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CN-121986879-A - Polygonatum sibiricum polysaccharide extract weaned piglet diet additive and application thereof

CN121986879ACN 121986879 ACN121986879 ACN 121986879ACN-121986879-A

Abstract

The invention provides a weaned piglet feed additive containing a polygonatum polysaccharide extract and application thereof, wherein the feed additive comprises the polygonatum polysaccharide extract, and the polygonatum polysaccharide extract comprises 36-49.8% of polygonatum polysaccharide, 3-12% of saponin, 2-8% of flavone, 30-45% of total amino acid and 0.2-1% of alkaloid by mass fraction. The Polygonatum polysaccharide has various pharmacological activities, such as anti-inflammatory and antibacterial effects, immunity regulation, anti-tumor effects, oxidation resistance, blood sugar and blood fat reduction effects, and the like, is reasonably added into weaned piglet basic diet culture, the application dosage of the Polygonatum polysaccharide extract is 150-600 mg per kg weaned piglet basic diet, can replace feeding antibiotics, can effectively reduce the diarrhea rate of weaned piglets, regulate the intestinal flora structure and improve the abdominal intestinal morphology of weaned piglets, further improves the survival rate of early weaned piglets, shortens the breeding period of a farm, and improves the reproductive performance.

Inventors

  • HUANG PENG
  • WANG WEI
  • LIU WEI

Assignees

  • 湖南农业大学

Dates

Publication Date
20260508
Application Date
20251125

Claims (10)

  1. 1. The weaned piglet feed additive is characterized by comprising a Polygonatum sibiricum polysaccharide extract, wherein the Polygonatum sibiricum polysaccharide extract comprises 36-49.8% of Polygonatum sibiricum polysaccharide, 3-12% of saponin, 2-8% of flavone, 30-45% of total amino acid and 0.2-1% of alkaloid by mass fraction.
  2. 2. The diet supplement according to claim 1, wherein the preparation method of the polygonatum polysaccharide extract comprises the following steps: Step 11, cutting rhizoma polygonati into slices with the thickness of 1-3 mm, and soaking the slices in water according to the feed liquid ratio of 1g (16-21) ml until the slices are penetrated; Step 12, continuously heating to 60 ℃, decocting for 4 hours, and filtering to obtain residues and filtrate; step 13, continuously decocting the residues obtained in the step 12 for 3 times according to the same feed liquid ratio, filtering, and combining all filtrate to obtain a combined solution; Step 14, concentrating the combined solution under reduced pressure until the relative density is 1.16-1.20, adding 95% ethanol, precipitating for 12h, centrifuging, collecting precipitate, and vacuum microwave drying to obtain rhizoma Polygonati polysaccharide extract.
  3. 3. The diet supplement according to claim 2, characterized in that in step 11 the feed to liquid ratio is 1g:16ml.
  4. 4. The diet supplement of claim 2, wherein in step 14, the combined liquor is concentrated under reduced pressure to a relative density of 1.16.
  5. 5. The diet supplement of claim 1, wherein the polyglucose comprises glucose and fructose in respective mole percentages of 6.37%, 93.63%.
  6. 6. The feed additive according to claim 1, wherein the additive is added in an amount of 150-600 mg of Polygonatum sibiricum polysaccharide extract per kg of weaned piglet base feed.
  7. 7. Use of the Polygonatum sibiricum polysaccharide extract weaned piglet diet additive according to any one of claims 1-6.
  8. 8. The use according to claim 7, characterized in that it is in particular the use for the preparation of a diet additive with a reduced diarrhea rate for weaned pigs.
  9. 9. The use according to claim 7, characterized in that it is in particular the use for the preparation of a diet additive for regulating the structure of the abdominal intestinal flora of weaned pigs.
  10. 10. The use according to claim 7, characterized in that it is in particular the use for the preparation of a diet additive for improving the morphology of the abdominal intestine of weaned piglets.

