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CN-121987506-A - Tooth whitening gel and preparation method thereof

CN121987506ACN 121987506 ACN121987506 ACN 121987506ACN-121987506-A

Abstract

The invention belongs to the technical field of supermolecular gel, and relates to tooth whitening gel and a preparation method thereof, wherein the tooth whitening gel is prepared from the following raw materials of hydrogen peroxide aqueous solution, glycyrrhizic acid compounds, polyvinyl alcohol, carbomer, glycerol and water; the polyvinyl alcohol and the glycyrrhizic acid compound generate a first cross-linked network structure, the carbomer and the glycyrrhizic acid compound self-assemble to form a fibrous aggregate to form a second cross-linked network structure, and the second cross-linked network structure and the first cross-linked network structure cooperate to fix hydrogen peroxide molecules. The invention realizes the synergistic promotion of gel viscosity, stability and coating property of the hydrogen peroxide gel by constructing a double-network structure, the hydrogen peroxide concentration can be adjusted according to requirements, the storage time is long, the tooth whitening capability is strong, the potential leakage risk of the hydrogen peroxide solution in the storage, transportation and application processes is reduced, and the tooth whitening requirement of people is met.

Inventors

  • JIANG JIAN
  • SONG ANDONG
  • HONG YU
  • YUAN CHENHUAN
  • SUN HUI
  • JIANG YUQIAN

Assignees

  • 国家纳米科学中心

Dates

Publication Date
20260508
Application Date
20260120

Claims (10)

  1. 1. The tooth whitening gel is characterized by being prepared from the following raw materials: aqueous hydrogen peroxide, glycyrrhizic acid, polyvinyl alcohol, carbomer, glycerol and water; the polyvinyl alcohol and the glycyrrhizic acid compound generate a first cross-linked network structure, and the carbomer and the fiber aggregate formed by self-assembly of the glycyrrhizic acid compound form a second cross-linked network structure; the static viscosity of the tooth whitening gel is 500-800 Pa.s.
  2. 2. The tooth whitening gel according to claim 1, wherein the mass concentration of the aqueous hydrogen peroxide solution is 10% -50%, the mass of the aqueous hydrogen peroxide solution is 30% -70% of the total mass of the raw material, the glycyrrhizic acid compound is 1% -3% of the total mass of the raw material, the polyvinyl alcohol is 0.3% -1% of the total mass of the raw material, the carbomer is 0.5% -1% of the total mass of the raw material, the glycerol is 10% -20% of the total mass of the raw material, and the balance is water.
  3. 3. The tooth whitening gel according to claim 1 or 2, wherein the carbomer is at least one of carbomer 934, carbomer 940, carbomer 941.
  4. 4. The tooth whitening gel according to claim 1 or 2, wherein the glycyrrhizic acid compound is at least one of glycyrrhizic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, diammonium glycyrrhizinate, trisodium glycyrrhizinate, and glycyrrhetinic acid, preferably at least one of glycyrrhizic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, and diammonium glycyrrhizinate, and more preferably glycyrrhizic acid.
  5. 5. Tooth whitening gel according to claim 1 or 2, characterized in that the polyvinyl alcohol has an average molecular weight of 80000-200000, an alcoholysis degree of 80-99%, preferably an average molecular weight of 80000-120000, and an alcoholysis degree of 89-99%.
  6. 6. A tooth whitening gel according to claim 3, characterized in that it is prepared from the following raw materials in mass percent: 65% -70% of hydrogen peroxide aqueous solution, 2% of glycyrrhizic acid, 0.6% of polyvinyl alcohol, 1% of carbomer, 20% of glycerol and the balance of water; The mass concentration of the aqueous hydrogen peroxide solution is 25% -35%, the average molecular weight of the polyvinyl alcohol is 120000, the alcoholysis degree is 99%, and the carbomer is carbomer 940 or carbomer 941.
  7. 7. The tooth whitening gel according to claim 4, wherein the gel is prepared from the following raw materials in percentage by mass: 30% -40% of hydrogen peroxide aqueous solution, 2% of glycyrrhizic acid, 0.6% of polyvinyl alcohol, 1% of carbomer, 20% of glycerol and the balance of water; The mass concentration of the aqueous hydrogen peroxide solution is 25% -35%, the average molecular weight of the polyvinyl alcohol is 120000, the alcoholysis degree is 99%, and the carbomer is carbomer 940 or carbomer 941.
  8. 8. A method of preparing a tooth whitening gel according to any one of claims 1 to 7, comprising the steps of: (1) Adding carbomer into the hydrogen peroxide water solution at 20-40 ℃, and stirring and mixing to obtain a solution I; (2) Adding glycerol into the first solution at 20-40 ℃, and stirring and mixing to obtain a second solution; (3) Raising the temperature of the solution II to 40-50 ℃, adding a glycyrrhizic acid compound into the solution II, and stirring and mixing to obtain a solution III; (4) And adding polyvinyl alcohol into water at 80-110 ℃, stirring, mixing, cooling to normal temperature, adding into the solution III, vibrating, uniformly mixing, and standing.
  9. 9. The method for preparing a tooth whitening gel according to claim 8, wherein in the step (1), the stirring speed is 300-3000 r/min, the stirring time is 0.1-5 h, preferably the stirring speed is 600-2000 r/min, and the stirring time is 0.5-3 h; And/or in the step (2), the stirring speed is 300-3000 r/min, the stirring time is 0.5-5 h, preferably, the stirring speed is 600-2000 r/min, and the stirring time is 0.5-1 h.
  10. 10. The method for preparing a tooth whitening gel according to claim 8, wherein in the step (3), the stirring speed is 300-3000 r/min, the stirring time is 0.5-2 h, preferably the stirring speed is 600-1000 r/min, and the stirring time is 0.5-1 h; And/or in the step (4), the stirring speed is 300-3000 r/min, the stirring time is 0.1-1 h, preferably, the stirring speed is 600-1000 r/min, the stirring time is 0.5-0.5 h, and the standing time is 2-10 h.

