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CN-121983232-A - CRRT dose real-time calibration method based on individual gain mapping

CN121983232ACN 121983232 ACN121983232 ACN 121983232ACN-121983232-A

Abstract

A CRRT dose real-time calibration method based on individual gain mapping comprises the steps of obtaining individual parameters of a patient and constructing a relation curve of prescription dose deviation and compensation force based on the individual parameters of the patient. A dose deviation trend set of the prescribed dose deviation within a preset time window is constructed. And calculating the compensation intensity parameter based on the relation curve of the prescription dose deviation and the compensation intensity and the dose deviation trend set. And calling the compensation intensity parameter in a preset time window, and updating the pump speed of the dialysate and the replacement liquid so as to increase or decrease the flow rates of the dialysate and the replacement liquid and obtain the pump speed running state. The pump speed operating state is monitored within the current time window, and the dialysate and replacement fluid pump speeds are updated when the prescribed dose deviation exceeds a set threshold. The method enables the compensation force and the deviation to be in a strict linear relation, and the compensation force has time stability by combining a deviation trend set, so that the pump speed is prevented from being changed frequently due to short-time level fluctuation.

Inventors

  • LI GANG

Assignees

  • 广州骅骝医疗科技有限公司

Dates

Publication Date
20260505
Application Date
20260122

Claims (10)

  1. 1. A method for real-time calibration of CRRT dose based on individual gain mapping, the method comprising: acquiring individual patient parameters, and constructing a relationship curve of prescription dose deviation and compensation force based on the individual patient parameters; constructing a dose deviation trend set of the prescription dose deviation in a preset time window; calculating a compensation intensity parameter based on the relation curve of the prescription dose deviation and the compensation intensity and the dose deviation trend set; Invoking the compensation intensity parameter in a preset time window, and updating the pump speed of the dialysate and the replacement liquid so as to increase or decrease the flow rates of the dialysate and the replacement liquid and obtain a pump speed running state; and monitoring the pump speed running state in the current time window, and updating the pump speeds of the dialysate and the replacement fluid when the deviation of the prescription dosage exceeds a set threshold.
  2. 2. The method for real-time calibration of CRRT dose based on individual gain mapping according to claim 1, wherein said obtaining patient individual parameters and constructing a prescribed dose deviation versus compensation force curve based on said patient individual parameters comprises: obtaining individual parameters of a patient, wherein the individual parameters of the patient are the weight of the patient, the hematocrit, the blood pump flow and the pre-dilution replacement fluid flow; determining a prescribed dose per unit weight, a blood dilution ratio, and a mixing ratio of blood to replacement fluid based on the patient weight, hematocrit, blood pump flow, and pre-dilution replacement fluid flow; and calculating a blood correction factor for quantifying the compensation force according to the body weight prescription dose, the blood dilution ratio and the mixing ratio of the blood and the replacement fluid.
  3. 3. The method for real-time calibration of CRRT dose based on individual gain mapping according to claim 2, wherein said obtaining patient individual parameters and constructing a prescribed dose deviation versus compensation force curve based on said patient individual parameters further comprises: obtaining the flow of the post-dilution replacement liquid, the flow of the dialyzate and the ultrafiltration flow, and calculating the real-time prescription dosage based on the blood correction factors, the individual parameters of the patient and the flow of the dilution replacement liquid, the flow of the dialyzate and the ultrafiltration flow; Calculating the prescription dose deviation of the real-time prescription dose and the target prescription dose in a plurality of preset time windows, and combining the blood correction factors to construct a relation curve.
  4. 4. The method of claim 1, wherein said constructing a dose deviation trend set for said prescribed dose deviation within a predetermined time window comprises: obtaining prescription dose deviations in a plurality of preset time windows according to the same time interval, and constructing a prescription dose deviation sequence based on the prescription dose deviations in the preset time windows so as to calculate deviation persistence proportion according to the prescription dose deviation sequence; And extracting non-zero dose deviation from the prescription dose deviation sequence, and correcting the non-zero dose deviation to perform direction consistency analysis on the deviation persistence proportion so as to obtain a deviation direction consistency analysis result.
  5. 5. The method of claim 4, wherein said constructing a dose deviation trend set for said prescribed dose deviation within a predetermined time window further comprises: When the deviation direction consistency analysis result is larger than zero, performing deviation amplitude trend analysis on the prescription dose deviation sequence to determine maximum deviation and minimum deviation in each preset time window, and outputting deviation amplitude change indexes based on the maximum deviation and the minimum deviation; and constructing the dose deviation trend set based on the deviation amplitude change index, the deviation persistence proportion and the deviation direction consistency analysis result.
  6. 6. The method of claim 5, wherein calculating the compensation intensity parameter based on the prescribed dose deviation versus compensation force relationship curve and the dose deviation trend set comprises: calculating a prescription dose deviation mean value of the prescription dose deviation sequence, and calculating a deviation intensity index according to the prescription dose deviation mean value, the deviation persistence proportion and the deviation direction consistency analysis result; based on the patient individual parameter and the deviation intensity index, determining patient individual proportional gain, and calculating primary compensation intensity by combining the deviation amplitude variation index; And calculating the compensation intensity parameter according to the primary compensation intensity and deviation direction consistency analysis result, wherein the compensation intensity parameter is the product of the primary compensation intensity and the deviation direction consistency analysis result.
  7. 7. The method for real-time calibration of CRRT dose based on individual gain mapping according to claim 1, wherein said invoking the compensation intensity parameter within a preset time window, updating the dialysate and replacement fluid pump speeds to increase or decrease the flow rates of the dialysate and replacement fluid, and obtaining the pump speed running state comprises: acquiring the current pump speed through a pump speed sensor, and converting the compensation intensity parameter into a pump speed variation, so as to adjust the current pump speed according to the pump speed variation, thereby obtaining updated pump speed; determining an operation baseline of the pump speed of the dialysate and the replacement fluid in response to the updated pump speed, and triggering a bottom layer control CPU to initialize the operation baseline so as to generate an initialization zone bit; And packaging the updated pump speed and the initialization zone bit into a flow rate updating result packet.
  8. 8. The method of claim 7, wherein monitoring the pump speed operating state during the current time window and updating the dialysate and replacement fluid pump speeds when the prescribed dose deviation exceeds a set threshold comprises: Monitoring the pump speed running state based on the flow rate updating result packet to obtain a current prescription dose in a current time window, and calculating a current prescription dose deviation of the current prescription dose and a target prescription dose; Writing the current prescription dose deviation into the dose deviation trend set to determine a deviation convergence index in a current time window, and updating the pump speed running state according to the deviation convergence index.
  9. 9. A terminal comprises a processor and a storage medium, and is characterized in that: The storage medium is used for storing instructions; The processor being operative according to the instructions to perform the steps of the method according to any one of claims 1-8.
  10. 10. A computer readable storage medium, on which a computer program is stored, characterized in that the program, when being executed by a processor, implements the steps of the method according to any one of claims 1-8.

