Search

CN-121987419-A - Thermoelectric gel dressing for recovery detection of diabetic wound surface and application thereof

CN121987419ACN 121987419 ACN121987419 ACN 121987419ACN-121987419-A

Abstract

The invention relates to a thermoelectric gel dressing for recovery detection of diabetic wounds and application thereof, wherein the thermoelectric gel dressing comprises a high-elasticity ion thermoelectric gel layer which is formed by a high-molecular elastomer and an ionic liquid through physical crosslinking or chemical crosslinking and has a three-dimensional network structure, the high-elasticity ion thermoelectric gel layer can generate thermoelectric voltage in response to temperature difference at two ends, meanwhile, the resistance value of the high-elasticity ion thermoelectric gel layer can be changed along with stretching/compression deformation of the high-elasticity ion thermoelectric gel layer, and a plurality of electrodes are arranged on the surface of the high-elasticity ion thermoelectric gel layer. The thermal electric gel dressing prepared by the invention has the advantages that the breaking elongation rate can reach 920%, the ion Seebeck coefficient is stable after stretching, the thermal electric gel dressing has the functions of thermal electric and strain sensing, two key parameters of wound temperature and deformation can be obtained simultaneously, more comprehensive wound healing information is provided, the ion thermal electric effect is utilized, the temperature monitoring can be realized without an external power supply, and the problem of continuous voyage of the traditional sensor is solved.

Inventors

  • LIU XUANYONG
  • CHEN YANQI
  • SUN TINGTING

Assignees

  • 东华大学

Dates

Publication Date
20260508
Application Date
20260324

Claims (10)

  1. 1. A thermoelectric gel dressing for recovery detection of a diabetic wound surface is characterized by comprising a high-elasticity ion thermoelectric gel layer which is formed by a high-molecular elastomer and an ionic liquid through physical crosslinking or chemical crosslinking and has a three-dimensional network structure, wherein the high-elasticity ion thermoelectric gel layer generates thermoelectric voltage in response to temperature difference at two ends, meanwhile, the resistance value of the high-elasticity ion thermoelectric gel layer changes along with stretching/compression deformation of the high-elasticity ion thermoelectric gel layer, and a plurality of electrodes are arranged on the surface of the high-elasticity ion thermoelectric gel layer.
  2. 2. The thermoelectric gel dressing for diabetic wound recovery detection according to claim 1, wherein the resistance value of the high-elasticity ion thermoelectric gel layer is detected by a wire connection signal processing and transmission module, thereby reflecting the deformation of the wound.
  3. 3. The thermoelectric gel dressing for diabetic wound healing detection according to claim 1, wherein the high molecular elastomer comprises any one of styrene-isoprene-styrene block copolymer, styrene-ethylene-butylene-styrene, or polyurethane elastomer.
  4. 4. The thermoelectric gel dressing for wound restoration detection of diabetes mellitus according to claim 1, wherein the ionic liquid comprises at least one of 1-ethyl-3-methylimidazole chloride salt, 1-ethyl-3-methylimidazole acetate salt, 1-ethyl-3-methylimidazole tetrafluoroborate salt, and 1-ethyl-3-methylimidazole bistrifluoromethanesulfonimide salt.
  5. 5. The thermoelectric gel dressing for recovery detection of diabetic wound according to claim 1, wherein the electrode is a copper foil electrode or a silver paste electrode, adhered to both ends of the highly elastic ionic thermoelectric gel layer.
  6. 6. The thermoelectric gel dressing for wound restoration detection of diabetes mellitus according to claim 1, wherein the preparation method of the high-elasticity ion thermoelectric gel layer comprises the following steps: 1) Mixing the high polymer elastomer with an organic solvent, and stirring under a sealing condition to obtain a polymer solution; 2) Adding the ionic liquid into the polymer solution obtained in the step 1), and continuing stirring under a sealing condition to obtain a mixture solution; 3) And (3) pouring the mixture solution obtained in the step (2) into a mold after ultrasonic defoaming, and obtaining the high-elasticity ionic thermoelectric gel layer after solvent volatilization and drying treatment.
  7. 7. The thermoelectric gel dressing for wound healing detection according to claim 6, wherein the ionic liquid in the step 2) accounts for 20-80% of the total mass of the highly elastic ionic thermoelectric gel layer.
  8. 8. The thermoelectric gel dressing for wound restoration detection according to claim 6, wherein the ultrasonic time in the step 3) is 20-30min, the drying temperature is 50-70 ℃, and the drying time is 4-6h.
  9. 9. Use of the thermoelectric gel dressing of claim 1 in monitoring diabetic wound recovery conditions, comprising: (1) Attaching the thermoelectric gel dressing to a diabetic wound surface, so that the high-elasticity ion thermoelectric gel layer is in contact with the wound surface; (2) The two ends of the electrode on the surface of the high-elasticity ion thermoelectric gel layer are connected with signal processing and transmission modules, and thermoelectric signals generated by wound temperature change and gel layer resistance change signals caused by wound swelling or shrinkage are continuously collected; (3) And judging the infection state or healing stage of the wound surface based on the change trend of the signal output by the thermoelectric gel dressing.
  10. 10. The method according to claim 9, wherein the step of determining the infection state or healing stage of the wound surface comprises determining that there is a risk of infection when the temperature of the wound surface is monitored to be continuously higher than the set threshold value of the surrounding normal tissue temperature, and determining that the wound surface enters the healing stage when the temperature of the wound surface is monitored to be gradually reduced and stabilized.