Description

Tooth whitening gel and preparation method thereof Technical Field The invention belongs to the technical field of supermolecular gel, and relates to tooth whitening gel and a preparation method thereof. Background Hydrogen peroxide is a high-density strong oxidation liquid composed of hydrogen and oxygen, and the decomposition products are water and oxygen, so that the hydrogen peroxide becomes a research hot spot in the fields of oxidants, bleaching agents, bactericides and the like of various countries due to the characteristics of high energy, environment friendliness and the like, but the hydrogen peroxide liquid has the characteristics of strong oxidation, flammability, explosiveness, fluidity and the like, and if leakage exists in the application process, the hydrogen peroxide liquid can bring great risks. Gelation of hydrogen peroxide is beneficial to reducing the leakage risk of the liquid flow dynamic state of the hydrogen peroxide and increasing the safety coefficient during storage, transportation and application. The hydrogen peroxide breaks down to generate free radicals (OH), which attack macromolecular pigments (such as porphyrin rings) in the enamel, breaking them down into small molecule colorless substances. The low molecular weight property enables the enamel to be permeated by the enamel to reach 200-300 mu m, and the enamel is effective for deep staining (such as tetracycline teeth). The hydrogen peroxide gel is brushed onto the enamel by a special needle or soft hair to whiten the teeth. However, the existing hydrogen peroxide gel is used as a tooth whitening gel, and the whitening effect, viscosity and coating performance of the gel need to be further improved. Disclosure of Invention The invention aims to overcome the defects in the prior art and provides a tooth whitening gel and a preparation method thereof. In order to achieve the above purpose, the specific technical scheme is as follows: The invention provides a tooth whitening gel, which is prepared from the following raw materials: aqueous hydrogen peroxide, glycyrrhizic acid, polyvinyl alcohol, carbomer, glycerol and water; the polyvinyl alcohol and the glycyrrhizic acid compound generate a first cross-linked network structure, and the carbomer and the fiber aggregate formed by self-assembly of the glycyrrhizic acid compound form a second cross-linked network structure; the static viscosity of the tooth whitening gel is 500-800 Pa.s. The tooth whitening gel disclosed by the invention forms a first cross-linked network structure with a glycyrrhizic acid compound under the action of a non-covalent bond through the polyvinyl alcohol, an acrylic skeleton in a carbomer molecular structure can form a second cross-linked network structure with free hydroxyl and carboxyl on the surface of a glycyrrhizic acid fibrous aggregate through hydrogen bond and electrostatic interaction, and the network and the polyvinyl alcohol-glycyrrhizic acid hydrogen bond network generate synergistic fixation of hydrogen peroxide molecules so as to enable the hydrogen peroxide molecules to be released slowly, so that a better tooth bleaching effect is achieved. The invention also improves the static viscosity of the gel through the synergistic effect of the second crosslinked network structure and the first crosslinked network structure, shows more excellent thixotropic recovery performance under the action of shearing force, has good coating performance in the test of the coating performance, can form a uniform and continuous film layer after being coated on the surface of a base material such as skin, metal and the like, has no sagging and flaking phenomena, and further ensures the wettability of the gel by adding glycerol. Further, the mass concentration of the aqueous hydrogen peroxide solution is 10% -50%, the mass of the aqueous hydrogen peroxide solution is 30% -70% of the total mass of the raw materials, the glycyrrhizic acid compound is 1% -3% of the total mass of the raw materials, the polyvinyl alcohol is 0.3% -1% of the total mass of the raw materials, the carbomer is 0.5% -1% of the total mass of the raw materials, the glycerol is 10% -20% of the total mass of the raw materials, and the balance is water. The raw material composition of the invention can better construct a double-network structure, and realizes the cooperative promotion of gel viscosity, stability and coating property. Further, the carbomer is at least one of carbomer 934, carbomer 940 and carbomer 941. Further, the glycyrrhizic acid compound is at least one of glycyrrhizic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, diammonium glycyrrhizinate, trisodium glycyrrhizinate and glycyrrhetinic acid, preferably at least one of glycyrrhizic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate and diammonium glycyrrhizinate, and more preferably glycyrrhizic acid. The glycyrrhizic acid compound can be self-assembled into a fibrous aggregate in a weak acid hydro