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CN-121987508-A - Toothpaste containing nano calcium polyphosphate and having repairing effect and preparation method thereof

CN121987508ACN 121987508 ACN121987508 ACN 121987508ACN-121987508-A

Abstract

The invention discloses a toothpaste containing nano calcium polyphosphate and having a repairing effect and a preparation method thereof. The toothpaste comprises the following components, by mass, 5-15% of water, 55-75% of a polyol humectant, 0.2-1% of sodium carboxymethylcellulose, 2-8% of sodium lauryl sulfate, 15-20% of silicon dioxide, 0.01-0.4% of peppermint scent, 0.01-0.07% of a preservative and 0.01-0.1% of nano calcium polyphosphate. According to the invention, nano calcium polyphosphate is introduced into a toothpaste system, and the micro defects on the enamel surface can be effectively attached and actively repaired by utilizing the high specific surface activity and the biomimetic mineralization characteristic of the nano calcium polyphosphate. The toothpaste not only has the conventional cleaning function, but also can obviously reduce the surface roughness of teeth, restore microhardness and relieve dentin sensitivity, realizes daily active repair of hard tissues of teeth, and overcomes the defect of the existing toothpaste in the aspect of direct structural repair.

Inventors

  • ZHANG FUXI

Assignees

  • 索萃实业(上海)有限公司

Dates

Publication Date
20260508
Application Date
20260409

Claims (10)

  1. 1. A toothpaste containing nano calcium polyphosphate and having a repairing effect is characterized by comprising, by mass, 5-15% of water, 55-75% of a polyol humectant, 0.2-1% of sodium carboxymethylcellulose, 2-8% of sodium lauryl sulfate, 15-20% of silicon dioxide, 0.01-0.4% of peppermint fragrance, 0.01-0.07% of a preservative and 0.01-0.1% of nano calcium polyphosphate.
  2. 2. The nano calcium polyphosphate-containing toothpaste with repairing effect according to claim 1, wherein the polyol humectant is one or more of sorbitol, glycerin and xylitol.
  3. 3. The toothpaste with repairing effect containing nano calcium polyphosphate according to claim 1, wherein the preservative is one or more of 1, 2-hexanediol, 1, 2-pentanediol, p-hydroxyacetophenone, phenoxyethanol and ethylhexyl glycerol.
  4. 4. The nano calcium polyphosphate-containing toothpaste with repairing effect according to claim 1, wherein the preparation method of the nano calcium polyphosphate-containing toothpaste with repairing effect comprises the following steps: step 1, adding water, a polyol humectant and sodium carboxymethyl cellulose into an emulsifying pot, stirring and homogenizing uniformly, and heating to 50-55 ℃; And 2, starting vacuum, adding silicon dioxide under homogenization, keeping the temperature at 50-55 ℃, stirring, adding sodium laurylsulfate, cooling to 40 ℃, adding peppermint fragrance, preservative and nano calcium polyphosphate, stirring uniformly, and cooling to room temperature to obtain the toothpaste containing the nano calcium polyphosphate and having a repairing effect.
  5. 5. The method for preparing toothpaste with repairing effect comprising nano calcium polyphosphate according to claim 4, wherein the stirring and homogenizing speed in the step 1 is 1000-3000rpm for 10-30min.
  6. 6. The method for preparing a toothpaste with repairing effect comprising nano calcium polyphosphate according to claim 4, wherein the time of the thermal insulation stirring in the step 2 is 20-40min.
  7. 7. The method for preparing a toothpaste with repairing effect comprising nano calcium polyphosphate according to claim 4, wherein the cooling rate in the step 2 is 1-3 ℃ per min.
  8. 8. The method for preparing toothpaste with repairing effect comprising nano calcium polyphosphate according to claim 4, wherein the cooling in step 2 is achieved by a circulating water cooling system.
  9. 9. The method for preparing a toothpaste with a repairing effect comprising nano calcium polyphosphate according to claim 4, wherein the stirring speed is 500-1500rpm.
  10. 10. The method for preparing toothpaste with repairing effect containing nano calcium polyphosphate according to claim 4, wherein the whole process of the step 2 is performed under the condition that the vacuum degree is-0.05 to-0.09 MPa.

