CN-121983316-A - Intelligent nutritional state assessment method based on leukemia infant chemotherapy stage

CN121983316ACN 121983316 ACN121983316 ACN 121983316ACN-121983316-A

Abstract

The invention relates to the technical field of health assessment, in particular to an intelligent assessment method based on nutritional status of leukemia children patients in chemotherapy. The method comprises the steps of obtaining daily weight, muscle mass, fat mass and nutrition intake of an infant in a chemotherapy period, determining an absorption capacity coefficient based on the nutrition intake and the change of the weight, determining a reserve capacity coefficient for converting nutrition intake in the period into effective reserve based on the change of the muscle mass and the change of the fat mass in adjacent days in the period, determining a nutrition state index by combining the absorption capacity coefficient and the reserve capacity coefficient, further determining a nutrition evaluation coefficient according to nutrition state indexes in all periods in the chemotherapy period before the current moment, and performing risk analysis based on the nutrition evaluation coefficient. The invention can evaluate the nutrition state of the infant in the chemotherapy period more comprehensively and reliably, and improves the accuracy of nutrition state evaluation.

Inventors

ZHANG JIAN
HAO LI
ZHAO LEIFENG
GAO PAN

Assignees

西北妇女儿童医院

Dates

Publication Date: 20260505
Application Date: 20260306

Claims (10)

1. An intelligent assessment method based on nutritional status of a leukemia child patient in a chemotherapy stage is characterized by comprising the following steps: Determining the degree of fluctuation of the body weight of the infant in each period according to the daily weight change, wherein each period comprises at least two days; Determining the consistency degree of the daily nutrition intake and the weight of the period according to the change trend and the change similar state of the daily nutrition intake and the weight of the period, and determining the absorption capacity coefficient of the period to the nutrition according to the consistency degree and the weight fluctuation degree; Determining a nutrient state index of the time period by combining the absorption capacity coefficient and the reserve capacity coefficient of the time period; And determining a nutrition evaluation coefficient according to nutrition state indexes of all the periods of the chemotherapy period before the current moment, and carrying out risk analysis based on the nutrition evaluation coefficient.
2. The intelligent assessment method based on the nutritional status of the leukemia-affected infant during the chemotherapy according to claim 1, wherein the determining the fluctuation degree of the body weight per time period according to the daily body weight change comprises: The standard deviation of body weight was calculated for all days during the period, and normalized as the degree of body weight fluctuation.
3. The intelligent assessment method based on the nutritional status of leukemia-affected infants during chemotherapy according to claim 1, wherein the combination period of daily nutritional intake and change trend and change similarity status of body weight, determining the consistency degree of period nutritional intake and body weight, comprises: Arranging the nutritional intake of all days in the period into an intake sequence according to time sequence, and arranging the weight of all days in the period into a weight sequence according to time sequence; Respectively using a least square method to carry out straight line fitting on the intake sequence and the weight sequence to obtain corresponding fitting straight line slope, taking the absolute value of the difference value of the fitting straight line slope of the intake sequence and the weight sequence, and taking the opposite number normalization processing of the absolute value of the difference value as a change trend consistency coefficient; Calculating the DTW values of the ingestion sequence and the weight sequence based on a dynamic time warping algorithm, and taking the inverse normalization processing of the DTW values as a change similarity consistency coefficient; and calculating the product value of the change trend consistency coefficient and the change similarity consistency coefficient, and normalizing to obtain the consistency degree.
4. The intelligent assessment method based on the nutritional status of leukemia-affected children in the chemotherapy stage according to claim 1, wherein the determining the absorption capacity coefficient of the period to the nutrition based on the combination of the consistency degree and the body weight fluctuation degree comprises the following steps: The difference between the degree of consistency and the degree of fluctuation of body weight was calculated, and the normalization treatment was used as the absorption capacity coefficient.
5. The intelligent assessment method based on the nutritional status of the infant with leukemia according to claim 1, wherein the determining the reserve capacity coefficient of the nutritional intake of the period to be converted into the effective reserve according to the muscle mass change and the fat mass change of the adjacent days in the period comprises: calculating the difference value of the muscle mass of the last day and the previous day in two adjacent days in the time period, and taking the difference value as a muscle difference index of the corresponding adjacent days; calculating the difference value of the fat mass of the next day and the previous day in two adjacent days in the time period, and taking the difference value as a fat difference index of the corresponding adjacent days; And determining the reserve capacity coefficient of the effective reserve converted from the nutritional intake in the period according to the values of the muscle difference index and the fat difference index.
6. The intelligent assessment method for nutritional status of a leukemia-based infant during chemotherapy according to claim 5, wherein determining the reserve capacity coefficient of the period of time for converting nutritional intake into effective reserve based on the values of the muscle difference index and the fat difference index comprises: the number of adjacent days with the simultaneous occurrence of the muscle difference index and the fat difference index being greater than 0 is used as the coincidence number, and the ratio of the coincidence number to the number of adjacent days in the period is calculated and used as the coincidence weight; normalizing the sum of all the muscle difference indexes to obtain a muscle growth coefficient, normalizing the sum of all the fat difference indexes to obtain a fat growth coefficient, and calculating the average value of the muscle growth coefficient and the fat growth coefficient to obtain a growth weight; And calculating the product value of the coincidence weight and the increment weight as a reserve capacity coefficient.
7. The intelligent assessment method based on the nutritional status of the leukemia infant during the chemotherapy according to claim 1, wherein the combination of the absorption capacity coefficient and the reserve capacity coefficient of the period of time, the determination of the nutritional status index of the period of time comprises: and calculating the product of the absorption capacity coefficient and the reserve capacity coefficient, and taking normalization treatment as a nutrition state index.
8. The intelligent assessment method for nutritional status of a leukemia-based infant during a chemotherapy period according to claim 1, wherein the determining the nutritional assessment coefficient according to the nutritional status index of all periods during the chemotherapy period before the current time comprises: arranging nutritional state indexes of all time periods in a chemotherapy period into a state sequence according to time sequence; taking a period in which continuously adjacent nutrition state indexes in the state sequence are larger than a preset state threshold value as a state improvement period; And determining a nutrition evaluation coefficient according to the duration time duty ratio of the state improvement period in all the periods and the nutrition state indexes of the preset target number of periods which are nearest to the current moment.
9. The intelligent assessment method for nutritional status of a leukemia-based infant during chemotherapy according to claim 8, wherein the preset target number is 4, and determining the nutritional assessment coefficient according to the duration ratio of the status improvement period in all periods and the nutritional status index of the preset target number of periods closest to the current time comprises: Taking 4 time periods closest to the current time as reference time periods of the current time, and calculating the average value of all nutrition state indexes in the reference time periods as a reference evaluation coefficient; Taking the duration ratio of the state improvement period in all periods as an improvement evaluation coefficient; and calculating a product value of the reference evaluation coefficient and the improvement evaluation coefficient, and normalizing the product value to obtain a nutrition evaluation coefficient.
10. The intelligent assessment method based on the nutritional status of the leukemia-affected infant in the chemotherapy stage according to claim 1, wherein the risk analysis based on the nutritional assessment coefficient comprises: and when the nutrition evaluation coefficient is smaller than a preset evaluation threshold value, carrying out nutrition risk early warning.

