CN-121986258-A - Data processing method, analysis system, and program

Abstract

A data processing method for processing a spectrum of a target sample obtained in an energy-dispersive fluorescent X-ray analysis apparatus is disclosed. The data processing method includes a step of reading a correction ratio which is a ratio of a detection intensity of the first energy range to a detection intensity of the second energy range with respect to a standard sample of Fe. The first energy range includes the kβ line energy of Fe and the kα line energy of Co, and the second energy range includes the kα line energy of Fe. The data processing method further comprises the step of calculating as a correction value the product of the correction ratio and the detected intensity of the second energy range of the spectrum, and the step of calculating the correction intensity by subtracting the correction value from the detected intensity of the first energy range of the spectrum.

Inventors

• NAKAO TAKAMI

Assignees

• 株式会社岛津制作所

Dates

Publication Date

20260505

Application Date

20241007

Priority Date

20231020

Claims (9)

1. 1. A data processing method for processing a spectrum of an object sample obtained in an energy-dispersive fluorescent X-ray analysis device, comprising: A step of reading a correction ratio, which is a ratio of a detection intensity of a first energy range including kβ line energy of Fe and kα line energy of Co to a detection intensity of a second energy range including kα line energy of Fe, with respect to a standard sample of Fe; a step of calculating, as a correction value, a product of the correction ratio and a detected intensity of the second energy range of the spectrum, and A step of calculating a correction intensity by subtracting the correction value from a detected intensity of the first energy range of the spectrum.
2. 2. The data processing method of claim 1, further comprising the step of determining the Co content in the subject sample using the calibration intensity and a standard curve of Co.
3. 3. The data processing method according to claim 1, wherein the concentration of Fe in the standard sample is 50 to 800ppm.
4. 4. The data processing method of claim 1, further comprising: a step of receiving a specification of Fe concentration corresponding to the object sample, and And selecting the correction ratio from two or more correction ratio candidates prepared for each of the two or more Fe concentrations according to the specification.
5. 5. An analysis system, comprising: Energy-dispersive fluorescent X-ray analyzer, and An information processing device configured to analyze a spectrum of a target sample in the energy-dispersive fluorescent X-ray analysis device, The information processing apparatus reads a correction ratio which is a ratio of a detection intensity of a first energy range to a detection intensity of a second energy range with respect to a standard sample of Fe, The first energy range includes the kβ line energy of Fe and the kα line energy of Co, The second energy range comprises the ka line energy of Fe, And the information processing apparatus is configured to calculate a product of the correction ratio and a detected intensity of the second energy range of the spectrum as a correction value, A correction intensity is calculated by subtracting the correction value from a detected intensity of the first energy range of the spectrum.
6. 6. The analytical system of claim 5, wherein the information processing device is configured to determine the Co content in the subject sample using the calibration intensity and a standard curve for Co.
7. 7. The analytical system of claim 5, wherein the concentration of Fe in the standard sample is 50-800 ppm.
8. 8. The analysis system according to claim 5, wherein the information processing device receives a designation of Fe concentration corresponding to the object sample, And selecting the correction ratio from two or more correction ratio candidates prepared for each of the two or more Fe concentrations according to the specification.
9. 9. A program which, when executed by a computer, causes the computer to implement the data processing method according to claim 1.

Description

Data processing method, analysis system, and program Technical Field The invention relates to data processing for processing spectra obtained according to energy dispersive fluorescent X-ray analysis. Background It is known that, in a spectrum obtained by an energy dispersive fluorescent X-ray analysis method (hereinafter referred to as "EDX"), since a peak of an element to be analyzed overlaps with a peak of another element, even if the peak intensity of the element to be analyzed is directly used, an accurate content of the element to be analyzed cannot be obtained. In order to cope with such a situation, japanese patent application laid-open No. 2004-138604 (patent document 1) proposes a technique for correcting a spectrum for a combination of an element to be analyzed and a part of other elements. Prior art literature Patent literature Patent document 1 Japanese patent application laid-open No. 2004-138604 Disclosure of Invention Technical problem to be solved by the invention In recent years, EDX is being studied for application in the field of pharmaceutical analysis. In the field of pharmaceutical analysis, it is required to obtain an accurate content of cobalt (Co) in a sample to be analyzed. In the field of pharmaceutical analysis, the sample to be analyzed often contains iron (Fe). The kα energy (6.92 keV) of Co is close to the kβ energy (7.06 keV) of Fe, and in the spectrum obtained by the fluorescent X-ray analysis, the kα peak of Co overlaps with the kβ peak of Fe, but conventionally, correction of the spectrum in consideration of the peak of Fe has not been specifically studied when obtaining the content of Co. Therefore, in particular in the field of pharmaceutical analysis, a technique for correcting a spectrum in consideration of the peak of Fe is required in order to obtain an accurate content of Co. The present invention has been made in view of the above circumstances, and an object thereof is to provide a technique for deriving an accurate content of Co in a target sample in fluorescent X-ray analysis. Solution to the above technical problems According to one aspect of the present disclosure, a data processing method is a data processing method for processing a spectrum of an object sample obtained in an energy-dispersive fluorescent X-ray analysis device, including a step of reading a correction ratio which is a ratio of a detection intensity of a first energy range including Kβ line energy of Fe and Kα line energy of Co to a detection intensity of a second energy range including Kα line energy of Fe with respect to a standard sample of Fe, a step of calculating a product of the correction ratio and the detection intensity of the second energy range of the spectrum as a correction value, and a step of calculating the correction intensity by subtracting the correction value from the detection intensity of the first energy range of the spectrum. According to an aspect of the present disclosure, an analysis system includes an energy-dispersive fluorescent X-ray analysis device, and an information processing device configured to analyze a spectrum of an object sample in the energy-dispersive fluorescent X-ray analysis device, the information processing device reads a correction ratio that is a ratio of a detection intensity of a first energy range including kβ line energy of Fe and kα line energy of Co to a detection intensity of a second energy range including kα line energy of Fe with respect to a standard sample of Fe, the information processing device calculates a product of the correction ratio and the detection intensity of the second energy range of the spectrum as a correction value, and calculates the correction intensity by subtracting the correction value from the detection intensity of the first energy range of the spectrum. The program according to one aspect of the present disclosure, when executed by a computer, causes the computer to implement the above-described data processing method. Effects of the invention In accordance with the present disclosure, a technique for deriving an accurate content of Co in a subject sample in a fluorescent X-ray analysis is provided. Drawings FIG. 1 is a diagram showing an example of a spectrum of a sample obtained by energy-dispersive fluorescent X-ray analysis and obtained by mixing Fe and Co. FIG. 2 is a diagram showing an example of a spectrum of a Fe standard sample obtained by an energy-dispersive fluorescent X-ray analysis method. Fig. 3 schematically shows the overall configuration of an analysis system including an energy-dispersive fluorescent X-ray analysis device. Fig. 4 is a diagram showing a hardware configuration of the information processing apparatus 20. Fig. 5 is a flowchart of a process performed for determining the Co content in an analysis target sample from the spectrum of the analysis target sample obtained by energy dispersive fluorescent X-ray analysis. Fig. 6 is a diagram showing an example of a data structure of a