CN-121985908-A - Intravascular plasma index determination system

Abstract

An intravascular plasma index measurement system includes a1 st irradiation unit that irradiates 1 st light onto a living body, a1 st light receiving unit that receives the 1 st light irradiated by the 1 st irradiation unit and transmitted through or reflected by the living body, a1 st calculation unit that calculates a measurement value C related to an amplitude of the 1 st light for a period T 1 seconds longer than a cardiac cycle of the living body from the 1 st light received by the 1 st light receiving unit, a2 nd calculation unit that calculates an average value C AV related to an amplitude of the 1 st light for a period T 2 seconds longer than the T 1 seconds from the 1 st light received by the 1 st light receiving unit, and a 3 rd calculation unit that calculates an intravascular index M related to plasma in the living body from the measurement value C calculated by the 1 st calculation unit and the average value C AV calculated by the 2 nd calculation unit.

Inventors

• MORIO KOICHI
• JIANG DAOCONG

Assignees

• 西格玛光机株式会社

Dates

Publication Date

20260505

Application Date

20231226

Claims (20)

1. 1. An intravascular plasma index determination system, characterized in that, The intravascular plasma index measurement system comprises: A 1 st irradiation unit that irradiates a 1 st light to a living body; A1 st light receiving unit that receives the 1 st light irradiated by the 1 st irradiation unit and transmitted through or reflected by the living body; A1 st calculation unit that calculates a measurement value C related to the amplitude of the 1 st light for T 1 seconds, which is longer than the cardiac cycle of the living body, from the 1 st light received by the 1 st light receiving unit; A2 nd calculation unit for calculating an average value C AV related to the amplitude of the 1 st light of T 2 seconds longer than the T 1 seconds from the 1 st light received by the 1 st light receiving unit, and And a 3 rd calculating unit that calculates an intravascular plasma index M related to the intravascular plasma of the living body based on the measured value C calculated by the 1 st calculating unit and the average value C AV calculated by the 2 nd calculating unit.
2. 2. The intravascular plasma index determination system according to claim 1, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formula (1), , Wherein K, L, n is a constant.
3. 3. The intravascular plasma index determination system according to claim 1, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formula (2), , Where f (x) is a function of differentiating f (x) with x when x is equal to or greater than a constant g, and a differential value obtained by differentiating f (x) with x is smaller than a differential value when x is smaller than a constant g.
4. 4. The intravascular plasma index determination system according to claim 1, wherein, The 1 st calculation means extracts an ac value a 1 indicating the amplitude of the 1 st light and a dc value D 1 based on the intensity of the 1 st light from the 1 st light received by the 1 st light receiving means, and calculates the measurement value C from the extracted ac value a 1 and dc value D 1 .
5. 5. The intravascular plasma index determination system according to claim 4, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formula (3), , Wherein K, L, n is a constant, c=a 1 /D 1 .
6. 6. The intravascular plasma index determination system according to claim 4, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formula (4), , Where f (x) is a function in which a differential value obtained by differentiating f (x) with x when x is equal to or greater than a constant g is smaller than a differential value when x is smaller than a constant g, and c=a 1 /D 1 .
7. 7. An intravascular plasma index determination system, characterized in that, The intravascular plasma index measurement system comprises: A 1 st irradiation unit that irradiates a 1 st light to a living body; A1 st light receiving unit that receives the 1 st light irradiated by the 1 st irradiation unit and transmitted through or reflected by the living body; A 1 st calculation unit that extracts, from the 1 st light received by the 1 st light receiving unit, an alternating current value a 1 indicating the amplitude of the 1 st light and a direct current value D 1 based on the intensity of the 1 st light; a2 nd irradiation unit that irradiates the living body with 2 nd light, the 2 nd light having a wavelength shorter than the 1 st light and having a wavelength smaller than the 1 st light in absorption characteristic of water; A2 nd light receiving unit that receives the 2 nd light irradiated by the 2 nd irradiation unit and transmitted through or reflected by the living body; A2 nd calculation unit for extracting an AC value A 2 representing the amplitude of the 2 nd light and a DC value D 2 based on the intensity of the 2 nd light from the 2 nd light received by the 2 nd light receiving unit, and And A3 rd calculation unit that calculates an intravascular plasma index M related to the intravascular plasma of the living body from the ac value a 1 , the ac value a 2 , the dc value D 1 , and the dc value D 2 calculated by the 1 st calculation unit and the 2 nd calculation unit.
