CN-121987333-A - Energy control method applied to radio frequency ablation control system

CN121987333ACN 121987333 ACN121987333 ACN 121987333ACN-121987333-A

Abstract

The application provides an energy control method applied to a radio frequency ablation control system, and relates to the technical field of instrument control. The system comprises radio frequency ablation equipment, a catheter and an ablation device, wherein the radio frequency ablation equipment is electrically connected with the catheter, the ablation device is arranged on the catheter, the radio frequency ablation equipment supplies ablation energy to the ablation device through the catheter, the method comprises the steps of determining an ablation position based on selection information of a user through the radio frequency ablation equipment, controlling the ablation device to move into a target area corresponding to the ablation position through the catheter, determining a blood flow index of the target area where the ablation device is located through the radio frequency ablation equipment, adjusting output power of the ablation device according to the blood flow index through the radio frequency ablation equipment and combining a preset segmentation control strategy, wherein the segmentation control strategy comprises a pre-test strategy, a heating strategy, a control strategy and a maintenance strategy, and working based on the output power through the ablation device.

Inventors

GUO JIULIN
WANG YAN
HUANG HANLI
HU HONGYU

Assignees

上海魅丽纬叶医疗科技股份公司

Dates

Publication Date: 20260508
Application Date: 20260410

Claims (18)

