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CN-121985972-A - Cannula with resilient cannula section and drug delivery device with cannula

CN121985972ACN 121985972 ACN121985972 ACN 121985972ACN-121985972-A

Abstract

The invention relates to a cannula (4), in particular an infusion cannula (4), for an administration device (32), in particular for an infusion pump (1), and to an administration device (32), wherein the cannula (4) comprises a container-side cannula end (6) and a recipient-side cannula end (7), at which a first cannula tip (8) is formed, wherein the cannula (4) comprises a central cannula section (9) and at least one adjacent, in particular adjoining, end-side cannula section, in particular a first end-side cannula section (10) adjacent to the recipient-side cannula end (7) and a second end-side cannula section (11) adjacent to the container-side cannula end (6), wherein the cannula (4), in particular the central cannula section (9), is elastically deformable, such that the cannula tip (8) can be displaced from an initial position (12) to a piercing position (13) and can be elastically restored with the central cannula section (9) elastically deformed and the first end-side cannula section (10) fixed or positionally fixed.

Inventors

  • Thomas. Bragania

Assignees

  • 特里彭索股份公司

Dates

Publication Date
20260505
Application Date
20241008
Priority Date
20231009

Claims (13)

  1. 1. Cannula (4) for an administration device (32), in particular an infusion pump (1), in particular an infusion cannula (4), comprising a container-side cannula end (6) and a recipient-side cannula end (7) at which a first cannula tip (8) is formed, wherein the cannula (4) comprises a central cannula section (9) and at least one adjacent end-side cannula section, in particular a first end-side cannula section (10) adjacent to the recipient-side cannula end (7) and a second end-side cannula section (11) adjacent to the container-side cannula end (6), characterized in that the cannula (4) is elastically deformable, in particular the central cannula section (9) is elastically deformable, such that the cannula tip (12) is elastically deformable and is displaceable from an initial cannula position (13) in the case the central cannula section (6) and the first end-side cannula section (10) is fixed or fixed.
  2. 2. Cannula (4) according to any of the preceding claims, characterized in that the central cannula section (9) has a higher bending strength and/or bending stiffness than the respective adjacent end side cannula sections (10, 11).
  3. 3. Cannula (4) according to any of the preceding claims, characterized in that the central cannula section (9) is reinforced, preferably the central cannula section (9) is provided with a sheath (18) and/or an increased material thickness, in particular the sheath is made of metal, further preferably the sheath (18) is fixed to the rest of the central cannula section (9) in a material-locking, force-fitting and/or form-fitting manner, in particular the sheath (18) is fixed to the rest of the central cannula section (9) with or without radial play.
  4. 4. Cannula (4) according to any of the preceding claims, characterized in that the cannula (4) comprises a sensing sheath, in particular a sensing coating, within the first end cannula section (10) near the cannula tip (8), wherein the sensing sheath is designed for subcutaneous measurement acquisition on the human body, preferably the sensing sheath is designed for subcutaneous measurement acquisition in the epidermis on the human body.
  5. 5. Cannula (4) according to any of the preceding claims, characterized in that the infusion cannula (4) comprises one or more deflection positions (23) between the container-side cannula end (6) and the recipient-side cannula end (7), in which deflection positions the infusion cannula (4) changes its direction along a longitudinal extension.
  6. 6. Cannula (4) according to any of the preceding claims, characterized in that the outer diameter of the respective cannula section is constant over the axial extension of the central cannula section (9) and/or over the axial extension of the first end side cannula section (10) and/or the second end side cannula section (11), and/or the inner diameter of the respective cannula section is constant over the axial extension of the central cannula section (9) and/or over the axial extension of the first end side cannula section (10) and/or the second end side cannula section (11), preferably the inner diameter is constant over the entire longitudinal extension of the infusion cannula (4).
  7. 7. Cannula (4) according to any of the preceding claims, characterized in that the cannula (4) can be fixed radially and/or axially by means of a fixed bearing (19) or in relation to the fixed bearing position, in particular the fixation is achieved via a central cannula section (9) of the cannula (4), wherein the central cannula section (9) preferably comprises a rigid partial section (20) which can be fixed by the fixed bearing (19) and/or a bendable partial section (21) extending adjacent thereto.
  8. 8. Cannula (4) according to claim 7, characterized in that the cannula (4) comprises at least one or exactly one deflection position (23) between the container-side cannula end (6) and the recipient-side cannula end (7), at which deflection position the cannula (4) changes its direction in longitudinal extension more than 70 °, preferably more than 80 °, further preferably more than or exactly 90 °, preferably the at least one or exactly one deflection position (23) is arranged adjacent or abutting the end of the central cannula section (9) and/or the bendable partial section (21) facing the recipient-side cannula end (7), and/or the at least one or exactly one deflection position (23) is followed by a straight penetration section ending at the first cannula tip (8).
