date
20260505
Application Date
20260112

Claims (7)

  1. 1. An intelligent temperature control system for a reaction disk of a biochemical analyzer, which is characterized by comprising: the temperature sensing unit is used for collecting multi-region real-time temperature distribution data of the reaction disc (1) and providing a precise data source for temperature control; An ambient temperature sensor (2) for monitoring the internal ambient temperature change of the instrument, monitoring the ambient temperature change in real time and providing an ambient parameter for anti-interference compensation; The thermal disturbance detection module is used for establishing a temperature disturbance model added by the reagent, providing a disturbance predicted value and improving the anti-disturbance capacity; the adjusting control module realizes double closed-loop control logic, calculates basic control quantity and compensation control quantity, and generates a total control instruction; A cooling/heating module (5) for adjusting the temperature of the reaction disk (1) by a cooling/heating operation in response to a control command; the main control module (4) is responsible for data overall planning, parameter management and control instruction issuing.
  2. 2. The intelligent temperature control system of a reaction disc of a biochemical analyzer according to claim 1, wherein the temperature sensing unit comprises 4 high-precision PT1000 platinum resistance sensors, 1 sensor is positioned in the geometric center of the reaction disc (1), the other 3 sensors are uniformly and annularly arranged at the edge position of the reaction disc (1), and all sensor signals are transmitted to the main control module (4).
  3. 3. The intelligent temperature control system of a reaction disc of a biochemical analyzer according to claim 1, wherein the ambient temperature sensor (2) is installed at an air inlet of the instrument and transmits ambient temperature data to the main control module (4) in real time.
  4. 4. The intelligent temperature control system of the reaction disk of the biochemical analyzer according to claim 1, wherein the thermal disturbance detection module constructs a reagent addition time sequence database based on an internal memory of a main control module (4), obtains a temperature disturbance model through MATLAB analysis, determines the relation among the reagent injection amount, the initial temperature of the reagent and the temperature disturbance amplitude, and outputs a temperature disturbance predicted value to the main control module (4) according to a current reagent addition parameter calling model.
  5. 5. The intelligent temperature control system of a reaction disk of a biochemical analyzer according to claim 1, wherein the regulation control module adopts a double closed-loop control architecture, the inner loop is a PID controller, and the outer loop is a temperature drift prediction compensator.
  6. 6. The intelligent temperature control system of a reaction plate of a biochemical analyzer according to claim 1, wherein the refrigerating and heating module (5) is integrated on a heat conducting layer at the bottom of the reaction plate (1).
  7. 7. An intelligent temperature control method for a reaction disk of a biochemical analyzer, which is realized by using the intelligent temperature control system for the reaction disk of the biochemical analyzer according to any one of claims 1 to 6, and is characterized by comprising the following steps: The method comprises the steps that firstly, system parameter initialization is completed through a main control module (4), a temperature sensing unit is triggered to collect the center and edge temperature of a reaction disc (1), an ambient temperature sensor (2) collects the internal ambient temperature of an instrument, a thermal disturbance detection module calls a reagent time sequence database and a disturbance model to output predicted values, and initialized system parameters, multi-region real-time temperature data, ambient temperature data and reagent injection temperature disturbance predicted values of the reaction disc (1) are obtained; Step two, based on the initialized system parameters obtained in the step one, the multi-region real-time temperature data, the environment temperature data and the reagent injection temperature disturbance predicted value of the reaction disc (1), obtaining a total control instruction through double closed-loop control and superposition of an adjusting control module; Step three, heating/refrigerating according to the need through a refrigerating and heating module (5) based on the total control instruction obtained in the step two, and obtaining a constant temperature result of the reaction disc (1) +/-0.1 ℃; And step four, based on the temperature regulation result of the reaction disc (1) obtained in the step three, re-triggering the temperature sensing unit, the environment temperature sensor (2) and the thermal disturbance detection module to acquire data every 0.1 second through the main control module (4), and repeating the control quantity calculation in the step two and the temperature regulation execution in the step three to obtain a continuously updated control instruction so as to maintain the constant temperature state of the reaction disc (1).

Description

Intelligent temperature control system and control method for reaction disc of biochemical analyzer Technical Field The invention relates to the technical field of temperature control of medical instruments, in particular to an intelligent temperature control system and method for a reaction disk based on a multi-sensor unit data combination and prediction algorithm. Background The traditional temperature control system depends on a single PID algorithm, has low response speed and large overshoot, is difficult to adapt to the dynamic requirements of different reagent reactions on temperature, has obvious temperature difference between the edge and the center of the reaction disk, and causes insufficient stability of the traditional control system due to environmental temperature fluctuation and load change (such as reagent heat capacity difference), thereby influencing the consistency of detection results. Disclosure of Invention In summary, in order to overcome the defects of the prior art, the technical problem to be solved by the invention is to provide an intelligent temperature control system and a control method for a reaction disk of a biochemical analyzer, wherein the system comprises a temperature sensing unit, an ambient temperature sensor, a thermal disturbance detection module, an adjustment control module, a refrigeration heating module and a main control module. The system fuses the multi-region real-time temperature data of the reaction disc, the reagent adding heating disturbance model and the environmental temperature fluctuation parameter, constructs a dynamic temperature control compensation algorithm, and the intelligent compensation layer predicts the temperature drift trend according to the heat load change rate and the environmental interference and outputs a compensation instruction in advance, so that the constant temperature precision of +/-0.1 ℃ of the whole temperature of the reaction disc is realized. Solves the problems of temperature overshoot and instability caused by reagent addition, mechanical movement and environmental fluctuation of the traditional temperature control system, and improves the accuracy of biochemical detection results. The technical scheme for solving the technical problems is as follows, the intelligent temperature control system of the reaction disk of the biochemical analyzer comprises: The temperature sensing unit is used for collecting multi-region real-time temperature distribution data of the reaction disc and providing an accurate data source for temperature control; The environment temperature sensor monitors the internal environment temperature change of the instrument, monitors the environment temperature change in real time and provides environment parameters for anti-interference compensation; The thermal disturbance detection module is used for establishing a temperature disturbance model added by the reagent, providing a disturbance predicted value and improving the anti-disturbance capacity; the adjusting control module realizes double closed-loop control logic, calculates basic control quantity and compensation control quantity, and generates a total control instruction; a cooling/heating module for adjusting the temperature of the reaction plate through cooling/heating actions in response to the control command; The main control module is responsible for data overall planning, parameter management and control instruction issuing. Based on the technical scheme, the invention can be further improved as follows: Further, the temperature sensing unit comprises 4 high-precision PT1000 platinum resistance sensors, wherein 1 sensor is located in the geometric center of the reaction disc, and the other 3 sensors are uniformly and annularly arranged at the edge of the reaction disc, and all sensor signals are transmitted to the main control module. Further, the ambient temperature sensor is installed at the air inlet of the instrument and transmits ambient temperature data to the main control module in real time. Further, the thermal disturbance detection module constructs a reagent addition time sequence database based on a memory in the main control module, obtains a temperature disturbance model through MATLAB analysis, determines the relation between the reagent injection quantity, the initial reagent temperature and the temperature disturbance amplitude, and outputs a temperature disturbance predicted value to the main control module according to the current reagent addition parameter calling model. Furthermore, the regulation control module adopts a double closed-loop control architecture, the inner loop is a PID controller, and the outer loop is a temperature drift prediction compensator. Further, the refrigerating and heating module is integrated on the heat conduction layer at the bottom of the reaction plate. The intelligent temperature control method for the reaction disc of the biochemical analyzer is realized by using the intelligent