CN-121987213-A - Magnetic compatible atomic magnetometer load state magnetocardiogram detection system and method

CN121987213ACN 121987213 ACN121987213 ACN 121987213ACN-121987213-A

Abstract

The invention discloses a magnetic compatible atomic magnetometer load state magnetocardiogram detection system and a method, and belongs to the technical field of biomedical engineering and weak magnetic field measurement. The system comprises a magnetic shielding device, an SERF atomic magnetometer array, a magnetic compatible load applying device, a data acquisition and magnetocardiogram generating module. The magnetic compatible load applying device comprises a fluid pressure remote transmission structure formed by a non-magnetic elastic capsule body, a non-metal impulse pipe and an external pressure detection unit, and the holding force of a subject is conducted to the outside of the shielding device in a non-magnetic mode. When the method is implemented, the maximum grip strength of a subject is measured and a target load interval is set, after the subject enters the shielding device, a resting state magnetocardiogram base line is collected, the subject continuously holds the non-magnetic elastic capsule body to perform isometric contraction movement, and when the pressure is stabilized in the target load interval, the collection of load state magnetocardiogram signals is automatically triggered. The invention realizes the real-time load state magnetocardiography imaging which is completely compatible with the high-sensitivity atomic magnetometer for the first time.

Inventors

ZHENG SHIQIANG
He yaxing
WANG YANMEI
XIANG MIN
ZHANG XU

Assignees

北京航空航天大学

Dates

Publication Date: 20260508
Application Date: 20260401

Claims (10)

1. A magnetic compatible atomic magnetometer load state magnetocardiogram detection system is characterized by comprising a magnetic shielding device, a SERF atomic magnetometer array, a magnetic compatible load applying device and a data acquisition and magnetocardiogram generation module, wherein, The magnetic shielding device is used for shielding an environmental magnetic field, and the SERF atomic magnetometer array is arranged in the magnetic shielding device and is used for measuring a magnetocardiogram signal of a subject; The magnetic compatible load applying device is used for applying quantifiable and electromagnetic interference-free mechanical load to the interior of the magnetic shielding device by a subject and comprises a non-magnetic elastic bag body, a non-metal impulse pipe and a pressure detection unit, wherein the non-magnetic elastic bag body is arranged in the magnetic shielding device, the non-metal impulse pipe extends to the exterior through a communication channel of the magnetic shielding device, and the pressure detection unit is arranged outside the magnetic shielding device; The data acquisition and magnetocardiogram generation module is connected with the SERF atomic magnetometer array and the pressure detection unit and is used for synchronously acquiring magnetocardiogram signals and pressure signals and processing the magnetocardiogram signals to generate magnetocardiogram.
2. The magnetic compatible atomic magnetometer load state heart magnetic detection system according to claim 1 is characterized in that the non-metal impulse pipe is a hard polyurethane pipe or a polyvinyl chloride pipe, and the non-magnetic elastic capsule is formed by integrally molding medical grade silica gel or rubber.
3. The system of claim 1, further comprising a non-magnetic bed for carrying a subject and being movable along a track to a detection region of the magnetic shielding device, wherein the non-metallic impulse piping extends outside the magnetic shielding device through a predetermined channel on the non-magnetic bed.
4. The system of claim 1, further comprising a remote non-magnetic blood pressure monitoring module comprising a non-magnetic blood pressure cuff for wearing on a non-force-applying side arm of a subject, an elongated airway passing through the magnetic shielding device, and an inflation-blood pressure monitoring unit disposed outside the magnetic shielding device for performing intermittent blood pressure measurements during loading.
5. The load state magnetocardiogram detection system of the magnetic compatible atomic magnetometer according to claim 1, further comprising a load closed loop feedback module, wherein the load closed loop feedback module comprises a nonmagnetic audio terminal arranged in the magnetic shielding device and a voice command system arranged outside the magnetic shielding device, the nonmagnetic audio terminal is connected with a sounding unit of the voice command system through an air conduit, and the voice command system is configured to generate and send a voice command for guiding a subject to adjust the force application to the nonmagnetic audio terminal according to a real-time pressure value output by the pressure detection unit.
6. The system of claim 5, wherein the non-magnetic audio terminal is an air-conduction earphone which transmits sound signals through an air conduit, and no current enters the magnetic shielding device.
7. The system of claim 1, wherein the data acquisition and magnetocardiogram generation module is configured to monitor the pressure signal output by the pressure detection unit in real time, and automatically trigger recording of the magnetocardiogram signals of the SERF atomic magnetometer array when the pressure signal is determined to be continuously in a preset target load interval and the duration exceeds a preset time threshold.
8. The magnetic compatible atomic magnetometer load state heart magnetic detection system according to claim 1 is characterized in that pressure transmission media filled in the nonmetallic pressure guide pipeline are air or nonmagnetic liquid, and a mechanical pressure release valve made of all plastic materials is further arranged in the pressure transmission channel.
9. A method for detecting load state magnetocardiogram of a magnetically compatible atomic magnetometer, applied to the system of any one of claims 1 to 8, comprising the steps of: Step S1, pressure calibration and test, namely determining the maximum grip strength value of a subject, and setting a target load interval based on the maximum grip strength value; step S2, preparing and positioning, namely enabling a subject to enter the magnetic shielding device, holding the nonmagnetic elastic capsule body by one hand, wearing the nonmagnetic blood pressure cuff on the arm at the other side, and positioning the SERF atomic magnetometer array above the chest of the subject; S3, collecting a resting baseline, namely collecting resting state magnetocardiogram signals as a baseline under the resting state of the subject; Step S4, load induction, namely applying acting force to the nonmagnetic elastic capsule by a subject to perform isometric contraction; S5, synchronously collecting, namely synchronously monitoring a pressure signal and a magnetocardiogram signal by the data collecting and magnetocardiogram generating module, and triggering and recording a load state magnetocardiogram signal when the pressure signal is stabilized in the target load interval; s6, safety monitoring, namely intermittently measuring the blood pressure of the subject by using the remote non-magnetic blood pressure monitoring module in the loading process; And S7, processing and analyzing the acquired load state magnetocardiogram signals to generate a load state magnetocardiogram, and comparing and analyzing the load state magnetocardiogram with the rest state baseline.
10. The method according to claim 9, wherein in step S6, the stress test is terminated when the blood pressure exceeds a safety threshold or the subject reports discomfort.

