CN-121985980-A - System for personalized neural stimulation

CN121985980ACN 121985980 ACN121985980 ACN 121985980ACN-121985980-A

Abstract

A system for delivering neural stimulation to a patient may include a personalization circuit and a pattern optimization circuit. The personalization circuitry may include an evaluation input to receive patient-specific information generated by a patient survey, a calibration input configured to receive calibration information generated by a calibration, and a personalization processing circuit. The patient-specific information may include patient dimensions of the neural stimulation. The calibration information may include the patient's response to the neural stimulation. The personalization processing circuit may be configured to determine a personalized objective function using the patient dimensions and determine a personalized model having model states personalized for the patient's response to the neural stimulus. The pattern optimization circuit may be configured to determine an optimal neural stimulation pattern using the personalized objective function and the personalized model to program the stimulation device to deliver neural stimulation according to the optimal neural stimulation pattern.

Inventors

ZHANG TIANHE
Brandon Theo

Assignees

波士顿科学神经调制公司

Dates

Publication Date: 20260505
Application Date: 20240923
Priority Date: 20231009

Claims (15)

1. A system for delivering neural stimulation to a patient using a stimulation device, the system comprising: a personalization circuit, the personalization circuit comprising: An evaluation input configured to receive patient-specific information generated by a patient survey, the patient-specific information including one or more patient dimensions of the neural stimulation; A calibration input configured to receive calibration information generated by a calibration, the calibration information including a response of the patient to the neural stimulation, and A personalization processing circuit configured to determine a personalized objective function using the one or more patient dimensions and to determine a personalized model having model states personalized for a patient's response to the neural stimulus, and A pattern optimization circuit comprising an optimization processing circuit configured to determine one or more optimal neural stimulation patterns using the personalized objective function and the personalized model to program the stimulation device to deliver the neural stimulation in accordance with the one or more optimal neural stimulation patterns.
2. The system of claim 1, wherein the personalization processing circuit is configured to determine a personalization cost function as the personalization objective function, the personalization cost function being a quantitative measure of the condition of the patient expressed as a function of the one or more patient dimensions.
3. The system of any of the preceding claims, wherein the personalization processing circuit is configured to optimize the personalization model by minimizing a difference between a patient's response to the neural stimulus predicted using the simulation of the personalization model and a received patient's response to the neural stimulus.
4. The system of any preceding claim, wherein the personalization processing circuit is configured to select one or more optimal neural stimulation patterns from stored neural stimulation patterns.
5. The system of any preceding claim, wherein the personalization processing circuit is configured to determine the personalization model by selecting a model state from a stored predefined model state.
6. The system of any one of claims 1 to 4, wherein the personalization processing circuit is configured to determine the personalization model by adjusting parameters of a stored model.
7. The system of any one of the preceding claims, comprising an implantable stimulator as the stimulation device and an external system communicatively coupled to the implantable stimulator via telemetry, the external system comprising the personalization circuitry and the pattern optimization circuitry.
8. The system of claim 7, wherein the external system comprises an external programmer including the mode optimization circuit and a remote device communicatively coupled to the external programmer via a telecommunications network and including the personalization circuit.
9. The system of claim 7, wherein the external system comprises an external programmer comprising the personalization circuitry and the pattern optimization circuitry.
10. The system of any of claims 7 to 9, wherein the external system is configured to perform patient assessment, including conducting a patient survey to determine one or more patient dimensions of the neural stimulation.
11. The system of any of claims 7 to 10, wherein the external system is configured to perform a calibration to determine the patient's response to the neural stimulation by programming the implantable stimulator to deliver the neural stimulation to the patient and measuring one or more parameters representative of the patient's response.
12. The system of claim 11, wherein the external system is configured to generate one or more response curves, each response curve being a measured parameter of the measured one or more parameters plotted as a function of a stimulation parameter used by the implantable stimulator to control delivery of the neural stimulation.
13. A non-transitory computer-readable storage medium comprising instructions that, when executed by a system, cause the system to perform a method for delivering neural stimulation to a patient using a stimulation device, the method comprising: receiving patient-specific information generated by a patient survey, the patient-specific information including one or more patient dimensions of the neural stimulation; Receiving calibration information resulting from a calibration, the calibration information comprising a patient's response to the neural stimulation; Determining a personalized objective function using the received one or more patient dimensions; determining a personalized model having model states personalized for the patient's response to the neural stimulus; determining one or more optimal neural stimulation patterns using the personalized objective function and the personalized model, and Information is generated for programming the stimulation device to deliver the neural stimulation according to the one or more optimal neural stimulation patterns.
14. The non-transitory computer-readable storage medium of claim 13, wherein determining the personalized objective function comprises determining a personalized cost function that is a quantitative measure of the condition of the patient expressed as a function of the one or more patient dimensions.
15. The non-transitory computer-readable storage medium of any one of claims 13 and 14, further comprising optimizing the personalized model by matching a patient's response to the neural stimulus predicted using the simulation of the personalized model to a received patient's response to the neural stimulus.