  9. 9. Cannula (4) according to any of the preceding claims, characterized in that the ratio of the axial length of the entire central cannula section (9) to the axial length of the first end side cannula section (10) is at least 3, preferably at least 3.5, further preferably at least 4, and/or the ratio of the axial length of the bendable local section (21) to the axial length of the first end side cannula section (10) is at least 2.5, preferably at least 3, further preferably at least 3.5.
  10. 10. A drug delivery device (37), in particular an infusion pump (1), for administering a fluid, preferably subcutaneously, comprising a housing (27), a storage container (2) having a container interior for containing the fluid, and a cannula assembly (3), Wherein the housing (27) is formed of a plurality of parts and comprises a first housing part (22) and a second housing part (28), -Wherein the cannula assembly (3) comprises a cannula insertion mechanism (5) and a cannula (4) according to any of the preceding claims, in particular an infusion cannula (4), the cannula having a container-side cannula end (6) and a receiver-side cannula end (7) at which a cannula tip is formed, Wherein the infusion cannula (4) is fluidly coupleable to the container interior, in particular to the container interior, at a container-side cannula end (6) thereof, Wherein the cannula insertion mechanism (5) is operatively connected to the infusion cannula (4) such that upon actuation of the cannula insertion mechanism (5) the recipient-side cannula end (7) is displaceable from an initial position (12) to a puncturing position (13), in particular the recipient-side cannula end (7) is abruptly displaceable from the initial position (12) to the puncturing position (13), in particular by elastic bending of the infusion cannula (1) and/or pivoting of the recipient-side cannula end (7) such that the fluid is subcutaneously administrable via the cannula tip (8) by means of the drug delivery device (37) and by displacement of the infusion cannula (4) to the recipient-side cannula end (7) of the puncturing position (13), It is characterized in that the method comprises the steps of, The cannula assembly (3) is designed, in particular the infusion cannula (4) is mounted and designed, such that, in particular when the cannula tip (8) is inserted into the tissue of an infusion recipient (14), the infusion cannula (4) can automatically perform an elastic return movement, such that the recipient-side cannula end (7) can be displaced back from the puncture position (13) towards the initial position (12), preferably into the initial position (12).
  11. 11. The drug delivery device (37) according to claim 10, characterized in that the cannula insertion mechanism (5) of the cannula assembly (3) is designed to radially load the infusion cannula (4) upon actuation thereof, in particular at the central cannula section (9), and to cause an elastic bending of the infusion cannula (4) such that the recipient-side cannula end (7) can be displaced from an initial position (12) to a piercing position (13), in particular the recipient-side cannula end (7) is abruptly displaced from an initial position (12) to a piercing position (13).
  12. 12. Drug delivery device (37) according to claim 10 or 11, characterized in that the drug delivery device (37) and/or the storage container (2) comprises a fixed bearing (19) associated with the infusion cannula (4), preferably the infusion cannula (4) is radially and/or axially fixed to the fixed bearing (19), in particular the infusion cannula (4) is radially and/or axially fixed to the fixed bearing (19) via its central cannula section (9), further preferably the central cannula section (9) comprises a rigid local section (20) fixed by the fixed bearing (19), and/or a bendable local section (21) extending from the fixed bearing (19) towards the direction of the first end cannula section (10).
  13. 13. A drug delivery device (37), in particular an infusion pump (1) for administering a defined amount of a fluid, in particular an infusion solution, Wherein the infusion pump (1) comprises a storage container (2) having a container interior, in particular configured to contain the fluid at least in one section, Wherein the infusion pump (1) comprises a cannula assembly (3) and a cannula insertion mechanism (5), the cannula assembly (3) having an infusion cannula (4) according to any of claims 1 to 9, Wherein the infusion cannula (4) is fluidically or connectable to the storage container (2) or to a container interior of the storage container (2) via a container-side cannula end (6) and the infusion cannula (4) extends axially thereof from the container-side cannula end (6) to a recipient-side cannula end (7) at which a first cannula tip (8) is formed, -Wherein the infusion cannula (4) comprises a central cannula section (9) and at least one adjacent end-side cannula section, in particular at least one adjacent end-side cannula section, between the container-side cannula end (6) and the recipient-side cannula end (7), in particular a first end-side cannula section (10) adjacent to the recipient-side cannula end (7) and a second end-side cannula section (11) adjacent to the container-side cannula end (6), and Wherein the cannula insertion mechanism (5) is designed to radially load the infusion cannula (4) and cause an elastic bending of the infusion cannula (4) upon actuation thereof such that the recipient-side cannula end (7) is displaced from an initial position (12) to a puncturing position (13), in particular the recipient-side cannula end (7) is abruptly displaced from the initial position (12) to the puncturing position (13), It is characterized in that the method comprises the steps of, The central cannula section (9) has a higher bending strength and/or bending stiffness than the respective adjacent end cannula sections (10, 11).

