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CN-121987155-A - Tomography and targeted energy thermotherapy system and method based on acousto-optic coupling functional film layer

CN121987155ACN 121987155 ACN121987155 ACN 121987155ACN-121987155-A

Abstract

The invention discloses a fault imaging and targeted energy thermotherapy system and method based on an acousto-optic coupling functional film layer, and relates to the technical field of noninvasive medical diagnosis and treatment. The system comprises an intelligent processing carrier, an acousto-optic coupling functional film layer, a scanning mechanism, an energy treatment module and a processing and temperature control module, wherein the intelligent processing carrier is at least provided with a 20Hz-20kHz audio unit, a pickup unit, an optical signal unit and a processor, the acousto-optic coupling functional film layer is of a single physical structure and is indistinguishable, the same physical area is used for realizing acoustic wave frequency conversion focusing imaging and 42-47 ℃ targeted heat delivery, the acoustic processing layer adopts a multi-stage resonant microcavity array to realize 1000-8000 times frequency multiplication, the echo signal-to-noise ratio is more than or equal to 15dB, the scanning mechanism comprises a plurality of modes such as rotation, translation, a multi-device array, human body movement, local limb movement, support device movement for bearing a human body and the like, and the energy forms comprise all types which can generate a heat effect such as light, electromagnetism and radio frequency and the like, including but not limited to a non-contact or contact energy delivery mode. The invention is suitable for all lesions which are sensitive to 42 ℃ to 47 ℃ in warm and heat, such as tumors, infections, inflammations, and nervous system lesions of gradual freezing diseases (amyotrophic lateral sclerosis), alzheimer's disease, parkinsonism, multiple sclerosis and the like, has low cost, no radiation, easy popularization and extremely high creativity and practical value.

Inventors

  • CHANG LE

Assignees

  • 常乐

Dates

Publication Date
20260508
Application Date
20260322

Claims (7)