Description

Magnetic compatible atomic magnetometer load state magnetocardiogram detection system and method Technical Field The invention belongs to the technical field of biomedical engineering and weak magnetic field measurement, and particularly relates to heart magnetic field measurement auxiliary equipment and method based on Spin-Exchange Relaxation-Free (SERF) atomic magnetometer, in particular to a load state magnetocardiogram detection system and method of a magnetically compatible atomic magnetometer. Background Magnetocardiography (Magnetocardiography, MCG) is an important technique to assess cardiac function by noninvasively measuring the weak magnetic fields generated by the electrophysiological activity of the heart. Compared with an electrocardiogram, the MCG has higher spatial resolution and diagnosis sensitivity, and the signal of the MCG is not influenced by the conductivity difference of human tissues, so that the MCG has unique advantages in early diagnosis of cardiovascular diseases such as coronary heart disease, myocardial ischemia and the like. In recent years, atomic magnetometers based on the SERF principle have evolved rapidly. The sensitivity of the magnetic resonance type magnetic resonance system reaches or even exceeds that of a traditional superconducting quantum interferometer (Superconducting Quantum INTERFERENCE DEVICE, SQUID), liquid helium cooling is not needed, the manufacturing cost and the operation and maintenance cost are greatly reduced, and the magnetic resonance type magnetic resonance system becomes a core sensor of a new generation of magnetic resonance measurement system. The prior art (such as Chinese patent publication No. CN 109998519B) has realized the use of SERF atomic magnetometer arrays for high sensitivity, close-fitting magnetocardiogram detection in a magnetically shielded environment. However, for patients with underlying coronary artery disease, the myocardial blood supply may be normal due to the compensatory mechanisms that the heart often has in its resting state, resulting in insufficient diagnostic sensitivity of the resting state magnetocardiogram. In clinical diagnosis, it is often necessary to increase cardiac oxygen consumption by stress tests (e.g., exercise) to induce a detectable manifestation of myocardial ischemia. Conventional physical exercise load devices (e.g., treadmills, grip gauges) typically include motors, metallic members, and electromagnetic components that produce intense electromagnetic interference during operation, which is fundamentally in conflict with the extremely low noise, high shielding measurement environment necessary for a SERF atomic magnetometer. Although the drug loading method can avoid motion and electromagnetic interference, the drug loading method is non-physiological, inflexible to regulate and control and has safety risks. In order to avoid interference, the prior art can only adopt a compromise mode of 'measurement after load', namely, a subject rapidly enters into a room for measurement after finishing movement outside a shielding room. This mode cannot capture the magnetocardiogram signal in the peak period of motion load (key window most easily appearing in myocardial ischemia), seriously impairing the real-time and sensitivity of diagnosis. Therefore, how to design a system which can apply quantifiable and physiological motion load and is completely compatible with an atomic magnetometer measuring environment with extremely high sensitivity, and realize safe, real-time and high signal-to-noise ratio load state magnetocardiography, has become a key technical bottleneck to be broken through in the field. Disclosure of Invention In order to solve the technical problems, the invention provides a magnetic compatible atomic magnetometer load state magnetocardiogram detection system and a magnetic compatible atomic magnetometer load state magnetocardiogram detection method, which are characterized in that a unique magnetic compatible load applying device is formed by a non-magnetic elastic capsule body arranged in a shield, a non-metal impulse pipe extending to the outside of the shield and an external pressure detection unit, so as to form a fluid pressure remote transmission structure. The system can conduct the grip strength isometric contraction load of a subject to external quantification without magnetic interference, combines remote non-magnetic blood pressure monitoring and voice closed-loop feedback, and realizes the synchronous acquisition and imaging of the real-time load state magnetocardiogram signals with high signal-to-noise ratio on the premise of ensuring safety. In order to achieve the above purpose, the invention adopts the following technical scheme: The invention provides a magnetic-compatible atomic magnetometer load state magnetocardiogram detection system which mainly comprises a magnetic shielding device, a SERF atomic magnetometer array, a magnetic-compatible load applying device and a d