CN-121986792-A - Antiviral heterocyclic compound

Abstract

The invention belongs to the technical field of chemical control of agricultural diseases and insect pests, and provides an antiviral heterocyclic compound. The heterocyclic compound has better inhibition effect on plant viruses, has passivation, protection and treatment effects after being applied to plants, is superior to commercial medicament ribavirin, has good biological activity and has commercial prospect, and the invention also provides a composition containing the heterocyclic compound. When Ningnanmycin is contained, the two have obvious synergistic effect within a certain proportion range, and the resistance risk of a single medicament can be reduced. The invention provides a new medicament for preventing and treating plant viruses and has important practical application value.

Inventors

• ZHANG XIANPENG
• CHENG CHUANYING
• SHI XUGEN
• HE SHIYU
• PAN XIAOYAN
• CUI RUQIANG
• SUN RANRAN
• LI JUAN
• CHENG HUIHUANG

Assignees

• 江西农业大学

Dates

Publication Date

20260508

Application Date

20260115

Claims (9)

1. 1. An application of a heterocyclic compound in preventing and treating plant viruses, which is characterized in that the structural formula of the heterocyclic compound is as follows: 。
2. 2. Use according to claim 1, characterized in that the plant virus is a virus of the family plant baculovirusaceae (VIRGAVIRIDAE), the family tomato spotted wilt virus (Tospoviridae), the family potyvirus (Potyviridae) or the family brome mosaic virus (Bromoviridae).
3. 3. Use according to claim 2, characterized in that the plant virus is a virus of the genus tobacco mosaic virus (Tobamovirus), orthotomato spotted wilt virus (Orthotospovirus), potyvirus (Potyvirus) or cucumber mosaic virus (Cucumovirus).
4. 4. Use according to claim 3, characterized in that the plant virus is Tobacco Mosaic Virus (TMV), tomato Spotted Wilt Virus (TSWV), potato Y virus (PVY) or Cucumber Mosaic Virus (CMV).
5. 5. An agrochemical comprising the heterocyclic compound as described in any one of claims 1 to 4.
6. 6. An agrochemical according to claim 5, characterised in that the agrochemical also contains other active ingredients and/or inert ingredients.
7. 7. An agrochemical according to claim 6, wherein the active ingredient is an antiviral ingredient or an insecticidal ingredient.
8. 8. An agrochemical according to claim 7, characterised in that the active ingredient is ningnanmycin.
9. 9. An agrochemical according to claim 7, characterised in that the mass ratio of heterocyclic compound 9 and ningnanmycin is 3:7-2:8.

Description

Antiviral heterocyclic compound Technical Field The invention belongs to the technical field of chemical control of agricultural diseases and insect pests, and relates to an antiviral heterocyclic compound. Background Plant viruses cause disease in a variety of vegetables and crops, causing economic losses of about 6000 million dollars per year for global agriculture. Because of the absolute parasitic nature of plant viruses, they are extremely difficult to control and are therefore known as "plant cancers". For example, tobacco Mosaic Virus (TMV) is one of the most common and serious plant viruses that infects 400 plants, including tobacco, vegetables and ornamental flowers. The use of chemical drugs is a major solution to control plant viral diseases. In recent years, china has made a certain progress in developing and screening antiviral drugs with high activity. However, to date, few highly potent antiviral agents have been able to fully control viral infection. For example, ningnanmycin has better effect on treating plant viruses such as TMV and Cucumber Mosaic Virus (CMV), but has unsatisfactory field effect, and ribavirin is commonly used for controlling vegetable virus diseases, but the inhibition effect of the ribavirin on plant viruses is still less than 50% when the ribavirin is used at the concentration of 500 mg/L, and the control cost is high. Thus, finding new and effective antiviral drugs remains a challenging task in pesticide research. Anthracene is a linear tricyclic aromatic hydrocarbon compound, and has been widely studied in the fields of chemical industry, pharmaceutical chemistry, semiconductors, and the like because of its large conjugated system and excellent charge transfer characteristics. Meanwhile, the polycyclic aromatic hydrocarbon skeleton of the compound is relatively active in chemical property, is often a matrix of other complex aromatic hydrocarbons, and is used as a raw material for synthesizing dyes, plastics, insulating materials and the like, and is also used as a raw material for synthesizing herbicides, bactericides, anthraquinone intermediates and the like. For example, anthraquinone derivatives have antibacterial, ester-reducing and blood pressure-reducing functions in medicine, and in the agricultural field, some anthraquinone derivatives can be used for preventing and treating various plant fungal diseases, such as powdery mildew, cladosporium cucumerinum and the like. However, the research of the compounds in the aspect of plant virus disease prevention and control is relatively limited at present, and a large expansion space still exists. Disclosure of Invention In order to provide a novel antiviral structure, the invention provides a heterocyclic compound containing a thiothiazolidinedione structure, which has passivation effect on TMV and protection and treatment effect on crops damaged by viruses. An application of a heterocyclic compound in preventing and treating plant viruses, wherein the heterocyclic compound is abbreviated as Ayt-1 and has a structural formula: The plant virus is a virus of the family plant baculovirusaceae (VIRGAVIRIDAE), the family tomato spotted wilt virus (Tospoviridae), the family potato virus (Potyviridae) or the family brome mosaic virus (Bromoviridae), preferably a virus of the genus tobacco mosaic virus (Tobamovirus), the genus orthotomato spotted wilt virus (Orthotospovirus), the genus potato virus (Potyvirus) or the genus cucumber mosaic virus (Cucumovirus), more preferably the plant virus is Tobacco Mosaic Virus (TMV), tomato Spotted Wilt Virus (TSWV), potato Virus Y (PVY) or Cucumber Mosaic Virus (CMV). The invention also provides an agricultural chemical containing the heterocyclic compound Ayt-1. The agricultural chemicals also contain other effective components and/or inert components. Preferably, the active ingredient is an antiviral or insecticidal ingredient, more preferably, the active ingredient is ningnanmycin. When the mass ratio of the heterocyclic compound Ayt-1 to the ningnanmycin is 3:7-2:8, the synergistic effect can be remarkably improved. The invention has the following advantages: the heterocyclic compound Ayt-1 provided by the invention has a good inhibition effect on plant viruses, has passivation, protection and treatment effects after being applied to plants, is superior to commercial medicament ribavirin, has good biological activity, has a broad-spectrum inhibition effect on various plant viruses, and has a commercial prospect, and the invention also provides a composition containing the heterocyclic compound. When the compound is compounded with Ningnanmycin, the two have obvious synergistic effect within a certain proportion range, and the resistance risk of a single medicament can be reduced. The invention provides a new medicament for preventing and treating plant viruses and has important practical application value. Detailed Description The present invention will be further illustrated with r