1. An energy control method applied to a radio frequency ablation control system is characterized in that the system comprises a radio frequency ablation device, a catheter and an ablation device; The radio frequency ablation device is electrically connected with the catheter, the ablation device is arranged on the catheter, and the radio frequency ablation device provides ablation energy to the ablation device through the catheter; The method comprises the following steps: determining an ablation position based on selection information of a user through the radio frequency ablation equipment, wherein the ablation position is a working position of the radio frequency ablation control system; Controlling the ablation device to move into a target area corresponding to the ablation position through the catheter; determining a blood flow index of the target area where the ablation device is located through the radio frequency ablation equipment; Adjusting the output power of the ablation device by the radio frequency ablation equipment according to the blood flow index and combining with a preset segmentation control strategy, wherein the segmentation control strategy comprises a pre-test strategy, a heating strategy, a control strategy and a maintenance strategy; and operating based on the output power by the ablation device.
2. The method of claim 1, wherein said determining, by said radio frequency ablation device, a blood flow index of said target region where said ablation device is located, comprises: Determining, by the radio frequency ablation device, a temperature rise rate index within the target region; Determining, by the radio frequency ablation device, a temperature uniformity index of the ablation device; determining, by the radio frequency ablation device, an impedance variation index based on an impedance characteristic of the ablation device; And determining, by the radio frequency ablation device, the blood flow index of the target region where the ablation device is located based on the temperature rise rate index, the impedance change index and the temperature uniformity index.
3. The method of claim 2, wherein the rate of temperature rise index is: ; Wherein, the Is the temperature variation in 0-a seconds, Is the temperature rise rate index; ; Wherein, the For a current temperature of tissue at the ablation site contacted by the ablation device, An initial temperature of tissue at the ablation site contacted by the ablation device; ; Wherein, the For effective convective heat transfer coefficients, positively correlated to blood flow velocity, For the power input rate of the ablation device, The energy absorption efficiency is 0 to less than or equal to ≤1, For the mass of tissue contacted by the ablation device, In order to organize the specific heat capacity, Is the ambient temperature of the target area.
4. The method of claim 2, wherein the impedance change index is: ; Wherein, the For the index of change in the impedance, For a baseline impedance before activation of the ablation device, The current impedance after b seconds for the ablation device to be activated.
5. The method of claim 2, wherein the temperature uniformity index comprises: ; Wherein, the In order to be an index of the temperature uniformity, For the standard deviation of the temperature of the plurality of electrodes in the ablation device, Is the average temperature of a plurality of electrodes in the ablation device.
6. The method of claim 2, wherein the determining, by the radio frequency ablation device, the blood flow index of the target region where the ablation device is located based on the temperature rise rate index, the impedance change index, and the temperature uniformity index comprises: respectively carrying out normalization processing on the temperature rise rate index, the impedance change index and the temperature uniformity index through the radio frequency ablation equipment to obtain a temperature rise rate mapping function, an impedance change mapping function and a temperature uniformity mapping function; determining, by the radio frequency ablation device, a plurality of weight coefficients based on machine learning training; And determining, by the radio frequency ablation device, the blood flow index of the target region where the ablation device is located based on a plurality of the weight coefficients, the temperature rise rate mapping function, the impedance change mapping function, the temperature uniformity mapping function and a preset position correction coefficient.
7. The method of claim 6, wherein the blood flow index comprises: ; Wherein, the As a result of the blood flow index, Is the weight coefficient, and , For the rate of temperature rise mapping function, For the impedance change mapping function, For the temperature uniformity mapping function, And correcting the coefficient for the position.
8. The method according to any one of claims 1-7, wherein said adjusting, by the radio frequency ablation device, the output power of the ablation device in accordance with the blood flow index in combination with a preset segment control strategy comprises: determining an adjustment strategy of each gain parameter based on the blood flow index by the radio frequency ablation equipment to obtain a gain parameter set; Determining, by the radio frequency ablation device, a power control algorithm based on the blood flow index and the set of gain parameters; and adjusting the output power of the ablation device by the radio frequency ablation equipment based on the power control algorithm and combining with a preset segmentation control strategy.
9. The method of claim 8, wherein the power control algorithm comprises: ; Wherein, the In order for the power control algorithm to be described, In order to achieve a proportional gain, In order to integrate the gain, In order to differentiate the gain of the gain, For the temperature difference between the current temperature of the ablation device and the target temperature, Is the integral of the temperature difference, Is the differential of the temperature difference, Is an adaptive power value.
10. The method of claim 8, wherein, in the case where the segment control strategy is the pre-test strategy, the adjusting, by the radio frequency ablation device, the output power of the ablation device based on the power control algorithm in combination with a preset segment control strategy includes: determining, by the radio frequency ablation device, an initial set of gain parameters for the ablation device based on the blood flow index and a pre-test power; a first output power of the ablation device is determined by the radio frequency ablation device based on the initial set of gain parameters and the power control algorithm.
11. The method of claim 8, wherein the segment control strategy is switched from the pre-test strategy to the warming strategy when a first preset condition is met by time and/or temperature, and wherein the adjusting the output power of the ablation device by the radio frequency ablation device based on the power control algorithm in combination with the preset segment control strategy comprises: Determining, by the radio frequency ablation device, a periodically updated first updated blood flow index under the warming strategy; Determining, by the radio frequency ablation device, a second output power of the ablation device in conjunction with the power control algorithm based on the first updated blood flow index.
12. The method of claim 8, wherein the segment control strategy is switched from the warming strategy to the control strategy when a second preset condition is met by time and/or temperature, wherein the adjusting the output power of the ablation device by the radio frequency ablation device based on the power control algorithm in combination with the preset segment control strategy comprises: Determining, by the radio frequency ablation device, a second updated blood flow index of the periodic updates under the control strategy; determining, by the radio frequency ablation device, a third output power of the ablation device in combination with the power control algorithm based on the second updated blood flow index; And carrying out attenuation processing based on the power control algorithm under the condition that the temperature of the ablation device is greater than or equal to the attenuation temperature corresponding to the target temperature by the radio frequency ablation equipment, so as to obtain attenuation power.
13. The method of claim 8, wherein the segment control strategy is switched from the control strategy to the maintenance strategy when a fourth preset condition is met, wherein the adjusting the output power of the ablation device by the radio frequency ablation device based on the power control algorithm in combination with the preset segment control strategy comprises: determining, by the radio frequency ablation device, a third updated blood flow index within a temperature range corresponding to a target temperature of the ablation device; And determining, by the radio frequency ablation device, a fourth output power of the ablation device in combination with the power control algorithm based on the third updated blood flow index.
14. The method of claim 8, wherein the method further comprises: and setting a corresponding power upper limit value for each segment control strategy through the radio frequency ablation equipment.
15. The method of claim 8, wherein the method further comprises: Monitoring, by the radio frequency ablation device, a rate of change of the blood flow index; and adjusting the output power by the radio frequency ablation equipment under the condition that the change rate is larger than or equal to a preset change rate threshold value.
16. The method of any one of claims 1-7, wherein the radio frequency ablation device has a display unit disposed therein, the method further comprising: Receiving the selection information generated by user interaction and modification information generated by user interaction in an ablation process through the display unit; And adjusting the output power based on the modification information through a radio frequency ablation device.
17. The method of any one of claims 1-7, wherein the ablation site includes at least a proximal trunk, a distal trunk, and a primary branch of a target artery of the target body.
18. The method of claim 17, wherein the target artery is at least one of a renal artery, a hepatic artery, and a pulmonary artery.