Description

Intelligent nutritional state assessment method based on leukemia infant chemotherapy stage Technical Field The invention relates to the technical field of health assessment, in particular to an intelligent assessment method based on nutritional status of leukemia children patients in chemotherapy. Background Leukemia is the most common childhood malignancy, a malignant clonal disorder of hematopoietic stem cells. Chemotherapy is a common method for clinical treatment of leukemia at the present stage, and can prolong the survival period of the infant to benefit the infant through active treatment, but the chemotherapy can inhibit proliferation and differentiation of normal cells while killing tumor cells, damage intestinal mucosa (such as intestinal epithelial cell shedding), cause the reduction of the absorption efficiency of nutrients (especially protein, fat and vitamins), and if not evaluated and interfered in time, the nutrition can be rapidly developed into malnutrition, which is manifested by weight dip, muscle atrophy, low immunity and the like, and directly affects the treatment tolerance. The prior art generally reflects the nutritional status of the infant through the BMI, which can indirectly reflect the overall reserve and development of body tissues (muscles, fat, bones and the like) through the association of weight and height. However, the patients with leukemia may have severe fluctuation of body weight, particularly weight loss, during chemotherapy, which does not fully reflect their nutritional status. Because chemotherapy drugs may cause loss of appetite, nausea, vomiting, diarrhea, etc. in children, they directly affect the food intake and digestive absorption capacity of children. Therefore, simply relying on a single element to evaluate the nutritional status reduces the accuracy of nutritional status assessment for the infant with leukemia at the chemotherapy stage. Disclosure of Invention In order to solve the technical problem that the accuracy of nutritional state assessment of a leukemia infant in a chemotherapy stage can be reduced by simply assessing the nutritional state by means of a single element in the related art, the invention provides an intelligent nutritional state assessment method based on the leukemia infant in the chemotherapy stage, which adopts the following technical scheme: The invention provides an intelligent assessment method based on nutritional status of leukemia children patients in chemotherapy stage, which comprises the following steps: Determining the degree of fluctuation of the body weight of the infant in each period according to the daily weight change, wherein each period comprises at least two days; Determining the consistency degree of the daily nutrition intake and the weight of the period according to the change trend and the change similar state of the daily nutrition intake and the weight of the period, and determining the absorption capacity coefficient of the period to the nutrition according to the consistency degree and the weight fluctuation degree; Determining a nutrient state index of the time period by combining the absorption capacity coefficient and the reserve capacity coefficient of the time period; And determining a nutrition evaluation coefficient according to nutrition state indexes of all the periods of the chemotherapy period before the current moment, and carrying out risk analysis based on the nutrition evaluation coefficient. Further, the determining the fluctuation degree of the weight per time period according to the daily weight change comprises the following steps: The standard deviation of body weight was calculated for all days during the period, and normalized as the degree of body weight fluctuation. Further, the combination period of time, the daily nutrient intake and the change trend and change similarity state of the body weight, the determination of the consistency degree of the period of time, the nutrient intake and the body weight, comprises: Arranging the nutritional intake of all days in the period into an intake sequence according to time sequence, and arranging the weight of all days in the period into a weight sequence according to time sequence; Respectively using a least square method to carry out straight line fitting on the intake sequence and the weight sequence to obtain corresponding fitting straight line slope, taking the absolute value of the difference value of the fitting straight line slope of the intake sequence and the weight sequence, and taking the opposite number normalization processing of the absolute value of the difference value as a change trend consistency coefficient; Calculating the DTW values of the ingestion sequence and the weight sequence based on a dynamic time warping algorithm, and taking the inverse normalization processing of the DTW values as a change similarity consistency coefficient; and calculating the product value of the change trend consistency coefficient an