Description

Toothpaste containing nano calcium polyphosphate and having repairing effect and preparation method thereof Technical Field The invention relates to the technical field of oral care products, in particular to toothpaste containing nano calcium polyphosphate and having a repairing effect and a preparation method thereof. Background Teeth are a central goal of dentistry and daily care as non-renewable hard tissue organs of the human body, and their health and long-term maintenance are a central goal. Once erupted, the permanent teeth are exposed to various irreversible risks of injury, such as chewing wear, acid erosion, bacterial metabolite action, and the like, along with the life of a person. Thus, in addition to therapeutic intervention, daily preventive and health repair is particularly important. The toothpaste is used as the most popular and highest-frequency oral care carrier, and the function of the toothpaste is gradually developed from simple cleaning in early stage to a comprehensive care platform with multiple effects of caries prevention, allergy resistance, bacteriostasis, inflammation resistance, whitening and the like. This evolution is mainly due to the introduction of specific functional ingredients such as fluoride (e.g. sodium fluoride, sodium monofluorophosphate) which significantly reduce the incidence of caries by promoting enamel remineralization, potassium nitrate, strontium chloride and the like which serve to alleviate tooth sensitivity by blocking dentinal tubules or inhibiting nerve signals, triclosan, zinc citrate and the like which serve as antibacterial agents which assist in controlling plaque and gum inflammation, and in addition, a combination of various abrasives (e.g. silica, calcium carbonate) and surfactants (e.g. sodium lauryl sulfate) which ensure basic cleaning efficacy. Despite the remarkable success of the prior art toothpastes in the above-mentioned fields, there are still significant short plates for the active repair and structural reinforcement of the microdropy of the hard dental tissue (the main component being hydroxyapatite) caused by physical abrasion or acid etching. Disclosure of Invention Aiming at the problems, the invention provides the toothpaste containing nano calcium polyphosphate and having the repairing effect and the preparation method thereof, and solves the problem that the existing toothpaste lacks the function of repairing the microdefect of teeth. The invention can be realized by the following technical scheme: A toothpaste containing nanometer calcium polyphosphate with repairing effect comprises, by mass, 5-15% of water, 55-75% of a polyol humectant, 0.2-1% of sodium carboxymethylcellulose, 2-8% of sodium lauryl sulfate, 15-20% of silicon dioxide, 0.01-0.4% of peppermint scent, 0.01-0.07% of a preservative, and 0.01-0.1% of nanometer calcium polyphosphate. Preferably, the polyol humectant is one or more of sorbitol, glycerol and xylitol. Preferably, the preservative is one or more of 1, 2-hexanediol, 1, 2-pentanediol, p-hydroxyacetophenone, phenoxyethanol and ethylhexyl glycerol. A preparation method of toothpaste containing nano calcium polyphosphate and having repairing effect comprises the following steps: step 1, adding water, a polyol humectant and sodium carboxymethyl cellulose into an emulsifying pot, stirring and homogenizing uniformly, and heating to 50-55 ℃; And 2, starting vacuum, adding silicon dioxide under homogenization, keeping the temperature at 50-55 ℃, stirring, adding sodium laurylsulfate, cooling to 40 ℃, adding peppermint fragrance, preservative and nano calcium polyphosphate, stirring uniformly, and cooling to room temperature to obtain the toothpaste containing the nano calcium polyphosphate and having a repairing effect. Preferably, the stirring and homogenizing speed in the step 1 is 1000-3000rpm, and the time is 10-30min. Preferably, the time of the heat preservation and stirring in the step 2 is 20-40min. Preferably, the cooling rate in the step 2 is 1-3 ℃ per min. Preferably, the cooling in the step 2 is realized through a circulating water cooling system. Preferably, the stirring speed is 500-1500rpm. Preferably, the whole process of the step 2 is carried out under the condition that the vacuum degree is minus 0.05 to minus 0.09 MPa. The beneficial effects of the invention are as follows: According to the invention, nano calcium polyphosphate is introduced into a traditional toothpaste matrix as a core active ingredient, so that a novel toothpaste capable of actively repairing the microdefect of the hard tissue of the tooth is prepared. The toothpaste utilizes the high specific surface area and strong surface activity of the nano particles, so that the toothpaste can be closely adhered to the enamel surface and the interior of the microdefect, effectively induces the biomimetic mineralization process, and realizes structural restoration from 'filling in' to 'surface reconstruction' on the microscopic level o