8. 8. The intravascular plasma index determination system according to claim 7, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formulas (5) and (6), , Wherein K, C AV , L, n are constants.
9. 9. The intravascular plasma index determination system according to claim 7, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formulas (7) and (8), , Wherein K, L, n is a constant and C AV is an average value of (A 1 /D 1 ）/（A 2 /D 2 ).
10. 10. The intravascular plasma index determination system according to claim 7, wherein, The 3 rd calculation unit calculates the intravascular plasma index M using the following formulas (9) and (10), , Where f (x) is a function in which a differential value obtained by differentiating f (x) with x when x is equal to or greater than a constant g is smaller than a differential value when x is smaller than a constant g, and C AV is an average value or a constant of (a 1 /D 1 ）/（A 2 /D 2 ).
11. 11. The intravascular plasma index determination system according to claim 1, wherein, The 1 st light has a wavelength in any range of 960nm to 1400 nm, 1440nm to 1460nm, 1930nm to 1950 nm.
12. 12. The intravascular plasma index determination system according to claim 7, wherein, The 1 st light has a wavelength in any range of 960nm to 1400 nm, 1440nm to 1460nm, 1930nm to 1950nm, The 2 nd light has a wavelength of 800nm or less.
13. 13. The intravascular plasma index determination system according to claim 1, wherein, The intravascular plasma index determination system also has any 1 or more of the following units: a display unit that displays the intravascular plasma index M calculated by the 3 rd calculation unit; A vibration unit that generates vibration according to the intravascular plasma index M calculated by the 3 rd calculation unit; a communication unit for communicating the intravascular plasma index M calculated by the 3 rd calculation unit to an external device, and And a sound unit that generates sound based on the intravascular plasma index M calculated by the 3 rd calculating unit.
14. 14. The intravascular plasma index determination system according to claim 1, wherein, The intravascular plasma index determination system further has: An acquisition unit that acquires temperature information related to temperature, and A determination unit that determines abnormality of the living body based on the temperature information acquired by the acquisition unit and the intravascular plasma index M calculated by the 3 rd calculation unit.
15. 15. The intravascular plasma index determination system according to claim 1, wherein, The intravascular plasma index determination system further has: An acquisition unit that acquires oxygen information related to blood oxygen saturation of the living body, and And a determination unit that determines abnormality of the living body based on the oxygen information acquired by the acquisition unit and the intravascular plasma index M calculated by the 3 rd calculation unit.
16. 16. The intravascular plasma index determination system according to claim 1, wherein, The 1 st light receiving unit receives 1 st external light different from the 1 st light, The 1 st calculation unit corrects the measurement value C based on the 1 st external light received by the 1 st light receiving unit.
17. 17. The intravascular plasma index determination system according to claim 7, wherein, The 1 st light receiving unit receives 1 st external light different from the 1 st light, The 1 st calculation unit corrects any 1 or more of the ac value a 1 and the dc value D 1 based on the 1 st external light received by the 1 st light receiving unit, The 2 nd light receiving unit receives 2 nd external light different from the 2 nd light, The 2 nd calculation unit corrects any 1 or more of the ac value a 2 and the dc value D 2 based on the 2 nd external light received by the 2 nd light receiving unit.
18. 18. The intravascular plasma index determination system according to claim 1, wherein, The intravascular plasma index determination system further has: an acquisition unit that acquires pulse information related to the pulse rate of the living body, and A determination unit that determines abnormality of the living body based on the pulse information acquired by the acquisition unit and the intravascular plasma index M calculated by the 3 rd calculation unit.
19. 19. The intravascular plasma index determination system according to claim 1, wherein, The intravascular plasma index determination system further has: an acquisition unit that acquires 1 or more of temperature information relating to temperature, oxygen information relating to blood oxygen saturation of the living body, and pulse information relating to pulse rate of the living body, and And a determination unit configured to determine a type of the moisture indicated to the living body based on the intravascular plasma index M calculated by the 3 rd calculation unit and 1 or more of the temperature information, the oxygen information, and the pulse information acquired by the acquisition unit.
20. 20. The intravascular plasma index determination system according to claim 8, wherein, The 3 rd calculation unit acquires attribute information related to the attribute of the living body, and sets the C AV based on the acquired attribute information.

