CN-121986872-A - Application of paeonol in preparation of products for improving liver function and ovary function of laying hens in later period of laying

CN121986872ACN 121986872 ACN121986872 ACN 121986872ACN-121986872-A

Abstract

The invention discloses application of paeonol in preparing a product for improving liver function and ovary function of laying hens in the later period of laying eggs, belongs to the technical field of feed additives, and particularly relates to application of paeonol in preparing a product for improving liver function and ovary function of laying hens in the later period of laying eggs. The invention discovers that paeonol can obviously reduce the activity of glutamic-pyruvic transaminase in liver, obviously reduce the cholesterol content and triglyceride content in serum, obviously reduce the fatty degeneration and lipid drop aggregation of liver cells in pathological sections of liver tissues, and further effectively improve the fatty liver hemorrhagic syndrome of laying hens in the later period of laying eggs, and also discovers that paeonol can restore the reserve capacity of ovaries, improve the egg laying performance of laying hens and the egg laying rate by improving the survival rate of follicles.

Inventors

TIAN YADONG
WANG CHENXU
LI JIATONG
LI CHAOYANG
YUAN WEIDONG
WU TONG
Qu Fengle
GONG YUJIE
WANG ZHENG
KANG XIANGTAO
JIANG RUIRUI
LI DONGHUA
ZHANG YANHUA
CAO ZHONGZHENG

Assignees

河南农业大学

Dates

Publication Date: 20260508
Application Date: 20260305

Claims (10)

1. Application of paeonol in preparing products for improving liver function and ovary function of laying hens in later period of laying.
2. The application of the feed additive according to claim 1, wherein paeonol is added into basic ration according to the addition amount of 200-280 mg/kg, and then the feed additive is fed to laying hens in the later period of laying for 7-9 weeks.
3. The use according to claim 1, wherein paeonol can relieve and treat fatty liver hemorrhagic syndrome of laying hens in the later period of laying, promote the recovery of ovarian reserve capacity and improve the breakage resistance of eggs laid by the laying hens in the later period of laying.
4. A product for improving liver function and ovary function of laying hens in the later period of egg production, which is characterized by comprising paeonol and acceptable auxiliary materials.
5. Application of paeonol in preparing product for relieving and treating fatty liver hemorrhage syndrome of laying hen in later period of egg production is provided.
6. The use according to claim 5, wherein paeonol reduces the abdominal fat rate, liver L value and liver b value of the laying hen in the later period of egg production, improves the abdominal lipid accumulation of the laying hen, improves the appearance color of the liver, reduces the activity and cholesterol content of serum glutamic oxaloacetic transaminase, reduces fatty vacuoles and lipid droplets of liver tissue, and reduces liver tissue damage.
7. Application of paeonol in preparing product for promoting recovery of ovarian reserve of laying hen in later period of laying.
8. The use according to claim 7, wherein paeonol restores the reserve capacity of the ovaries by increasing follicular viability.
9. A product for promoting the recovery of ovarian reserve capacity of laying hens in the later period of egg production, which is characterized by comprising paeonol and acceptable auxiliary materials.
10. The application of paeonol in preparing a product for improving the breakage resistance of eggs laid by laying hens in the later period of laying eggs is characterized in that paeonol is added into basic ration according to the addition amount of 200-280 mg/kg, and the basic ration is fed for 7-9 weeks to the laying hens in the later period of laying eggs.

Description

Application of paeonol in preparation of products for improving liver function and ovary function of laying hens in later period of laying Technical Field The invention belongs to the technical field of feed additives, and particularly relates to application of paeonol in preparation of products for improving liver function and ovary function of laying hens in later period of egg production. Background The ovarian function of the laying hens gradually declines in the later period of laying, the laying rate gradually decreases from the peak (usually more than 85%), but the feed intake is always kept at a higher level, if the proportion of energy substances (such as corn, wheat bran and the like) in the feed is too high, the supply of functional nutrients (such as choline, vitamin E, vitamin B and the like) for promoting fat metabolism is insufficient, and the redundant energy can be converted into triglyceride in the liver. Under normal conditions, triglyceride can be combined with apolipoprotein to form very low density lipoprotein, and the very low density lipoprotein is transported to ovary to synthesize yolk through blood, but when the synthesis of the apolipoprotein is blocked, the triglyceride cannot be output effectively, so that lipid accumulation of liver can be caused, the metabolism burden of the liver is increased, the production performance and health of laying hens are seriously affected, the laying rate is reduced, the egg quality is reduced, the death rate is increased, and huge economic loss is caused for the breeding industry. The current commonly used drugs have limited therapeutic effects and may present a risk of drug residue. Paeonol (Paeonol) is a phenolic ketone compound extracted and separated from root bark of Paeonia suffruticosa of Ranunculaceae or whole plant of Cynanchum paniculatum of Asclepiadaceae, and is generally white or yellowish glossy needle crystal, and is dissolved in organic solvent such as methanol and ethanol, and is dissolved in hot water, and is insoluble in cold water. In recent years, pharmacological actions of paeonol in various diseases have been widely studied, and have various biological activities such as anti-inflammatory, anti-tumor, neuroprotection, immunoregulation and treatment of cardiovascular diseases. However, studies on the use of paeonol in poultry have not been reported, and how it can exert on poultry is still unclear. Disclosure of Invention In order to solve the technical problems, the invention provides application of paeonol in preparing a product for improving liver function and ovary function of laying hens in the later period of laying, so as to solve the technical problems of dual requirements of prevention and control of the production performance and liver health of the laying hens in the later period of laying in the prior art. In order to achieve the aim, the invention provides application of paeonol in preparing products for improving liver function and ovarian function of laying hens in the later period of laying eggs. Preferably, paeonol is added into basic ration according to the addition amount of 200-280 mg/kg, and then the basic ration is fed for 7-9 weeks to the laying hens in the later period of laying. Preferably, paeonol can relieve and treat fatty liver hemorrhagic syndrome of laying hens in the later period of laying, promote the recovery of ovarian reserve capacity and improve the breakage resistance of eggs laid by the laying hens in the later period of laying. The invention also provides a product for improving liver function and ovarian function of the laying hen in the later period of egg production, which comprises paeonol and acceptable auxiliary materials. The invention also provides application of paeonol in preparing a product for relieving and treating the fatty liver hemorrhagic syndrome of laying hens in the later period of laying. Preferably, paeonol reduces the abdominal fat rate, the liver L value and the liver b value of the laying hen in the later period of laying, improves the accumulation of abdominal lipid of the laying hen, improves the appearance color of the liver, reduces the activity and cholesterol content of serum glutamic-oxaloacetic transaminase, reduces fatty vacuoles and lipid droplets of liver tissues, and reduces liver tissue damage. The invention also provides application of paeonol in preparing a product for promoting recovery of ovarian reserve capacity of laying hens in the later period of laying. Preferably, paeonol restores the reserve capacity of the ovaries by increasing follicular viability. The invention also provides a product for promoting the recovery of the ovarian reserve capacity of the laying hen in the later period of egg production, which comprises paeonol and acceptable auxiliary materials. The invention also provides application of paeonol in preparing a product for improving the breakage resistance of eggs laid by laying hens in the later period of laying, and the