  1. 1. The fault imaging and targeting energy thermotherapy system based on the acousto-optic coupling functional film layer is characterized by comprising an intelligent processing carrier, the acousto-optic coupling functional film layer, a scanning mechanism, an energy treatment module and a processing and temperature control module; the intelligent processing carrier is any electronic equipment with an acoustic unit, a pickup unit, an optical unit and a processor, including but not limited to a mobile phone, a tablet, a computer, a medical integrated machine, an embedded terminal and a special diagnosis and treatment host, and at least comprises a unit capable of generating 20Hz-20kHz audio/vibration signals, a pickup unit capable of collecting echo signals, a unit capable of transmitting/receiving optical signals or positioning calibration signals, and a processor capable of executing signal processing and control; the acousto-optic coupling functional film layer is arranged on the carrier in any form and comprises a flexible film, a hard film sheet, an equipment built-in layer, an integrated structure layer, a surface coating, a film coating or a shell embedded component, the film layer is of a single physical structure and simultaneously realizes (1) acoustic wave frequency conversion, focusing and transmission type human tissue/body fluid tomography, (2) any form of targeting energy is delivered to a focus/infection range to realize 42-47 ℃ local thermotherapy, the imaging and therapy functions are realized by the same physical area of the same film layer in a time sharing way, the film layer is of a single physical structure and is not divided into independent functional modules, the scanning mechanism comprises at least one of rotation, translation, arc swing, multi-equipment fixed array, human body movement, local limb movement and support device movement for bearing human body, and the targeting energy comprises light, laser, infrared, electromagnetism, radio frequency, microwaves, the ultrasonic treatment and plasma treatment device comprises a treatment and temperature control module, an acoustic treatment layer and a sound absorption unit, wherein the treatment and temperature control module is used for realizing focus/infection focus positioning, imaging and treatment time-sharing control, energy output adjustment and 42-47 ℃ closed loop temperature control, the acoustic treatment layer of the film adopts a multi-stage resonant microcavity array, single-stage frequency multiplication coefficient is 10-20, three-stage serial connection can realize 1000-8000 frequency multiplication, the three-stage serial connection frequency multiplication efficiency is stable through actual measurement, 2MHz output power meets clinical ultrasonic imaging requirements, the acoustic treatment layer of the film is formed by alternating arrangement of a micron-sized film and air gaps, the film thickness is 0.5-5 mu m, the air gap thickness is 1-10 mu m, frequency multiplication is realized through film vibration, a20 Hz-20kHz low-frequency signal is multiplied to a 2MHz-10MHz medical ultrasonic frequency band, and the echo signal to noise ratio is more than or equal to 15dB after echo frequency reduction.
  2. 2. The system of claim 1, wherein the materials, flexible/rigid forms, molding process, and assembly modes (film pasting/integration/built-in/coating) of the acousto-optic coupling functional film layer are all within the scope of the invention as long as the functions of acoustic frequency conversion focusing, imaging conduction and targeted warm delivery are realized.
  3. 3. The system of claim 1, wherein the membrane layer is built-in and integrated when the carrier leaves the factory, and can be attached at the user side, and the protection range is not limited by the assembly time and mode.
  4. 4. The system of claim 1, wherein the system employs a time-sharing isolation mechanism for imaging and therapy, wherein the acoustic imaging channels are closed prior to therapy, and wherein the imaging channels are restarted for verifying therapeutic effects by delayed cooling for at least 5 seconds after therapy, thereby avoiding energy crosstalk.
  5. 5. The system of claim 1, wherein the temperature control module is matched with a micro temperature sensor, can be integrated in a film layer, monitors the temperature of a treatment area in real time, adjusts energy output in a closed loop manner, and ensures the safety and effectiveness of 42-47 ℃ thermotherapy.
  6. 6. The system of claim 1, wherein the universal hyperthermia treatment of deep lesions (> 3 cm), hematological tumors, systemic infections, multiple metastases is achieved by multi-device multi-angle energy superposition using single or multiple carriers of any type, including but not limited to multi-device synergy, single device multi-output head, multi-device time-sharing irradiation, multi-device multi-angle energy superposition.
  7. 7. A fault imaging and targeted energy thermotherapy method based on an acousto-optic coupling functional film layer is characterized by comprising the following steps of 1, configuring the acousto-optic coupling functional film layer (film pasting, built-in, integration, coating, film plating, embedded and the like) in an arbitrary mode in an acousto-optic unit corresponding area of an arbitrary intelligent processing carrier, wherein the intelligent processing carrier at least comprises a unit capable of generating 20Hz-20kHz audio/vibration signals, a pickup unit capable of collecting echo signals, a unit capable of transmitting/receiving optical signals or positioning calibration signals, and a processor capable of executing signal processing and control; step 2, complete the whole-domain scanning of human tissues/body fluids through a scanning mechanism (comprising rotation, translation, arc swing, multi-device fixed array, human body movement, local limb movement and support device movement for carrying the human body) or a multi-device array, realize tomographic imaging by utilizing a membrane layer sound wave frequency conversion focusing function (a multi-stage resonant microcavity array, a single-stage frequency multiplication coefficient of 10-20, a film thickness of 0.5-5 μm and an air gap thickness of 1-10 μm), precisely locate a virus infection focus and an inflammation area (only aiming at pathological tissues and cells which are sensitive to 42-47 ℃ temperature heat), step 3, strictly and time-sharing imaging and treatment, closing an acoustic imaging channel before treatment, delivering any form of targeted energy to the focus/infection focus through the same physical area of the same membrane layer, wherein the targeted energy comprises light, laser, infrared, electromagnetism, radio frequency, microwave, ultrasound, plasma and energy forms capable of generating 42-47 ℃ local temperature heat effect, the method comprises the steps of stabilizing the temperature of a treatment area at 42-47 ℃ by a temperature control module in a non-contact or contact energy delivery mode, realizing the warm inactivation/apoptosis induction of lesion cells, carrying out delayed cooling after treatment, restarting an imaging channel to verify the treatment effect, and recording diagnosis and treatment data in the whole course, and carrying out global warm treatment on deep, blood, whole body or multiple lesions by adopting multi-equipment cooperation and energy superposition, wherein the realization method comprises the steps of multi-equipment cooperation, single-equipment multi-output head, multi-equipment time-sharing irradiation and multi-equipment multi-angle energy superposition, and the change of the film layer form, the carrier type, the treatment energy type and the applicable disease type does not deviate from the core protection scope of the invention.