Description

Energy control method applied to radio frequency ablation control system Technical Field The application relates to the technical field of instrument control, in particular to an energy control method applied to a radio frequency ablation control system. Background Renal Denervation (RDN) ablates the sympathetic nerve fibers of the adventitia of the renal artery by radiofrequency energy, and has become an effective means of treating refractory hypertension. However, the prior RDN products are mainly designed for patients with refractory hypertension with normal or slightly impaired renal function, and the technical scheme has the key limitation that Chronic Kidney Disease (CKD) patients, particularly moderately severe patients with eGFR <40 mL/min/1.73m2 (which means that the patients are in the late G3b phase or enter the G4 phase, which indicates that the filtration function of the kidneys is impaired to a more serious degree), are frequently accompanied by renal atherosclerosis, such as reduced vascular compliance, stiff tube walls, occurrence rate of Renal Artery Stenosis (RAS) in the CKD patients is as high as 20-40%, and blood flow dynamics abnormality, such as reduced renal blood flow, great blood flow velocity variation and the like. Existing RDN systems can only monitor temperature and impedance, and cannot sense local blood flow conditions. The method has the advantages of uncontrollable ablation depth, rapid heat removal at high blood flow speed, insufficient ablation at actual tissue temperature lower than a set value, and safety risk, and possible arterial intima injury, thrombus formation and the like due to local heat accumulation at low blood flow or blood flow stagnation. Moreover, existing RDN systems employ fixed parameter PID control or simple power limitations, without consideration of anatomical location differences, individual blood flow variations, and the effects of pathological conditions, such simple control strategies are particularly dangerous in CKD patients because vascular lesions can lead to highly unpredictable blood flow patterns. Thus, current RDN systems are less effective and less safe to ablate and cannot be used to effectively treat chronic kidney disease patients. Disclosure of Invention In view of the above, an objective of the embodiments of the present application is to provide an energy control method applied to a radio frequency ablation control system, so as to solve the problems of poor effect and low safety when an RDN system in the prior art is used for ablation. In order to solve the problems, in a first aspect, an embodiment of the present application provides an energy control method applied to a radio frequency ablation control system, the system including a radio frequency ablation device, a catheter, and an ablation apparatus; The radio frequency ablation device is electrically connected with the catheter, the ablation device is arranged on the catheter, and the radio frequency ablation device provides ablation energy to the ablation device through the catheter; The method comprises the following steps: determining an ablation position based on selection information of a user through the radio frequency ablation equipment, wherein the ablation position is a working position of the radio frequency ablation control system; Controlling the ablation device to move into a target area corresponding to the ablation position through the catheter; determining a blood flow index of the target area where the ablation device is located through the radio frequency ablation equipment; Adjusting the output power of the ablation device by the radio frequency ablation equipment according to the blood flow index and combining with a preset segmentation control strategy, wherein the segmentation control strategy comprises a pre-test strategy, a heating strategy, a control strategy and a maintenance strategy; and operating based on the output power by the ablation device. In the implementation process, the ablation position during working can be determined according to the selection information of the user, so that the ablation device is controlled to move into a target area corresponding to the proper ablation position to perform the ablation work based on actual requirements. In addition, in order to achieve a better ablation effect, the radio frequency ablation device can determine a blood flow index reflecting the actual blood flow condition in a target area where the ablation device is located, so that the output power of the ablation device is adjusted and controlled in real time based on the blood flow index in combination with a plurality of preset different segmentation control strategies, and the ablation device can perform corresponding ablation work based on the output power controlled in real time. The method can quantify the influence of blood flow on ablation work, dynamically adjusts the output power of the ablation device based on the actual blood flow in