Description

Cannula with resilient cannula section and drug delivery device with cannula The present invention relates to a cannula for a drug delivery device and a drug delivery device comprising a cannula according to the invention, in particular an infusion cannula, for subcutaneous and/or intravenous administration of a defined amount of a fluid, in particular an infusion solution, a liquid pharmaceutical solution or a therapeutic agent, and/or for subcutaneous and/or intravenous sampling and/or measurement by means of the cannula. In general, the drug delivery device may be understood as an infusion pump as a possible embodiment. Infusion pumps, also known as patch pumps, are the subject of the solutions proposed below, which can be worn fixedly on the body and deliver a certain amount of fluid, in particular an infusion solution, subcutaneously or intravenously into the human body, continuously or through a predetermined quantity-time curve over a certain period of time, to achieve the desired concentration, thereby achieving the corresponding effect in the human body. Such fluids (particularly infusion solutions) range from low to high viscosities, from simple low molecular weight substances with molecular sizes of a few daltons to high molecular weight substances with molecular sizes up to 1,000,000 daltons. From simple saline solutions to highly complex bioactive components such as peptides, proteins, monoclonal antibodies, various vaccines, analgesics, cancer therapeutics or nutritional solutions, the desired amounts can be delivered precisely and safely to the appropriate location in the human body by the drug delivery device. However, with such infusion pumps it is not only possible to administer immunological, prophylactic or prophylactically effective fluids or infusion solutions with the required accuracy and/or within the desired therapeutic and/or useful window, but also fluids of importance in the analysis as well as fluids containing nutrients or even combinations of all of the foregoing fluids. Drug delivery devices, particularly infusion pumps, have been known since the 70 s of the 20 th century, and are primarily used for the treatment of diabetes. These pumps typically deliver a fluid comprising water, auxiliary substances and peptide (hormone) insulin. Sometimes such infusion pumps also deliver other fluids. Over the years, with continued innovation, such infusion pumps delivering insulin-containing infusion solutions have been reduced in size from the hikers backpack to the most compact infusion pumps currently available (Omnipod by instret, akton, massachusetts, usa), in size 52 x 39 x 14 mm. During 1990 to 2015 pumps were typically used which were worn on a belt (or in a pocket or under clothing) and carried an infusion set (in short, this is a tube with a connector at one end for connecting an infusion pump and an infusion port at the other end, which port usually establishes a direct connection to the body of the infusion recipient), but for several years patients have been increasingly turning to particularly small, fixed or adhered to the skin drug delivery devices, so called patch pumps. Patch pumps are not only extremely compact and therefore generally unobtrusive, but in many cases have the advantage that an infusion set connected to the pump is no longer needed as an interface with the human body. The tube of the infusion set has the disadvantage that it may become entangled and in the worst case may be torn off, especially when the child is playing or exercising. In addition, the tubing may kink and thus build up pressure within the tubing and/or infusion pump that may suddenly release when the kink reopens. Furthermore, tubing may lead to errors in accurate infusion, because, for example, the difference in height potential between an infusion pump worn in the abdomen and an infusion port attached to the upper arm may create a back pressure, for example, up to a1 meter high column of fluid on a person of high height, equivalent to 10000 Pa, acting on the mechanical means of the infusion pump. If the infusion recipient now moves to a horizontal position, e.g. sleeps, the pressure created by the aforementioned fluid column disappears. These positional changes in turn lead to variations in the accuracy of application. In theoretical tests according to IEC 60601-2-24, such fluctuations in infusion rate accuracy are not taken into account, since only one static system is tested. Nevertheless, risk analysis regarding infusion set risk is often critical. Continuous and intimate monitoring of infusion pumps with infusion sets is essential, especially for young children. Patch pumps are provided either as a ready-to-use infusion pump (in addition to the filling operation) or as a kit of parts. After unpacking and, if necessary, assembly, the infusion pumps are filled. Filling is typically performed by means of a syringe, which typically transfers a portion of the contents of a vial containing