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CN-121985991-A - Membrane module with oblique inflow

CN121985991ACN 121985991 ACN121985991 ACN 121985991ACN-121985991-A

Abstract

The invention relates to a membrane module (1) for treating blood (B), comprising at least one treatment space (3), an exchange membrane (5) with a plurality of semi-permeable hollow fibers (7), each hollow fiber extending through the treatment space (3) in a fiber longitudinal direction (RF 1, RF 2), a potting (21), wherein a first fiber end (17) and a second fiber end of the hollow fibers (7) of the exchange membrane (5) are fixed in the potting (21) and at least partially define the treatment space (3), wherein at least a first subset (37) of the hollow fibers is arranged in the treatment space (3) such that their fiber longitudinal directions (RF 1, RF 2) are inclined with respect to a main flow direction (RH). The invention also relates to a blood treatment system (200), two methods (300, 400) for manufacturing a membrane module (1), an assembly method and a method (500) for extracorporeal treatment of blood (B).

Inventors

  • Peter Schlanstein
  • Nicholas Stoyer
  • Matthias inside the door
  • Benedict Shopuf

Assignees

  • HBOX治疗有限公司

Dates

Publication Date
20260505
Application Date
20240823
Priority Date
20230823

Claims (20)

  1. 1. A membrane module (1) for treating blood (B), comprising: At least one treatment space (3) with at least one blood inlet (13) and at least one blood outlet (15) connected to each other in a main flow direction (RH) through the treatment space (3), An exchange membrane (5) having a plurality of hollow fibers (7), each extending through the treatment space (3) in a fiber longitudinal direction (RF 1, RF 2) and being configured to flow in the fiber longitudinal direction (RF 1, RF 2) through the treatment medium (M) from a first fiber end (17) to an opposite second fiber end (19), A potting (21), wherein the first fiber ends (17) and the second fiber ends (19) of the hollow fibers (7) of the exchange membrane (5) are fixed in the potting (21) and at least partially define the treatment space (3), It is characterized in that At least a first subset (37) of the plurality of hollow fibers (7) is arranged in the treatment space (3) such that its fiber longitudinal direction (RF 1, RF 2) is inclined with respect to the main flow direction (RH).
  2. 2. Membrane module (1) according to claim 1, wherein the treatment space (3) has a main cross section (QH, QH1, QH 2) perpendicular to the main flow direction (RH) in the main flow direction.
  3. 3. Membrane module (1) according to claim 1 or 2, wherein the treatment space (3) is rotationally asymmetric.
  4. 4. A membrane module (1) according to any one of claims 1 to 3, wherein the potting (21) has a first potting portion (24) and a second potting portion (26), wherein the first potting portion (24) constitutes a first side wall (23) of the treatment space (3) and the second potting portion (26) constitutes a second side wall (25) of the treatment space (3) opposite the first side wall (23), wherein the first side wall (23) and/or the second side wall (25) is concave.
  5. 5. Membrane module (1) according to claim 4, further comprising at least one cover plate (31) of the process space (3), wherein the cover plate (31) is at least partially transparent in at least some parts, and wherein the cover plate (31) is preferably substantially planar.
  6. 6. Membrane module (1) according to any one of claims 1 to 5, wherein the packing density of the hollow fibers (7) varies in the main flow direction (RH), wherein the packing density preferably increases in the main flow direction (RH) from the blood inlet (13) towards a central portion of the treatment space (3) and/or decreases from the central portion towards the blood outlet (15).
  7. 7. Membrane module (1) according to any one of claims 1 to 6, wherein the orientation of the hollow fibers (7) of the second subset (39) of hollow fibers of the plurality of hollow fibers (7) of the exchange membrane (5) is different from the orientation of the hollow fibers (7) of the first subset (37) of hollow fibers.
  8. 8. Membrane module (1) according to claim 7, wherein in the inlet region of the treatment space (3) adjacent to the blood inlet (13) only the hollow fibers (7) of the first subset of hollow fibers (37) are arranged and/or in the outlet region upstream of the blood outlet (15) only the hollow fibers (7) of the second subset of hollow fibers (39) are arranged.