Description

Thermoelectric gel dressing for recovery detection of diabetic wound surface and application thereof Technical Field The invention belongs to the technical field of medical instruments and medical materials, and particularly relates to a thermoelectric gel dressing for recovery detection of diabetic wounds and application thereof. Background Chronic wounds, such as diabetic foot ulcers, venous leg ulcers, and pressure injuries (decubitus ulcers), are serious challenges facing the world public health. Diabetic foot ulcers are one of the serious complications of diabetes, and according to the latest statistics of IDF, more than 5 million adults worldwide suffer from diabetes, of which about 30% of patients develop diabetic foot ulcers during their lifetime, which is the leading cause of non-traumatic amputation of the diabetic patient. Because of neuropathy and vascular lesions, diabetic wounds heal slowly, are extremely susceptible to infection, and patients are slow in pain sensation and cannot timely perceive signs of infection. At present, the clinical monitoring of the wound surface mainly depends on frequent dressing replacement and naked eye observation and palpation of medical staff, the method is high in subjectivity, cannot be used for real-time continuous monitoring, and frequent dressing replacement can increase pain of patients, medical cost and risk of secondary infection. In the prior art, some "smart dressings" have emerged that integrate sensors. For example, conventional rigid or semi-flexible temperature sensors (e.g., thermocouples, thermistors) are integrated into the dressing. However, these sensors are generally not capable of achieving a fit with a soft, irregular human wound, may stress the wound, cause secondary damage, and are less comfortable. In addition, these sensors often require an external power source to power, making the system cumbersome and inconvenient to wear for extended periods of time. The ion thermoelectric gel is an emerging flexible thermoelectric material, and can directly convert the temperature difference at two ends into electric energy to realize self-powered temperature sensing. Meanwhile, the components of the material can be regulated and controlled to have high elasticity so as to adapt to the deformation of human tissues. However, no report on the successful integration of the high-elasticity ion thermoelectric gel into the medical dressing and the simultaneous monitoring of the temperature change and deformation state of the diabetic wound surface to realize the real-time and noninvasive diagnosis of the wound surface recovery condition is currently available. Disclosure of Invention The invention aims to solve the technical problem of providing a thermoelectric gel dressing for recovery detection of a diabetic wound surface and application thereof, so as to realize real-time, continuous and noninvasive monitoring of the recovery condition of the diabetic wound surface. The invention provides a thermoelectric gel dressing for recovery detection of diabetic wounds, which comprises a high-elasticity ion thermoelectric gel layer with a three-dimensional network structure formed by physical crosslinking or chemical crosslinking of a high-molecular elastomer and an ionic liquid, wherein the high-elasticity ion thermoelectric gel layer can generate thermoelectric voltage in response to temperature difference at two ends, meanwhile, the resistance value of the high-elasticity ion thermoelectric gel layer can be changed along with stretching/compression deformation of the high-elasticity ion thermoelectric gel layer, and a plurality of electrodes are arranged on the surface of the high-elasticity ion thermoelectric gel layer. Preferably, the resistance value of the high-elasticity ion thermoelectric gel layer is detected through a wire connecting signal processing and transmission module, so that deformation of a wound surface is reflected. Further, the signal processing and transmission module includes, but is not limited to, any of a nanovoltameter, an electrochemical workstation, a flexible electronic test instrument, and a multimeter. Preferably, the polymeric elastomer includes, but is not limited to, any of styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene-butylene-styrene, or polyurethane elastomer. Preferably, the ionic liquid includes, but is not limited to, at least one of 1-ethyl-3-methylimidazole chloride salt (EMIMCl), 1-ethyl-3-methylimidazole acetate salt (EMIMOAC), 1-ethyl-3-methylimidazole tetrafluoroborate salt (EMIMBF 4), 1-ethyl-3-methylimidazole bistrifluoromethanesulfonimide salt (EMIMTFSI). Preferably, the electrodes are copper foil electrodes or silver paste electrodes, and are adhered to two ends of the high-elasticity ion thermoelectric gel layer. Preferably, the preparation method of the high-elasticity ionic thermoelectric gel layer comprises the following steps: 1) Mixing the high polymer elastomer with an organic sol