Description

System for personalized neural stimulation Cross Reference to Related Applications The application claims the benefits of U.S. provisional application No. 63/543,133 and U.S. provisional application No. 63/543,137, both filed on 10/2023, which are incorporated herein by reference in their entirety. Technical Field This document relates generally to neurostimulation and, more particularly, to methods and systems for personalizing neurostimulation therapies for patients. Background Neural stimulation, also known as neuromodulation, has been proposed as a therapy for a number of conditions. Examples of neural stimulation include spinal cord stimulation (Spinal Cord Stimulation, SCS), deep brain stimulation (Deep Brain Stimulation, DBS), peripheral neural stimulation (PERIPHERAL NERVE Stimulation, PNS), and functional electrical stimulation (Functional Electrical Stimulation, FES). Implantable neurostimulation systems have been used to provide such therapies. The implantable neurostimulation system may include an implantable neurostimulator, also referred to as an implantable pulse generator (implantable pulse generator, IPG), and one or more implantable leads, each including one or more electrodes. Implantable neurostimulators deliver neurostimulation energy through one or more electrodes placed at or near a target site in the nervous system. An external programming device is used to program the implantable neurostimulator with stimulation parameters that control the delivery of neurostimulation energy. In one example, the neural stimulation energy is delivered to the patient in the form of electrical neural stimulation pulses. Stimulation parameters in terms of space (where to stimulate), time (when to stimulate), and information (pulse pattern that directs the nervous system to react as desired) specifying the neural stimulation pulse pattern are used to control delivery. When neural stimulation is delivered to a patient to treat a medical condition (e.g., pain), the stimulation parameters used by the neural stimulator need to be determined based on the ability and programmability of the neural stimulator, the patient's symptoms and preferences, and the patient's response to the neural stimulation, among other factors and considerations. Disclosure of Invention An example of a system for delivering neural stimulation to a patient using a stimulation device is provided ("example 1"). The system may include a personalization circuit and a pattern optimization circuit. The personalization circuitry may include an evaluation input, a calibration input, and a personalization processing circuit. The assessment input may be configured to receive patient-specific information generated by a patient survey. The patient-specific information may include one or more patient dimensions of the neural stimulation. The calibration input may be configured to receive calibration information generated by a calibration. The calibration information may include the patient's response to the neural stimulation. The personalization processing circuit may be configured to determine a personalized objective function using one or more patient dimensions and determine a personalized model having model states personalized for the patient's response to the neural stimulus. The pattern optimization circuit may include an optimization processing circuit configured to determine one or more optimal neural stimulation patterns using the personalized objective function and the personalized model to program the stimulation device to deliver neural stimulation in accordance with the one or more optimal neural stimulation patterns. In example 2, the subject matter of example 1 can optionally be configured such that the personalization processing circuit is configured to determine the personalization cost function as a personalization objective function. The personalized cost function is a quantitative measure of the condition of the patient expressed as a function of one or more patient dimensions. In example 3, the subject matter of example 2 can optionally be configured such that the personalization processing circuit is configured to optimize the personalization model by minimizing a difference between a patient's response to the neural stimulus predicted using the simulation of the personalization model and a received patient's response to the neural stimulus. In example 4, the subject matter of any one or any combination of examples 1-3 may optionally be configured such that the personalization processing circuitry is configured to select one or more optimal neural stimulation patterns from the stored neural stimulation patterns. In example 5, the subject matter of any one or any combination of examples 1-4 may optionally be configured such that the personalization processing circuit is configured to determine the personalization model by selecting a model state from among the stored predefined model states. In example 6, the subject matter o