Description

Tomography and targeted energy thermotherapy system and method based on acousto-optic coupling functional film layer Technical Field The invention relates to the technical fields of noninvasive medical imaging, acousto-optic coupling and targeted energy thermotherapy, in particular to an integrated system and method for realizing local thermotherapy at 42-47 ℃ by realizing tomography positioning of human tissues/body fluids through an acousto-optic coupling functional film layer and delivering targeted energy in any form to a focus/infection focus through the same film layer by depending on intelligent processing equipment with any acoustic and optical units, and is suitable for all pathological tissues and cells which are sensitive to 42-47 ℃ thermotherapy. Background The conventional intelligent terminal (such as a mobile phone, a tablet and the like) has no transmitting and receiving capability of medical ultrasonic frequency bands, and cannot realize integrated closed loop of deep tissue/body fluid imaging and targeted thermal therapy. Clinical and basic researches prove that the temperature of a lesion area is maintained at 42-47 ℃, so that cancer cells, virus-infected cells and abnormal proliferation cells can be effectively induced to apoptosis/inactivate, surrounding normal tissues are protected to the greatest extent, the 42-47 ℃ warming effect is proved to be effective to the cancer cells, the virus-infected cells and the abnormal proliferation cells, wherein clinical researches prove that the 42-45 ℃ can induce the apoptosis of breast cancer cells (references: int J Hyperthermia and 2022), the 43-47 ℃ can inactivate HIV-infected cells (references: J Virol and 2021), the warming effect is suitable for various diseases such as solid tumors, blood tumors (such as leukemia), virus infection (such as HIV), chronic inflammation and fibrosis lesions, and the prior art does not disclose a low-cost and popular diagnosis and treatment integrated scheme combining sound-light transmission imaging, flexible/integrated functional membrane layer, random targeting energy delivery and whole disease seed warming treatment. Disclosure of Invention System composition 1. Intelligent processing carrier The intelligent treatment carrier is at least provided with a unit capable of generating 20Hz-20kHz audio/vibration signals, a pickup unit capable of collecting echo signals, a unit capable of transmitting/receiving optical signals or positioning calibration signals, and a processor capable of performing signal processing and control, and the system can be adapted without modifying hardware, wherein the optical signals are mainly used for positioning calibration, are not necessary and can be replaced by other modes. 2. Film layer with acousto-optic coupling function The membrane layer is a core functional structure for realizing coupling delivery of acousto-optic imaging and targeted energy, and the existence forms comprise, but are not limited to, a flexible independent film, a hard composite membrane, a built-in, integrated and integrally formed structural layer when an intelligent treatment carrier leaves a factory, a coating, a film plating and a deposited film on the surface of the carrier, a functional film component embedded in a carrier shell, a probe and a lens cover, and a single-layer or multi-layer composite structure. Whether materials, processes, flexibility/hardness, assembly modes (film pasting/integration/built-in/coating), the acoustic frequency conversion/focusing, imaging signal conduction and targeted energy delivery functions of the invention are realized, namely the functions belong to the protection scope of the invention. The film layer at least comprises a coupling matching layer, an acoustic treatment layer, an optical/energy conduction layer and an acoustic/energy isolation layer, wherein the coupling matching layer is made of biocompatible materials (medical hydrophilic gel, optical resin and the like) and is used for realizing acoustic, optical and energy impedance matching and eliminating air loss, the acoustic treatment layer is a multistage resonant microcavity array, each stage of resonant cavity array is composed of a micron-sized film and an air gap, the thickness of the film is 0.5-5 mu m, the thickness of the air gap is 1-10 mu m, frequency multiplication is realized through film vibration, a 20Hz-20kHz low-frequency signal is multiplied to a 2MHz-10MHz medical ultrasonic frequency band, the single-stage frequency multiplication coefficient is 10-20, three-stage series connection can be realized to 1000-8000 frequency multiplication, acoustic collimation, focusing and transmission are realized, the echo can be collected by a sound pickup unit after echo frequency reduction, the echo signal to noise ratio is more than or equal to 15dB, the optical/energy conduction layer is used for conducting imaging optical signals, and meanwhile, the coupling and focusing delivery of any form of t