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CN-121986779-A - High-stability composite peroxyacetic acid disinfectant and preparation process thereof

CN121986779ACN 121986779 ACN121986779 ACN 121986779ACN-121986779-A

Abstract

The invention relates to the technical field of disinfectant, in particular to a high-stability composite peroxyacetic acid disinfectant and a preparation process thereof, wherein the high-stability composite peroxyacetic acid disinfectant comprises, by total mass of the disinfectant, 4-6% of peroxyacetic acid, 10-15% of hydrogen peroxide, 15.0-25% of acetic acid, 0.1-0.3% of terpolymer and the balance of water. The invention reduces the decomposition of PAA and H2O2 in the storage process by improving the stability of the PAA and H2O2, thereby ensuring the durability of the sterilizing efficiency of the sterilizing liquid.

Inventors

  • WANG YONG
  • SU HAITAO
  • MA YUNFENG
  • LI XUE
  • WANG XIQING
  • ZHANG SHIYAN
  • ZHAO AIJUN
  • CHEN XIAOJIN

Assignees

  • 山东安卫士医疗科技有限公司

Dates

Publication Date
20260508
Application Date
20260130

Claims (10)

  1. 1. The preparation process of the high-stability composite peroxyacetic acid disinfectant is characterized by comprising the following steps of: S1, dispersing a terpolymer in a solvent to obtain a pre-dispersion liquid; S2, mixing water, glacial acetic acid and hydrogen peroxide solution for the first time to obtain a base solution, adding the pre-dispersion solution under stirring, mixing, and homogenizing to obtain a homogenized mixed solution; And S3, dropwise adding the peracetic acid solution into the homogeneous mixed solution, adding water to the total amount after the dropwise adding, carrying out secondary mixing to obtain a second mixed solution, and heating, standing and curing the second mixed solution under the sealed and light-proof condition to obtain the high-stability composite peracetic acid disinfectant.
  2. 2. The preparation process according to claim 1, wherein the terpolymer in step S1 is prepared by the steps of: And (2) dissolving hydroxypropyl acrylate, methacryloxyethyl trimethyl ammonium chloride, N-vinyl pyrrolidone and an initiator in a solvent, controlling the temperature under an inert atmosphere, stirring for reaction, transferring the reaction solution into a precipitant for precipitation after the reaction is finished, and filtering, washing and drying to obtain the terpolymer.
  3. 3. The process according to claim 1, wherein the solvent in step S1 is selected from glacial acetic acid or a mixed solvent of glacial acetic acid and ethanol in an amount of 8 to 20 times the mass of the terpolymer, and the dispersion comprises adding the terpolymer to the solvent at 20 to 25 ℃ and stirring at 400 to 600rpm for 45 to 60 minutes.
  4. 4. The preparation process according to claim 1, wherein the hydrogen peroxide solution in step S2 is an aqueous hydrogen peroxide solution having a mass concentration of 25-35%, the homogenizing treatment is performed by a homogenizer at a pressure of 30-60 MPa and the cyclic treatment is performed for 2-4 times, or the treatment is performed by a shearing machine at a rotation speed of 8000-12000rpm for 3-10min.
  5. 5. The preparation process according to claim 1, wherein the temperature at the time of the first mixing in step S2 is 5-15 ℃, the stirring speed is 100-200rpm, and the mixing time is 20-60min.
  6. 6. The preparation process according to claim 1, wherein the peracetic acid solution in the step S3 is an aqueous peracetic acid solution with a mass concentration of 35-45%, the temperature during the second mixing is 8-12 ℃, the stirring speed is 300-500rpm, and the mixing time is 30-90min.
  7. 7. The preparation process according to claim 1, wherein the heating, standing and curing in the step S3 comprises three stages which are sequentially performed, namely, firstly, standing for 20-28 hours at 5-10 ℃ in a dark place, then, standing for 40-56 hours at 15-20 ℃ in a dark place, and finally, standing for 96-144 hours at 20-25 ℃ in a dark place.
  8. 8. The preparation process according to claim 2, wherein the mass ratio of the hydroxypropyl acrylate, the methacryloxyethyl trimethyl ammonium chloride and the N-vinyl pyrrolidone is (5.9-8.6): 1 (2-3): 1 (1), and the initiator is selected from azodiisobutyronitrile, and the dosage of the initiator is 0.3-0.6% of the total mass of the hydroxypropyl acrylate, the methacryloxyethyl trimethyl ammonium chloride and the N-vinyl pyrrolidone.
  9. 9. The preparation process according to claim 2, wherein the reaction temperature is 65-75 ℃ and the stirring speed is 200-400rpm and the reaction time is 18-30h when the temperature is controlled and the stirring is performed.
  10. 10. The high-stability composite peroxyacetic acid disinfectant prepared by the preparation process according to claims 1-9, wherein the disinfectant comprises, by total mass, 4-6% of peroxyacetic acid, 10-15% of hydrogen peroxide, 15.0-25% of acetic acid, 0.1-0.3% of terpolymer and the balance of water.