  9. 9. Membrane module (1) according to claim 7, wherein in the inlet portion (43) of the treatment space (3) adjacent to the blood inlet (13) the hollow fibers (7) of the first subset of hollow fibers (37) protrude at least partly beyond the hollow fibers (7) of the second subset of hollow fibers (39) and/or the hollow fibers (7) of the second subset of hollow fibers (39) protrude at least partly beyond the hollow fibers (7) of the first subset of hollow fibers (37), And/or In an outlet portion (45) of the treatment space (3) upstream of the blood outlet (15), the hollow fibers (7) of the first subset of hollow fibers (37) protrude at least partly outside the hollow fibers (7) of the second subset of hollow fibers (39), and/or wherein the hollow fibers (7) of the second subset of hollow fibers (39) protrude at least partly outside the hollow fibers (7) of the first subset of hollow fibers (37).
  10. 10. Membrane module (1) according to any one of claims 7 to 9, wherein the fiber longitudinal directions (RF 1, RF 2) of the hollow fibers (7) of the first subset of hollow fibers (37) and the fiber longitudinal directions (RF 1, RF 2) of the hollow fibers (7) of the second subset of hollow fibers (39) form an intersection angle (a) which ranges between more than 0 ° and less than 180 °, wherein the main flow direction (RH) preferably bisects the intersection angle (a).
  11. 11. Membrane module (1) according to any one of claims 1 to 10, wherein the exchange membrane (5) comprises fiber mats (33) of unidirectional hollow fibers (7), wherein the fiber mats (33) overlap each other in a height direction (H) transverse to the main flow direction (RH), wherein the mat surface of the fiber mats (33) preferably varies in the height direction (H), in particular decreases towards the outside.
  12. 12. Membrane module (1) according to any one of claims 1 to 11, wherein the treatment space (3) is configured to receive blood (B) under pressure, in particular blood (B) having an absolute pressure (pa) of 3 bar or less.
  13. 13. Membrane module (1) according to any one of claims 1 to 12, wherein the membrane module (1) is designed as coreless.
  14. 14. Membrane module (1) according to any one of claims 1 to 13, wherein the membrane module (1) is a direct through-flow module, wherein the blood inlet (13) is opposite the blood outlet (15) along a main axis (a), in particular a longitudinal axis, of the membrane module (1).
  15. 15. Membrane module (1) according to any one of claims 1 to 14, wherein the membrane module (1) has a second process space (47) connected to the first process space (3), wherein the hollow fibers (7) in the first process space (3) are preferably different from the hollow fibers (7) in the second process space (3).
  16. 16. Membrane module (1) according to any one of claims 1 to 15, wherein the exchange membrane (5) has a main portion (57) and at least one secondary portion (59), wherein the main packing density of the hollow fibers (7) in the main portion (57) is constant, and wherein the secondary packing density of the hollow fibers (7) in the secondary portion (59) differs from the main packing density at least in some portions.
  17. 17. A membrane module (1) for treating blood (B), comprising: At least one treatment space (3) with at least one blood inlet (13) and at least one blood outlet (15) connected to each other in a main flow direction (RH) through the treatment space (3), An exchange membrane (5) having a plurality of hollow fibers (7), each extending through the treatment space (2) in a fiber longitudinal direction (RF 1, RF 2) and being configured to flow in the fiber longitudinal direction (RF 1, RF 2) through the treatment medium (M) from a first fiber end (17) to an opposite second fiber end (19), A potting (21), wherein the first fiber end (17) and the second fiber end (19) of the hollow fibers (7) of the exchange membrane (5) are fixed in the potting (21) and at least partially define the treatment space (3), It is characterized in that The exchange membrane (5) comprises a main portion (57) and at least one secondary portion (59), wherein a main packing density of hollow fibers (7) in the main portion (57) is constant, and wherein a secondary packing density of hollow fibers (7) in the secondary portion (59) is different from the main packing density at least in some portions.
  18. 18. Membrane module (1) according to claim 17, wherein the secondary portion (59) is arranged in an inlet portion (43) of the treatment space (3) adjacent to the blood inlet (13) and/or wherein the secondary portion (59) is arranged in an outlet portion (45) of the treatment space (3) upstream of the blood outlet (15).
  19. 19. Membrane module (1) according to claim 17 or 18, wherein the secondary portion (59) comprises at least two sub-portions (61) arranged on opposite sides of a main axis (a) of the membrane module (1) extending from the blood inlet (13) to the blood outlet (15).
  20. 20. Membrane module (1) according to claim 19, wherein the sub-portion (61) is symmetrical with respect to the main axis (a).