Description

CRRT dose real-time calibration method based on individual gain mapping Technical Field The application relates to the technical field of medical assistance, in particular to a CRRT dose real-time calibration method based on individual gain mapping. Background Currently, the existing Continuous Renal Replacement Therapy (CRRT) equipment still has the following technical drawbacks in terms of dose control: (1) The small dose deviation cannot be identified and responded in real time. Most of the prior art is based on a "deviation threshold triggering" approach, in which compensation is only performed when the dose deviation exceeds a set range, and accumulated deviations below the threshold cannot be handled in time, resulting in a tendency of continuous accumulation after the dose deviates from the prescribed value. For example, when the set dose is 30 mL/kg/h, a brief alarm or filter resistance rise causes the actual dose to drop to 28.8 mL/kg/h, the deviation is only 1.2 mL/kg/h, this deviation does not exceed the + -3 mL/kg/h threshold set by conventional systems, so the device does not trigger compensation. After 2 hours of treatment, the cumulative dose may lag by more than 2.4L and may not return to the prescribed dose level. (2) The dose calculation has nonlinear effect, and the prior art cannot stably compensate. The CRRT dose is subjected to the combined action of blood pump flow, hematocrit, pre-dilution ratio, post-dilution ratio, dialysate and ultrafiltration flow, and particularly the pre-dilution part is subjected to dilution correction factor treatment, so that the dose is obviously nonlinear. In the prior art, the flow rate is used for approximately replacing the dosage, and a proper compensation channel cannot be selected according to nonlinear influence. For example, in a patient with 45% hematocrit, the true dose boost is less than 70 mL/h at a 100 mL/h increase in pre-dilution flow, while in a patient with 20% hematocrit, the same pre-dilution increase can be more than 120 mL/h. The existing equipment adopts unified compensation logic, so that the compensation amplitude is too small or too large, and the dosage is difficult to stably return to the prescription. Disclosure of Invention The application provides a CRRT dose real-time calibration method based on individual gain mapping, which is used for solving the technical problem that the dose is difficult to stably return to a prescription due to too small or too large compensation amplitude in the prior art. The invention adopts the following technical scheme. The invention discloses a CRRT dose real-time calibration method based on individual gain mapping, which comprises the following steps: acquiring individual patient parameters, and constructing a relationship curve of prescription dose deviation and compensation force based on the individual patient parameters; constructing a dose deviation trend set of the prescription dose deviation in a preset time window; calculating a compensation intensity parameter based on the relation curve of the prescription dose deviation and the compensation intensity and the dose deviation trend set; Invoking the compensation intensity parameter in a preset time window, and updating the pump speed of the dialysate and the replacement liquid so as to increase or decrease the flow rates of the dialysate and the replacement liquid and obtain a pump speed running state; and monitoring the pump speed running state in the current time window, and updating the pump speeds of the dialysate and the replacement fluid when the deviation of the prescription dosage exceeds a set threshold. Further, the obtaining the patient individual parameter and constructing a relationship curve of the prescription dose deviation and the compensation force based on the patient individual parameter includes: obtaining individual parameters of a patient, wherein the individual parameters of the patient are the weight of the patient, the hematocrit, the blood pump flow and the pre-dilution replacement fluid flow; determining a prescribed dose per unit weight, a blood dilution ratio, and a mixing ratio of blood to replacement fluid based on the patient weight, hematocrit, blood pump flow, and pre-dilution replacement fluid flow; and calculating a blood correction factor for quantifying the compensation force according to the body weight prescription dose, the blood dilution ratio and the mixing ratio of the blood and the replacement fluid. Further, the obtaining the patient individual parameter, and constructing a relationship curve of the prescription dose deviation and the compensation force based on the patient individual parameter, further includes: obtaining the flow of the post-dilution replacement liquid, the flow of the dialyzate and the ultrafiltration flow, and calculating the real-time prescription dosage based on the blood correction factors, the individual parameters of the patient and the flow of the dilution replace