Description

Polygonatum sibiricum polysaccharide extract weaned piglet diet additive and application thereof Technical Field The invention relates to the technical field of animal breeding, in particular to a weaned piglet diet additive containing Polygonatum sibiricum polysaccharide extract and application thereof. Background With the continuous improvement of the breeding level, the weaning age of the piglets gradually advances from the past 60 days to 35 days or earlier, thereby greatly improving the litter size of the sows. However, due to improper weaning at early stage or improper feeding management after early weaning, diarrhea symptoms are very likely to occur in early weaning of piglets, and economic benefit is reduced. At present, the causes of diarrhea of piglets are classified into two major types, namely non-infectious diarrhea and infectious diarrhea, wherein the non-infectious diarrhea mainly comprises various causes of imperfect physiological functions, poor feeding management, stress response and the like of piglets, and the infectious diarrhea comprises bacterial diarrhea, viral diarrhea and diarrhea caused by parasites. Meanwhile, early weaning can also cause structural disturbance of intestinal flora of piglets, intestinal pathogenic bacteria act on intestinal mucosa barriers to further cause weaning diarrhea, the intestinal flora formed by piglets in the lactation period is mainly anaerobic bacilli, early weaning stress induces loss of diversity of the intestinal flora, the relative abundance of the flora changes, the number of anaerobic bacilli such as lactobacillus is reduced, the number of facultative anaerobic bacilli such as escherichia coli is increased, and pathogenic escherichia coli is a main pathogenic bacteria inducing early weaning diarrhea of the piglets. Enteric pathogens act on intestinal mucosal epithelial cells in an invasive or toxin-producing manner and exacerbate inflammation by affecting the intestinal mucosal immune barrier. In the past, feed antibiotics have been widely used to prevent weaning diarrhea and promote growth, but abuse thereof resulted in exacerbation of bacterial resistance, threatening human health. At present, feed antibiotics are totally prohibited in multiple countries worldwide. Therefore, the development of safe and efficient alternative products (such as plant extracts) for regulating intestinal flora and enhancing the barrier function of mucous membranes becomes a key research direction for solving the problem of early weaning diarrhea. The invention application of publication No. CN117562185A discloses a diet for improving the growth performance of piglets and a preparation method thereof, wherein a slow release microsphere of kangle acid is added into weaned diet of piglets as an acidulant, the kangle acid is a compound acidulant containing phosphoric acid, lactic acid, citric acid and fumaric acid, anhydrous calcium chloride is used as a cross-linking agent, chitosan and carboxymethyl cellulose are used for preparing hydrogel microsphere through a coacervation method, and the kangle acid is wrapped, so that the pH environment of stomach of piglets can be improved, but the preparation is relatively complex and the cost is higher, and further, the diet which has high cost performance and can be used for weaning of piglets is continuously provided. Disclosure of Invention The invention mainly aims to provide a polygonatum polysaccharide extract weaned piglet feed additive and application thereof, and aims to solve the technical problem of low cost performance of the existing feed. In order to achieve the aim, the invention provides a weaned piglet feed additive containing a polygonatum polysaccharide extract, which comprises 36% -49.8% of polygonatum polysaccharide, 3% -12% of saponin, 2% -8% of flavone, 30% -45% of total amino acid and 0.2% -1% of alkaloid. Optionally, the preparation method of the polygonatum polysaccharide extract comprises the following steps: Step 11, cutting rhizoma polygonati into slices with the thickness of 1-3 mm, and soaking the slices in water according to the feed liquid ratio of 1g (16-21) ml until the slices are penetrated; Step 12, continuously heating to 80-90 ℃, decocting for 2-3 hours, and filtering to obtain residues and filtrate; Step 13, continuously decocting the residues obtained in the step 12 for 2-3 times according to the same feed liquid ratio, filtering, and combining all filtrate to obtain a combined solution; And 14, concentrating the combined solution under reduced pressure until the relative density is 1.16-1.20, adding 96% ethanol, precipitating for 10-12h, centrifuging, collecting precipitate, and drying in vacuum by microwave to obtain rhizoma polygonati crude polysaccharide. And 15, removing impurities of crude polysaccharide, adding pure water into the crude polysaccharide extract solid for dissolving, carrying out enzymolysis by papain overnight, sequentially carrying out treatment by adding 1/4 vol