Description

High-stability composite peroxyacetic acid disinfectant and preparation process thereof Technical Field The invention relates to the technical field of disinfectant, in particular to a high-stability composite peroxyacetic acid disinfectant and a preparation process thereof. Background Peracetic acid disinfectant is a highly efficient oxidizing disinfectant that is typically prepared by reacting acetic acid with hydrogen peroxide under catalytic conditions. From a chemical structural point of view, peracetic acid is an acyl-substituted derivative of hydrogen peroxide, which exhibits weak acidity in aqueous solution, has a pKa of about 8.2, and therefore coexists in both neutral and dissociated states. The disinfectant has high oxidation-reduction potential, so that the disinfectant has broad-spectrum sterilization capability and can effectively inactivate various microorganisms such as bacteria, spores, viruses, mold fungi and the like. Compared with the traditional chlorination and disinfection, the peroxyacetic acid has the remarkable advantages of high sterilization efficiency, lower pH dependence, simple and convenient operation, less chemical residue and the like, so that the peroxyacetic acid becomes an important substitute of the chlorine disinfectant in the fields of water treatment, medical treatment, health and the like. The invention patent with the publication number of CN114747575A discloses a peroxyacetic acid disinfectant and a preparation method thereof, wherein the peroxyacetic acid disinfectant comprises an agent A and an agent B, the peroxyacetic acid solution prepared by the invention has stable property, the method is convenient to transport, simple in preparation method, high in reaction speed, low in foam quantity and corrosiveness, good in stability, and can be used for high-level disinfection and sterilization. In the prior art, peroxyacetic acid is generated by the dynamic reversible reaction of hydrogen peroxide and acetic acid. The equilibrium is extremely sensitive to temperature, concentration, pH and spontaneously shifts in the direction of decomposition during storage, resulting in a gradual decrease in the concentration of the active ingredient, affecting the effectiveness of the disinfection. In addition, high concentrations of peracetic acid and hydrogen peroxide are highly corrosive to most metals, and also to some plastics, rubber and paint, with great demands on the materials of storage containers, transport pipes and application equipment. Meanwhile, commonly used inorganic or small molecule stabilizers such as sodium pyrophosphate, stannate, organic phosphonic acid and the like are often effective only in a specific pH or narrow concentration range, have insufficient long-term stability, and may influence the disinfection effect or introduce new toxicity/environmental problems. Disclosure of Invention In order to solve the problems in the background art, the invention provides a high-stability composite peroxyacetic acid disinfectant and a preparation process thereof. In order to achieve the above purpose, the present invention adopts the following technical scheme: A preparation process of a high-stability composite peroxyacetic acid disinfectant comprises the following steps: S1, dispersing a terpolymer in a solvent to obtain uniform pre-dispersion liquid; S2, mixing water, glacial acetic acid and hydrogen peroxide solution for the first time at low temperature to obtain a base solution, adding the pre-dispersion solution into the base solution under stirring, uniformly mixing, and homogenizing to obtain a homogeneous mixed solution; And S3, slowly dropwise adding the peracetic acid solution into the homogeneous mixed solution obtained in the step S2, adding the rest water to the total amount of the formula after the dropwise adding is finished, carrying out secondary mixing to obtain a second mixed solution, and finally carrying out programmed heating, standing and curing on the second mixed solution under the sealed and light-proof condition to obtain the high-stability composite peracetic acid disinfectant. Further, the terpolymer in step S1 is prepared by the following method: The method comprises the steps of dissolving hydroxypropyl acrylate, methacryloxyethyl trimethyl ammonium chloride, N-vinyl pyrrolidone and an initiator in a solvent, wherein the feeding mass ratio of the hydroxypropyl acrylate to the methacryloxyethyl trimethyl ammonium chloride to the N-vinyl pyrrolidone is (5.9-8.6), the initiator is preferably selected from azodiisobutyronitrile, the dosage of the initiator is 0.3-0.6% of the total mass of three monomers, the polymerization solvent is selected from one of water, N-dimethylformamide, ethanol or a mixed solvent of water and ethanol, the volume ratio of the water and the ethanol in the mixed solvent of water and ethanol is (1:1-4), and the dosage of the solvent is 5-15 times of the total mass of the three monomers. Under the protection of