Description

Intravascular plasma index determination system Technical Field The present invention relates to an intravascular plasma index measurement system capable of easily and accurately measuring the ratio of intravascular plasma to blood (hereinafter, referred to as the ratio of plasma) in a non-invasive manner, and calculating an intravascular plasma index, which is a criterion for dehydration symptoms, from the ratio of plasma. Background Conventionally, many accidents have occurred due to dehydration. The replenishment of moisture is essential for the maintenance of human life. In general, the replenishment of water is caused by insufficient water in blood plasma in blood vessels and as a main component thereof, and as a result, living organisms other than humans are caused to autonomously proceed according to subjective symptoms such as "thirst" associated with a decrease in water reaching the body through blood. However, when the living body is in a certain stress or excited state, the consciousness is weakened, and particularly, the possibility of dehydration accidents under the sun is high. Further, after the aging, the feeling of the insufficient water becomes dull, and an accident of changing from insufficient water to dehydration due to an autonomous action such as failure to make up water frequently occurs. When the water content in the blood vessel decreases, thrombus may be generated in the blood vessel, and serious symptoms may occur. It is considered that when water is lost by 2 to 3% or more of the weight (1.2 to 1.8 liters in the case of a person weighing 60 Kg), there is a life hazard. Therefore, for example, a device for detecting the amount of moisture in blood as shown in patent document 1 is required. Patent document 1 discloses a device for detecting a moisture content in blood, which removes noise of a low-frequency component due to a fluctuation associated with an activity of an autonomic nerve function or the like from a pulse wave detected by a pulse wave detecting unit, and calculates an index that changes depending on the moisture content in blood. Patent document 2 discloses a device for irradiating a living body with a plurality of wavelengths and measuring biological information capable of acquiring the moisture content of the skin or the like by using the transmitted or reflected light quantity. Prior art literature Patent literature Patent document 1 International publication No. WO2004/006769 Patent document 2 Japanese patent application laid-open No. 2019-130070 Disclosure of Invention Problems to be solved by the invention In general, the waveform of the pulse wave is greatly affected by weight and personal differences. In addition, when there is an arrhythmia or when the influence of a vibration during walking, which is generated at a rhythm substantially equal to that of a pulse wave, is detected as noise by the pulse wave detection unit, it is difficult to remove the noise. In particular, in patent document 1, since the detected pulse wave is differentiated on the time axis, there is a problem that the higher-order frequency component included in arrhythmia, walking, or the like is calculated to be a large value, the water content cannot be accurately calculated, and the tendency of dehydration symptoms cannot be detected. In patent document 2, detection of the amount of moisture that stops on the skin is not disclosed to suggest detection of the amount of plasma in the blood vessel. Since the moisture of the skin cannot improve the dehydration symptom, there is a problem that the dehydration symptom is not detected. The present invention has been made to solve the above-described problems, and an object of the present invention is to provide an intravascular plasma index measurement system capable of accurately detecting an intravascular plasma index as an indicator of insufficient water required in the body even when fluctuation of pulse waves is large due to influence of noise or the like caused by disturbance such as arrhythmia or walking, or when water content in cells such as skin is high due to perspiration or the like. Means for solving the problems The intravascular plasma index measurement system according to claim 1 is characterized by comprising 1 st irradiation means for irradiating a living body with 1 st light, 1 st light receiving means for receiving the 1 st light irradiated by the 1 st irradiation means and transmitted through or reflected by the living body, 1 st calculation means for calculating a measurement value C relating to the amplitude of the 1 st light for a period T 1 seconds longer than the cardiac cycle of the living body from the 1 st light received by the 1 st light receiving means, 2 nd calculation means for calculating an average value C AV relating to the amplitude of the 1 st light for a period T 2 seconds longer than the T 1 seconds from the 1 st light received by the 1 st light receiving means, and 3 rd calculation means for calculatin