Description

Membrane module with oblique inflow The invention relates to a membrane module for treating blood, comprising at least one treatment space having at least one blood inlet and at least one blood outlet connected to one another in a main flow direction through the treatment space, an exchange membrane having a plurality of semi-permeable hollow fibers, each semi-permeable hollow fiber extending through the treatment space in a fiber longitudinal direction and being designed to flow from a first fiber end to an opposite second fiber end in the fiber longitudinal direction by a treatment medium, and a potting, wherein the first fiber end and the second fiber end of the hollow fibers of the exchange membrane are fixed in the potting and at least partially define the treatment space. Furthermore, the invention relates to a method for manufacturing a membrane module, a blood treatment system, an assembly method and a blood extracorporeal treatment method. Filling the fluid with a gas and controlling the temperature of the fluid in the heat exchange membrane is a well known technique for preparing fluids for subsequent processes or procedures. In medical technology, these principles are very important for the treatment of blood. In particular in the case of acute deterioration of respiratory function, it is important to provide oxygen to the patient. In particularly severe cases, it is desirable to enrich the blood of the patient (oxygenation). In extracorporeal membrane lung oxygenation (ECMO), a significant portion of the blood of the patient being treated is enriched in vitro by a suitable device. Drawing large amounts of blood can place great stress on the body and present considerable risks. For example, large amounts of anticoagulants must be used to prevent thrombosis in patients or to cause clogging of ECMO devices due to thrombosis. ECMO is therefore often used as a final means during particularly severe cases of respiratory failure or surgery. However, in other situations, such as carbon monoxide poisoning, ischemia treatment or cancer treatment support, it may also be beneficial to fill the patient's blood with oxygen. In addition, filling and/or removal of gases in the fluid is often necessary. For example, carbon dioxide is removed from the blood of a patient undergoing treatment. However, there is little any suitable device on the market to support oxygenation of a patient's blood. As previously mentioned, conventional devices for extracorporeal membrane oxygenation are designed for high blood flow and are therefore not suitable for supportive treatment of conscious patients. Because of the high blood flow rates required, known devices, particularly membrane modules for treating blood, present significant health risks, particularly thrombosis, when used at relatively low flow rates. In view of the above, it is an object of the present invention to provide a membrane module which allows for improved blood treatment, in particular gentle treatment of the patient and/or efficient blood treatment, in particular at relatively low blood flow rates. The present invention solves this problem in a first aspect by a membrane module according to claim 1. In particular, the invention solves this object by a membrane module for treating blood, comprising at least one treatment space having at least one blood inlet and at least one blood outlet connected to each other in a main flow direction through the treatment space, an exchange membrane having a plurality of hollow fibers, each hollow fiber extending through the treatment space in a fiber longitudinal direction and being designed to flow from a first fiber end to an opposite second fiber end in the fiber longitudinal direction by a treatment medium, a potting, wherein the first fiber end and the second fiber end of the hollow fibers of the exchange membrane are fixed in the potting and at least partially define the treatment space, wherein at least a first subset of the hollow fibers are arranged in the treatment space such that their fiber longitudinal directions are inclined with respect to the main flow direction. Preferably, some, particularly preferably all, of the hollow fibers are semipermeable. Thus, the exchange membrane may comprise a plurality of semi-permeable hollow fibers. In a variant, some or all of the hollow fibers may also be completely airtight, for example when the hollow fibers are used for temperature treatment of blood. In other variations, some or all of the hollow fibers may be porous. The fluid to be treated, in particular blood, flowing through the treatment space can be treated by a treatment medium flowing through the hollow fibers. The treatment may comprise a temperature treatment, in particular heating and/or heat dissipation, warming, cooling and/or temperature stabilization and/or substance exchange, in particular gas exchange. Such gas exchange may be, inter alia, oxygenation (oxygenation) and/or reduction of carbon dioxide